Model-based design space determination of peptide chromatographic purification processes

Journal of Chromatography A

Volumn 1284, Issue , 2013, Pages 80-87

  Gétaz, David ^a   Butté, Alessandro ^b   Morbidelli, Massimo ^a  

^a ETH ZURICH   (Switzerland)

^b LONZA AG   (Switzerland)

Author keywords

Design space; Peptide; Preparative; Reversed phase chromatography; Robustness; Sensitivity

Indexed keywords

CHROMATOGRAPHIC PURIFICATION; CRITICAL PROCESS PARAMETERS; DESIGN SPACES; MANUFACTURING PROCESS; PREPARATIVE; PROCESS DISTURBANCES; REVERSED-PHASE CHROMATOGRAPHY; SENSITIVITY;

CHROMATOGRAPHIC ANALYSIS; DESIGN; PEPTIDES; ROBUSTNESS (CONTROL SYSTEMS);

CHROMATOGRAPHY;

PEPTIDE;

ARTICLE; CASE STUDY; CHROMATOGRAPHY; MATHEMATICAL MODEL; PREDICTION; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS DEVELOPMENT; PROCESS MODEL; PROTEIN PURIFICATION; RELIABILITY;

CHROMATOGRAPHY, REVERSE-PHASE; KINETICS; MODELS, CHEMICAL; PEPTIDES; RESEARCH DESIGN;

EID: 84874989385     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2013.01.117     Document Type: Article

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