Dual-channel in-situ optical imaging system for quantifying lipid uptake and lymphatic pump function

Journal of Biomedical Optics

Volumn 17, Issue 8, 2012, Pages

  Kassis, Timothy ^a,b   Kohan, Alison B ^d   Weiler, Michael J ^a   Nipper, Matthew E ^a,c   Cornelius, Rachel ^a   Tso, Patrick ^d   Dixona, J Brandon ^a,d  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

BODIPY C16; Diameter tracking; In vivo motion compensation; Lipid transport; Lipid uptake; Lymph flow; Lymphatic vessel imaging; Mesentery lymphatic vessel

Indexed keywords

ACTIVE TRANSPORT; ANIMAL; ARTICLE; CYTOLOGY; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FLOW KINETICS; INSTRUMENTATION; LIPID METABOLISM; LYMPH VESSEL; MALE; METABOLISM; MULTIPHOTON MICROSCOPY; PHYSIOLOGY; RAT; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; VIDEORECORDING;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; LIPID METABOLISM; LYMPHATIC VESSELS; MALE; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; RHEOLOGY; SENSITIVITY AND SPECIFICITY; VIDEO RECORDING;

EID: 84874952886     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.17.8.086005     Document Type: Article

References (65)

1. L. V. Leak, "The structure of lymphatic capillaries in lymph formation," Fed. Proc. 35(8), 1863-1871 (1976).
2. P. Baluk et al., "Functionally specialized junctions between endothelial cells of lymphatic vessels," J. Exp. Med. 204(10), 2349-2362 (2007). (Pubitemid 47529321)
3. J. Trzewik et al., "Evidence for a second valve system in lymphatics: endothelial microvalves," FASEB J. 15(10), 1711-1717 (2001). (Pubitemid 32730218)
4. D. Helden and J. Zhao, "Lymphatic vasomotion," Clin. Exp. Pharmacol. Physiol. 27(12), 1014-1018 (2000).
5. P.-Y. von der Weid and D. C. Zawieja, "Lymphatic smooth muscle: the motor unit of lymph drainage," Int. J. Biochem. cell biol. 36(7), 1147-1153 (2004). (Pubitemid 38515655)
6. M. C. Mazzoni, T. C. Skalak, and G. W. Schmid-Schönbein, "Structure of lymphatic valves in the spinotrapezius muscle of the rat," Blood Ves. 24(6), 304-312 (1987). (Pubitemid 18006267)
7. A. R. Hargens and B. W. Zweifach, "Contractile stimuli in collecting lymph vessels," Am. J. Physiol. 233(1), H57-H65 (1977). (Pubitemid 8171374)
8. A. A. Gashev et al., "Regional variations of contractile activity in isolated rat lymphatics," Microcirculation 11(6), 477-492 (2004).
9. P. Tso and J. a Balint, "Formation and transport of chylomicrons by enterocytes to the lymphatics," Am. J. Physiol. 250(6 Pt 1), G715-G726 (1986).
10. T. G. Redgrave, "Chylomicron metabolism," Biochem. Soc. Trans. 32(Pt 1), 79-82 (2004). (Pubitemid 38283018)
11. C. M. Mansbach and F. Gorelick, "Development and physiological regulation of intestinal lipid absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons," Am. J. Physiol. Gastr. Liver Physiol. 293(4), G645-G650 (2007). (Pubitemid 47605912)
12. J. B. Dixon, "Mechanisms of chylomicron uptake into lacteals," Ann. NY Acad. Sci. 1207(Suppl. 1), 52-57 (2010).
13. M. Hussain et al., "A proposed model for the assembly of chylomicrons," Atherosclerosis 148(1), 1-15 (2000).
14. N. L. Harvey et al., "Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity," Nat. Genet. 37, 1072-1081 (2005). (Pubitemid 41486659)
15. E. M. Straarup et al., "Lymphatic transport in rats of interesterified oils containing conjugated linoleic acids," Lipids 40(7), 677-684 (2005). (Pubitemid 41266306)
16. P. Tso, V. Pitts, and D. N. Granger, "Role of lymph flow in intestinal chylomicron transport," Am. J. Physiol. 249(1 Pt 1), G21-G28 (1985). (Pubitemid 15231426)
17. S. Miura, E. Sekizuka, and H. Nagata, "Increased lymphocyte transport by lipid absorption in rat mesenteric lymphatics," Am. J. Physiol. 253(5 Pt 1), G596-G600 (1987).
18. J. B. Dixon, S. Raghunathan, and M. A. Swartz, "A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics," Biotechnol. Bioeng. 103(6), 1224-1235 (2009).
19. W. Olszewski et al., "Experimental lymphedema in dogs," J. Cardiovasc. Surg. 9(2), 178-183 (1968).
20. A. Hayashi et al., "Increased intrinsic pumping of intestinal lymphatics following hemorrhage in anesthetized sheep," Circ. Res. 60, 265-272 (1987). (Pubitemid 17078841)
21. N. McHale and T. Adair, "Reflex modulation of lymphatic pumping in sheep," Circ. Res. 64, 1165-1171 (1989). (Pubitemid 19155787)
22. T. Naito et al., "New method for evaluation of lung lymph flow rate with intact lymphatics in anaesthetized sheep," Acta. Physiol. 188(2), 139-149 (2006). (Pubitemid 44337811)
23. M. Muthuchamy et al., "Molecular and functional analyses of the contractile apparatus in lymphatic muscle," FASEB J. 17(8), 920-922 (2003).
24. S. D. Zawieja et al., "Impairments in the intrinsic contractility of mesenteric collecting lymphatics in a rat model of metabolic syndrome," Am. J. Physiol. Heart Circ. Physiol. 302(3), H643-H653 (2012).
25. H. G. Bohlen et al., "Phasic contractions of rat mesenteric lymphatics increase basal and phasic nitric oxide generation in vivo," Am. J. Physiol. Heart Circ. Physiol. 297(4), H1319-H1328 (2009).
26. P. M. Lynch, F. A. Delano, and G.W. Schmid-Schönbein, "The primary valves in the initial lymphatics during inflammation," Lymph. Res. Biol. 5(1), 3-10 (2007). (Pubitemid 46753894)
27. T. V. Karlsen et al., "Transcapillary fluid balance consequences of missing initial lymphatics studied in a mouse model of primary lymphoedema," J. Physiol. 574(Pt 2), 583-596 (2006).
28. H. Y. Lim et al., "Hypercholesterolemic mice exhibit lymphatic vessel dysfunction and degeneration," Am. J. Pathol. 175(3), 1328-1337 (2009).
29. T. Karpanen and S. Schulte-Merker, "Zebrafish provides a novel method for lymphatic vascular research," in The Zebrafish: Disease Models and Chemical Screens, pp. 223-238, Academic Press, Massachusetts (2011).
30. K. Yaniv et al., "Live imaging of lymphatic development in the zebrafish," Nat. Med. 12(6), 711-716 (2006). (Pubitemid 43865243)
31. G. A. Edwards et al., "Animal models for the study of intestinal lymphatic drug transport," Adv. Drug. Deliver. Rev. 50(1-2), 45-60 (2001). (Pubitemid 32727276)
32. J. Bollman, J. Cain, and J. Grindlay, "Techniques for the collection of lymph from the liver, small intestine, or thoracic duct of the rat," J. Lab. Clin. Med. 33, 1349-1352 (1948).
33. J. B. Dixon et al., "Image correlation algorithm for measuring lymphocyte velocity and diameter changes in contracting microlymphatics," Ann. Biomed. Eng. 35(3), 387-396 (2007). (Pubitemid 46325726)
34. T. J. Akl et al., "Mesenteric lymph flow in adult and aged rats," Am. J. Physiol. Heart Circ. Physiol. 301(5), H1828-H1840 (2011).
35. J. B. Dixon et al., "Measuring microlymphatic flow using fast video microscopy," J. Biomed. Opt. 10(6), 064016 (2005).
36. J. P. Otis and S. A. Farber, "Imaging vertebrate digestive function and lipid metabolism in vivo," Drug Discov. Today Dis. Model. xxx, 6-11 (2012).
37. A. C. Guyton and J. E. Hall, Textbook of Medical Physiology, Saunders, Philadelphia, PA (2011).
38. B. Zitová and J. Flusser, "Image registration methods: a survey," Image Vision Comput. 21(11), 977-1000 (2003).
39. J. D. Briers, "Laser Doppler, speckle and related techniques for blood perfusion mapping and imaging," Physiol. Meas. 22(4), 35-66 (2001).
40. M. J. Rossow, W. W. Mantulin, and E. Gratton, "Scanning laser image correlation for measurement of flow," J. Biomed. Opt. 15(2), 026003 (2010).
41. J. B. Dixon et al., "Lymph flow, shear stress, and lymphocyte velocity in rat mesenteric prenodal lymphatics," Microcirculation 13(7), 597-610 (2006). (Pubitemid 44446639)
42. G. Rozenberg, Microscopic Haematology: A Practical Guide for the Haematology Laboratory, p. 100, Informa Healthcare, London, UK (2002).
43. L. Yang et al., "Effect of ezetimibe on incretin secretion in response to the intestinal absorption of a mixed meal," Am. J. Physiol-Gastr. Liver Physiol. 299(5), 1003-1011 (2010).
44. D. C. Zawieja et al., "Distribution, propagation, and coordination of contractile activity in lymphatics," Am. J. Physiol. 264(4 Pt 2), 1283-1291 (1993).
45. T. Nagai, E. A. Bridenbaugh, and A. A. Gashev, "Aging-associated alterations in contractility of rat mesenteric lymphatic vessels," Microcirculation 18(6), 463-473 (2011).
46. E. Rahbar and J. E. Moore, "A model of a radially expanding and contracting lymphangion," J. Biomech. 44(6), 1001-1007 (2011).
47. R. Burton-Opitz and R. Nemser, "The viscosity of lymph," Am. J. Physiol. 45(1), 25-29 (1917).
48. N. E. Miller et al., "Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transport," Am. J. Physiol-Endoc. M. 301(4), 659-667 (2011).
49. J. R. Lakowicz and B. R. Masters, Principles of Fluorescence Spectroscopy, Springer, NY (2008).
50. J.W. Breslin et al., "Vascular endothelial growth factor-C stimulates the lymphatic pump by a VEGF receptor-3-dependent mechanism," Am. J. Physiol-Heart Circ. Physiol. 293(1), H709-H718 (2007). (Pubitemid 47105133)
51. T. J. Akl et al., "Measuring contraction propagation and localizing pacemaker cells using high speed video microscopy," J. Biomed. Opt. 16(2), 026016 (2011).
52. F. Zhang et al., "Preclinical lymphatic imaging," Mol. Imaging Biol. 13(4), 599-612 (2011).
53. M. Weiler, T. Kassis, and J. B. Dixon, "Sensitivity analysis of nearinfrared functional lymphatic imaging," J. Biomed. Opt. 17(6), 066019 (2012).
54. G. W. Schmid-Schonbein, "Microlymphatics and lymph flow," Physiol. Rev. 70(4), 987-1028 (1990). (Pubitemid 20364821)
55. A. A. Gashev, "Lymphatic vessels: pressure- and flow-dependent regulatory reactions," Ann. NY Acad. Sci. 1131, 100-109 (2008). (Pubitemid 351758507)
56. A. A. Gashev, "Basic mechanisms controlling lymph transport in the mesenteric lymphatic net," Ann. NY Acad. Sci. 1207(Suppl), 16-20 (2010).
57. A. E. Thumser and J. Storch, "Characterization of a BODIPY-labeled fluorescent fatty acid analogue. Binding to fatty acid-binding proteins, intracellular localization, and metabolism," Mol. Cell. Biochem. 299(1-2), 67-73 (2007). (Pubitemid 46767539)
58. J. D. Carten, M. K. Bradford, and S. A. Farber, "Visualizing digestive organ morphology and function using differential fatty acid metabolism in live zebrafish," Dev. Biol. 360(2), 276-285 (2011).
59. N. L. Trevaskis,W. N. Charman, and C. J. H. Porter, "Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update," Adv. Drug Deliver. Rev. 60(6), 702-716 (2008).
60. J. A. Yáñez et al., "Intestinal lymphatic transport for drug delivery," Adv. Drug. Deliver. Rev. 63(10-11), 923-942 (2011).
61. N. L. Trevaskis, W. N. Charman, and C. J. H. Porter, "Acute hypertriglyceridemia promotes intestinal lymphatic lipid and drug transport: a positive feedback mechanism in lipid and drug absorption," Mol. Pharm. 8(4), 1132-1139 (2011).
62. M. Servelle, "Congenital malformation of the lymphatics of the small intestine," J. Cardiovasc. Surg. 32(2), 159-165 (1991).
63. S. Vignes and J. Bellanger, "Primary intestinal lymphangiectasia (Waldmann's disease)," Orphanet J. Rare Dis. 3, 5 (2008).
64. J. S. Alexander et al., "Emerging roles of lymphatics in inflammatory bowel disease," Ann. NY Acad. Sci. 1207, E75-E85 (2010).
65. J. B. Dixon, "Lymphatic lipid transport: sewer or subway?," Trends Endocrin. Met. 21(8), 480-487 (2010).