Trans-10, cis-12-conjugated linoleic acid modulates NF-κB activation and TNF-α production in porcine peripheral blood mononuclear cells via a PPAR-dependent pathway

British Journal of Nutrition

Volumn 105, Issue 9, 2011, Pages 1329-1336

  Kim, Dong In ^a   Kim, Keun Hwa ^a   Kang, Ji Houn ^a   Jung, Eui Man ^a   Kim, Sung Soo ^a   Jeung, Eui Bae ^a   Yang, Mhan Pyo ^a  

^a Department of Veterinary Medicine   (South Korea)

Author keywords

cis 12 conjugated linoleic acid: TNF PPARg: NF B: Pigs: Lipopolysaccharide; Trans 10

Indexed keywords

CONJUGATED LINOLEIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNOMODULATION; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; SWINE; UPREGULATION;

ANIMALS; CELLS, CULTURED; GENE EXPRESSION REGULATION; LEUKOCYTES, MONONUCLEAR; LINOLEIC ACIDS, CONJUGATED; LIPOPOLYSACCHARIDES; NF-KAPPA B; PPAR GAMMA; RNA, MESSENGER; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

SUIDAE; SUS;

EID: 79956016327     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S000711451000499X     Document Type: Article

References (50)

1. Pariza MW & Ha YL (1990) Conjugated dienoic derivatives of linoleic acid: a new class of anticarcinogens. Med Oncol Tumor Pharmacother 7, 169-171. (Pubitemid 20267985)
2. Smedman A & Vessby B (2001) Conjugated linoleic acid supplementation in humans - metabolic effects. Lipids 36, 773-781. (Pubitemid 32924104)
3. Ryder JW, Portocarrero CP, Song XM, et al. (2001) Isomerspecific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression. Diabetes 50, 1149-1157. (Pubitemid 32374547)
4. Watkins BA & Seifert MF (2000) Conjugated linoleic acid and bone biology. J Am Coll Nutr 19, 478-486.
5. Palombo JD, Ganguly A, Bistrian BR, et al. (2002) The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells. Cancer Lett 177, 163-172. (Pubitemid 34127917)
6. Lee KN, Kritchevsky D & Pariza MW (1994) Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 108, 19-25. (Pubitemid 24216366)
7. Bhattacharya A, Banu J, Rahman M, et al. (2006) Biological effects of conjugated linoleic acids in health and disease. J Nutr Biochem 17, 789-810. (Pubitemid 44738517)
8. Yamasaki M, Kishihara K, Mansho K, et al. (2000) Dietary conjugated linoleic acid increases immunoglobulin productivity of Sprague-Dawley rat spleen lymphocytes. Biosci Biotechnol Biochem 64, 2159-2164.
9. Cho MH, Kang JH & Yang MP (2008) Immunoenhancing effect of trans-10, cis-12 conjugated linoleic acid on the phagocytic capacity and oxidative burst activity of canine peripheral blood phagocytes. Res Vet Sci 85, 269-278.
10. Yu Y, Correll PH & Vanden Heuvel JP (2002) Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gammadependent mechanism. Biochim Biophys Acta 1581, 89-99. (Pubitemid 34521887)
11. Daynes RA & Jones DC (2002) Emerging roles of PPARs in inflammation and immunity. Nat Rev Immunol 2, 748-759. (Pubitemid 37328715)
12. Jiang C, Ting AT & Seed B (1998) PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391, 82-86. (Pubitemid 28079219)
13. Changhua L, Jindong Y, Defa L, et al. (2005) Conjugated linoleic acid attenuates the production and gene expression of proinflammatory cytokines in weaned pigs challenged with lipopolysaccharide. J Nutr 135, 239-244. (Pubitemid 40194485)
14. Ji JD, Kim HJ, Rho YH, et al. (2005) Inhibition of IL-10-induced STAT3 activation by 15-deoxy-Delta12,14- prostaglandin J2. Rheumatology 44, 983-988. (Pubitemid 41487169)
15. Ghosh S & Karin M (2002) Missing pieces in the NF-kappaB puzzle. Cell 109, 81-96.
16. Verma IM, Stevenson JK, Schwarz EM, et al. (1995) Rel/NFkappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev 9, 2723-2735. (Pubitemid 3009952)
17. Meldrum DR (1998) Tumor necrosis factor in the heart. Am J Physiol 274, 577-595.
18. Wright G, Singh IS, Hasday JD, et al. (2002) Endotoxin stressresponse in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression. Am J Physiol Heart Circ Physiol 282, 872-879.
19. Chen GG, Lee JF, Wang SH, et al. (2002) Apoptosis induced by activation of peroxisome-proliferator activated receptorgamma is associated with Bcl-2 and NF-kappaB in human colon cancer. Life Sci 70, 2631-2646. (Pubitemid 34310556)
20. Ringseis R, Gahler S, Herter C, et al. (2006) Conjugated linoleic acids exert similar actions on prostanoid release from aortic and coronary artery smooth muscle cells. Int J Vitam Nutr Res 76, 281-289.
21. Tsuboyama-Kasaoka N, Takahashi M, Tanemura K, et al. (2000) Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49, 1534-1542.
22. Poirier H, Shapiro JS, Kim RJ, et al. (2006) Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue. Diabetes 55, 1634-1641. (Pubitemid 44324115)
23. Kelley DS, Warren JM, Simon VA, et al. (2002) Similar effects of c9, t11-CLA and t10, c12-CLA on immune cell functions in mice. Lipids 37, 725-728.
24. Kang JH, Lee GS, Jeung EB, et al. (2007) Trans-10, cis-12- conjugated linoleic acid increases phagocytosis of porcine peripheral blood polymorphonuclear cells in vitro. Br J Nutr 97, 117-125.
25. Son SM, Kang JH, Lee GS, et al. (2006) Induction of interleukin- 8 expression in porcine peripheral blood mononuclear cells by trans10-cis12 conjugated linoleic acid. Vet Immunol Immunopathol 112, 284-289.
26. Nakamura YK & Omaye ST (2009) Conjugated linoleic acid isomers' roles in the regulation of PPAR-gamma and NF-kappaB DNA binding and subsequent expression of antioxidant enzymes in human umbilical vein endothelial cells. Nutrition 25, 800-811.
27. Chung S, Brown JM, Provo JN, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production. J Biol Chem 280, 38445-38456. (Pubitemid 43853742)
28. Loscher CE, Draper E, Leavy O, et al. (2005) Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction. J Immunol 175, 4990-4998. (Pubitemid 41456381)
29. Eskdale J, Kube D, Tesch H, et al. (1997) Mapping of the human IL10 gene and further characterization of the 50 flanking sequence. Immunogenetics 46, 120-128. (Pubitemid 27234709)
30. Moore KW, de Waal Malefyt R, Coffman RL, et al. (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19, 683-765. (Pubitemid 32368050)
31. Hwang DM, Kundu JK, Shin JW, et al. (2007) cis-9, trans-11-Conjugated linoleic acid down-regulates phorbol ester-induced NF-kappaB activation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-Akt. Carcinogenesis 28, 363-371. (Pubitemid 46321852)
32. Zhao L, Yin J, Li D, et al. (2005) Conjugated linoleic acid can prevent tumor necrosis factor gene expression by inhibiting nuclear factor binding activity in peripheral blood mononuclear cells from weaned pigs challenged with lipopolysaccharide. Arch Anim Nutr 59, 429-438. (Pubitemid 41770210)
33. Cheng WL, Lii CK, Chen HW, et al. (2004) Contribution of conjugated linoleic acid to the suppression of inflammatory responses through the regulation of the NF-kappaB pathway. J Agric Food Chem 52, 71-78.
34. Meadus WJ, MacInnis R, Dugan ME, et al. (2002) Prolonged dietary treatment with conjugated linoleic acid stimulates porcine muscle peroxisome proliferator activated receptor gamma and glutamine-fructose aminotransferase gene expression in vivo. J Mol Endocrinol 28, 79-86. (Pubitemid 34428758)
35. Evans M, Park Y, Pariza M, et al. (2001) trans-10, cis-12 Conjugated linoleic acid reduces triglyceride content while differentially affecting peroxisome proliferator activated receptor gamma2 and aP2 expression in 3T3-L1 preadipocytes. Lipids 36, 1223-1232. (Pubitemid 34007976)
36. Alibin CP, Kopilas MA, Anderson HD, et al. (2008) Suppression of cardiac myocyte hypertrophy by conjugated linoleic acid: role of peroxisome proliferator-activated receptors alpha and gamma. J Biol Chem 283, 10707-10715.
37. Nakatani T, Tsuboyama-Kasaoka N, Takahashi M, et al. (2002) Mechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes. J Biol Chem 277, 9562-9569. (Pubitemid 34953045)
38. Song DH, Kang JH, Lee GS, et al. (2007) Upregulation of tumor necrosis factor-alpha expression by trans10-cis12 conjugated linoleic acid enhances phagocytosis of RAW macrophages via a peroxisome proliferator-activated receptor gamma-dependent pathway. Cytokine 37, 227-235.
39. Szatmari I, Rajnavolgyi E & Nagy L (2006) PPARgamma, a lipid-activated transcription factor as a regulator of dendritic cell function. Ann N Y Acad Sci 1088, 207-218. (Pubitemid 47092034)
40. Marion-Letellier R, Butler M, Déchelotte P, et al. (2008) Comparison of cytokine modulation by natural peroxisome proliferator-activated receptor gamma ligands with synthetic ligands in intestinal-like Caco-2 cells and human dendritic cells - potential for dietary modulation of peroxisome proliferator- activated receptor gamma in intestinal inflammation. Am J Clin Nutr 87, 939-948. (Pubitemid 351549239)
41. Ringseis R, Gahler S & Eder K (2008) Conjugated linoleic acid isomers inhibit platelet-derived growth factor-induced NF-kappaB transactivation and collagen formation in human vascular smooth muscle cells. Eur J Nutr 47, 59-67.
42. Hontecillas R, Wannemeulher MJ, Zimmerman DR, et al. (2002) Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid. J Nutr 132, 2019-2027. (Pubitemid 34742894)
43. Bassaganya-Riera J & Hontecillas R (2006) CLA and n-3 PUFA differentially modulate clinical activity and colonic PPARresponsive gene expression in a pig model of experimental IBD. Clin Nutr 25, 454-465. (Pubitemid 43843028)
44. Bassaganya-Riera J, Reynolds K, Martino-Catt S, et al. (2004) Activation of PPARg and d by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology 127, 777-791. (Pubitemid 39208411)
45. Evans NP, Misyak SA, Schmelz EM, et al. (2010) Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARg. J Nutr 140, 515-521.
46. Jaudszus A, Krokowski M, Möckel P, et al. (2008) cis-9, trans- 11-Conjugated linoleic acid inhibits allergic sensitization and airway inflammation via a PPARgamma-related mechanism in mice. J Nutr 138, 1336-1342. (Pubitemid 351930999)
47. Larsen AE, Cameron-Smith D & Crowe TC (2008) Conjugated linoleic acid suppresses myogenic gene expression in a model of human muscle cell inflammation. J Nutr 138, 12-16.
48. Vereecke L, Beyaert R & van Loo G (2009) The ubiquitinediting enzyme A20 (TNFAIP3) in a central regulator of immunopathology. Trends Immunol 30, 383-391.
49. Coornaert B, Carpentier I & Beyaert R (2009) A20: central gatekeeper in inflammation and immunity. J Biol Chem 284, 8217-8221.
50. Hitotsumatsu O, Ahmad RC, Tavares R, et al. (2008) The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity 28, 381-390. (Pubitemid 351343859)