Discovery and characterization of novel allosteric FAK inhibitors

European Journal of Medicinal Chemistry

Volumn 61, Issue , 2013, Pages 49-60

  Iwatani, Misa ^a   Iwata, Hidehisa ^a   Okabe, Atsutoshi ^a   Skene, Robert J ^b   Tomita, Naoki ^a   Hayashi, Yoko ^a   Aramaki, Yoshio ^a   Hosfield, David J ^b,c   Hori, Akira ^a   Baba, Atsuo ^a   Miki, Hiroshi ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b Takeda San Diego Inc   (United States)

^c Molecular Tagging Systems Inc   (United States)

Author keywords

Allosteric inhibitor; Cancer; Focal adhesion kinase; Slow dissociation

Indexed keywords

ADENOSINE TRIPHOSPHATE; BENZOTHIAZINE DERIVATIVE; FOCAL ADHESION KINASE; PYRAZOLE;

ALLOSTERISM; ARTICLE; BINDING COMPETITION; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZINES;

EID: 84874938176     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.06.035     Document Type: Article

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