Requirement of Gβγ and c-Src in D2 dopamine receptor-mediated nuclear factor-κB activation

Molecular Pharmacology

Volumn 64, Issue 2, 2003, Pages 447-455

  Yang, Ming ^a   Zhang, Hongmei ^a   Voyno Yasenetskaya, Tatyana ^a   Ye, Richard D ^a,b  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 AMINO 1 TERT BUTYL 3 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; BETA ARRESTIN; BETA ARRESTIN 1; CHEMOATTRACTANT; DNA; DOPAMINE 2 RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GENISTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PHOSPHOLIPASE C BETA; PROTEIN TYROSINE KINASE; PYRAZOLOPYRIMIDINE DERIVATIVE; QUINPIROLE; TRANSDUCIN; TYROSINE; TYRPHOSTIN; UNCLASSIFIED DRUG; DOPAMINE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR UPREGULATION; REPORTER GENE; TRANSACTIVATION; METABOLISM; ONCOGENE SRC; PHYSIOLOGY;

DOPAMINE; GENES, SRC; GTP-BINDING PROTEINS; HELA CELLS; HUMANS; NF-KAPPA B; PERTUSSIS TOXIN; PROTEIN-TYROSINE KINASES; RECEPTORS, DOPAMINE D2; TRANS-ACTIVATION (GENETICS);

EID: 0041341922     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.2.447     Document Type: Article

References (39)

1. Brami-Cherrier K, Valjent E, Garcia M, Pages C, Hipskind RA, and Caboche J (2002) Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: a new route to cAMP response element-binding protein phosphorylation. J Neurosci 22:8911-8921.
2. Bushman WA, Wilson LK, Luttrell DK, Moyers JS, and Parsons SJ (1990) Overexpression of c-src enhances beta-adrenergic-induced cAMP accumulation. Proc Natl Acad Sci USA 87:7462-7466.
3. Cao W, Luttrell LM, Medvedev AV, Pierce KL, Daniel KW, Dixon TM, Lefkowitz RJ, and Collins S (2000) Direct binding of activated c-Sre to the beta 3-adrenergic receptor is required for MAP kinase activation. J Biol Chem 275:38131-38134.
4. Ghosh S, May MJ, and Kopp EB (1998) NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16:225-260.
5. Gilman AG (1987) G proteins: transducers of receptor-generated signals. Annu Rev Biochem 56:615-649.
6. Goodman OBJ, Krupnick JG, Santini F, Gurevich W, Penn RB, Gagnon AW, Keen JH, and Benovic JL (1996) Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Nature (Lond) 383:447-450.
7. Gschwind A, Zwick E, Prenzel N, Leserer M, and Ullrich A (2001) Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission. Oncogene 20:1594-1600.
8. Imbert V, Rupec RA, Livolsi A, Pahl HL, Traenckner EB, Mueller-Dieckmann C, Farahifar D, Rossi B, Auberger P, Baeuerle PA, et al. (1996) Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. Cell 86:787-798.
9. Iwamoto H, Nakamuta M, Tada S, Sugimoto R, Enjoji M, and Nawata H (2000) Platelet-derived growth factor receptor tyrosine kinase inhibitor AG1295 attenuates rat hepatic stellate cell growth. J Lab Clin Med 135:406-412.
10. Jiang M, Spicher K, Boulay G, Wang Y, and Birnbaumer L (2001) Most central nervous system D2 dopamine receptors are coupled to their effectors by Go. Proc Natl Acad Sci USA 98:3577-3582.
11. Karin M and Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-kappa B activity. Annu Rev Immunol 18:621-663.
12. Kravchenko VV, Pan Z, Han J, Herbert JM, Ulevitch RJ, and Ye RD (1995) Platelet-activating factor induces NF-kappa B activation through a G protein-coupled pathway. J Biol Chem 270:14928-14934.
13. Lachowicz JE and Sibley DR (1997) Molecular characteristics of mammalian dopamine receptors. Pharmacol Toxicol 81:105-113.
14. Lee HJ, Kim SH, Kim KW, Um JH, Lee HW, Chung BS, and Kang CD (2001) Antiapoptotic role of NF-kappaB in the auto-oxidized dopamine-induced apoptosis of PC12 cells. J Neurochem 76:602-609.
15. Luo Y, Hattori A, Munoz J, Qin ZH, and Roth GS (1999) Intrastriatal dopamine injection induces apoptosis through oxidation-involved activation of transcription factors AP-1 and NF-kappaB in rats. Mol Pharmacol 56:254-264.
16. Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, et al. (1999) Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science (Wash DC) 283:655-661.
17. Luttrell LM, Hawes BE, van Biesen T, Luttrell DK, Lansing TL, and Lefkowitz RJ (1996) Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gβγ subunit-mediated activation of mitogen-activated protein kinases. J Biol Chem 271:19443-19450.
18. Madrid LV, Mayo MW, Reuther JY, and Baldwin AS Jr (2001) Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem 276:18934-18940.
19. Miller WE and Lefkowitz RJ (2001) Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking. Curr Opin Cell Biol 13:139-145.
20. Miller WE, Maudsley S, Ahn S, Khan KD, Luttrell LM, and Lefkowitz RJ (2000) beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. J Biol Chem 275:11312-11319.
21. Montaner S, Sodhi A, Pece S, Mesri EA, and Gutkind JS (2001) The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B. Cancer Res 61:2641-2648.
22. Oak JN, Lavine N, and Van Tol HH (2001) Dopamine D(4) and D(2L) receptor stimulation of the mitogen-activated protein kinase pathway is dependent on trans-activation of the platelet-derived growth factor receptor. Mol Pharmacol 60:92-103.
23. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, and Donner DB (1999) NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature (Lond) 401:82-85.
24. Pan ZK, Chen LY, Cochrane CG, and Zuraw BL (2000) fmet-Leu-Phe stimulates proinflammatory cytokine gene expression in human peripheral blood monocytes: the role of phosphatidylinositol 3-kinase. J Immunol 164:404-411.
25. Panet H, Barzilai A, Daily D, Melamed E, and Offen D (2001) Activation of nuclear transcription factor kappa B (NF-kappaB) is essential for dopamine-induced apoptosis in PC12 cells. J Neurochem 77:391-398.
26. Rohr O, Sawaya BE, Lecestre D, Aunis D, and Schaeffer E (1999) Dopamine stimulates expression of the human immunodeficiency virus type 1 via NF-kappaB in cells of the immune system. Nucleic Acids Res 27:3291-3299.
27. Senogles SE, Spiegel AM, Padrell E, Iyengar R, and Caron MG (1990) Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system. J Biol Chem 265:4507-4514.
28. Shepard LW, Yang M, Xie P, Browning DD, Voyno-Yasenetskaya T, Kozasa T, and Ye RD (2001) Constitutive activation of NF-{kappa}B and secretion of IL-8 induced by the G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus involves G{alpha}(13) and RhoA. J Biol Chem 276:45979-45987.
29. Shi CS and Kehrl JH (2001) PYK2 links G(q)alpha and G(13)alpha signaling to NF-kappa B activation. J Biol Chem 276:31845-31850.
30. Siehler S, Wang Y, Fan X, Windh RT, and Manning DR (2001) Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells. J Biol Chem 276:48733-48739.
31. Tsuruta K, Frey EA, Grewe CW, Cote TE, Eskay RL, and Kebabian JW (1981) Evidence that LY-141865 specifically stimulates the D-2 dopamine receptor. Nature (Lond) 292:463-465.
32. Weingarten P, Bermak J, and Zhou QY (2001) Evidence for non-oxidative dopamine cytotoxicity: potent activation of NF-kappa B and lack of protection by antioxidants. J Neurochem 76:1794-1804.
33. Xie P, Browning DD, Hay N, Mackman N, and Ye RD (2000) Activation of NF-kappa B by bradykinin through a Galpha(q)- and Gbeta gamma-dependent pathway that involves phosphoinositide 3-kinase and Akt. J Biol Chem 275:24907-24914.
34. Yang M, Buscher R, Taguchi K, Grubbel B, Insel PA, and Michel MC (1998) Protein kinase C does not mediate phenylephrine-induced down-regulation of Madin-Darby canine kidney cell alpha-1B adrenoceptors. J Pharmacol Exp Ther 286:36-43.
35. Yang M and Leonard JP (2001) Identification of mouse NMDA receptor subunit NR2A C-terminal tyrosine sites phosphorylated by coexpression with v-Src. J Neurochem 77:580-588.
36. Yang M, Sang H, Rahman A, Wu D, Malik AB, and Ye RD (2001) G alpha 16 couples chemoattractant receptors to NF-kappa B activation. J Immunol 166:6885-6892.
37. Ye RD (2001) Regulation of nuclear factor kappa B activation by G-protein-coupled receptors. J Leukoc Biol 70:839-848.
38. Ye RD, Pan Z, Kravchenko V, Browning DD, and Prossnitz ER (1996) Gene transcription through activation of G protein-coupled chemoattractant receptors. Gene Exp 5:205-215.
39. Zhen X, Zhang J, Johnson GP, and Friedman E (2001) D4 dopamine receptor differentially regulates Akt/nuclear factor-κB and extracellular signal-regulated kinase pathways in D4MN9D cells. Mol Pharmacol 60:857-864.