Modeling of the chromatographic solvent gradient reversed phase purification of a multicomponent polypeptide mixture

Separation Science and Technology

Volumn 43, Issue 6, 2008, Pages 1310-1337

  Aumann, Lars ^a   Buttè, Alessandro ^a   Morbidelli, Massimo ^a   Büscher, Klaus ^b   Schenkel, Berthold ^b  

^a ETH ZURICH   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Bi Langmuir isotherm; Chromatographic modeling; Multicomponent competitive adsorption isotherm; Peptide purification; Reversed phase chromatography; Solvent gradient chromatography

Indexed keywords

CORRELATION METHODS; ISOTHERMS; PARAMETER ESTIMATION; POLYPEPTIDES; PURIFICATION;

BI-LANGMUIR ISOTHERM; CHROMATOGRAPHIC MODELING; MULTICOMPONENT COMPETITIVE ADSORPTION ISOTHERM; PEPTIDE PURIFICATION; REVERSED-PHASE CHROMATOGRAPHY; SOLVENT GRADIENT CHROMATOGRAPHY;

ORGANIC SOLVENTS;

CORRELATION METHODS; ISOTHERMS; ORGANIC SOLVENTS; PARAMETER ESTIMATION; POLYPEPTIDES; PURIFICATION;

ADSORPTION; CHROMATOGRAPHY; IMPURITY; POLYPEPTIDE; PURIFICATION; SOLVENT;

EID: 42649118763     PISSN: 01496395     EISSN: 15205754     Source Type: Journal    
DOI: 10.1080/01496390801941026     Document Type: Article

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