Brillouin microscopy of collagen crosslinking: Noncontact depth-dependent analysis of corneal elastic modulus

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 2, 2013, Pages 1418-1425

  Scarcelli, Giuliano ^a,b   Kling, Sabine ^c   Quijano, Elena ^a   Pineda, Roberto ^d   Marcos, Susana ^c   Yun, Seok Hyun ^a,b,e  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c INSTITUTO DE ÓPTICA   (Spain)

^d MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^e HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN;

ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BRILLOUIN MICROSCOPY; CONTROLLED STUDY; CORNEA; CORNEA EDEMA; CORNEA EPITHELIUM; CORNEA STROMA; FLOW MEASUREMENT; LIGHT EXPOSURE; LIGHT SCATTERING; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; REFRACTION INDEX; RIGIDITY; SWINE; VISUAL SYSTEM PARAMETERS; YOUNG MODULUS;

EID: 84874960711     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-11387     Document Type: Article

References (47)

1. Dupps WJ. Biomechanical modeling of corneal ectasia. J Refract Surg. 2005;21:186-190.
2. Wollensak G. Crosslinking treatment of progressive keratoconus: new hope. Curr Opin Ophthalmol. 2006;17:356-360.
3. Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-Ainduced collagen crosslinking for the treatment of keratoconus. Amer J Ophthalmol. 2003;135:620-627.
4. Caporossi A, Baiocchi S, Mazzotta C, Traversi C, Caporossi T. Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: preliminary refractive results in an Italian study. J Cataract Refract Surg. 2006;32:837-845.
5. Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg. 2008;34: 796-801.
6. Wittig-Silva C, Whiting M, Lamoreaux E, Lindsay RG, Sullivan LJ, Snibson GR. Randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: preliminary results. J Refract Surg. 2008;24:S720-S725.
7. Wollensak G, Iomdina E. Biomechanical and histological changes after corneal crosslinking with and without epithelial debridement. J Cataract Refract Surg. 2009;35:540-546.
8. Hafezi F, Mrochen M, Iseli HP, Seiler T. Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas. J Cataract Refract Surg. 2009;35:621-624.
9. Kymionis GD, Diakonis VF, Coskunseven E, Jankov M, Yoo SH, Pallikaris IG. Customized pachymetric guided epithelial debridement for corneal collagen cross linking. BMC Ophthalmol. 2009;9:10.
10. Yuen L, Chan C, Wachler BSB. Effect of epithelial debridement in corneal collagen crosslinking therapy in porcine and human eyes. J Cataract Refract Surg. 2008;34:1815-1816.
11. Discher D, Dong C, Fredberg JJ, et al. Biomechanics: cell research and applications for the next decade. Ann Biomed Eng. 2009;37:847-859.
12. Luce DA. Determining in vivo biomechanical properties of the cornea with an ocular response analyzer. J Cataract Refract Surg. 2005;31:156-162.
13. Shah S, Laiquzzaman M, Bhojwani R, Mantry S, Cunliffe I. Assessment of the biomechanical properties of the cornea with the ocular response analyzer in normal and keratoconic eyes. Invest Ophthalmol Vis Sci. 2007;48:3026-3031.
14. Spoerl E, Terai N, Scholz F, Raiskup F, Pillunat LE. Detection of biomechanical changes after corneal cross-linking using ocular response analyzer software. J Refract Surg. 2011;27:452-457.
15. Fontes BM, Ambrosio R Jr, Velarde GC, Nose W. Ocular response analyzer measurements in keratoconus with normal central corneal thickness compared with matched normal control eyes. J Refract Surg. 2011;27:209-215.
16. Fontes BM, Ambrosio R Jr, Jardim D, Velarde GC, Nose W. Corneal biomechanical metrics and anterior segment parameters in mild keratoconus. Ophthalmology. 2011;117:673-679.
17. Dorronsoro C, Pascual D, Perez-Merino P, Kling S, Marcos S. Dynamic OCT measurement of corneal deformation by an air puff in normal and cross-linked corneas. Biomed Opt Exp. 2012;3:473-487.
18. Wang HC, Prendiville PL, McDonnell PJ, Chang WV. An ultrasonic technique for the measurement of the elastic moduli of human cornea. J Biomech. 1996;29:1633-1636.
19. He X, Liu JA. Quantitative ultrasonic spectroscopy method for noninvasive determination of corneal biomechanical properties. Invest Ophthalmol Vis Sci. 2009;50:5148-5154.
20. Ambrosio R Jr, Caldas D, Ramos I, Santos R, Belin M. Corneal Biomechanical Assessment Using Dynamic Ultra High-Speed Scheimpflug Technology Non-contact Tonometry (UHS-ST NCT): Preliminary Results. Presented at the American Society of Cataract and Refractive Surgery-American Society of Ophthalmic Administrators (ASCRS-ASOA) Symposium and Congress. San Diego, CA, March 25-29, 2011.
21. Ford MR, Dupps WJ Jr, Rollins AM, Roy AS, Hu Z. Method for optical coherence elastography of the cornea. J Biomed Opt. 2011;16:016005.
22. Grabner G, Eilmsteiner R, Steindl C, Ruckhofer J, Mattioli R, Husinsky W. Dynamic corneal imaging. J Cataract Refract Surg. 2005;31:163-174.
23. Scarcelli G, Yun SH. Confocal Brillouin microscopy for threedimensional mechanical imaging. Nat Photonics. 2008;2:39-43.
24. Scarcelli G, Pineda R, Yun S. Brillouin optical microscopy for corneal biomechanics. Invest Ophthalmol Vis Sci. 2012;53: 185-190.
25. Scarcelli G, Yun SH. In vivo Brillouin optical microscopy of the human eye. Opt Express. 2012;20:9197-9202.
26. Scarcelli G, Kim P, Yun SH. Cross-axis cascading of spectral dispersion. Opt Lett. 2008;33:2979-2981.
27. Scarcelli G, Yun SH. Multistage VIPA etalons for high-extinction parallel Brillouin spectroscopy. Opt Express. 2011;19:10913-10922.
28. Randall J, Vaughan JM. The measurement and interpretation of Brillouin scattering in the lens of the eye. Proc R Soc Lond B Biol Sci. 1982;214:449-470.
29. Kikkawa Y, Hirayama K. Uneven swelling of corneal stroma. Invest Ophthalmol. 1970;9:735-741.
30. Wilson G, Oleary DJ, Vaughan W. Differential swelling in compartments of the corneal stroma. Invest Ophthalmol Vis Sci. 1984;25:1105-1108.
31. Ortiz S, Siedlecki D, Grulkowski I, et al. Optical distortion correction in optical coherence tomography for quantitative ocular anterior segment by three-dimensional imaging. Opt Express. 2010;18:2782-2796.
32. Scarcelli G, Kim P, Yun SH. In vivo measurement of age-related stiffening in the crystalline lens by Brillouin optical microscopy. Biophys J. 2011;101:1539-1545.
33. Raiskup F, Pinelli R, Spoerl E. Riboflavin osmolar modification for transepithelial corneal cross-linking. Curr Eye Res. 2012; 37:234-238.
34. Kohlhaas M, Spoerl E, Schilde T, Unger G, Wittig C, Pillunat LE. Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet A light. J Cataract Refract Surg. 2006;32:279-283.
35. Schumacher S, Mrochen M, Wernli J, Bueeler M, Seiler, T. Optimization model for uv-riboflavin corneal cross-linking. Invest Ophthalmol Vis Sci. 2012;53:762-769.
36. Kissner A, Spoerl E, Jung R, Spekl K, Pillunat LE, Raiskup F. Pharmacological modification of the epithelial permeability by benzalkonium chloride in UVA/riboflavin corneal collagen cross-linking. Curr Eye Res. 2010;35:715-721.
37. Suri K, Hammersmith KM, Nagra PK. Corneal collagen crosslinking: ectasia and beyond. Curr Opin Ophthalmol. 2012;23: 280-287.
38. Bueno JM, Gualda EJ, Giakoumaki A, Pérez-Merino P, Marcos S, Artal P. Multiphoton microscopy of ex vivo corneas after collagen cross-linking. Invest Ophthalmol Vis Sci. 2011;52: 5325-5331.
39. Sondergaard AP, Hjortdal J, Breitenbach T, Ivarsen A. Corneal distribution of riboflavin prior to collagen cross-linking. Curt Eye Res. 2010;35:116-121.
40. Spoerl E, Raiskup-Wolf F, Pillunat LE. Biophysical principles of collagen cross-linking. Klin Monbl Augenheilkd. 2008;225: 131-137.
41. Kling S, Ginis H, Marcos S. Corneal biomechanical properties from two-dimensional corneal flap extensiometry: application to UV-riboflavin cross-linking. Invest Ophthalmol Vis Sci. 2012;53:5010-5015.
42. Kling S, Remon L, Perez-Escudero A, Merayo-Lloves J, Marcos S. Corneal biomechanical changes after collagen cross-linking from porcine eye inflation experiments. Invest Ophthalmol Vis Sci. 2010;51:3961-3968.
43. Koppen C, Wouters K, Mathysen D, Rozema J, Tassignon MJ. Refractive and topographic results of benzalkonium chlorideassisted transepithelial crosslinking. J Cataract Refract Surg. 2012;38:1000-1005.
44. Holopainen JM, Krootila K. Transient corneal thinning in eyes undergoing corneal cross-linking. Amer J Ophthalmol. 2011; 152:533-536.
45. Kymionis, GD, Kounis GA, Portaliou DM, et al. Intraoperative pachymetric measurements during corneal collagen crosslinking with riboflavin and ultraviolet A irradiation. Ophthalmology. 2009;116:2336-2339.
46. Jayasuriya AC, Scheinbeim JI, Lubkin V, Bennett G, Kramer P. Piezoelectric and mechanical properties in bovine cornea. J Biomed Mater Res A. 2003;66:260-265.
47. Nicolle S, Palierne JF. Dehydration effect on the mechanical behaviour of biological soft tissues: observations on kidney tissues. J Mech Behav Biomed Mat. 2010;3:630-635.