CD8+ T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ

Journal of Investigative Dermatology

Volumn 133, Issue 4, 2013, Pages 955-963

  Gunderson, Andrew J ^a   Mohammed, Javed ^a   Horvath, Frank J ^a   Podolsky, Michael A ^a   Anderson, Cherie R ^a   Glick, Adam B ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 17; RAG1 PROTEIN; RAS PROTEIN;

ACANTHOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CELLULAR IMMUNITY; HUMAN; HYPERKERATOSIS; KERATINOCYTE; LYMPHOCYTIC INFILTRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; SIGNAL TRANSDUCTION; TH1 CELL; TH17 CELL;

EID: 84875151879     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.390     Document Type: Article

References (40)

1. Austin LM, Ozawa M, Kikuchi T et al. (1999) The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferongamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. J Invest Dermatol 113:752-9
2. Barker JN, Goodlad JR, Ross EL et al. (1993) Increased epidermal cell proliferation in normal human skin in vivo following local administration of interferon-gamma. Am J Pathol 142:1091-7
3. Bruch-Gerharz D, Fehsel K, Suschek C et al. (1996) A proinflammatory activity of interleukin 8 in human skin: expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes. J Exp Med 184:2007-12
4. Cai Y, Shen X, Ding C et al. (2011) Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation. Immunity 35:596-610
5. Caruso R, Botti E, Sarra M et al. (2009) Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis. Nat Med 15:1013-5
6. Cataisson C, Joseloff E, Murillas R et al. (2003) Activation of cutaneous protein kinase Calpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways. J Immunol 171:2703-13
7. Cataisson C, Pearson AJ, Tsien MZ et al. (2006) CXCR2 ligands and G-CSF mediate PKCalpha-induced intraepidermal inflammation. J Clin Invest 116:2757-66
8. Chin L, Tam A, Pomerantz J et al. (1999) Essential role for oncogenic Ras in tumour maintenance. Nature 400:468-72
9. Conrad C, Boyman O, Tonel G et al. (2007) Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Nat Med 13:836-42
10. Cook PW, Brown JR, Cornell KA et al. (2004) Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis. Exp Dermatol 13:347-56
11. Cook PW, Piepkorn M, Clegg CH et al. (1997) Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. J Clin Invest 100:2286-94
12. Corey MJ, Kinders RJ, Brown LG et al. (1997) A very sensitive coupled luminescent assay for cytotoxicity and complement-mediated lysis. J Immunol Methods 207:43-51
13. Di Cesare A, Di Meglio P, Nestle FO (2009) The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol 129:1339-50
14. Funding AT, Johansen C, Kragballe K et al. (2006) Mitogen- and stress-activated protein kinase 1 is activated in lesional psoriatic epidermis and regulates the expression of pro-inflammatory cytokines. J Invest Dermatol 126:1784-91
15. Glick AB, Sporn MB, Yuspa SH (1991) Altered regulation of TGF-b 1 and TGFa in primary keratinocytes and papillomas expressing v-Ha-ras. Mol Carcinog 4:210-9
16. Gunther C, Carballido-Perrig N, Kaesler S et al. (2012) CXCL16 and CXCR6 are upregulated in psoriasis and mediate cutaneous recruitment of human CD8 T cells. J Invest Dermatol 132:626-34
17. Hinrichs CS, Kaiser A, Paulos CM et al. (2009) Type 17 CD8 T cells display enhanced antitumor immunity. Blood 114:596-9
18. Hobbs RM, Silva-Vargas V, Groves R et al. (2004) Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions. J Invest Dermatol 123:503-15
19. Huber M, Heink S, Grothe H et al. (2009) A Th17-like developmental process leads to CD8() Tc17 cells with reduced cytotoxic activity. Eur J Immunol 39:1716-25
20. Iwakura Y, Ishigame H, Saijo S et al. (2011) Functional specialization of interleukin-17 family members. Immunity 34:149-62
21. Jaubert J, Patel S, Cheng J et al. (2004) Tetracycline-regulated transactivators driven by the involucrin promoter to achieve epidermal conditional gene expression. J Invest Dermatol 123:313-8
22. Karvonen SL, Koivunen J, Nissinen M et al. (2004) Neurofibromatosis type 1 tumour suppressor gene expression is deficient in psoriatic skin in vivo and in vitro: a potential link to increased Ras activity. Br J Dermatol 150:211-9
23. Kolls JK, Linden A (2004) Interleukin-17 family members and inflammation. Immunity 21:467-76
24. Kryczek I, Bruce AT, Gudjonsson JE et al. (2008) Induction of IL-17 T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol 181:4733-41
25. Lin P, Baldassare JJ, Voorhees JJ et al. (1999) Increased activation of Ras in psoriatic lesions. Skin Pharmacol Appl Skin Physiol 12:90-7
26. Lowes MA, Chamian F, Abello MV et al. (2005) Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). Proc Natl Acad Sci USA 102:19057-62
27. Mohammed J, Ryscavage A, Perez-Lorenzo R et al. (2010) TGFbeta1-induced inflammation in premalignant epidermal squamous lesions requires IL-17. J Invest Dermatol 130:2295-303
28. Monteleone G, Pallone F, MacDonald TT et al. (2011) Psoriasis: from pathogenesis to novel therapeutic approaches. Clin Sci (Lond) 120:1-11
29. Ortega C, Fernandez A, Carrillo JM et al. (2009) IL-17-producing CD8 T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines. J Leukoc Biol 86:435-43
30. Res PC, Piskin G, de Boer OJ et al. (2010) Overrepresentation of IL-17A and IL- 22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis. PLoS One 5:e14108
31. Roberts SJ, Ng BY, Filler RB et al. (2007) Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis. Proc Natl Acad Sci USA 104:6770-5
32. Sarra M, Caruso R, Cupi ML et al. (2011) IL-21 promotes skin recruitment of CD4() cells and drives IFN-gamma-dependent epidermal hyperplasia. J Immunol 186:5435-42
33. Tarutani M, Imai Y, Yasuda K et al. (2010) Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice. J Dermatol Sci 58:28-35
34. Teige I, Backlund A, Svensson L et al. (2010) Induced keratinocyte hyperproliferation in alpha2beta1 integrin transgenic mice results in systemic immune cell activation. Int Immunopharmacol 10:107-14
35. Teige I, Hvid H, Svensson L et al. (2009) Regulatory T cells control VEGFdependent skin inflammation. J Invest Dermatol 129:1437-45
36. van der Fits L, Mourits S, Voerman JS et al. (2009) Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol 182:5836-45
37. Wennerberg K, Rossman KL, Der CJ (2005) The Ras superfamily at a glance. J Cell Sci 118:843-6
38. Yen HR, Harris TJ, Wada S et al. (2009) Tc17 CD8 T cells: functional plasticity and subset diversity. J Immunol 183:7161-8
39. Yu XJ, Li CY, Dai HY et al. (2007) Expression and localization of the activated mitogen-activated protein kinase in lesional psoriatic skin. Exp Mol Pathol 83:413-8
40. Zheng Y, Danilenko DM, Valdez P et al. (2007) Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445:648-51