Pooling control in variable preparative chromatography processes

Bioprocess and Biosystems Engineering

Volumn 33, Issue 3, 2010, Pages 375-382

  Westerberg, Karin ^a   Degerman, Marcus ^a   Nilsson, Bernt ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

PAT; Preparative chromatography; Robustness analysis; Sensitivity analysis; UV cut points

Indexed keywords

CHROMATOGRAPHIC COLUMN; CONTROL SIGNAL; CONTROL STRATEGIES; CRITICAL PARAMETER; CRITICAL PROCESS PARAMETERS; CUT POINT; DIRECT MEASUREMENT; HIGH DEMAND; HIGH LOAD; HIGHLY SENSITIVE; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; HYDROPHOBIC INTERACTIONS; INDIRECT MEASUREMENTS; MODEL-BASED; NEW APPROACHES; PREPARATIVE CHROMATOGRAPHY; PROCESS PARAMETERS; PRODUCT FRACTION; PRODUCT PURITY; PROOF OF CONCEPT; PROTEIN CHROMATOGRAPHY; REVERSED PHASE CHROMATOGRAPHY; ROBUSTNESS ANALYSIS; UV DETECTOR;

CHROMATOGRAPHIC ANALYSIS; HYDROPHOBICITY; ROBUSTNESS (CONTROL SYSTEMS); SENSITIVITY ANALYSIS;

HYDROPHOBIC CHROMATOGRAPHY;

ALCOHOL; BUFFER; INSULIN;

ARTICLE; CHROMATOGRAPHY; HYDROPHOBICITY; POSITIVE FEEDBACK; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION;

ADSORPTION; BIOTECHNOLOGY; CALIBRATION; CHROMATOGRAPHY; COMPUTER SIMULATION; ETHANOL; HYDROPHOBICITY; IMMUNOGLOBULIN G; INSULIN; KINETICS; MODELS, STATISTICAL; SERUM ALBUMIN, BOVINE; SPECTROPHOTOMETRY, ULTRAVIOLET; STOCHASTIC PROCESSES;

EID: 77649236686     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-009-0335-8     Document Type: Article

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