Involvement of Ras/Raf-1/p44/42 MAPK in YC-1-induced cyclooxygenase-2 expression in human pulmonary epithelial cells

Pharmacological Research

Volumn 60, Issue 4, 2009, Pages 247-253

  Chang, Ming Shyan ^a   Chen, Bing Chang ^a   Weng, Chih Ming ^a   Lee, Wen Sen ^a   Lin, Chien Huang ^a,b,c  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

A549 cells; Cyclooxygenase 2; IKK ; NF B; p44 42 MAPK; Raf 1; Ras; YC 1

Indexed keywords

1 BENZYL 3 (5 HYDROXYMETHYL 2 FURYL)INDAZOLE; 1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 3 (3,5 DIBROMO 4 HYDROXYBENZYLIDENE) 1,3 DIHYDRO 5 IODO 2 INDOLONE; 3 [8 [(DIMETHYLAMINO)METHYL] 6,7,8,9 TETRAHYDROPYRIDO[1,2 A]INDOL 10 YL] 4 (1 METHYL 1H INDOL 3 YL) 1H PYRROLE 2,5 DIONE; 8 BROMO CYCLIC GMP; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLOOXYGENASE 2; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KT 5823; MANUMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C ALPHA; PROTEIN RAF1; PROTEIN TYROSINE KINASE; RAS PROTEIN; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

CELL LINE, TUMOR; CYCLOOXYGENASE 2; ENZYME ACTIVATORS; EPITHELIAL CELLS; GENE EXPRESSION; HUMANS; I-KAPPA B KINASE; INDAZOLES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-RAF; PULMONARY ALVEOLI; RAS PROTEINS; SIGNAL TRANSDUCTION;

EID: 69249202636     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2009.03.015     Document Type: Article

References (34)

1. Smith W.L., Garavito R.M., and DeWitt D.L. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 271 (1996) 33157-33160
2. Mitchell J.A., Larkin S., and Williams T.J. Cyclooxygenase-2: regulation and relevance in inflammation. Biochem Pharmacol 50 (1995) 1535-1542
3. 2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo. J Exp Med 184 (1996) 883-891
4. Vane J.R., Bakhle Y.S., and Botting R.M. Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 38 (1998) 97-120
5. Vane J.R., Mitchell J.A., Appleton I., Tomlinson A., Bishop-Bailey D., Croxtall J., et al. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc Natl Acad Sci USA 91 (1994) 2046-2050
6. Kujubu D.A., Fletcher B.S., Varnum B.C., Lim R.W., and Herschman H.R. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem 266 (1991) 12866-12872
7. Mitchell J.A., Belvisi M.G., Akarasereenont P., Robbins R.A., Kwon O.J., Croxtall J., et al. Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone. Br J Pharmacol 113 (1994) 1008-1014
8. Devaliaand J.L., and Davies R.J. Airway epithelial cells and mediators of inflammation. Respir Med 87 (1993) 405-408
9. Campbell S.L., Khosravi-Far R., Rossman K.L., Clark G.J., and Der C.J. Increasing complexity of Ras signaling. Oncogene 17 (1998) 1395-1413
10. Zhang X.F., Settleman J., Kyriakis J.M., Takeuchi-Suzuki E., Elledge S.J., Marshall M.S., et al. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature 364 (1993) 308-313
11. Whitmarshand A.J., and Davis R.J. Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals. Trends Biochem Sci 23 (1998) 481-485
12. Kerkhoffand E., and Rapp U.R. The Ras-Raf relationship: an unfinished puzzle. Adv Enzyme Regul 41 (2001) 261-267
13. Luo Z., Diaz B., Marshall M.S., and Avruch J. An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ. Mol Cell Biol 17 (1997) 46-53
14. Williams J.G., Drugan J.K., Yi G.S., Clark G.J., Der C.J., and Campbell S.L. Elucidation of binding determinants and functional consequences of Ras/Raf-cysteine-rich domain interactions. J Biol Chem 275 (2000) 22172-22179
15. Subbaramaiah K., Hart J.C., Norton L., and Dannenberg A.J. Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2. Evidence for involvement of ERK1/2 AND p38 mitogen-activated protein kinase pathways. J Biol Chem 275 (2000) 14838-14845
16. Van Putten V., Refaat Z., Dessev C., Blaine S., Wick M., Butterfield L., et al. Induction of cytosolic phospholipase A2 by oncogenic Ras is mediated through the JNK and ERK pathways in rat epithelial cells. J Biol Chem 276 (2001) 1226-1232
17. Chen B.C., Chang Y.S., Kang J.C., Hsu M.J., Sheu J.R., Chen T.L., et al. Peptidoglycan induces nuclear factor-κB activation and cyclooxygenase-2 expression via Ras, Raf-1, and ERK in RAW 264.7 macrophages. J Biol Chem 279 (2004) 20889-20897
18. Norrisand J.L., and Baldwin Jr. A.S. Oncogenic Ras enhances NF-κB transcriptional activity through Raf-dependent and Raf-independent mitogen-activated protein kinase signaling pathways. J Biol Chem 274 (1999) 13841-13846
19. Baumann B., Weber C.K., Troppmair J., Whiteside S., Israel A., Rapp U.R., et al. Raf induces NF-κB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation. Proc Natl Acad Sci USA 97 (2000) 4615-4620
20. Ko F.N., Wu C.C., Kuo S.C., Lee F.Y., and Teng C.M. YC-1, a novel activator of platelet guanylate cyclase. Blood 84 (1994) 4226-4233
21. Hwang T.L., Wu C.C., and Teng C.M. YC-1 potentiates nitric oxide-induced relaxation in guinea-pig trachea. Br J Pharmacol 128 (1999) 577-584
22. Tulis D.A., Bohl Masters K.S., Lipke E.A., Schiesser R.L., Evans A.J., Peyton K.J., et al. YC-1-mediated vascular protection through inhibition of smooth muscle cell proliferation and platelet function. Biochem Biophys Res Commun 291 (2002) 1014-1021
23. Friebe A., Mullershausen F., Smolenski A., Walter U., Schultz G., and Koesling D. YC-1 potentiates nitric oxide- and carbon monoxide-induced cyclic GMP effects in human platelets. Mol Pharmacol 54 (1998) 962-967
24. Chang M.S., Lee W.S., Teng C.M., Lee H.M., Sheu J.R., Hsiao G., et al. YC-1 increases cyclo-oxygenase-2 expression through protein kinase G- and p44/42 mitogen-activated protein kinase-dependent pathways in A549 cells. Br J Pharmacol 136 (2002) 558-567
25. Chang M.S., Lee W.S., Chen B.C., Sheu J.R., and Lin C.H. YC-1-induced cyclooxygenase-2 expression is mediated by cGMP-dependent activations of Ras, phosphoinositide-3-OH-kinase, Akt, and nuclear factor-κB in human pulmonary epithelial cells. Mol Pharmacol 66 (2004) 561-571
26. Lin C.H., Kuan I.H., Wang C.H., Lee H.M., Lee S., Sheu J.R., et al. Lipoteichoic acid-induced cyclooxygenase-2 expression requires activations of p44/42 and p38 mitogen-activated protein kinase signal pathways. Eur J Pharmacol 450 (2002) 1-9
27. Lackey K., Cory M., Davis R., Frye S.V., Harris P.A., Hunter R.N., et al. The discovery of potent cRaf1 kinase inhibitors. Bioorg Med Chem Lett 10 (2000) 223-226
28. Diaz B., Barnard D., Filson A., MacDonald S., King A., and Marshall M. Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling. Mol Cell Biol 17 (1997) 4509-4516
29. Chang M.S., Chen B.C., Yu M.T., Sheu J.R., Chen T.F., and Lin C.H. Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-κB, but not p38 MAPK, pathways. Cell Signal 17 (2005) 299-310
30. Wang C.Y., Wang Y.T., Tzeng D.W., and Yang J.L. Lead acetate induces EGFR activation upstream of SFK and PKCα linkage to the Ras/Raf-1/ERK signaling. Toxicol Appl Pharmacol 1 (2009) 244-252
31. Duca L., Lambert E., Debret R., Rothhut B., Blanchevoye C., Delacoux F., et al. Elastin peptides activate extracellular signal-regulated kinase 1/2 via a Ras-independent mechanism requiring both p110γ/Raf-1 and protein kinase A/B-Raf signaling in human skin fibroblasts. Mol Pharmacol 67 (2005) 1315-1324
32. Ghosh S., May M.J., and Kopp E.B. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16 (1998) 225-260
33. DiDonato J.A., Hayakawa M., Rothwarf D.M., Zandi E., and Karin M. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388 (1997) 548-554
34. Arsura M., Mercurio F., Oliver A.L., Thorgeirsson S.S., and Sonenshein G.E. Role of the IkappaB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells. Mol Cell Biol 20 (2000) 5381-5391