Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice

Journal of Dermatological Science

Volumn 58, Issue 1, 2010, Pages 28-35

  Tarutani, Masahito ^a,b   Imai, Yasutomo ^a   Yasuda, Koubun ^a   Tsutsui, Hiroko ^a   Nakanishi, Kenji ^a   Yamanishi, Kiyofumi ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b KOCHI UNIVERSITY   (Japan)

Author keywords

Neutrophil; Psoriasis; Raf; Skin inflammation; Transgenic mice

Indexed keywords

4 HYDROXYTAMOXIFEN; CXCL1 CHEMOKINE; CYTOKERATIN 14; ESTROGEN RECEPTOR; GAMMA INTERFERON; GRANULOCYTE ANTIBODY; INTERLEUKIN 17; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RAF PROTEIN; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME PHOSPHORYLATION; EPIDERMIS HYPERPLASIA; HYPERKERATOSIS; IMMUNE RESPONSE; IN VIVO STUDY; INFLAMMATORY INFILTRATE; KERATINOCYTE; LIGAND BINDING; LYMPH NODE; MOUSE; NEUTROPHIL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PSORIASIS; SIGNAL TRANSDUCTION; SKIN INFILTRATE; SKIN INFLAMMATION; TH1 CELL; TH2 CELL; TRANSGENIC MOUSE;

ANIMALS; CELLS, CULTURED; CHEMOKINE CXCL1; DISEASE MODELS, ANIMAL; EPIDERMIS; HYPERPLASIA; INTERFERON-GAMMA; INTERLEUKIN-17; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUTROPHILS; PSORIASIS; RAF KINASES; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; TH1 CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77950369436     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2010.01.004     Document Type: Article

References (29)

1. Crespo P., León J. Ras proteins in the control of the cell cycle and cell differentiation. Cell Mol Life Sci 2000, 57:1613-1636.
2. Shields J.M., Pruitt K., McFall A., Shaub A., Der C.J. Understanding Ras: 'it ain't over 'til it's over'. Trends Cell Biol 2000, 10:147-154.
3. Tarutani M., Cai T., Dajee M., Khavari P.A. Inducible activation of Ras and Raf in adult epidermis. Cancer Res 2003, 63:319-323.
4. Khavari T.A., Rinn J. Ras/Erk MAPK signaling in epidermal homeostasis and neoplasia. Cell Cycle 2007, 6:2928-2931.
5. Scholl F.A., Dumesic P.A., Barragan D.I., Charron J., Khavari P.A. Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin. Oncogene 2009, 28:1485-1495.
6. Krontiris T.G., Devlin B., Karp D.D., Robert N.J., Risch N. An association between the risk of cancer and mutations in the HRAS1 minisatellite locus. N Engl J Med 1993, 329:517-523.
7. Pierceall W.E., Goldberg L.H., Tainsky M.A., Mukhopadhyay T., Ananthaswamy H.N. Ras gene mutation and amplification in human nonmelanoma skin cancers. Mol Carcinog 1991, 4:196-202.
8. Lin P., Baldassare J.J., Voorhees J.J., Fisher G.J. Increased activation of Ras in psoriatic lesions. Skin Pharmacol Appl Skin Physiol 1999, 12:90-97.
9. Bos J.D., De Rie M.A. The pathogenesis of psoriasis: immunological facts and speculations. Immunol Today 1999, 20:40-46.
10. Carroll J.M., Romero M.R., Watt F.M. Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Cell 1995, 83:957-968.
11. Li A.G., Wang D., Feng X.H., Wang X.J. Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder. EMBO J 2004, 23:1770-1781.
12. Sano S., Chan K.S., Carbajal S., Clifford J., Peavey M., Kiguchi K., et al. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med 2005, 11:43-49.
13. Hvid H., Teige I., Kvist P.H., Svensson L., Kemp K. TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis. Int Immunol 2008, 20:1097-1106.
14. Kanamori H., Tanaka M., Kawaguchi H., Yamaji S., Fujimaki K., Tomita N., et al. Resolution of psoriasis following allogeneic bone marrow transplantation for chronic myelogenous leukemia: case report and review of the literature. Am J Hematol 2002, 71:41-44.
15. Krueger G., Callis K. Potential of tumor necrosis factor inhibitors in psoriasis and psoriatic arthritis. Arch Dermatol 2004, 140:218-225.
16. Krueger G.G., Langley R.G., Leonardi C., Yeilding N., Guzzo C., Wang Y., et al. A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med 2007, 356:580-592.
17. Uyemura K., Yamamura M., Fivenson D.F., Modlin R.L., Nickoloff B.J. The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell-mediated response. J Invest Dermatol 1993, 101:701-705.
18. Fitch E., Harper E., Skorcheva I., Kurtz S.E., Blauvelt A. Pathophysiology of psoriasis: recent advances on IL-23 and Th17 cytokines. Curr Rheumatol Rep 2007, 9:461-467.
19. Lowes M.A., Chamian F., Abello M.V., Fuentes-Duculan J., Lin S.L., Nussbaum R., et al. Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). Proc Natl Acad Sci U S A 2005, 102:19057-19062.
20. Terada M., Tsutsui H., Imai Y., Yasuda K., Mizutani H., Yamanishi K., et al. Contribution of IL-18 to atopic-dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice. Proc Natl Acad Sci U S A 2006, 103:8816-8821.
21. Lowes M.A., Bowcock A.M., Krueger J.G. Pathogenesis and therapy of psoriasis. Nature 2007, 445:866-873.
22. Wang L., Yang L., Gao L., Gao T.W., Li W., Liu Y.F. A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with psoriasis. Int J Immunogenet 2008, 35:45-49.
23. Pietrzak A., Lecewicz-Torun B., Chodorowska G., Rolinski J. Interleukin-18 levels in the plasma of psoriatic patients correlate with the extent of skin lesions and the PASI score. Acta Derm Venereol 2003, 83:262-265.
24. Park C.W., Lee B.H., Han H.J., Lee C.H., Ahn H.K. Tacrolimus decreases the expression of eotaxin, CCR3, RANTES and interleukin-5 in atopic dermatitis. Br J Dermatol 2005, 152:1173-1181.
25. Rückert R., Asadullah K., Seifert M., Budagian V.M., Arnold R., Trombotto C., et al. Inhibition of keratinocyte apoptosis by IL-15: a new parameter in the pathogenesis of psoriasis?. J Immunol 2000, 165:2240-2250.
26. Detmar M., Brown L.F., Claffey K.P., Yeo K.T., Kocher O., Jackman R.W., et al. Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J Exp Med 1994, 180:1141-1146.
27. Xia Y.P., Li B., Hylton D., Detmar M., Yancopoulos G.D., Rudge J.S. Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. Blood 2003, 102:161-168.
28. Tesmer L.A., Lundy S.K., Sarkar S., Fox D.A. Th17 cells in human disease. Immunol Rev 2008, 223:87-113.
29. Lowes M.A., Kikuchi T., Fuentes-Duculan J., Cardinale I., Zaba L.C., Haider A.S., et al. Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol 2008, 128:1207-1211.