The interface between plant metabolic engineering and human health

Current Opinion in Biotechnology

Volumn 24, Issue 2, 2013, Pages 344-353

  Martin, Cathie ^a  

^a JOHN INNES CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FRUIT AND VEGETABLES; FUNDAMENTAL RESEARCH; NATURAL VARIATION; NUTRITIONAL VALUE; PHYSIOLOGICAL EFFECTS; PLANT METABOLIC ENGINEERING; PREVENTIVE MEDICINES; SYNERGISTIC INTERACTION;

DISEASES; NUTRITION;

GENETIC ENGINEERING;

ANTHOCYANIN; FLAVONOL; FOLIC ACID; GENISTEIN; GLUCOSE; ISOFLAVONOID; LYCOPENE; PROANTHOCYANIDIN; RESVERATROL; TRANSCRIPTION FACTOR;

ADIPOCYTE; BEHAVIOR; BIOAVAILABILITY; BIODEGRADATION; BIOFORTIFICATION; BIOLOGICAL ACTIVITY; CALORIC INTAKE; CANCER PREVENTION; CONCENTRATION (PARAMETERS); DIET; DIET SUPPLEMENTATION; ECONOMIC ASPECT; FOOD COMPOSITION; FOOD INTAKE; FOOD PROCESSING; FRUIT; GASTROINTESTINAL ABSORPTION; GENE LOCUS; GENE MAPPING; GENETIC ENGINEERING; GENETIC TRAIT; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; METABOLIC ENGINEERING; NATURAL VARIATION; NUTRITIONAL HEALTH; PHYTONUTRIENT; PLANT METABOLISM; PRIORITY JOURNAL; REVERSE GENETICS; REVIEW; SOCIAL ASPECT; SUGAR INTAKE; TRANSCRIPTION REGULATION; VEGETABLE; WEIGHT REDUCTION;

CHRONIC DISEASE; CROPS, AGRICULTURAL; DIET; FOOD, FORTIFIED; FRUIT; HEALTH; HUMANS; METABOLIC ENGINEERING; NUTRITIVE VALUE; VEGETABLES;

EID: 84874991229     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2012.11.005     Document Type: Review

References (73)

1. U.S.Department of Agriculture, U.S.Department of Health and Human Services, U.S.Government Printing Office Washington, DC Dietary Guidelines for Americans, 2010 2010, U.S. Government Printing Office, Washington, DC. edn 7.
2. Carter P., Gray L.J., Troughton J., Khunti K., Davies M.J. Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis. BMJ 2010, 341:c4229.
3. Aatola H., Koivistoinen T., Hutri-Kähönen N., Juonala M., Mikkilä V., Lehtimäki T., Viikari J.S., Raitakari O.T., Kähönen M. Lifetime fruit and vegetable consumption and arterial pulse wave velocity in adulthood: the cardiovascular risk in young Finns study. Circulation 2010, 122:2521-2528.
4. Dauchet L., Amouyel P., Hercberg S., Dallongeville J. Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies. J Nutr 2006, 136:2588-2593.
5. He F.J., Nowson C.A., MacGregor G.A. Fruit and vegetable consumption and stroke: meta-analysis of cohort studies. Lancet 2006, 367:320-326.
6. Michimi A., Wimberly M.C. Associations of supermarket accessibility with obesity and fruit and vegetable consumption in the conterminous United States. Int J Health Geogr 2010, 9:49.
7. Ledoux T.A., Hingle M.D., Baranowski T. Relationship of fruit and vegetable intake with adiposity: a systematic review. Obes Rev 2010, 12:e143-e150.
8. Boggs D.A., Palmer J.R., Wise L.A., Spiegelman D., Stampfer M.J., Adams-Campbell L.L., Rosenberg L. Fruit and vegetable intake in relation to risk of breast cancer in the black women's health study. Am J Epidemiol 2010, 172:1268-1279.
9. Fernández E., Gallus S., La Vecchia C. Nutrition and cancer risk: an overview. J Br Menopause Soc 2006, 12:139-142.
10. Kushi L.H., Doyle C., McCullough M., Rock C.L., Demark-Wahnfried W., Bandera E.V., Gapstur S., Patel A.V., Andrews K., Gansler T., the American Cancer Society 2010 Nutrition and Physical Activity Guidelines Advisory Committee American Cancer Society guidelines on nutrition and physical activity for cancer prevention. CA Cancer J Clin 2012, 62:30-67.
11. Eaton S.B., Konnor M. Paleolithic nutrition: a consideration of its nature and current implications. New Engl J Med 1985, 312:283-289.
12. Frassetto L.A., Schloetter M., Mietus-Synder M., Morris R.C., Sebastian A. Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet. Eur J Clin Nutr 2009, 63:947-955.
13. Jonsson T., Granfeldt Y., Ahren B., Brandell U.-C., Palsson G., Hansson A., Soderstrom M., Lindeberg S. Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomised cross-over pilot study. Cardiovasc Diabet 2009, 8:35.
14. Osterdahl M., Kocturk T., Koochek A., Wandell P.E. Effects of short-term intervention with a paleolithic diet in healthy volunteers. Eur J Clin Nutr 2008, 62:682-685.
15. Pavkov M.E., Narayan K.M.V., Nelson R.G., Hanson R.L., Knowler W.C. Non-caucasian North American populations: native Americans. The Epidemiology of Diabetes Mellitus 2008, John Wiley & Sons, Ltd., Chichester, UK. edn 2. J.-M. Ekoé, M. Rewers, R. Williams, P. Zimmet (Eds.).
16. Lindeberg S., Jonsson T., Granfeldt Y., Borgstrand E., Soffman J., Sjostrom K., Ahren B. A Paleolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease. Diabetologia 2007, 50:1807-1975.
17. Acton K.J., Burrows N.R., Wang J., Thompson T. Diagnosed diabetes among American Indians and Alaska Natives aged <35 years - United States, 1994-2004. MMWR Morb Mortal Wkly Rep 2006, 55:1201-1203.
18. Angel L.J. Health as a crucial factor in the changes from hunting to developed farming in the Eastern Mediterranean. Paleopathology at the Origins of Agriculture 1984, 51-73. Academic Press, Orlando. M.N. Cohen, G.J. Armelagos (Eds.).
19. Calder J.F., Wachira M.W., van Sant T., Malik M.S., Bonny R.N. Diverticular disease, carcinoma of the colon and diet in urban and rural Kenyan Africans. Diagn Imaging Clin Med 1980, 42:23-28.
20. Crawley H. Fruit and veg - are we eating more?. Food Mag 2009, 84:5-7.
21. Truhe D. 5-a-day for better health failure campaign among low-income neighborhoods: a critique based on social and behavioural science principles. Challenging Dogma 2006, http://sb721.blogspot.co.uk/.
22. Pomerleau J., Lock K., Knai C., McKee M. Effectiveness of interventions and programmes promoting fruit and vegetable intake. Joint FAO/WHO Workshop on Fruit and Vegetables for Health 2004.
23. National Cancer Institute: 5 A Day for Better Health Program Evaluation Report; 2000. http://dccps.nci.nih.gov/5aday_12-4-00.pdf.
24. Martin C., Butelli E., Petroni K., Tonelli C. How can research on plants contribute to promoting human health?. Plant Cell 2011, 23:1685-1699.
25. Harcombe Z. This cynical five a day myth. Daily Mail 2011.
26. Alsiö J., Olszewski P.K., Levine A.S., Schiöth H.B. Feed-forward mechanisms: addiction-like behavioral and molecular adaptations in overeating. Front Neuroendocrinol 2012, 33:127-139.
27. Steiner C., Arnould S., Scalbert A., Manach C. Isoflavones and the prevention of breast and prostate cancer: new perspectives opened by nutrigenomics. Br J Nutr 2008, 99(E Suppl 1):ES78-ES108.
28. Wu A.H., Wan P., Hankin J., Tseng C.C., Yu M.C., Pike M.C. Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis 2002, 23:1491-1496.
29. Cornwall T., Cohick W., Raskin I. Dietary phytoestrogens and health. Phytochemistry 2004, 65:995-1016.
30. Dixon R., Ferreira D. Genistein. Phytochemistry 2002, 60:205-211.
31. De Amicis F., Giordano F., Vivacqua A., Pellegrino M., Panno M.L., Tramontano D., Fuqua S.A.W., Ando S. Resveratrol, through NF-Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits estrogen receptor gene expression via p38MAPK/CK2 signaling in human breast cancer cells. FASEB J 2011, 25:3695-3707.
32. Garvin S., Ollinger K., Dabrosin C. Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer Lett 2006, 231:113-122.
33. Pozo-Guisado E., Merino J.M., Mulero-Navarro S., Lorenzo-Benayas M.J., Centeno F., Alvarez-Barrientos A., Fernandez-Salguero P.M. Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB. Int J Cancer 2005, 115:74-84.
34. Provinciali M., Re F., Donnini A., Orlando F., Bartozzi B., Di Stasio G., Smorlesi A. Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Int J Cancer 2005, 115:36-45.
35. Banerjee S., Bueso-Ramos C., Aggarwal B.B. Suppression of 7,12-dimethylbenz(a) anthracene-induced mammary carcinogenesis in rats by resveratrol: Role of nuclear factor-kappa B, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 2002, 62:4945-4954.
36. Cassileth B.R., Yarett I. Soy phytoestrogens and breast cancer: an enduring dilemma. ASCO Post 2012, 3.
37. Vang O., Ahmad N., Baile C.A., Baur J.A., Brown K., Csiszar A., Das D.K., Delmas D., Gottfried C., Lin H.Y., et al. What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PLoS ONE 2011, 6:e19881.
38. Messina M., Wu A.H. Perspectives on the soy-breast cancer relation. Am J Clin Nutr 2009, 89:1673S-1679S.
39. Banerjee S., Li Y., Wang Z., Sarkar F.H. Multi-targeted therapy of cancer by genistein. Cancer Lett 2008, 269:226-242.
40. Adlercreutz H. Phyto-estrogens and cancer. Lancet Oncol 2002, 3:364-373.
41. The Myeloma Beacon, 6th May 2010. Suspended resveratrol clinical trial: more details emerge. http://www.myelomabeacon.com/news/2010/05/06.
42. Bjelakovic G., Gluud C. Surviving antioxidant supplements. J Natl Cancer Inst 2007, 99:742-743.
43. Lawson K.A., Wright M.E., Subar A., Mouw T., Schatzkin A., Leitzmann M.F. Multivitamin use and risk of prostate cancer in the National Institutes of Health - AARP Diet and Health Study. J Natl Cancer Inst 2007, 99:754-764.
44. Miller E.R., Pastor-Barriuso R., Dalal D., Riemersma R.A., Appel L.J., Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005, 142:37-46.
45. Story E.N., Kopec R.E., Schwartz S.J., Harris G.K. An update on the health effects of tomato lycopene. Ann Rev Food Sci Technol 2010, 1:189-210.
46. Nguyen M.L., Schwartz S.J. Lycopene stability during food processing. Proc Soc Exp Biol Med 1998, 218:101-105.
47. Gärtner C., Stahl W., Sies H. Lycopene is more bioavailable from tomato paste than from fresh tomatoes. Am J Clin Nutr 1997, 66:116-122.
48. Titta L., Trinci M., Stendardo M., Berniakovich I., Petroni K., Tonelli C., Riso P., Porrini M., Minucci S., Pelicci P.G., et al. Blood orange juice inhibits fat accumulation in mice. Int J Obesity 2010, 34:578-585.
49. Prior R.L., Wu X.L., Gu L.W., Hager T.J., Hager A., Howard L.R. Whole berries versus berry anthocyanins: interactions with dietary fat levels in the C57BL/6J mouse model of obesity. J Agric Food Chem 2008, 56:647-653.
50. Jayaprakasam B., Olson L.K., Schutzki R.E., Tai M.H., Nair M.G. Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). J Agric Food Chem 2006, 54:243-248.
51. Tsuda T., Ueno Y., Aoki H., Koda T., Horio F., Takahashi N., Kawada T., Osawa T. Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. Biochem Biophys Res Commun 2004, 316:149-157.
52. Guo H., Ling W., Wang Q., Liu C., Hu Y., Xia M., Feng X., Xia X. Effect of anthocyanin-rich extract from black rice (Oryza sativa l Indica) on hyperlipidemia and insulin resistance in fructose-fed rats. Plant Foods Hum Nutr 2007, 62:1-6.
53. Putnam J., Allshouse J., Kantor L.S. U.S. per capita food supply trends: more calories, refined carbohydrates, and fats. Food Rev 2002, 25:2-15.
54. Bremmer P., Dalziel D., Evans L. Evaluation of the 5 a day Program. Final Report 2006, Big Lottery Fund, London.
55. Yach D., Khan M., Bradley D., Hargrove R., Kehoe S., Mensah G. The role and challenges of the food industry in addressing chronic disease. Global Health 2010, 6:10.
56. Toufektsian M.C., de Lorgeril M., Salen P., Nagy N., Donati M.B., Giordano L., Mock H.-P., Peterek S., Petroni K., Pilu R., et al. Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury. J Nutr 2008, 138:747-752.
57. Butelli E., Titta L., Giorgio M., Mock H.P., Matros A., Peterek S., Schijlen E.G.W.M., Hall R.D., Bovy A.G., Luo J., Martin C. Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors. Nat Biotechnol 2008, 26:1301-1308.
58. Luo J., Butelli E., Hill L., Parr A., Niggeweg R., Bailey P., Weisshaar B., Martin C. AtMYB12 regulates caffeoyl quinic acid and flavonol synthesis in tomato: expression in fruit results in very high levels of both types of polyphenol. Plant J 2008, 56:316-326.
59. Ye X., Al-Babili S., Klöti A., Zhang J., Lucca P., Beyer P., Potrykus I. Engineering the provitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science 2000, 287:303-305.
60. Paine J.A., Shipton C.A., Chaggar S., Howells R.M., Kennedy M.J., Vernon G., Wright S.Y., Hinchliffe E., Adams J.L., Silverstone A.L., Drake R. Improving the nutritional value of Golden Rice through increased pro-vitamin A content. Nat Biotechnol 2005, 23:482-487.
61. Diaz de la Garza R.I., Gregory J.F., Hanson A.D. Folate biofortification of tomato fruit. Proc Natl Acad Sci USA 2007, 104:4218-4222.
62. Diaz de la Garza R., Quinlivan E.P., Klaus S.M., Basset G.J., Gregory J.F., Hanson A.D. Folate biofortification in tomatoes by engineering the pteridine branch of folate synthesis. Proc Natl Acad Sci USA 2004, 101:13720-13725.
63. Hossain T., Rosenberg I., Selhub J., Kishore G., Beachy R., Schubert K. Enhancement of folates in plants through metabolic engineering. Proc Natl Acad Sci USA 2004, 101:5158-5163.
64. Storozhenko S., De Brouwer V., Volckaert M., Navarrete O., Blancquaert D., Zhang G.F., Lambert W., Van der Straeten D. Folate fortification of rice by metabolic engineering. Nat Biotechnol 2007, 25:1277-1279.
65. Giovinazzo G., D'Amico L., Paradiso A., Bollini R., Sparvoli F., DeGara L. Antioxidant metabolite profiles in tomato fruit constitutively expressing the grapevine stilbene synthase gene. Plant Biotechnol J 2005, 3:57-69.
66. Bekaert S., Storozhenko S., Mehrshahi P., Bennett M.J., Lambert W., Gregory J.F., Schubert K., Hugenholtz J., van der Straeten D., Hansen A.D. Folate biofortification in food plants. Trends Plant Sci 2007, 13:28-35.
67. Schwinn K., Venail J., Shang Y.J., Mackay S., Alm V., Butelli E., Oyama R., Bailey P., Davies K., Martin C. A small family of MYB-regulatory genes controls floral pigmentation intensity and patterning in the genus Antirrhinum. Plant Cell 2006, 18:831-851.
68. Bovy A., de Vos R., Kemper M., Schijlen E., Pertejo M.A., Muir S., Collins G., Robinson S., Verhoeyen M., Hughes S., et al. High-flavonol tomatoes resulting from the heterologous expression of the maize transcription factor genes LC and C1. Plant Cell 2002, 14:2509-2526.
69. Harjes C.E., Rocheford T.R., Bai L., Brutnell T.P., Kandianis C.B., Sowinski S.G., Stapleton A.E., Vallabhaneni R., Williams M., Wurtzel E.T., et al. Natural genetic variation in lycopene epsilon cyclase tapped for maize biofortification. Science 2008, 319:330-333.
70. Yan J., Kandianis C.B., Harjes C.E., Bai L., Kim E.-H., Yang X., Skinner D.J., Fu Z., Mitchell S., Li Q., et al. Rare genetic variation at Zea mays crtRB1 increases β-carotene in maize grain. Nat Genet 2010, 42:322-327.
71. Naqvi S., Zhu C.F., Farre G., Ramessar K., Bassie L., Breitenbach J., Conesa D.P., Ros G., Sandmann G., Capell T., Christou P. Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways. Proc Natl Acad Sci USA 2009, 106:7762-7767.
72. Pilu R., Piazza P., Petroni K., Ronchi A., Martin C., Tonelli C. pl-bol3, a complex allele of the anthocyanin regulatory pl1 locus that arose in a naturally occurring maize population. Plant J 2003, 36:510-521.
73. Martin C, Zhang Y, Tonelli C, Petroni K: Plants, diet and health. Annu Rev Plant Biol 2013, in press.