Trypanocidal activity of the proteasome inhibitor and anti-cancer drug bortezomib

Parasites and Vectors

Volumn 2, Issue 1, 2009, Pages

  Steverding, Dietmar ^a   Wang, Xia ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; MELARSOPROL;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; HUMAN; HUMAN CELL; IN VITRO STUDY; MYELOID LEUKEMIA; NONHUMAN; TRYPANOSOMA BRUCEI;

TRYPANOSOMA BRUCEI;

EID: 68149139527     PISSN: None     EISSN: 17563305     Source Type: Journal    
DOI: 10.1186/1756-3305-2-29     Document Type: Article

References (22)

1. The history of African trypanosomiasis. D Steverding, Parasit Vectors 2008 1 3 18275594 10.1186/1756-3305-1-3
2. Chemotherapy of human African trypanosomiasis: current and future prospects. AH Fairlamb, Trends Parasitol 2003 19 488 94 14580959 10.1016/j.pt.2003.09.002 (Pubitemid 37329657)
3. Drug resistance in Trypanosoma brucei spp., the causative agents of sleeping sickness in man and nagana in cattle. E Matovu T Seebeck JCK Enyaru R Kaminsky, Microbes Infect 2001 3 763 70 10.1016/S1286-4579(01)01432-0 11489425 (Pubitemid 32727386)
4. Drugs and drug resistance in African trypanosomiasis. V Delespaux HP de Koning, Drug Resist Updat 2007 10 30 50 10.1016/j.drup.2007.02.004 17409013 (Pubitemid 46636383)
5. Resurrecting the resurrection drug. P Wickware, Nat Med 2002 8 908 9 10.1038/nm0902-908b 12205439
6. Recent initiatives and strategies to developing new drugs for tropical parasitic diseases. CR Caffrey D Steverding, Expert Opin Drug Discov 2008 3 173 86 10.1517/17460441.3.2.173 (Pubitemid 351279487)
7. Anti-sleeping sickness drugs and cancer chemotherapy. SV Barrett MP Barrett, Parasitol Today 2000 16 7 9 10.1016/S0169-4758(99)01560-4 10637579 (Pubitemid 30101609)
8. Antitrypanosomal activities of proteasome inhibitors. J Nkemgu-Njinkeng V Rosenkranz M Wink D Steverding, Antimicrob Agents Chemother 2002 46 2038 40 12019136 10.1128/AAC.46.6.2038-2040.2002 (Pubitemid 34535242)
9. Trypanocidal effect of α', β'-epoxyketones indicates that trypanosomes are particularly sensitive to inhibitors of proteasome trypsin-like activity. RJ Glenn AJ Pemberton HJ Royle RW Spackman E Smith AJ Rivett D Steverding, Int J Antimicrob Agents 2004 24 286 9 10.1016/j.ijantimicag.2004.02. 023 15325434 (Pubitemid 39140548)
10. Trypanocidal activities of trileucine methyl vinyl sulfone proteasome inhibitors. D Steverding RW Spackman HJ Royle RJ Glenn, Parasitol Res 2005 95 73 6 10.1007/s00436-004-1253-y 15578221
11. Evaluation of the anti-trypanosomal activity of tyropeptin A. D Steverding AJ Pemberton H Royle RW Spackman AJ Rivett, Planta Med 2006 72 761 3 10.1055/s-2006-931600 16732530 (Pubitemid 44073463)
12. The proteasome as a potential target for chemotherapy of African trypanosomiasis. D Steverding, Drug Dev Res 2007 68 205 12 10.1002/ddr.20188 (Pubitemid 350223931)
13. Bortezomib: a novel chemotherapeutic agent for hematologic malignancies. KN Utecht J Kolesar, Am J Health Syst Pharm 2008 65 1221 31 10.2146/ajhp070272 18574011 (Pubitemid 351898355)
14. In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense. K Merschjohann F Sporer D Steverding M Wink, Planta Med 2001 67 623 7 10.1055/s-2001-17351 11582539 (Pubitemid 32929572)
15. Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense. T Baltz D Baltz C Giroud J Crockett, EMBO J 1985 4 1273 7 4006919
16. A comparison of three methods of estimating EC 50 in studies of drug resistance of malaria parasites. W Huber JC Koella, Acta Trop 1993 55 257 61 10.1016/0001-706X(93)90083-N 8147282
17. Proteasome inhibitors: a novel class of potent and effective antitumor agents. J Adams VJ Palombella EA Sausville J Johnson A Destree DD Lazarus J Maas CS Pien S Prakash PJ Elliot, Cancer Res 1999 59 2615 22 10363983
18. Velcade® (bortezomib) for injection. Full prescribing information. Cambridge, MA, USA; issued June 2008. Millennium Pharmaceuticals Inc, http://velcade.com/full-prescrib-velcade.pdf
19. Prospective comparison of subcutaneous versus intravenous administration of bortezomib in patients with multiple myeloma. P Moreau V Coiteux C Hulin X Leleu H van de Velde M Acharya JL Harousseau, Haematologica 2008 93 1908 11 10.3324/haematol.13285 18768528
20. A novel cultivation technique for long-term maintenance of bloodstream form trypanosomes in vitro. F Hesse PM Selzer K Mühlstädt M Duszenko, Mol Biochem Parasitol 1995 70 157 66 10.1016/0166-6851(95)00027-X 7637696
21. Current situation of African trypanosomiasis. FA Kuzoe, Acta Trop 1993 54 153 62 10.1016/0001-706X(93)90089-T 7902654
22. Innovative lead discovery strategies for tropical diseases. S Nwaka A Hudson, Nat Rev Drug Discov 2006 5 941 55 10.1038/nrd2144 17080030 (Pubitemid 44660607)