메뉴 건너뛰기




Volumn 24, Issue 4, 2013, Pages 672-679

Trans-10,cis-12 Conjugated linoleic acid promotes bone formation by inhibiting adipogenesis by peroxisome proliferator activated receptor-γ-dependent mechanisms and by directly enhancing osteoblastogenesis from bone marrow mesenchymal stem cells

Author keywords

Adipogenesis; Cis 12 CLA; Cis 9; CLA; Osteoblastogenesis; Trans 10; Trans 11 CLA

Indexed keywords

CALCIUM; CONJUGATED LINOLEIC ACID; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR RUNX2;

EID: 84875065100     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2012.03.017     Document Type: Article
Times cited : (19)

References (90)
  • 1
    • 0141499867 scopus 로고    scopus 로고
    • Bone strength and its determinants
    • Ammann P., Rizzoli R. Bone strength and its determinants. Osteoporos Int 2003, 14(Suppl. 3):S13-S18.
    • (2003) Osteoporos Int , vol.14 , Issue.SUPPL. 3
    • Ammann, P.1    Rizzoli, R.2
  • 2
    • 27944502794 scopus 로고    scopus 로고
    • National Osteoporosis Foundation, Available at: (accessed May 18, 2012)
    • National Osteoporosis Foundation Fast facts 2005, Available at:, (accessed May 18, 2012). http://www.nof.org/node/40.
    • (2005) Fast facts
  • 3
    • 23844551316 scopus 로고    scopus 로고
    • Novel treatments for obesity and osteoporosis: targeting apoptotic pathways in adipocytes
    • Nelson-Dooley C., Della-Fera M.A., Hamrick M., Baile C.A. Novel treatments for obesity and osteoporosis: targeting apoptotic pathways in adipocytes. Curr Med Chem 2005, 12:2215-2225.
    • (2005) Curr Med Chem , vol.12 , pp. 2215-2225
    • Nelson-Dooley, C.1    Della-Fera, M.A.2    Hamrick, M.3    Baile, C.A.4
  • 5
    • 0141723284 scopus 로고    scopus 로고
    • Reduced bone formation and increased bone resorption: Rational targets for the treatment of osteoporosis
    • Seeman E. Reduced bone formation and increased bone resorption: Rational targets for the treatment of osteoporosis. Osteoporos Int 2003, 14(Suppl. 3):S2-S8.
    • (2003) Osteoporos Int , vol.14 , Issue.SUPPL. 3
    • Seeman, E.1
  • 6
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg H.M. Developmental regulation of the growth plate. Nature 2003, 423:332-336.
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 8
    • 0037706865 scopus 로고    scopus 로고
    • Osteoblasts: novel roles in orchestration of skeletal architecture
    • Mackie E.J. Osteoblasts: novel roles in orchestration of skeletal architecture. Int J Biochem Cell Biol 2003, 35:1301-1305.
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 1301-1305
    • Mackie, E.J.1
  • 9
    • 0033926146 scopus 로고    scopus 로고
    • Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?
    • Nuttall M.E., Gimble J.M. Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?. Bone 2000, 27:177-184.
    • (2000) Bone , vol.27 , pp. 177-184
    • Nuttall, M.E.1    Gimble, J.M.2
  • 11
    • 37249051759 scopus 로고    scopus 로고
    • Suppression of PPAR transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts
    • Takada I., Suzawa M., Matsumoto K., Kato S. Suppression of PPAR transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts. Ann N Y Acad Sci 2007, 1116:182-195.
    • (2007) Ann N Y Acad Sci , vol.1116 , pp. 182-195
    • Takada, I.1    Suzawa, M.2    Matsumoto, K.3    Kato, S.4
  • 12
    • 2142652189 scopus 로고    scopus 로고
    • PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
    • Akune T., Ohba S., Kamekura S., Yamaguchi M., Chung U.I., Kubota N., et al. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 2004, 113:846-855.
    • (2004) J Clin Invest , vol.113 , pp. 846-855
    • Akune, T.1    Ohba, S.2    Kamekura, S.3    Yamaguchi, M.4    Chung, U.I.5    Kubota, N.6
  • 13
    • 0029847076 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells
    • Gimble J.M., Robinson C.E., Wu X., Kelly K.A., Rodriguez B.R., Kliewer S.A., et al. Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. Mol Pharmacol 1996, 50:1087-1094.
    • (1996) Mol Pharmacol , vol.50 , pp. 1087-1094
    • Gimble, J.M.1    Robinson, C.E.2    Wu, X.3    Kelly, K.A.4    Rodriguez, B.R.5    Kliewer, S.A.6
  • 14
    • 33846307827 scopus 로고    scopus 로고
    • Mechanisms of body fat modulation by conjugated linoleic acid (CLA)
    • Park Y., Pariza M.W. Mechanisms of body fat modulation by conjugated linoleic acid (CLA). Food Res Int 2007, 40:311-323.
    • (2007) Food Res Int , vol.40 , pp. 311-323
    • Park, Y.1    Pariza, M.W.2
  • 16
    • 0014027234 scopus 로고
    • Intermediates and products of the biohydrogenation of linoleic acid by butyrinvibrio fibrisolvens
    • Kepler C.R., Hirons K.P., McNeill J.J., Tove S.B. Intermediates and products of the biohydrogenation of linoleic acid by butyrinvibrio fibrisolvens. J Biol Chem 1966, 241:1350-1354.
    • (1966) J Biol Chem , vol.241 , pp. 1350-1354
    • Kepler, C.R.1    Hirons, K.P.2    McNeill, J.J.3    Tove, S.B.4
  • 17
    • 0034964992 scopus 로고    scopus 로고
    • The biologically active isomers of conjugated linoleic acid
    • Pariza M.W., Park Y., Cook M.E. The biologically active isomers of conjugated linoleic acid. Prog Lipid Res 2001, 40:283-298.
    • (2001) Prog Lipid Res , vol.40 , pp. 283-298
    • Pariza, M.W.1    Park, Y.2    Cook, M.E.3
  • 18
    • 2942668265 scopus 로고    scopus 로고
    • Perspective on the safety and effectiveness of conjugated linoleic acid
    • Pariza M.W. Perspective on the safety and effectiveness of conjugated linoleic acid. Am J Clin Nutr 2004, 79:1132S-1136S.
    • (2004) Am J Clin Nutr , vol.79
    • Pariza, M.W.1
  • 19
    • 0036439367 scopus 로고    scopus 로고
    • Conjugated linoleic acid isomers and mammary cancer prevention
    • Ip C., Dong Y., Ip M.M., Banni S., Carta G., Angioni E., et al. Conjugated linoleic acid isomers and mammary cancer prevention. Nutr Cancer 2002, 43:52-58.
    • (2002) Nutr Cancer , vol.43 , pp. 52-58
    • Ip, C.1    Dong, Y.2    Ip, M.M.3    Banni, S.4    Carta, G.5    Angioni, E.6
  • 20
    • 0942279573 scopus 로고    scopus 로고
    • Isomers of conjugated linoleic acid differ in their effects on angiogenesis and survival of mouse mammary adipose vasculature
    • Masso-Welch P.A., Zangani D., Ip C., Vaughan M.M., Shoemaker S.F., McGee S.O., et al. Isomers of conjugated linoleic acid differ in their effects on angiogenesis and survival of mouse mammary adipose vasculature. J Nutr 2004, 134:299-307.
    • (2004) J Nutr , vol.134 , pp. 299-307
    • Masso-Welch, P.A.1    Zangani, D.2    Ip, C.3    Vaughan, M.M.4    Shoemaker, S.F.5    McGee, S.O.6
  • 21
    • 1342303693 scopus 로고    scopus 로고
    • Lipid atherogenic risk markers can be more favourably influenced by the cis-9, trans-11-octadecadienoate isomer than a conjugated linoleic acid mixture or fish oil in hamsters
    • Valeille K., Gripois D., Blouquit M.F., Souidi M., Riottot M., Bouthegourd J.C., et al. Lipid atherogenic risk markers can be more favourably influenced by the cis-9, trans-11-octadecadienoate isomer than a conjugated linoleic acid mixture or fish oil in hamsters. Br J Nutr 2004, 91:191-199.
    • (2004) Br J Nutr , vol.91 , pp. 191-199
    • Valeille, K.1    Gripois, D.2    Blouquit, M.F.3    Souidi, M.4    Riottot, M.5    Bouthegourd, J.C.6
  • 22
    • 0032955643 scopus 로고    scopus 로고
    • Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice
    • Park Y., Storkson J.M., Albright K.J., Liu W., Pariza M.W. Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 1999, 34:235-241.
    • (1999) Lipids , vol.34 , pp. 235-241
    • Park, Y.1    Storkson, J.M.2    Albright, K.J.3    Liu, W.4    Pariza, M.W.5
  • 23
    • 0032899791 scopus 로고    scopus 로고
    • Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid
    • Park Y., Albright K.J., Storkson J.M., Liu W., Cook M.E., Pariza M.W. Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 1999, 34:243-248.
    • (1999) Lipids , vol.34 , pp. 243-248
    • Park, Y.1    Albright, K.J.2    Storkson, J.M.3    Liu, W.4    Cook, M.E.5    Pariza, M.W.6
  • 24
    • 51349144766 scopus 로고    scopus 로고
    • Co-supplementation of dietary calcium and conjugated linoleic acid (CLA) improves bone mass in mice
    • Park Y., Pariza M.W., Park Y. Co-supplementation of dietary calcium and conjugated linoleic acid (CLA) improves bone mass in mice. J Food Sci 2008, 73:C556-C560.
    • (2008) J Food Sci , vol.73
    • Park, Y.1    Pariza, M.W.2    Park, Y.3
  • 25
    • 0141739735 scopus 로고    scopus 로고
    • Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes
    • Brown J.M., Boysen M.S., Jensen S.S., Morrison R.F., Storkson J., Lea-Currie R., et al. Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes. J Lipid Res 2003, 44:1287-1300.
    • (2003) J Lipid Res , vol.44 , pp. 1287-1300
    • Brown, J.M.1    Boysen, M.S.2    Jensen, S.S.3    Morrison, R.F.4    Storkson, J.5    Lea-Currie, R.6
  • 26
    • 0141851324 scopus 로고    scopus 로고
    • Trans10, cis12-conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARgamma modulator
    • Granlund L., Juvet L.K., Pedersen J.I., Nebb H.I. Trans10, cis12-conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARgamma modulator. J Lipid Res 2003, 44:1441-1452.
    • (2003) J Lipid Res , vol.44 , pp. 1441-1452
    • Granlund, L.1    Juvet, L.K.2    Pedersen, J.I.3    Nebb, H.I.4
  • 27
    • 79958727624 scopus 로고    scopus 로고
    • T10c12-CLA maintains higher bone mineral density during aging by modulating osteoclastogenesis and bone marrow adiposity
    • Rahman M.M., Halade G.V., Williams P.J., Fernandes G. t10c12-CLA maintains higher bone mineral density during aging by modulating osteoclastogenesis and bone marrow adiposity. J Cell Physiol 2011, 226:2406-2414.
    • (2011) J Cell Physiol , vol.226 , pp. 2406-2414
    • Rahman, M.M.1    Halade, G.V.2    Williams, P.J.3    Fernandes, G.4
  • 28
    • 79954571944 scopus 로고    scopus 로고
    • Combination of conjugated linoleic acid with fish oil prevents age-associated bone marrow adiposity in C57Bl/6J mice
    • Halade G.V., Rahman M.M., Williams P.J., Fernandes G. Combination of conjugated linoleic acid with fish oil prevents age-associated bone marrow adiposity in C57Bl/6J mice. J Nutr Biochem 2011, 22:459-469.
    • (2011) J Nutr Biochem , vol.22 , pp. 459-469
    • Halade, G.V.1    Rahman, M.M.2    Williams, P.J.3    Fernandes, G.4
  • 29
    • 34247608127 scopus 로고    scopus 로고
    • Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells
    • Zhou H., Yang X., Wang N., Zhang Y., Cai G. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells. Mol Cell Endocrinol 2007, 270:17-22.
    • (2007) Mol Cell Endocrinol , vol.270 , pp. 17-22
    • Zhou, H.1    Yang, X.2    Wang, N.3    Zhang, Y.4    Cai, G.5
  • 30
    • 49949144072 scopus 로고
    • An improved automated procedure for the determination of calcium in biological specimens
    • Hillel J.G. An improved automated procedure for the determination of calcium in biological specimens. Anal Biochem 1967, 18:521-531.
    • (1967) Anal Biochem , vol.18 , pp. 521-531
    • Hillel, J.G.1
  • 31
    • 0034783355 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases during ascorbate-induced differentiation of osteoblastic MC3T3-E1 cells
    • Mizutani A., Sugiyama I., Kuno E., Matsunaga S., Tsukagoshi N. Expression of matrix metalloproteinases during ascorbate-induced differentiation of osteoblastic MC3T3-E1 cells. J Bone Miner Res 2001, 16:2043-2049.
    • (2001) J Bone Miner Res , vol.16 , pp. 2043-2049
    • Mizutani, A.1    Sugiyama, I.2    Kuno, E.3    Matsunaga, S.4    Tsukagoshi, N.5
  • 32
    • 0034892766 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis
    • Fajas L., Debril M.B., Auwerx J. Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis. J Mol Endocrinol 2001, 27:1-9.
    • (2001) J Mol Endocrinol , vol.27 , pp. 1-9
    • Fajas, L.1    Debril, M.B.2    Auwerx, J.3
  • 33
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 1997, 89:755-764.
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3    Yamaguchi, A.4    Sasaki, K.5    Deguchi, K.6
  • 35
    • 0025316785 scopus 로고
    • Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix
    • Owen T.A., Aronow M., Shalhoub V., Barone L.M., Wilming L., Tassinari M.S., et al. Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol 1990, 143:420-430.
    • (1990) J Cell Physiol , vol.143 , pp. 420-430
    • Owen, T.A.1    Aronow, M.2    Shalhoub, V.3    Barone, L.M.4    Wilming, L.5    Tassinari, M.S.6
  • 36
    • 77950665927 scopus 로고    scopus 로고
    • Physiological role of alkaline phosphatase explored in hypophosphatasia
    • Whyte M.P. Physiological role of alkaline phosphatase explored in hypophosphatasia. Ann N Y Acad Sci 2010, 1192:190-200.
    • (2010) Ann N Y Acad Sci , vol.1192 , pp. 190-200
    • Whyte, M.P.1
  • 37
    • 0003603482 scopus 로고
    • The propeptide of rat bone gamma-carboxyglutamic acid protein shares homology with other vitamin K-dependent protein precursors
    • Pan L.C., Price P.A. The propeptide of rat bone gamma-carboxyglutamic acid protein shares homology with other vitamin K-dependent protein precursors. Proc Natl Acad Sci U S A 1985, 82:6109-6113.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 6109-6113
    • Pan, L.C.1    Price, P.A.2
  • 38
    • 0023202335 scopus 로고
    • Expression of differentiated function by mineralizing cultures of chicken osteoblasts
    • Gerstenfeld L.C., Chipman S.D., Glowacki J., Lian J.B. Expression of differentiated function by mineralizing cultures of chicken osteoblasts. Dev Biol 1987, 122:49-60.
    • (1987) Dev Biol , vol.122 , pp. 49-60
    • Gerstenfeld, L.C.1    Chipman, S.D.2    Glowacki, J.3    Lian, J.B.4
  • 39
    • 0033304730 scopus 로고    scopus 로고
    • Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
    • Suda T., Takahashi N., Udagawa N., Jimi E., Gillespie M.T., Martin T.J. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 1999, 20:345-357.
    • (1999) Endocr Rev , vol.20 , pp. 345-357
    • Suda, T.1    Takahashi, N.2    Udagawa, N.3    Jimi, E.4    Gillespie, M.T.5    Martin, T.J.6
  • 40
    • 0038607705 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-gamma inhibits the Runx2-mediated transcription of osteocalcin in osteoblasts
    • Jeon M.J., Kim J.A., Kwon S.H., Kim S.W., Park K.S., Park S.W., et al. Activation of peroxisome proliferator-activated receptor-gamma inhibits the Runx2-mediated transcription of osteocalcin in osteoblasts. J Biol Chem 2003, 278:23270-23277.
    • (2003) J Biol Chem , vol.278 , pp. 23270-23277
    • Jeon, M.J.1    Kim, J.A.2    Kwon, S.H.3    Kim, S.W.4    Park, K.S.5    Park, S.W.6
  • 41
    • 71649093576 scopus 로고    scopus 로고
    • Regulation of osteoblast and adipocyte differentiation from human mesenchymal stem cells by conjugated linoleic acid
    • Platt I.D., El-Sohemy A. Regulation of osteoblast and adipocyte differentiation from human mesenchymal stem cells by conjugated linoleic acid. J Nutr Biochem 2009, 20:956-964.
    • (2009) J Nutr Biochem , vol.20 , pp. 956-964
    • Platt, I.D.1    El-Sohemy, A.2
  • 42
    • 71749089611 scopus 로고    scopus 로고
    • Conjugated linoleic acid (CLA): good or bad trans fat?
    • Park Y. Conjugated linoleic acid (CLA): good or bad trans fat?. J Food Comp Anal 2009, 22S:S4-S12.
    • (2009) J Food Comp Anal , vol.22 S
    • Park, Y.1
  • 43
    • 0035851187 scopus 로고    scopus 로고
    • PPARgamma: a nuclear regulator of metabolism, differentiation, and cell growth
    • Rosen E.D., Spiegelman B.M. PPARgamma: a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem 2001, 276:37731-37734.
    • (2001) J Biol Chem , vol.276 , pp. 37731-37734
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 44
    • 0033213631 scopus 로고    scopus 로고
    • PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro
    • Rosen E.D., Sarraf P., Troy A.E., Bradwin G., Moore K., Milstone D.S., et al. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 1999, 4:611-617.
    • (1999) Mol Cell , vol.4 , pp. 611-617
    • Rosen, E.D.1    Sarraf, P.2    Troy, A.E.3    Bradwin, G.4    Moore, K.5    Milstone, D.S.6
  • 45
    • 0035661902 scopus 로고    scopus 로고
    • Trans-10, cis-12 conjugated linoleic acid reduces triglyceride content while differentially affecting peroxisome proliferator activated receptor gamma2 and aP2 expression in 3T3-L1 preadipocytes
    • Evans M., Park Y., Pariza M., Curtis L., Kuebler B., McIntosh M. trans-10, cis-12 conjugated linoleic acid reduces triglyceride content while differentially affecting peroxisome proliferator activated receptor gamma2 and aP2 expression in 3T3-L1 preadipocytes. Lipids 2001, 36:1223-1232.
    • (2001) Lipids , vol.36 , pp. 1223-1232
    • Evans, M.1    Park, Y.2    Pariza, M.3    Curtis, L.4    Kuebler, B.5    McIntosh, M.6
  • 46
    • 46749104743 scopus 로고    scopus 로고
    • Dietary conjugated linoleic acid increases PPAR gamma gene expression in adipose tissue of obese rat, and improves insulin resistance
    • Zhou X.R., Sun C.H., Liu J.R., Zhao D. Dietary conjugated linoleic acid increases PPAR gamma gene expression in adipose tissue of obese rat, and improves insulin resistance. Growth Horm IGF Res 2008, 18:361-368.
    • (2008) Growth Horm IGF Res , vol.18 , pp. 361-368
    • Zhou, X.R.1    Sun, C.H.2    Liu, J.R.3    Zhao, D.4
  • 48
    • 0033861304 scopus 로고    scopus 로고
    • Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice
    • Tsuboyama-Kasaoka N., Takahashi M., Tanemura K., Kim H.J., Tange T., Okuyama H., et al. Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 2000, 49:1534-1542.
    • (2000) Diabetes , vol.49 , pp. 1534-1542
    • Tsuboyama-Kasaoka, N.1    Takahashi, M.2    Tanemura, K.3    Kim, H.J.4    Tange, T.5    Okuyama, H.6
  • 49
    • 16544392835 scopus 로고    scopus 로고
    • Influence of dietary conjugated linoleic acid and fat source on body fat and apoptosis in mice
    • Hargrave K.M., Meyer B.J., Li C., Azain M.J., Baile C.A., Miner J.L. Influence of dietary conjugated linoleic acid and fat source on body fat and apoptosis in mice. Obes Res 2004, 12:1435-1444.
    • (2004) Obes Res , vol.12 , pp. 1435-1444
    • Hargrave, K.M.1    Meyer, B.J.2    Li, C.3    Azain, M.J.4    Baile, C.A.5    Miner, J.L.6
  • 50
    • 53049087888 scopus 로고    scopus 로고
    • Bone morphogenetic protein-smad pathway as drug targets for osteoporosis and cancer therapy
    • Li B. Bone morphogenetic protein-smad pathway as drug targets for osteoporosis and cancer therapy. Endocr Metab Immune Disord Drug Targets 2008, 8:208-219.
    • (2008) Endocr Metab Immune Disord Drug Targets , vol.8 , pp. 208-219
    • Li, B.1
  • 51
    • 33745958768 scopus 로고    scopus 로고
    • Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo
    • Arnold S.J., Maretto S., Islam A., Bikoff E.K., Robertson E.J. Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. Dev Biol 2006, 296:104-118.
    • (2006) Dev Biol , vol.296 , pp. 104-118
    • Arnold, S.J.1    Maretto, S.2    Islam, A.3    Bikoff, E.K.4    Robertson, E.J.5
  • 52
    • 30044440540 scopus 로고    scopus 로고
    • SMAD 8 binding to mice Msx1 basal promoter is required for transcriptional activation
    • Binato R., Alvarez Martinez C.E., Pizzatti L., Robert B., Abdelhay E. SMAD 8 binding to mice Msx1 basal promoter is required for transcriptional activation. Biochem J 2006, 393:141-150.
    • (2006) Biochem J , vol.393 , pp. 141-150
    • Binato, R.1    Alvarez Martinez, C.E.2    Pizzatti, L.3    Robert, B.4    Abdelhay, E.5
  • 55
    • 67349273265 scopus 로고    scopus 로고
    • Conjugated linoleic acid isomers' roles in the regulation of PPAR-gamma and NF-kappaB DNA binding and subsequent expression of antioxidant enzymes in human umbilical vein endothelial cells
    • Nakamura Y.K., Omaye S.T. Conjugated linoleic acid isomers' roles in the regulation of PPAR-gamma and NF-kappaB DNA binding and subsequent expression of antioxidant enzymes in human umbilical vein endothelial cells. Nutrition 2009, 25:800-811.
    • (2009) Nutrition , vol.25 , pp. 800-811
    • Nakamura, Y.K.1    Omaye, S.T.2
  • 56
    • 78549266210 scopus 로고    scopus 로고
    • Trans-10, cis-12 conjugated linoleic acid inhibits skeletal muscle differentiation and GLUT4 expression independently from NF-kappaB activation
    • Hommelberg P.P., Plat J., Remels A.H., van Essen A.L., Kelders M.C., Mensink R.P., et al. trans-10, cis-12 conjugated linoleic acid inhibits skeletal muscle differentiation and GLUT4 expression independently from NF-kappaB activation. Mol Nutr Food Res 2010, 54:1763-1772.
    • (2010) Mol Nutr Food Res , vol.54 , pp. 1763-1772
    • Hommelberg, P.P.1    Plat, J.2    Remels, A.H.3    van Essen, A.L.4    Kelders, M.C.5    Mensink, R.P.6
  • 57
    • 33644680390 scopus 로고    scopus 로고
    • Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production
    • Chung S., Brown J.M., Provo J.N., Hopkins R., McIntosh M.K. Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production. J Biol Chem 2005, 280:38445-38456.
    • (2005) J Biol Chem , vol.280 , pp. 38445-38456
    • Chung, S.1    Brown, J.M.2    Provo, J.N.3    Hopkins, R.4    McIntosh, M.K.5
  • 58
    • 79956016327 scopus 로고    scopus 로고
    • Trans-10, cis-12-conjugated linoleic acid modulates NF-kappaB activation and TNF-alpha production in porcine peripheral blood mononuclear cells via a PPARgamma-dependent pathway
    • Kim D.I., Kim K.H., Kang J.H., Jung E.M., Kim S.S., Jeung E.B., et al. Trans-10, cis-12-conjugated linoleic acid modulates NF-kappaB activation and TNF-alpha production in porcine peripheral blood mononuclear cells via a PPARgamma-dependent pathway. Br J Nutr 2011, 105:1329-1336.
    • (2011) Br J Nutr , vol.105 , pp. 1329-1336
    • Kim, D.I.1    Kim, K.H.2    Kang, J.H.3    Jung, E.M.4    Kim, S.S.5    Jeung, E.B.6
  • 59
    • 75749089240 scopus 로고    scopus 로고
    • NF-kappaB activation stimulates osteogenic differentiation of mesenchymal stem cells derived from human adipose tissue by increasing TAZ expression
    • Cho H.H., Shin K.K., Kim Y.J., Song J.S., Kim J.M., Bae Y.C., et al. NF-kappaB activation stimulates osteogenic differentiation of mesenchymal stem cells derived from human adipose tissue by increasing TAZ expression. J Cell Physiol 2010, 223:168-177.
    • (2010) J Cell Physiol , vol.223 , pp. 168-177
    • Cho, H.H.1    Shin, K.K.2    Kim, Y.J.3    Song, J.S.4    Kim, J.M.5    Bae, Y.C.6
  • 60
    • 65949099511 scopus 로고    scopus 로고
    • Prostaglandin E2 (PGE2) and thromboxane A2 (TXA2) synthesis is regulated by conjugated linoleic acids (CLA) in human macrophages
    • Stachowska E., Dolegowska B., Dziedziejko V., Rybicka M., Kaczmarczyk M., Bober J., et al. Prostaglandin E2 (PGE2) and thromboxane A2 (TXA2) synthesis is regulated by conjugated linoleic acids (CLA) in human macrophages. J Physiol Pharmacol 2009, 60:77-85.
    • (2009) J Physiol Pharmacol , vol.60 , pp. 77-85
    • Stachowska, E.1    Dolegowska, B.2    Dziedziejko, V.3    Rybicka, M.4    Kaczmarczyk, M.5    Bober, J.6
  • 61
    • 40449089260 scopus 로고    scopus 로고
    • Trans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytes
    • Kennedy A., Chung S., LaPoint K., Fabiyi O., McIntosh M.K. Trans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytes. J Nutr 2008, 138:455-461.
    • (2008) J Nutr , vol.138 , pp. 455-461
    • Kennedy, A.1    Chung, S.2    LaPoint, K.3    Fabiyi, O.4    McIntosh, M.K.5
  • 62
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • Boyle W.J., Simonet W.S., Lacey D.L. Osteoclast differentiation and activation. Nature 2003, 423:337-342.
    • (2003) Nature , vol.423 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 63
    • 0028035150 scopus 로고
    • Mechanisms by which cells of the osteoblast lineage control osteoclast formation and activity
    • Martin T.J., Ng K.W. Mechanisms by which cells of the osteoblast lineage control osteoclast formation and activity. J Cell Biochem 1994, 56:357-366.
    • (1994) J Cell Biochem , vol.56 , pp. 357-366
    • Martin, T.J.1    Ng, K.W.2
  • 64
    • 61449123058 scopus 로고    scopus 로고
    • PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells
    • Shockley K.R., Lazarenko O.P., Czernik P.J., Rosen C.J., Churchill G.A., Lecka-Czernik B. PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells. J Cell Biochem 2009, 106:232-246.
    • (2009) J Cell Biochem , vol.106 , pp. 232-246
    • Shockley, K.R.1    Lazarenko, O.P.2    Czernik, P.J.3    Rosen, C.J.4    Churchill, G.A.5    Lecka-Czernik, B.6
  • 65
    • 77749270565 scopus 로고    scopus 로고
    • Pharmaceutical modulation of canonical wnt signaling in multipotent stromal cells for improved osteoinductive therapy
    • Krause U., Harris S., Green A., Ylostalo J., Zeitouni S., Lee N., et al. Pharmaceutical modulation of canonical wnt signaling in multipotent stromal cells for improved osteoinductive therapy. Proc Natl Acad Sci U S A 2010, 107:4147-4152.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 4147-4152
    • Krause, U.1    Harris, S.2    Green, A.3    Ylostalo, J.4    Zeitouni, S.5    Lee, N.6
  • 66
    • 0036288940 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor gamma inhibits osteoprotegerin gene expression in human aortic smooth muscle cells
    • Fu M., Zhang J., Lin Yg Y., Zhu X., Willson T.M., Chen Y.E. Activation of peroxisome proliferator-activated receptor gamma inhibits osteoprotegerin gene expression in human aortic smooth muscle cells. Biochem Biophys Res Commun 2002, 294:597-601.
    • (2002) Biochem Biophys Res Commun , vol.294 , pp. 597-601
    • Fu, M.1    Zhang, J.2    Lin Yg, Y.3    Zhu, X.4    Willson, T.M.5    Chen, Y.E.6
  • 67
    • 33747109877 scopus 로고    scopus 로고
    • Conjugated linoleic acid inhibits osteoclast differentiation of RAW264.7 cells by modulating RANKL signaling
    • Rahman M.M., Bhattacharya A., Fernandes G. Conjugated linoleic acid inhibits osteoclast differentiation of RAW264.7 cells by modulating RANKL signaling. J Lipid Res 2006, 47:1739-1748.
    • (2006) J Lipid Res , vol.47 , pp. 1739-1748
    • Rahman, M.M.1    Bhattacharya, A.2    Fernandes, G.3
  • 68
    • 84862110789 scopus 로고    scopus 로고
    • Implication of conjugated linoleic acid (CLA) in human health
    • Dilzer A., Park Y. Implication of conjugated linoleic acid (CLA) in human health. Crit Rev Food Sci Nutr 2012, 52:488-513.
    • (2012) Crit Rev Food Sci Nutr , vol.52 , pp. 488-513
    • Dilzer, A.1    Park, Y.2
  • 69
    • 0036693309 scopus 로고    scopus 로고
    • Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers
    • Kreider R.B., Ferreira M.P., Greenwood M., Wilson M., Almada A.L. Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. J Strength Cond Res 2002, 16:325-334.
    • (2002) J Strength Cond Res , vol.16 , pp. 325-334
    • Kreider, R.B.1    Ferreira, M.P.2    Greenwood, M.3    Wilson, M.4    Almada, A.L.5
  • 70
    • 23944464765 scopus 로고    scopus 로고
    • Association between dietary conjugated linoleic acid and bone mineral density in postmenopausal women
    • Brownbill R.A., Petrosian M., Ilich J.Z. Association between dietary conjugated linoleic acid and bone mineral density in postmenopausal women. J Am Coll Nutr 2005, 24:177-181.
    • (2005) J Am Coll Nutr , vol.24 , pp. 177-181
    • Brownbill, R.A.1    Petrosian, M.2    Ilich, J.Z.3
  • 71
    • 0034933093 scopus 로고    scopus 로고
    • Differences between humans and mice in efficacy of the body fat lowering effect of conjugated linoleic acid: Role of metabolic rate
    • Terpstra A.H. Differences between humans and mice in efficacy of the body fat lowering effect of conjugated linoleic acid: Role of metabolic rate. J Nutr 2001, 131:2067-2068.
    • (2001) J Nutr , vol.131 , pp. 2067-2068
    • Terpstra, A.H.1
  • 72
    • 0034790944 scopus 로고    scopus 로고
    • Calcium modulation of hypertension and obesity: Mechanisms and implications
    • [discussion 440S-442S]
    • Zemel M.B. Calcium modulation of hypertension and obesity: Mechanisms and implications. J Am Coll Nutr 2001, 20:428S-435S. [discussion 440S-442S].
    • (2001) J Am Coll Nutr , vol.20
    • Zemel, M.B.1
  • 74
    • 79960011245 scopus 로고    scopus 로고
    • Interaction between dietary conjugated linoleic acid and calcium supplementation affecting bone and fat mass
    • Park Y., Terk M., Park Y. Interaction between dietary conjugated linoleic acid and calcium supplementation affecting bone and fat mass. J Bone Miner Metab 2011, 29:268-278.
    • (2011) J Bone Miner Metab , vol.29 , pp. 268-278
    • Park, Y.1    Terk, M.2    Park, Y.3
  • 75
    • 0141975203 scopus 로고    scopus 로고
    • The effect of polyunsaturated fatty acids, including conjugated linoleic acid, on calcium absorption and bone metabolism and composition in young growing rats
    • Kelly O., Cusack S., Jewell C., Cashman K.D. The effect of polyunsaturated fatty acids, including conjugated linoleic acid, on calcium absorption and bone metabolism and composition in young growing rats. Br J Nutr 2003, 90:743-750.
    • (2003) Br J Nutr , vol.90 , pp. 743-750
    • Kelly, O.1    Cusack, S.2    Jewell, C.3    Cashman, K.D.4
  • 76
    • 0035001538 scopus 로고    scopus 로고
    • Fatty acids and epithelial permeability: effect of conjugated linoleic acid in caco-2 cells
    • Roche H.M., Terres A.M., Black I.B., Gibney M.J., Kelleher D. Fatty acids and epithelial permeability: effect of conjugated linoleic acid in caco-2 cells. Gut 2001, 48:797-802.
    • (2001) Gut , vol.48 , pp. 797-802
    • Roche, H.M.1    Terres, A.M.2    Black, I.B.3    Gibney, M.J.4    Kelleher, D.5
  • 77
    • 0020662582 scopus 로고
    • Vertebral bone loss: an unheeded side effect of therapeutic bed rest
    • Krolner B., Toft B. Vertebral bone loss: an unheeded side effect of therapeutic bed rest. Clin Sci (Lond) 1983, 64:537-540.
    • (1983) Clin Sci (Lond) , vol.64 , pp. 537-540
    • Krolner, B.1    Toft, B.2
  • 79
    • 0032975907 scopus 로고    scopus 로고
    • The effect of exercise training programs on bone mass: a meta-analysis of published controlled trials in pre- and postmenopausal women
    • Wolff I., van Croonenborg J.J., Kemper H.C., Kostense P.J., Twisk J.W. The effect of exercise training programs on bone mass: a meta-analysis of published controlled trials in pre- and postmenopausal women. Osteoporos Int 1999, 9:1-12.
    • (1999) Osteoporos Int , vol.9 , pp. 1-12
    • Wolff, I.1    van Croonenborg, J.J.2    Kemper, H.C.3    Kostense, P.J.4    Twisk, J.W.5
  • 80
    • 80053928715 scopus 로고    scopus 로고
    • Treadmill training prevents bone loss by inhibition of PPARgamma expression but not promoting of Runx2 expression in ovariectomized rats
    • Chen Y., Wang S., Bu S., Wang Y., Duan Y., Yang S. Treadmill training prevents bone loss by inhibition of PPARgamma expression but not promoting of Runx2 expression in ovariectomized rats. Eur J Appl Physiol 2011, 111:1759-1767.
    • (2011) Eur J Appl Physiol , vol.111 , pp. 1759-1767
    • Chen, Y.1    Wang, S.2    Bu, S.3    Wang, Y.4    Duan, Y.5    Yang, S.6
  • 81
    • 0033048393 scopus 로고    scopus 로고
    • High-fat dairy product consumption increases delta 9c,11t-18:2 (rumenic acid) and total lipid concentrations of human milk
    • Park Y., McGuire M.K., Behr R., McGuire M.A., Evans M.A., Shultz T.D. High-fat dairy product consumption increases delta 9c,11t-18:2 (rumenic acid) and total lipid concentrations of human milk. Lipids 1999, 34:543-549.
    • (1999) Lipids , vol.34 , pp. 543-549
    • Park, Y.1    McGuire, M.K.2    Behr, R.3    McGuire, M.A.4    Evans, M.A.5    Shultz, T.D.6
  • 83
    • 0031930902 scopus 로고    scopus 로고
    • Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans
    • Herbel B.K., McGuire M.K., McGuire M.A., Shultz T.D. Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. Am J Clin Nutr 1998, 67:332-337.
    • (1998) Am J Clin Nutr , vol.67 , pp. 332-337
    • Herbel, B.K.1    McGuire, M.K.2    McGuire, M.A.3    Shultz, T.D.4
  • 84
    • 46249130552 scopus 로고    scopus 로고
    • Cis-9, trans-11-conjugated linoleic acid inhibits allergic sensitization and airway inflammation via a PPARgamma-related mechanism in mice
    • Jaudszus A., Krokowski M., Mockel P., Darcan Y., Avagyan A., Matricardi P., et al. Cis-9, trans-11-conjugated linoleic acid inhibits allergic sensitization and airway inflammation via a PPARgamma-related mechanism in mice. J Nutr 2008, 138:1336-1342.
    • (2008) J Nutr , vol.138 , pp. 1336-1342
    • Jaudszus, A.1    Krokowski, M.2    Mockel, P.3    Darcan, Y.4    Avagyan, A.5    Matricardi, P.6
  • 85
    • 28444498355 scopus 로고    scopus 로고
    • Cis-9, trans-11-CLA exerts anti-inflammatory effects in human bronchial epithelial cells and eosinophils: Comparison to trans-10, cis-12-CLA and to linoleic acid
    • Jaudszus A., Foerster M., Kroegel C., Wolf I., Jahreis G. Cis-9, trans-11-CLA exerts anti-inflammatory effects in human bronchial epithelial cells and eosinophils: Comparison to trans-10, cis-12-CLA and to linoleic acid. Biochim Biophys Acta 2005, 1737:111-118.
    • (2005) Biochim Biophys Acta , vol.1737 , pp. 111-118
    • Jaudszus, A.1    Foerster, M.2    Kroegel, C.3    Wolf, I.4    Jahreis, G.5
  • 86
    • 65649149046 scopus 로고    scopus 로고
    • Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytes
    • Platt I., El-Sohemy A. Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytes. Lipids Health Dis 2009, 8:15.
    • (2009) Lipids Health Dis , vol.8 , pp. 15
    • Platt, I.1    El-Sohemy, A.2
  • 87
    • 35848965462 scopus 로고    scopus 로고
    • Conjugated linoleic acid alters global gene expression in human intestinal-like caco-2 cells in an isomer-specific manner
    • Murphy E.F., Hooiveld G.J., Muller M., Calogero R.A., Cashman K.D. Conjugated linoleic acid alters global gene expression in human intestinal-like caco-2 cells in an isomer-specific manner. J Nutr 2007, 137:2359-2365.
    • (2007) J Nutr , vol.137 , pp. 2359-2365
    • Murphy, E.F.1    Hooiveld, G.J.2    Muller, M.3    Calogero, R.A.4    Cashman, K.D.5
  • 88
    • 0037721580 scopus 로고    scopus 로고
    • The effect of conjugated linoleic acid and medium-chain fatty acids on transepithelial calcium transport in human intestinal-like caco-2 cells
    • Jewell C., Cashman K.D. The effect of conjugated linoleic acid and medium-chain fatty acids on transepithelial calcium transport in human intestinal-like caco-2 cells. Br J Nutr 2003, 89:639-647.
    • (2003) Br J Nutr , vol.89 , pp. 639-647
    • Jewell, C.1    Cashman, K.D.2
  • 89
    • 84875077464 scopus 로고    scopus 로고
    • Effects of conjugated linoleic acid (CLA) on calcium homeostasis in ovariectomized mice
    • Park Y.H., Park Y. Effects of conjugated linoleic acid (CLA) on calcium homeostasis in ovariectomized mice. FASEB J 2010, 24:lb377.
    • (2010) FASEB J , vol.24
    • Park, Y.H.1    Park, Y.2
  • 90
    • 12344253928 scopus 로고    scopus 로고
    • The effect of conjugated linoleic acid on transepithelial calcium transport and mediators of paracellular permeability in human intestinal-like CaCo-2 cells
    • Jewell C., Cusack S., Cashman K.D. The effect of conjugated linoleic acid on transepithelial calcium transport and mediators of paracellular permeability in human intestinal-like CaCo-2 cells. Prostaglandins Leukot Essent Fatty Acids 2005, 72:163-171.
    • (2005) Prostaglandins Leukot Essent Fatty Acids , vol.72 , pp. 163-171
    • Jewell, C.1    Cusack, S.2    Cashman, K.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.