Trypanocidal activity of β-lactone-γ-lactam proteasome inhibitors

Planta Medica

Volumn 78, Issue 2, 2012, Pages 131-134

  Steverding, Dietmar ^a   Wang, Xia ^a   Potts, Barbara C M ^b   Palladino, Michael A ^b  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b Nereus Pharmaceuticals Inc   (United States)

Author keywords

lactone lactam proteasome inhibitors; sleeping sickness; trypanocidals; Trypanosoma brucei

Indexed keywords

ANTITRYPANOSOMAL AGENT; BETA LACTONE GAMMA LACTAM PROTEASOME INHIBITOR; BORTEZOMIB; GAMMA LACTAM DERIVATIVE; LACTACYSTIN BETA LACTONE; MELARSOPROL; NPI 2053; NPI 2058; NPI 2070; PROTEASOME INHIBITOR; SALINOSPORAMIDE A; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANTIPROTOZOAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG CYTOTOXICITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI;

BIOLOGICAL AGENTS; ENZYME INHIBITORS; LACTAMS; LACTONES; PROTEASOME ENDOPEPTIDASE COMPLEX; PYRROLES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

SALINISPORA TROPICA; TRYPANOSOMA BRUCEI;

EID: 84856267589     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0031-1280315     Document Type: Article

References (23)

1. WHO. African trypanosomiasis (sleeping sickness). Geneva World Health Organization Fact Sheet 2010 259
2. Steverding D. The history of African trypanosomiasis. Parasit Vectors 2008 1 3
3. Steverding D. The development of drugs for treatment of sleeping sickness: a historical review. Parasit Vectors 2010 3 15
4. Fairlamb A H. Chemotherapy of human African trypanosomiasis: current and future prospects. Trends Parasitol 2003 19 488-494 (Pubitemid 37329657)
5. Matovu E, Seebeck T, Enyaru J C., Kaminsky R. Drug resistance in Trypanosoma brucei spp., the causative agents of sleeping sickness in man and nagana in cattle. Microbes Infect 2001 3 763-770 (Pubitemid 32727386)
6. Delespaux V, de Koning H P. Drugs and drug resistance in African trypanosomiasis. Drug Resist Updat 2007 10 30-50 (Pubitemid 46636383)
7. Steverding D. The proteasome as a potential target for chemotherapy of African trypanosomiasis. Drug Dev Res 2007 68 205-212 (Pubitemid 350223931)
8. Dick L R., Cruikshank A A., Grenier L, Melandri F D., Nunes S L., Stein R L. Mechanistic studies on the inactivation of the proteasome by lactacystin. A central role for clasto-lactacystin -lactone. J Biol Chem 1996 271 7273-7276
9. Omura S, Fujimoto T, Otoguro K, Matsuzaki K, Moriguchi R, Tanaka H, Sasaki Y. Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. J Antibiot (Tokyo) 1991 44 113-116
10. Feling R H., Buchanan G O., Mincer T J., Kauffman C A., Jensen P R., Fenical W. Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora. Angew Chem Int Ed 2003 42 355-357 (Pubitemid 36176323)
11. Macherla V R., Mitchell S S., Manam R R., Reed K A., Chao T-H, Nicholson B, Deyanat-Yazdi G, Mai B, Jensen P R., Fenical W F., Neuteboom S T. C., Lam K S., Palladino M P., Potts B C. M. Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. J Med Chem 2005 48 3684-3687 (Pubitemid 40776841)
12. Potts B C., Albitar M X., Anderson K C., Baritaki S, Berkers C, Bonavida B, Chandra J, Chauhan D, Cusack jr. J C., Fenical W, Ghobrial I M., Groll M, Jensen P R., Lam K S., Lloyd G K., McBride W, McConkey D J., Miller C P., Neuteboom S T. C., Oki Y, Ovaa H, Pajonk F, Richardson P G., Roccaro A M., Sloss C M., Spear M A., Valashi E, Younes A, Palladino M A. Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Curr Cancer Drug Targets 2011 11 254-284
13. Manam R R., Macherla V R., Tsueng G, Dring C W., Weiss J, Neuteboom S T. C., Lam K S., Potts B C. Antiprotealide is a natural product. J Nat Prod 2009 72 295-297
14. Groll M, Potts B C. Proteasome structure, function, and lessons learned from -lactone inhibitors. Curr Top Med Chem published online 8 9 2011 (PMID: 21824111)
15. Räz B, Iten M, Grether-Bühler Y, Kaminsky R, Brun R. The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro. Acta Trop 1997 68 139-147 (Pubitemid 27438330)
16. Li Z, Zou C B., Yao Y, Hoyt M A., McDonough S, Mackey Z B., Coffino P, Wang C C. An easily dissociated 26 S proteasome catalyzes an essential ubiquitin-mediated protein degradation pathway in Trypanosoma brucei. J Biol Chem 2002 277 15486-15498 (Pubitemid 34967815)
17. Chauhan D, Catley L, Li G, Podar K, Hideshima T, Velankar M, Mitsiades C, Mitsiades N, Yasui H, Letai A, Ovaa H, Berkers C, Nicholson B, Chao T-H, Neuteboom S T. C., Richardson P, Palladino M A., Anderson K C. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib. Cancer Cell 2005 8 407-419 (Pubitemid 41579835)
18. Muehlbauer S M., Lima jr. H, Goldman D L., Jacobson L S., Rivera J, Goldberg M F., Palladino M A., Casadevall A, Brojatsch J. Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin. Am J Pathol 2010 177 735-743
19. Reed K A., Manam R R., Mitchell S S., Xu J, Chao T-H, Deyanat-Yazdi G, Neuteboom S T. C., Lam K S., Potts B C. M. Salinosporamides DJ from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome. J Nat Prod 2007 70 269-276 (Pubitemid 46447642)
20. Hirumi H, Hirumi K, Doyle J J., Cross G A. M. In vitro cloning of animal-infective bloodstream forms of Trypanosoma brucei. Parasitology 1980 80 371-382 (Pubitemid 10019838)
21. Collins S R., Gallo R C., Gallagher R E. Continuous growth and differentiation of human myeloid leukaemic cells in suspension cultures. Nature 1977 270 347-349
22. Baltz T, Baltz D, Giroud C, Crockett J. Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense. EMBO J 1985 4 1273-1277
23. 50 in studies of drug resistance of malaria parasites. Acta Trop 1993 55 257-261