Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma

Journal of Translational Medicine

Volumn 11, Issue 1, 2013, Pages

  Dementyeva, Elena ^a   Kryukov, Fedor ^a   Kubiczkova, Lenka ^a   Nemec, Pavel ^a   Sevcikova, Sabina ^a   Ihnatova, Ivana ^a   Jarkovsky, Jiri ^a   Minarik, Jiri ^b   Stefanikova, Zdena ^c   Kuglik, Petr ^a   Hajek, Roman ^a  

^a MASARYK UNIVERSITY   (Czech Republic)

^b UNIVERSITY HOSPITAL OLOMOUC   (Czech Republic)

^c UNIVERSITY HOSPITAL BRATISLAVA   (Slovakia)

Author keywords

Centrosome amplification; Multiple myeloma; Overall survival

Indexed keywords

CENTRIN; IMMUNOGLOBULIN LIGHT CHAIN; SYNDECAN 1;

ADULT; AGED; ARTICLE; AURKA GENE; AURKB GENE; CANCER PROGNOSIS; CARCINOGENESIS; CCNB1 GENE; CCNB2 GENE; CENTROSOMAL FUNCTIONAL GENE; CENTROSOME; CETN2 GENE; CONTROLLED STUDY; DISEASE MARKER; DOWN REGULATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE AMPLIFICATION; GENE EXPRESSION; HMMR GENE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; OVERALL SURVIVAL; PCNT GENE; PLASMA CELL; PLK4 GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TACC3 GENE; TUBG1 GENE;

ADULT; AGED; AGED, 80 AND OVER; CELL PROLIFERATION; CELL SEPARATION; CENTROSOME; DNA REPAIR; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; MITOSIS; MULTIPLE MYELOMA; POLYMERASE CHAIN REACTION; PROGNOSIS; RECURRENCE; SYNDECAN-1;

EID: 84875207947     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-11-77     Document Type: Article

References (39)

1. Hinchcliffe EH, Sluder G. " It takes two to tango" : understanding how centrosome duplication is regulated throughout the cell cycle. Genes Dev 2001, 15:1167-1181. 10.1101/gad.894001, 11358861.
2. Kramer A, Neben K, Ho AD. Centrosome replication, genomic instability and cancer. Leukemia 2002, 16:767-775. 10.1038/sj.leu.2402454, 11986936.
3. Anderhub SJ, Kramer A, Maier B. Centrosome amplification in tumorigenesis. Cancer Lett 2012, 322(1):8-17. 10.1016/j.canlet.2012.02.006, 22342684.
4. Nigg EA. Centrosome aberrations: cause or consequence of cancer progression?. Nat Rev Cancer 2002, 2:815-825.
5. Ried T, Heselmeyer-Haddad K, Blegen H, Schrock E, Auer G. Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: a phenotype/genotype correlation. Genes Chromosomes Cancer 1999, 25:195-204. 10.1002/(SICI)1098-2264(199907)25:3<195::AID-GCC1>3.0.CO;2-8, 10379865.
6. Mantel C, Braun SE, Reid S, Henegariu O, Liu L, Hangoc G, Broxmeyer HE. p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells. Blood 1999, 93:1390-1398.
7. Hollander MC, Sheikh MS, Bulavin DV, Lundgren K, Augeri-Henmueller L, Shehee R, Molinaro TA, Kim KE, Tolosa E, Ashwell JD. Genomic instability in Gadd45a-deficient mice. Nat Genet 1999, 23:176-184. 10.1038/13802, 10508513.
8. Smith L, Liu SJ, Goodrich L, Jacobson D, Degnin C, Bentley N, Carr A, Flaggs G, Keegan K, Hoekstra M, Thayer MJ. Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest. Nat Genet 1998, 19:39-46. 10.1038/ng0598-39, 9590286.
9. Pihan GA, Purohit A, Wallace J, Knecht H, Woda B, Quesenberry P, Doxsey SJ. Centrosome defects and genetic instability in malignant tumors. Cancer Res 1998, 58:3974-3985.
10. Lingle WL, Salisbury JL. Altered centrosome structure is associated with abnormal mitoses in human breast tumors. Am J Pathol 1999, 155:1941-1951. 10.1016/S0002-9440(10)65513-7, 1866918, 10595924.
11. Sato N, Mizumoto K, Nakamura M, Maehara N, Minamishima YA, Nishio S, Nagai E, Tanaka M. Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cells. Cancer Genet Cytogenet 2001, 126:13-19. 10.1016/S0165-4608(00)00384-8, 11343773.
12. Duensing S, Munger K. Centrosome abnormalities, genomic instability and carcinogenic progression. Biochim Biophys Acta 2001, 1471:M81-M88.
13. Skyldberg B, Fujioka K, Hellstrom AC, Sylven L, Moberger B, Auer G. Human papillomavirus infection, centrosome aberration, and genetic stability in cervical lesions. Mod Pathol 2001, 14:279-284. 10.1038/modpathol.3880303, 11301343.
14. Lingle WL, Barrett SL, Negron VC, D'Assoro AB, Boeneman K, Liu W, Whitehead CM, Reynolds C, Salisbury JL. Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Acad Sci U S A 2002, 99:1978-1983. 10.1073/pnas.032479999, 122305, 11830638.
15. Shono M, Sato N, Mizumoto K, Maehara N, Nakamura M, Nagai E, Tanaka M. Stepwise progression of centrosome defects associated with local tumor growth and metastatic process of human pancreatic carcinoma cells transplanted orthotopically into nude mice. Lab Invest 2001, 81:945-952. 10.1038/labinvest.3780306, 11454983.
16. Lange BM. Integration of the centrosome in cell cycle control, stress response and signal transduction pathways. Curr Opin Cell Biol 2002, 14:35-43. 10.1016/S0955-0674(01)00291-5, 11792542.
17. Hinchcliffe EH, Miller FJ, Cham M, Khodjakov A, Sluder G. Requirement of a centrosomal activity for cell cycle progression through G1 into S phase. Science 2001, 291:1547-1550. 10.1126/science.1056866, 11222860.
18. Pines J. Four-dimensional control of the cell cycle. Nat Cell Biol 1999, 1:E73-E79. 10.1038/11041, 10559915.
19. Rieder CL, Faruki S, Khodjakov A. The centrosome in vertebrates: more than a microtubule-organizing center. Trends Cell Biol 2001, 11:413-419. 10.1016/S0962-8924(01)02085-2, 11567874.
20. Sibon OC, Kelkar A, Lemstra W, Theurkauf WE. DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos. Nat Cell Biol 2000, 2:90-95. 10.1038/35000041, 10655588.
21. Meraldi P, Nigg EA. The centrosome cycle. FEBS Lett 2002, 521:9-13. 10.1016/S0014-5793(02)02865-X, 12067716.
22. Sugihara E, Kanai M, Saito S, Nitta T, Toyoshima H, Nakayama K, Nakayama KI, Fukasawa K, Schwab M, Saya H, Miwa M. Suppression of centrosome amplification after DNA damage depends on p27 accumulation. Cancer Res 2006, 66:4020-4029. 10.1158/0008-5472.CAN-05-3250, 16618721.
23. Hose D, Reme T, Hielscher T, Moreaux J, Meissner T, Seckinger A, Benner A, Shaughnessy JD, Barlogie B, Zhou YM. Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma (vol 96, pg 87, 2010). Haematol-Hematol J 2011, 96:484-489.
24. Witzig TE, Timm M, Larson D, Therneau T, Greipp PR. Measurement of apoptosis and proliferation of bone marrow plasma cells in patients with plasma cell proliferative disorders. Br J Haematol 1999, 104:131-137. 10.1046/j.1365-2141.1999.01136.x, 10027725.
25. Boccadoro M, Gavarotti P, Fossati G, Pileri A, Marmont F, Neretto G, Gallamini A, Volta C, Tribalto M, Testa MG. Low plasma cell 3(H) thymidine incorporation in monoclonal gammopathy of undetermined significance (MGUS), smouldering myeloma and remission phase myeloma: a reliable indicator of patients not requiring therapy. Br J Haematol 1984, 58:689-696. 10.1111/j.1365-2141.1984.tb06116.x, 6518137.
26. Greipp PR, Lust JA, O'Fallon WM, Katzmann JA, Witzig TE, Kyle RA. Plasma cell labeling index and beta 2-microglobulin predict survival independent of thymidine kinase and C-reactive protein in multiple myeloma. Blood 1993, 81:3382-3387.
27. Greipp PR, Katzmann JA, O'Fallon WM, Kyle RA. Value of beta 2-microglobulin level and plasma cell labeling indices as prognostic factors in patients with newly diagnosed myeloma. Blood 1988, 72:219-223.
28. San Miguel JF, Garcia-Sanz R, Gonzalez M, Moro MJ, Hernandez JM, Ortega F, Borrego D, Carnero M, Casanova F, Jimenez R. A new staging system for multiple myeloma based on the number of S-phase plasma cells. Blood 1995, 85:448-455.
29. Steensma DP, Gertz MA, Greipp PR, Kyle RA, Lacy MQ, Lust JA, Offord JR, Plevak MF, Therneau TM, Witzig TE. A high bone marrow plasma cell labeling index in stable plateau-phase multiple myeloma is a marker for early disease progression and death. Blood 2001, 97:2522-2523. 10.1182/blood.V97.8.2522, 11290618.
30. Minarik J, Scudla V, Ordeltova M, Pika T, Bacovsky J, Steinbach M, Kumar V, Van Ness B. Combined measurement of plasma cell proliferative and apoptotic index in multiple myeloma defines patients with good and poor prognosis. Leuk Res 2011, 35:44-48. 10.1016/j.leukres.2010.04.015, 20488540.
31. Chng WJ, Ahmann GJ, Henderson K, Santana-Davila R, Greipp PR, Gertz MA, Lacy MQ, Dispenzieri A, Kumar S, Rajkumar SV. Clinical implication of centrosome amplification in plasma cell neoplasm. Blood 2006, 107:3669-3675. 10.1182/blood-2005-09-3810, 1895774, 16373658.
32. Dementyeva E, Nemec P, Kryukov F, Raja KRM, Smetana J, Zaoralova R, Greslikova H, Kupska R, Kuglik P, Hajek R. Centrosome amplification as a possible marker of mitotic disruptions and cellular carcinogenesis in multiple myeloma. Leukemia Res 2010, 34:1007-1011.
33. Chng WJ, Braggio E, Mulligan G, Bryant B, Remstein E, Valdez R, Dogan A, Fonseca R. The centrosome index is a powerful prognostic marker in myeloma and identifies a cohort of patients that might benefit from aurora kinase inhibition. Blood 2008, 111:1603-1609.
34. Kryukov F, Dementyeva E, Kuglik P, Hajek R. Visualization of numerical centrosomal abnormalities by immunofluorescent staining. Klinicka onkologie: casopis Ceske a Slovenske onkologicke spolecnosti 2011, 24(Suppl):S49-S52.
35. Nemec P, Zemanova Z, Kuglik P, Michalova K, Tajtlova J, Kaisarova P, Oltova A, Filkova H, Holzerova M, Balcarkova J. Complex karyotype and translocation t(4;14) define patients with high-risk newly diagnosed multiple myeloma: results of CMG2002 trial. Leuk Lymphoma 2011, 53(5):920-927.
36. Sevcikova S, Nemec P, Pour L, Hajek R. Genomics in multiple myeloma research. Klinicka onkologie: casopis Ceske a Slovenske onkologicke spolecnosti 2011, 24(Suppl):S34-S38.
37. Delaval B, Birnbaum D. A cell cycle hypothesis of cooperative oncogenesis (Review). Int J Oncol 2007, 30:1051-1058.
38. Sato N, Mizumoto K, Nakamura M, Ueno H, Minamishima YA, Farber JL, Tanaka M. A possible role for centrosome overduplication in radiation-induced cell death. Oncogene 2000, 19:5281-5290. 10.1038/sj.onc.1203902, 11077445.
39. Fukasawa K. Oncogenes and tumour suppressors take on centrosomes. Nat Rev Cancer 2007, 7:911-924. 10.1038/nrc2249, 18004399.