Global sensitivity analysis for the determination of parameter importance in the chromatographic purification of polyclonal antibodies

Journal of Chemical Technology and Biotechnology

Volumn 83, Issue 2, 2008, Pages 201-208

  Chhatre, Sunil ^a   Francis, Richard ^b   Newcombe, Anthony R ^b   Zhou, Yuhong ^a   Titchener Hooker, Nigel ^a   King, Josh ^a   Keshavarz Moore, Eli ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b BIOCOMPATIBLES UK LTD   (United Kingdom)

Author keywords

Antibody; Global sensitivity analysis; Model; Simulation; Throughput; Window of operation; Yield

Indexed keywords

CHROMATOGRAPHY; COMPUTER SIMULATION; DRUG PRODUCTS; MATHEMATICAL MODELS; SENSITIVITY ANALYSIS;

CHROMATOGRAPHIC PURIFICATION; POLYCLONAL ANTIBODIES;

PURIFICATION;

ADSORBENT; POLYCLONAL ANTIBODY; SNAKE VENOM ANTISERUM;

CHROMATOGRAPHY; COMPUTER SIMULATION; DRUG PRODUCTS; MATHEMATICAL MODELS; PURIFICATION; SENSITIVITY ANALYSIS;

ARTICLE; BINDING KINETICS; CHROMATOGRAPHY; COMPUTER MODEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG APPROVAL; DRUG INDUSTRY; DRUG MANUFACTURE; DRUG SYNTHESIS; FINANCIAL MANAGEMENT; FLOW RATE; FOOD AND DRUG ADMINISTRATION; MATHEMATICAL MODEL; PROCESS OPTIMIZATION; PROTEIN PURIFICATION; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SHEEP; UNITED KINGDOM;

OVIS;

EID: 38849085166     PISSN: 02682575     EISSN: 10974660     Source Type: Journal    
DOI: 10.1002/jctb.1801     Document Type: Article

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