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Volumn 111, Issue 8, 2011, Pages 1759-1767

Treadmill training prevents bone loss by inhibition of PPARγ expression but not promoting of Runx2 expression in ovariectomized rats

Author keywords

Bone marrow adipogenesis; Osteogenic factors; Osteoporosis; OVX rats; Treadmill training

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RUNX2 PROTEIN, RAT; TRANSCRIPTION FACTOR RUNX2;

EID: 80053928715     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-010-1820-0     Document Type: Article
Times cited : (33)

References (39)
  • 2
    • 59649098627 scopus 로고    scopus 로고
    • Effect of increasing vertebral marrow fat content on BMD measurement, T-score status and fracture risk prediction by DXA
    • Blake GM, Griffith JF, Yeung DK, Leung PC, Fogelman I (2009) Effect of increasing vertebral marrow fat content on BMD measurement, T-score status and fracture risk prediction by DXA. Bone 44(3):495-501
    • (2009) Bone , vol.44 , Issue.3 , pp. 495-501
    • Blake, G.M.1    Griffith, J.F.2    Yeung, D.K.3    Leung, P.C.4    Fogelman, I.5
  • 3
    • 42749083244 scopus 로고    scopus 로고
    • Evidence for multiple peroxisome proliferator-activated receptor gamma transcripts in bone: Fine-tuning by hormonal regulation and mRNA stability
    • Bruedigam C, Koedam M, Chiba H, Eijken M, van Leeuwen JP (2008) Evidence for multiple peroxisome proliferator-activated receptor gamma transcripts in bone: fine-tuning by hormonal regulation and mRNA stability. FEBS Lett 582(11):1618-1624
    • (2008) FEBS Lett , vol.582 , Issue.11 , pp. 1618-1624
    • Bruedigam, C.1    Koedam, M.2    Chiba, H.3    Eijken, M.4    Van Leeuwen, J.P.5
  • 5
    • 34249776946 scopus 로고    scopus 로고
    • Mechanical loading down-regulates peroxisome proliferator-activated receptor γ in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis
    • DOI 10.1210/en.2006-1704
    • David V, Martin A, Lafage-Proust MH, Malaval L, Peyroche S, Jones DB, Vico L, Guignandon A (2007) Mechanical loading downregulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology 148(5):2553-2562 (Pubitemid 47007541)
    • (2007) Endocrinology , vol.148 , Issue.5 , pp. 2553-2562
    • David, V.1    Martin, A.2    Lafage-Proust, M.-H.3    Malaval, L.4    Peyroche, S.5    Jones, D.B.6    Vico, L.7    Guignandon, A.8
  • 7
    • 71349086901 scopus 로고    scopus 로고
    • Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6 J mice
    • Elbaz A, Rivas D, Duque G (2009) Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6 J mice. Biogerontology 10:747-755
    • (2009) Biogerontology , vol.10 , pp. 747-755
    • Elbaz, A.1    Rivas, D.2    Duque, G.3
  • 8
    • 0036333736 scopus 로고    scopus 로고
    • High bone resorption in adult aging transgenic mice overexpressing Cbfa1/Runx2 in cells of the osteoblastic lineage
    • DOI 10.1128/MCB.22.17.6222-6233.2002
    • Geoffroy V, Kneissel M, Fournier B, Boyde A, Matthias P (2002) High bone resorption in adult aging transgenic mice overexpressing cbfa1/Runx2 in cells of the osteoblastic lineage. Mol Cell Biol 22(17):6222-6233 (Pubitemid 34857841)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.17 , pp. 6222-6233
    • Geoffroy, V.1    Kneissel, M.2    Fournier, B.3    Boyde, A.4    Matthias, P.5
  • 9
    • 77954144200 scopus 로고    scopus 로고
    • Effects of treadmill exercise training on liver fat accumulation and estrogen receptor alpha expression in intact and ovariectomized rats with or without estrogen replacement treatment
    • Hao LK, Wang Y, Duan Y, Bu S (2010) Effects of treadmill exercise training on liver fat accumulation and estrogen receptor alpha expression in intact and ovariectomized rats with or without estrogen replacement treatment. Eur J Appl Physiol 109(5): 879-886
    • (2010) Eur J Appl Physiol , vol.109 , Issue.5 , pp. 879-886
    • Hao, L.K.1    Wang, Y.2    Duan, Y.3    Bu, S.4
  • 11
    • 68949120822 scopus 로고    scopus 로고
    • Role of sport and exercise in the maintenance of female bone health
    • Iwamoto J, Sato Y, Takeda T, Matsumoto H (2009) Role of sport and exercise in the maintenance of female bone health. J Bone Miner Metab 27(5):530-537
    • (2009) J Bone Miner Metab , vol.27 , Issue.5 , pp. 530-537
    • Iwamoto, J.1    Sato, Y.2    Takeda, T.3    Matsumoto, H.4
  • 12
    • 0034842784 scopus 로고    scopus 로고
    • Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis
    • DOI 10.1023/A:1011513223894
    • Justesen J, Stenderup K, Ebbesen EN, Mosekilde L, Steiniche T, Kassem M (2001) Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis. Biogerontology 2:165-171 (Pubitemid 32851325)
    • (2001) Biogerontology , vol.2 , Issue.3 , pp. 165-171
    • Justesen, J.1    Stenderup, K.2    Ebbesen, E.N.3    Mosekilde, L.4    Steiniche, T.5    Kassem, M.6
  • 13
    • 0026068145 scopus 로고
    • The ovariectomized rat model of postmenopausal bone loss
    • Kalu DN (1991) The ovariectomized rat model of postmenopausal bone loss. Bone Miner 15(3):175-191
    • (1991) Bone Miner , vol.15 , Issue.3 , pp. 175-191
    • Kalu, D.N.1
  • 15
    • 22644447278 scopus 로고    scopus 로고
    • Regulation of skeletal development by the Runx family of transcription factors
    • DOI 10.1002/jcb.20420
    • Komori T (2005) Regulation of skeletal development by the Runx family of transcription factors. J Cell Biochem 95:445-453 (Pubitemid 41420175)
    • (2005) Journal of Cellular Biochemistry , vol.95 , Issue.3 , pp. 445-453
    • Komori, T.1
  • 17
    • 80053897136 scopus 로고    scopus 로고
    • Simvastatin induces estrogen receptor-alpha expression in bone, restores bone loss, and decreases ERa expression and uterine wet weight in ovariectomized rats
    • Epub ahead of print
    • Li X, Song QS, Wang JY, Leng HJ, Chen ZQ, Liu ZJ, Dang GT, Song CL (2010) Simvastatin induces estrogen receptor-alpha expression in bone, restores bone loss, and decreases ERa expression and uterine wet weight in ovariectomized rats. J Bone Miner Metab (Epub ahead of print)
    • (2010) J Bone Miner Metab
    • Li, X.1    Song, Q.S.2    Wang, J.Y.3    Leng, H.J.4    Chen, Z.Q.5    Liu, Z.J.6    Dang, G.T.7    Song, C.L.8
  • 19
    • 58149084456 scopus 로고    scopus 로고
    • Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesity
    • Luu YK, Capilla E, Rosen CJ, Gilsanz V, Pessin JE, Judex S, Rubin CT (2009) Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesity. J Bone Miner Res 24(1): 50-61
    • (2009) J Bone Miner Res , vol.24 , Issue.1 , pp. 50-61
    • Luu, Y.K.1    Capilla, E.2    Rosen, C.J.3    Gilsanz, V.4    Pessin, J.E.5    Judex, S.6    Rubin, C.T.7
  • 20
    • 0025854709 scopus 로고    scopus 로고
    • Relationships between marrow fat and bone turnover in ovariectomized and intact rats
    • Martin RB, Zissimos SL (2001) Relationships between marrow fat and bone turnover in ovariectomized and intact rats. Bone 12:123-131
    • (2001) Bone , vol.12 , pp. 123-131
    • Martin, R.B.1    Zissimos, S.L.2
  • 22
    • 0034531688 scopus 로고    scopus 로고
    • A comparison of resistance and aerobic training for mass, strength and turnover of bone in growing rats
    • DOI 10.1007/s004210000316
    • Notomi T, Okazaki Y, Okimoto N, Saitoh S, Nakamura T, Suzuki M (2000) A comparison of resistance and aerobic training for mass, strength and turnover of bone in growing rats. Eur J Appl Physiol 83(6):469-474 (Pubitemid 32015612)
    • (2000) European Journal of Applied Physiology , vol.83 , Issue.6 , pp. 469-474
    • Notomi, T.1    Okazaki, Y.2    Okimoto, N.3    Saitoh, S.4    Nakamura, T.5    Suzuki, M.6
  • 23
    • 0037216438 scopus 로고    scopus 로고
    • Tower climbing exercise started 3 months after ovariectomy recovers bone strength of the femur and lumbar vertebrae in aged osteopenic rats
    • DOI 10.1359/jbmr.2003.18.1.140
    • Notomi T, Okimoto N, Okazaki Y, Nakamura T, Suzuki M (2003) Tower climbing exercise started 3 months after ovariectomy recovers bone strength of the femur and lumbar vertebrae in aged osteopenic rats. J Bone Miner Res 18(1):140-149 (Pubitemid 36008350)
    • (2003) Journal of Bone and Mineral Research , vol.18 , Issue.1 , pp. 140-149
    • Notomi, T.1    Okimoto, N.2    Okazaki, Y.3    Nakamura, T.4    Suzuki, M.5
  • 26
    • 65949113378 scopus 로고    scopus 로고
    • Marrow fat and the bone microenvironment: Developmental, functional, and pathological implications
    • Rosen CJ, Ackert-Bicknell C, Rodriguez JP, Pino AM (2009) Marrow fat and the bone microenvironment: developmental, functional, and pathological implications. Crit Rev Eukaryot Gene Expr 19(2):109-124
    • (2009) Crit Rev Eukaryot Gene Expr , vol.19 , Issue.2 , pp. 109-124
    • Rosen, C.J.1    Ackert-Bicknell, C.2    Rodriguez, J.P.3    Pino, A.M.4
  • 27
    • 67349084598 scopus 로고    scopus 로고
    • The role of physical activity in the prevention of osteoporosis in postmenopausal women-an update
    • Schmitt NM, Schmitt J, Dören M (2009) The role of physical activity in the prevention of osteoporosis in postmenopausal women-an update. Maturitas 63(1):34-38
    • (2009) Maturitas , vol.63 , Issue.1 , pp. 34-38
    • Schmitt, N.M.1    Schmitt, J.2    Dören, M.3
  • 29
    • 61449123058 scopus 로고    scopus 로고
    • PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells
    • Shockley KR, Lazarenko OP, Czernik PJ, Rosen CJ, Churchill GA, Lecka-Czernik B (2009) PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells. J Cell Biochem 106(2):232-246
    • (2009) J Cell Biochem , vol.106 , Issue.2 , pp. 232-246
    • Shockley, K.R.1    Lazarenko, O.P.2    Czernik, P.J.3    Rosen, C.J.4    Churchill, G.A.5    Lecka-Czernik, B.6
  • 30
  • 33
    • 80053905695 scopus 로고    scopus 로고
    • The effects of native and synthetic estrogenic compounds as well as vitamin D less-calcemic analogs on adipocytes content in rat bone marrow
    • Epub ahead of print
    • Somjen D, Katzburg S, Kohen F, Gayer B, Posner GH, Yoles I, Livne E (2010) The effects of native and synthetic estrogenic compounds as well as vitamin D less-calcemic analogs on adipocytes content in rat bone marrow. J Endocrinol Invest (Epub ahead of print)
    • (2010) J Endocrinol Invest
    • Somjen, D.1    Katzburg, S.2    Kohen, F.3    Gayer, B.4    Posner, G.H.5    Yoles, I.6    Livne, E.7
  • 35
    • 49549089736 scopus 로고    scopus 로고
    • Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women
    • Syed FA, Oursler MJ, Hefferanm TE, Peterson JM, Riggs BL, Khosla S (2008) Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women. Osteoporos Int 19(9): 1323-1330
    • (2008) Osteoporos Int , vol.19 , Issue.9 , pp. 1323-1330
    • Syed, F.A.1    Oursler, M.J.2    Hefferanm, T.E.3    Peterson, J.M.4    Riggs, B.L.5    Khosla, S.6
  • 37
    • 41949132327 scopus 로고    scopus 로고
    • Effects of jump training on bone are preserved after detraining, regardless of estrogen secretion state in rats
    • DOI 10.1152/japplphysiol.00937.2007
    • Umemura Y, Nagasawa S, Sogo N, Honda A (2008) Effects of jump training on bone are preserved after detraining, regardless of estrogen secretion state in rats. J Appl Physiol 104(4):1116-1120 (Pubitemid 351507952)
    • (2008) Journal of Applied Physiology , vol.104 , Issue.4 , pp. 1116-1120
    • Umemura, Y.1    Nagasawa, S.2    Sogo, N.3    Honda, A.4
  • 38
    • 57049102852 scopus 로고    scopus 로고
    • Differential regulation of dehydroepiandrosterone and estrogen on bone and uterus in ovariectomized mice
    • Wang L, Wang YD, Wang WJ, Li DJ (2009) Differential regulation of dehydroepiandrosterone and estrogen on bone and uterus in ovariectomized mice. Osteoporosis Int 20:79-92
    • (2009) Osteoporosis Int , vol.20 , pp. 79-92
    • Wang, L.1    Wang, Y.D.2    Wang, W.J.3    Li, D.J.4
  • 39
    • 77954886940 scopus 로고    scopus 로고
    • Upregulation of osteogenic factors induced by high-impact jumping suppresses adipogenesis in marrow but not adipogenic transcription factors in rat tibiae
    • Yuki A, Yotani K, Tamaki H, Kasuga N, Takekura H (2010) Upregulation of osteogenic factors induced by high-impact jumping suppresses adipogenesis in marrow but not adipogenic transcription factors in rat tibiae. Eur J Appl Physiol 109: 641-650
    • (2010) Eur J Appl Physiol , vol.109 , pp. 641-650
    • Yuki, A.1    Yotani, K.2    Tamaki, H.3    Kasuga, N.4    Takekura, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.