Phasic contractions of rat mesenteric lymphatics increase basal and phasic nitric oxide generation in vivo

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 4, 2009, Pages

  Bohlen, H Glenn ^a   Wang, Wei ^b   Gashev, Anatoliy ^b   Gasheva, Olga ^b   Zawieja, Dave ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Frequency contraction; Lymph flow

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; SODIUM CHLORIDE;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIASTOLE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LYMPH FLOW; LYMPH VESSEL ENDOTHELIUM; MALE; MESENTERY LYMPH NODE; MICROELECTRODE; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

ANIMALS; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; LYMPHATIC VESSELS; MALE; MESENTERY; MICROELECTRODES; MUSCLE CONTRACTION; MUSCLE RELAXATION; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PERIODICITY; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHLORIDE; UP-REGULATION;

EID: 70349630102     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00039.2009     Document Type: Article

References (37)

1. Bauser-Heaton HD, Bohlen HG. Cerebral microvascular dilation during hypotension and decreased oxygen tension: a role for nNOS. Am J Physiol Heart Circ Physiol 293: H2193-H2201, 2007.
2. Bauser-Heaton HD, Song J, Bohlen HG. Cerebral microvascular nNOS responds to lowered oxygen tension through a bumetanide-sensitive cotransporter and sodium-calcium exchanger. Am J Physiol Heart Circ Physiol 294: H2166-H2173, 2008.
3. Benoit JN, Zawieja DC. Effects of f-Met-Leu-Phe-induced inflammation on intestinal lymph flow and lymphatic pump behavior. Am J Physiol Gastrointest Liver Physiol 262: G199-G202, 1992.
4. Benoit JN, Zawieja DC, Goodman AH, Granger HJ. Characterization of intact mesenteric lymphatic pump and its responsiveness to acute edemagenic stress. Am J Physiol Heart Circ Physiol 257: H2059-H2069, 1989.
5. Bohlen HG. Intestinal mucosal oxygenation influences absorptive hyperemia. Am J Physiol Heart Circ Physiol 239: H489-H493, 1980.
6. Bohlen HG. Integration of intestinal structure, function, and microvascular regulation. Microcirculation 5: 27-37, 1998. (Pubitemid 128644121)
7. Buerk DG, Riva CE, Cranstoun SD. Nitric oxide has a vasodilatory role in cat optic nerve head during flicker stimuli. Microvasc Res 52: 13-26, 1996.
8. Dixon JB, Greiner ST, Gashev AA, Cote GL, Moore JE, Zawieja DC. Lymph flow, shear stress, and lymphocyte velocity in rat mesenteric prenodal lymphatics. Microcirculation 13: 597-610, 2006.
9. Ferguson MK, DeFilippi VJ. Nitric oxide and endothelium-dependent relaxation in tracheobronchial lymph vessels. Microvasc Res 47: 308-317, 1994.
10. Friedemann MN, Robinson SW, Gerhardt GA. o-Phenylenediamine-modified carbon fiber electrodes for the detection of nitric oxide. Anal Chem 68: 2621-2628, 1996. (Pubitemid 126496599)
11. Gashev AA, Davis MJ, Zawieja DC. Inhibition of the active lymph pump by flow in rat mesenteric lymphatics and thoracic duct. J Physiol 540: 1023-1037, 2002.
12. Gasheva OY, Zawieja DC, Gashev AA. Contraction-initiated NO-dependent lymphatic relaxation: a self-regulatory mechanism in rat thoracic duct. J Physiol 575: 821-832, 2006.
13. Granger HJ. Role of the interstitial matrix and lymphatic pump in regulation of transcapillary fluid balance. Microvasc Res 18: 209-216, 1979.
14. Hargens AR, Zweifach BW. Contractile stimuli in collecting lymph vessels. Am J Physiol Heart Circ Physiol 233: H57-H65, 1977.
15. Koller A, Mizuno R, Kaley G. Flow reduces the amplitude and increases the frequency of lymphatic vasomotion: role of endothelial prostanoids. Am J Physiol Regul Integr Comp Physiol 277: R1683-R1689, 1999.
16. Lash JM, Nase GP, Bohlen HG. Acute hyperglycemia depresses arteriolar NO formation in skeletal muscle. Am J Physiol Heart Circ Physiol 277: H1513-H1520, 1999.
17. Leak LV, Cadet JL, Griffin CP, Richardson K. Nitric oxide production by lymphatic endothelial cells in vitro. Biochem Biophys Res Commun 217: 96-105, 1995. (Pubitemid 26004766)
18. McHale NG, Meharg MK. Co-ordination of pumping in isolated bovine lymphatic vessels. J Physiol 450: 503-512, 1992.
19. McHale NG, Roddie IC. The effect of transmural pressure on pumping activity in isolated bovine lymphatic vessels. J Physiol 261: 255-269, 1976.
20. Mizuno R, Dornyei G, Koller A, Kaley G. Myogenic responses of isolated lymphatics: modulation by endothelium. Microcirculation 4: 413-420, 1997. (Pubitemid 127675115)
21. Mizuno R, Koller A, Kaley G. Regulation of the vasomotor activity of lymph microvessels by nitric oxide and prostaglandins. Am J Physiol Regul Integr Comp Physiol 274: R790-R796, 1998.
22. 2 increases nitric oxide release from endothelial cells. Am J Physiol Heart Circ Physiol 285: H507-H515, 2003.
23. Ohhashi T, Azuma T, Sakaguchi M. Active and passive mechanical characteristics of bovine mesenteric lymphatics. Am J Physiol Heart Circ Physiol 239: H88-H95, 1980. (Pubitemid 10045521)
24. Orlov RS, Lobacheva A. Intravascular pressure and spontaneous contraction of the lymphatics. Bull Exp Biol Med 83: 448-450, 1977. (Pubitemid 8205065)
25. Peng X, Haldar S, Deshpande S, Irani K, Kass DA. Wall stiffness suppresses Akt/eNOS and cytoprotection in pulse-perfused endothelium. Hypertension 41: 378-381, 2003. (Pubitemid 36204918)
26. Pezzuto L, Bohlen HG. Extracellular arginine rapidly dilates in vivo intestinal arteries and arterioles through a nitric oxide mechanism. Microcirculation 15: 123-135, 2008. (Pubitemid 351228637)
27. Shirasawa Y, Ikomi F, Ohhashi T. Physiological roles of endogenous nitric oxide in lymphatic pump activity of rat mesentery in vivo. Am J Physiol Gastrointest Liver Physiol 278: G551-G556, 2000. (Pubitemid 30213120)
28. Soucy KG, Ryoo S, Benjo A, Lim HK, Gupta G, Sohi JS, Elser J, Aon MA, Nyhan D, Shoukas AA, Berkowitz DE. Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness. J Appl Physiol 101: 1751-1759, 2006.
29. Takeda H, Komori K, Nishikimi N, Nimura Y, Sokabe M, Naruse K. Bi-phasic activation of eNOS in response to uni-axial cyclic stretch is mediated by differential mechanisms in BAECs. Life Sci 79: 233-239, 2006. (Pubitemid 43782545)
30. Tsunemoto H, Ikomi F, Ohhashi T. Flow-mediated release of nitric oxide from lymphatic endothelial cells of pressurized canine thoracic duct. Jpn J Physiol 53: 157-163, 2003. (Pubitemid 37229290)
31. von der Weid PY, Crowe MJ, van Helden DF. Endothelium-dependent modulation of pacemaking in lymphatic vessels of the guinea-pig mesentery. J Physiol 493: 563-575, 1996.
32. von der Weid PY, Zhao J, van Helden DF. Nitric oxide decreases pacemaker activity in lymphatic vessels of guinea pig mesentery. Am J Physiol Heart Circ Physiol 280: H2707-H2716, 2001. (Pubitemid 32553312)
33. Yokoyama S, Ohhashi T. Effects of acetylcholine on spontaneous contractions in isolated bovine mesenteric lymphatics. Am J Physiol Heart Circ Physiol 264: H1460-H1464, 1993. (Pubitemid 23154131)
34. Zani BG, Bohlen HG. Sodium channels are required during in vivo sodium chloride hyperosmolarity to stimulate increase in intestinal endothelial nitric oxide production. Am J Physiol Heart Circ Physiol 288: H89-H95, 2005.
35. Zani BG, Bohlen HG. Transport of extracellular L-arginine via the cationic amino acid transporter is required during in vivo endothelial nitric oxide production. Am J Physiol Heart Circ Physiol 289: H1381-H1390, 2005.
36. Zawieja DC, Barber BJ. Lymph protein concentration in initial and collecting lymphatics of the rat. Am J Physiol Gastrointest Liver Physiol 252: G602-G606, 1987.
37. Zawieja DC, Davis KL, Schuster R, Hinds WM, Granger HJ. Distribution, propagation, and coordination of contractile activity in lymphatics. Am J Physiol Heart Circ Physiol 264: H1283-H1291, 1993. (Pubitemid 23115305)