Shikonin, a natural product from the root of Lithospermum erythrorhizon, is a cytotoxic DNA-binding agent

European Journal of Pharmaceutical Sciences

Volumn 49, Issue 1, 2013, Pages 18-26

  Chen, Changmin ^a   Shanmugasundaram, Kumaran ^b   Rigby, Alan C ^b   Kung, Andrew L ^c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c Department of Medicine   (United States)

Author keywords

Cytotoxic chemotherapy; Ewing sarcoma; High throughput screen; Natural product; Shikonin; Transcription

Indexed keywords

CISPLATIN; DACTINOMYCIN; DNA TOPOISOMERASE; DOXORUBICIN; SHIKONIN; TRANSCRIPTION FACTOR; ANTINEOPLASTIC AGENT; BIOLOGICAL PRODUCT; DNA; NAPHTHOQUINONE;

APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; DRUG CYTOTOXICITY; EWING SARCOMA; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LITHOSPERMUM; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; SARCOMA CELL; CHEMISTRY; DNA CLEAVAGE; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOLOGICAL PRODUCTS; CELL LINE, TUMOR; DNA; DNA CLEAVAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LITHOSPERMUM; NAPHTHOQUINONES; PLANT ROOTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84874937007     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.02.003     Document Type: Article

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