Novel antitumor activities of Kushen flavonoids in vitro and in vivo

Phytotherapy Research

Volumn 21, Issue 3, 2007, Pages 269-277

  Sun, Mingyu ^a,b   Han, Jun ^a,b   Duan, Jifeng ^a   Cui, Yumin ^a   Wang, Tao ^a   Zhang, Weihan ^a   Liu, Wei ^a   Hong, Jianrong ^a   Yao, Minghui ^b   Xiong, Sidong ^b   Yan, Xiaoqiang ^a  

^a Hutchison Medipharma Ltd   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Antitumor activities; Kushen; Sophora flavescens Aiton

Indexed keywords

FLAVONOID; KUSHEN; PACLITAXEL; SOPHORA FLAVESCENS EXTRACT; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD CELL COUNT; CELL PROLIFERATION; CHINA; CONTROLLED STUDY; DRUG SCREENING; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PERIPHERAL CIRCULATION; TUMOR MODEL; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL PROLIFERATION; DRUGS, CHINESE HERBAL; HUMANS; MICE; MICE, INBRED ICR; PHYTOTHERAPY; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; TRANSPLANTATION, HETEROLOGOUS;

MURINAE; MUS; SOPHORA FLAVESCENS;

EID: 33947686806     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2066     Document Type: Article

References (37)

1. Bai H. 1996. Clinical observation of matrine injection in the treatment of middle and late stage cancers. Shenzhen Yi Xue Za Zhi 9: 33-34.
2. Bao LQ, Peng AM, Yuan HY. 2001. Clinic study on the role of hydroxycamptothecin and mateling postoperative arterial infusion in the prevention of recurrence after curative resection for human hepatocellular carcinoma. Zhong Liu Fang Zhi Yan Jiu Za Zhi 28: 303-305.
3. Bissery MC, Guenard D, Gueritte-Voegelein F, Lavelle F. 1991. Experimental antitumor activity of Taxotere (RP 56976, NSC 628503), a Taxol analogue. Cancer Res 51: 4845-4852.
4. Carmichael J, Mitchell JB, DeGraff WG et al. 1988. Chemosensitivity testing of human lung cancer cell lines using the MTT assay. Br J Cancer 57: 540-547.
5. Cheng H, Xia B, Zhang L et al. 2006. Matrine improves 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. Pharmacol Res 53: 202-208.
6. Cui HL, Wang YF, Li XL, Kang QX. 1993. Clinical observation of matrine injection in the treatment of 51 cases of various types of cancers. Shanxi Yi Xue Za Zhi 22: 232-233.
7. Ding PL, Chen DF, Kenneth FB, Alexander KN, Wang XH, Lee KH. 2004. Cytotoxic isoprenylated flavonoids from the roots of Sophora flavescens. Helv Chim Acta 87: 2574-2580.
8. Han J, Sun MY, Cui YM et al. 2006. Kushen flavonoids induce apoptosis in tumor cells by inhibition of NF-κB activation and multiple receptor tyrosine kinase activities. Phytother Res (in press).
9. Hu MJ, Zeng H, Wu YL et al. 2005. Synergistic effects of matrine and 5-fluorouracil on tumor growth of the implanted gastric cancer in nude mice. Chin J Dig Dis 6: 68-71.
10. Huang S, Li J, Zhu JL, Hu XL. 1997. Clinical observation on the efficacy of matrine injection in treating middle and late stage gastric cancer. Chin J Integr Trad Western Med 17: 364.
11. Kang TH, Jeong SJ, Ko WG et al. 2000. Cytotoxic lavandulyl flavanones from Sophora flavescens. J Nat Prod 63: 680-681.
12. Kong QZ, Huang T, Huang DS et al. 2003. Inhibitory effects of oxymatrine on angiogenesis of murine S180 sarcoma. Zhongguo Yao Shi Za Zhi 6: 769-771.
13. Kuroyanagi M, Arakawa T, Hirayama Y, Hayashi T. 1999. Antibacterial and antiandrogen flavonoids from Sophora flavescens. J Nat Prod 62: 1595-1599.
14. Lee CT, Wu S, Gabrilovich D et al. 1996. Antitumor effects of an adenovirus expressing antisense insulin-like growth factor I receptor on human lung cancer cell lines. Cancer Res 56: 3038-3041.
15. Li LJ, Chen ZQ, Zheng YY, Tang WX, Yu Y. 2003. In vitro effects of oxymatrine on human ovarian cancer cell SKOV-3. Shi Yong Zhong Liu Xue Za Zhi 17: 100-101.
16. Liu J, Zhu M, Shi R, Yang M. 2003. Radix Sophorae flavescentis for chronic hepatitis B: a systematic review of randomized trials. Am J Chin Med 31: 337-354.
17. Ma LT, Zhang Y, Wen SH, He YJ, Kang GF, Jiang JK. 2005. Experimental study of the antitumor effects of oxymatrine on murine H22 hepatoma. Chongqing Yi Ke Da Xue Xue Bao 30: 178-182.
18. Mao HS, Li C. 1996. Modulatory effects of matrine on phenotype and immunology of tumor cells. Zhongguo Zhong Liu Lin Chuang Za Zhi 23: 799-803.
19. Mei ZJ, Hong YK, Zhao SB et al. 1993. Clinical investigation of matrine injection in treating late stage cancers. Huaxi Yi Xue Za Zhi 8: 334.
20. Qin Z, Den H, Zhuang H. 1990. Effect of oxymatrine on prolonging the survival time of cardiac tissue allograft in mice and its immunologic mechanisms. Chin J Integr Trad Western Med 10: 99-100.
21. Ryu SY, Choi SU, Kim SK, No Z, Lee CO, Ahn JW. 1997. In vitro antitumour activity of flavonoids from Sophora flavescens. Phytother Res 11: 51-53.
22. Scaradavou A, Isola L, Rubinstein P et al. 1997. A murine model for human cord blood transplantation: near-term fetal and neonatal peripheral blood cells can achieve long-term bone marrow engraftment in sublethally irradiated adult recipients. Blood 89: 1089-1099.
23. Shi LH, Qiu YH. 2001. Clinical investigation of kosam combined with chemotherapy to treat advanced malignant tumor. Zhong Liu Xue Za Zhi 7: 95-97.
24. Wang Y. 1997. Research progress on chemical constituents, preparative separation and quality of Sophora flavescens. Zhong Cheng Yao Za Zhi 19: 39-41.
25. Wang Y, Si WK, Li P, Yao J. 2004. Effects of matrine and oxymatrine on the proliferation and apoptosis of A549 cells. Di San Jun Yi Da Xue Xue Bao 26: 778-780.
26. Woo ER, Kwak JH, Kim HJ, Park H. 1998. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod 61: 1552-1554.
27. Xu GL, Yao L, Rao SY, Gong ZN, Zhang SQ, Yu SQ. 2005. Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase. J Ethnopharmacol 98: 177-183.
28. Xu GW, Man SJ, Wang ZS, Wang LB. 2001. Effect of oxymatrine on immunology of tumor-bearing mice. Chin J Clin Oncol Rehab 8: 9-10.
29. Yang L, Chen JW, Lin YS. 1996. Clinical observation on the efficacy of mateling injection combined with radiotherapy in treating nasopharyngeal tumors. Hai Xia Yao Xue Za Zhi 8: 41-43.
30. Zhang MJ, Huang J. 2004. Recent research progress of anti-tumor mechanism matrine. Chin J Chin Mater Med 29: 115-118.
31. Zhang ZJ. 1998. Effects of matrine injection in treating 44 cases of primary carcinoma of the liver. Guangxi Trad Med 21: 19-20.
32. Zhao HJ, Sun WJ. 2005. Research progress on chemical constituents and pharmacology of kushen flavonoids. Chin Med Mater 28: 247-251.
33. Zhao YY, Zhang RY. 1991. Research on chemical constituents of Sophora flavescens. Nat Prod Res Dev 3: 93-103.
34. Zhou YF. 2004. Clinical observation on the efficacy of mateling injection combined with abdominal chemotherapy in treating malignant ascites. Zhongguo Zhong Yi Ji Zheng Za Zhi 13: 286-287.
35. Zhu JL, Chen JZ. 2003. Short-term observation on the efficacy of matrine injection in treating 79 cases of late stage cancers. Shandong Yi Xue Za Zhi 43: 40.
36. Zhu YJ, Chen XF, Huang YL. 2000. Clinical observation on the efficacy of mateling injection combined with abdominal chemotherapy in treating 21 cases of malignant ascites. Zhongguo Zhong Xi Yi Jie He Pi Wei Za Zhi 8: 311-312.
37. Zou J, Ran ZH, Xu Q, Xiao SD. 2005. Experimental study of the killing effects of oxymatrine on human colon cancer cell line SW1116. Chin J Dig Dis 6: 15-20.