Trypanocidal activity of salinomycin is due to sodium influx followed by cell swelling

Parasites and Vectors

Volumn 6, Issue 1, 2013, Pages

  Steverding, Dietmar ^a   Sexton, Darren W ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

African trypanosomiasis; Drug screening; Salinomycin; Trypanosoma brucei

Indexed keywords

ANTITRYPANOSOMAL AGENT; IONOPHORE; REACTIVE OXYGEN METABOLITE; SALINOMYCIN; SODIUM;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL SWELLING; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG MECHANISM; GROWTH RATE; HUMAN; HUMAN CELL; IN VITRO STUDY; SODIUM CELL LEVEL; SODIUM TRANSPORT; TRYPANOSOMA BRUCEI; WATER TRANSPORT;

ANTIPROTOZOAL AGENTS; INHIBITORY CONCENTRATION 50; OSMOTIC PRESSURE; PYRANS; SODIUM; TRYPANOSOMA BRUCEI BRUCEI;

TRYPANOSOMA BRUCEI;

EID: 84875159128     PISSN: None     EISSN: 17563305     Source Type: Journal    
DOI: 10.1186/1756-3305-6-78     Document Type: Article

References (27)

1. African trypanosomiasis in man. Molyneux DH, Pentreath V, Doua F, Manson's Tropical Diseases London: W.B. Saunders, Cook GC, 20 1996 1171 1196 23528909
2. Trypanosomiasis, human African (sleeping sickness). World Health Organization, World Health Org Fact Sheet 2012 259 http://www.who.int/ mediacentre/factsheets/fs259/en/
3. Measuring the costs of African animal trypanosomiasis, the potential benefits of control and returns to research. Kristjanson PM, Swallow BM, Rowlands GJ, Kruska RL, de Leeuw PN, Agr Sys 1999 59 79 98 10.1016/S0308- 521X(98)00086-9 (Pubitemid 29107430)
4. Drugs and drug resistance in African trypanosomiasis. Delespaux V, de Koning HP, Drug Resist Updat 2007 10 30 50 10.1016/j.drup.2007.02.004 17409013 (Pubitemid 46636383)
5. Recent initiatives and strategies to developing new drugs for tropical parasitic diseases. Caffrey CR, Steverding D, Expert Opin Drug Discov 2008 3 173 186 10.1517/17460441.3.2.173 23480221 (Pubitemid 351279487)
6. Salinomycin, a new polyether antibiotic. Miyazaki Y, Shibuya M, Sugawara H, Kawaguchi O, Hirose C, Nagatsu J, Esumi S, J Antibiot (Tokyo) 1974 27 814 821 10.7164/antibiotics.27.814
7. Salinomycin: a new monovalent cation ionophore. Mitani M, Yamanishi T, Miyazaki Y, Biochem Biophys Res Commun 1975 66 1231 1236 10.1016/0006-291X(75) 90490-8 1191289
8. Use of anticoccidial drugs in broiler chickens in the USA: analysis for the years 1995 to 1999. Chapman HD, Poult Sci 2001 80 572 580 11372705 (Pubitemid 33659933)
9. Use of antibiotics and roxarsone in broiler chickens in the USA: analysis for the years 1995 to 2000. Chapman HD, Johnson ZB, Poult Sci 2002 81 356 364 11902412 (Pubitemid 39615861)
10. Salinomycin: a new cancer drug candidate. Huczynski A, Chem Biol Drug Des 2012 79 235 238 10.1111/j.1747-0285.2011.01287.x 22145602
11. Anti-trypanosomal activities of DNA topoisomerase inhibitors. Deterding A, Dungey FA, Thompson KA, Steverding D, Acta Trop 2005 93 311 316 10.1016/j.actatropica.2005.01.005 15715983 (Pubitemid 40348835)
12. Trypanocidal activity of the proteasome inhibitor and anti-cancer drug Bortezomib. Steverding D, Wang X, Parasit Vectors 2009 2 29 10.1186/1756-3305-2- 29 19583840
13. Trypanocidal activity of β-lactone-γ-lactam proteasome inhibitors. Steverding D, Wang X, Potts BC, Palladino MA, Planta Med 2012 78 131 134 10.1055/s-0031-1280315 22034066
14. In vitro cloning of animal-infective bloodstream forms of Trypanosoma brucei. Hirumi H, Hirumi K, Doyle JJ, Cross GAM, Parasitology 1980 80 371 382 10.1017/S0031182000000822 6154276 (Pubitemid 10019838)
15. Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense. Baltz T, Baltz D, Giroud C, Crockett J, EMBO J 1985 4 1273 1277 4006919
16. Culture of normal human leukocytes. Moore GE, Gerner RE, Franklin HA, J Am Med Assoc 1967 199 519 524 10.1001/jama.1967.03120080053007
17. Finney DJ, Statistical method in biological assay London: Charles Griffin & Co 3 1978
18. Giardia intestinalis: volume recovery in response to cell swelling. Park JH, Schofield PJ, Edwards MR, Exp Parasitol 1997 86 19 28 10.1006/expr.1996.4130 9149237 (Pubitemid 27224197)
19. Antiproliferative activity of salinomycin and its derivatives. Huczyński A, Janczak J, Antoszczak M, Wietrzyk J, Maj E, Brzezinski B, Bioorg Med Chem Lett 2012 22 7146 7150 10.1016/j.bmcl.2012.09.068 23079523
20. Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress. Ketola K, Hilvo M, Hyötyläinen T, Vuoristo A, Ruskeepää AL, Orešič M, Kallioniemi O, Iljin K, Br J Can 2012 106 99 106 10.1038/bjc.2011.530
21. A Trk/HKT-type K§ssup§+§esup§ transporter from Trypanosoma brucei. Mosimann M, Goshima S, Wenzler T, Lüscher A, Uozumi N, Mäser P, Eukaryot Cell 2010 9 539 546 10.1128/EC.00314-09 20190075
22. Factors that determine the plasma-membrane potential in bloodstream forms of Trypanosoma brucei. Nolan DP, Voorheis HP, Eur J Biochem 2000 267 4615 4623 10.1046/j.1432-1327.2000.01477.x 10903493 (Pubitemid 30619450)
23. Functional characterization of three aquaglyceroporins from Trypanosoma brucei in osmoregulation and glycerol transport. Bassarak B, Uzcátegui NL, Schönfeld C, Duszenko M, Cell Physiol Biochem 2011 27 411 420 10.1159/000327968 21471730
24. Salinomycin-induced apoptosis of human prostate cancer cells due to accumulated reactive oxygen species and mitochondrial membrane depolarization. Kim KY, Yu SN, Lee SY, Chun SS, Choi YL, Park YM, Song CS, Chatterjee B, Ahn SC, Biochem Biophys Res Commun 2011 413 80 86 10.1016/j.bbrc.2011.08.054 21871443
25. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Lu D, Choi MY, Yu J, Castro JE, Kipps TJ, Carson DA, Proc Natl Acad Sci USA 2011 108 13253 13257 10.1073/pnas.1110431108 21788521
26. Innovative lead discovery strategies for tropical diseases. Nwaka S, Hudson A, Nat Rev Drug Discov 2006 5 941 955 10.1038/nrd2144 17080030 (Pubitemid 44660607)
27. Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis. Simarro PP, Franco J, Diarra A, Postigo JA, Jannin J, Parasitology 2012 139 842 846 10.1017/S0031182012000169 22309684