Genome wide association study of obesity

Journal of Central South University (Medical Sciences)

Volumn 38, Issue 1, 2013, Pages 95-100

  Xu, Xiaojing ^a   Zeng, Hui ^b   Xiao, Di ^a   Zhou, Honghao ^a   Liu, Zhaoqian ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b Changsha Health School   (China)

Author keywords

Genes; Genome wide association study (GWAS); Obesity

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR, HUMAN; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN; FTO PROTEIN, HUMAN; GLUCOSAMINE 6 PHOSPHATE ISOMERASE; GLUCOSAMINE-6-PHOSPHATE ISOMERASE; ISOMERASE; PROTEIN;

GENETIC ASSOCIATION; GENETICS; HUMAN; OBESITY; PATHOPHYSIOLOGY; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

ALDOSE-KETOSE ISOMERASES; BRAIN-DERIVED NEUROTROPHIC FACTOR; GENOME-WIDE ASSOCIATION STUDY; HUMANS; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS;

EID: 84874896249     PISSN: 16727347     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1672-7347.2013.01.003     Document Type: Review

References (29)

1. Haslam DW, James WP. Obesity[J]. Lancet, 2005,366(9492): 1197-1209.
2. Sweeting HN. Measurement and definitions of obesity in childhood and adolescence: a field guide for the uninitiated[J]. Nutr J, 2007,6:32.
3. Hoffman PC, Mauer AM, Vokes EE. Lung cancer[J]. Lancet, 2000,355(9202): 479485.
4. Grundy SM. Obesity, metabolic syndrome, and cardiovascular disease[J]. J Clin Endocrinol Metab, 2004,89(6): 2595-2600. (Pubitemid 38766337)
5. Maruthur NM, Bolen SD, Brancati FL, et al. The association of obesity and cervical cancer screening: a systematic review and meta-analysis[J]. Obesity (Silver Spring), 2009,17(2): 375-381.
6. LeRoith D, Novosyadlyy R, Gallagher EJ, et al. Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence[J]. Exp Clin Endocrinol Diabetes, 2008,116 (Suppl 1): S4-S6.
7. Lau DC, Douketis JD, Morrison KM, et al. 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary][J]. CMAJ, 2007,176(8):S1-S13.
8. Bleich S, Cutler D, Murray C, et al. Why is the developed world obese?[J]. Annu Rev Public Health, 2008,29:273-295.
9. Poirier P, Giles TD, Bray GA, et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss[J]. Arteriosder Thromb Vase Biol, 2006,26(5): 968-976. (Pubitemid 43732100)
10. Ogden CL, Yanovski SZ, Carroll MD, et al. The epidemiology of obesity[J]. Gastroenterology, 2007,132(6):2087-2102.
11. Manolio TA. Genomewide association studies and assessment of the risk of disease[J]. N Engl J Med, 2010,363(2): 166-176.
12. Hainerova IA. Genetics of obesity[J]. Vnitr Lek, 2010,56(10): 1035-1042.
13. Thorleifsson G, Walters GB, Gudbjartsson DF, et al. Genome-wide association yields new sequence variants at seven loci that associate with measures ofobesity[J]. Nat Genet, 2009,41(1): 18-24.
14. Lee YS. The role of genes in the current obesity epidemic[J]. Ann Acad Med Singapore, 2009,38(1): 45-53.
15. Zhao J, Bradfield JP, Li M, et al. The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI[J]. Obesity (Silver Spring), 2009,17(12): 2254-2257.
16. Zhao J, Bradfield JP, Zhang H, et al. Role of BMI-associated loci identified in GWAS meta-analyses in the context of common childhood obesity in European Americans[J]. Obesity (Silver Spring), 2011,19(12): 2436-2439.
17. Dorajoo R, Blakemore AI, Sim X, et al. Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations[J]. Int J Obes(Lond), 2012,36(1):159-163.
18. Garver WS. Gene-diet interactions in childhood obesity[J]. Curr Genomics, 2011,12(3): 180-189.
19. Wang K, Li WD, Zhang CK, et al. A genome-wide association study on obesity and obesity-related traits[J]. PLoS One, 2011,6(4): e18939.
20. Hotta K, Nakamura M, Nakata Y, et al. INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese[J]. J Hum Genet, 2008,53(9): 857-862.
21. Campa D, Hüsing A, McKay JD, et al. The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk[J]. BMC Cancer, 2010,10:563.
22. Bille DS, Banasik K, Justesen JM, et al. Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult Danes[J]. PLoS One, 2011,6(6): e20640.
23. Hotta K, Nakamura M, Nakamura T, et al. Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population[J]. J Hum Genet, 2010,55(11): 738-742.
24. Renstrom F, Payne F, Nordström A, et al. Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden[J]. Hum Mol Genet, 2009,18(8): 1489-1496.
25. Delahanty RJ, Beeghly-Fadiel A, Xiang YB, et al. Association of obesity-related genetic variants with endometrial cancer risk: a report from the shanghai endometrial cancer genetics study[J]. Am J Epidemiol, 2011,174(10): 1115-1126.
26. Sandholt CH, Vestmar MA, Bille DS, et al. Studies of metabolic phenotypic correlates of 15 obesity associated gene variants[J]. PLoS One, 2011,6(9): e23531.
27. Liu YZ, Pei YF, Liu JF, et al. Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males[J]. PLoS One, 2009,4(8): e6827.
28. Almén MS, Jacobsson JA, Shaik JH, et al. The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children[J]. BMC Med Genet, 2010,11:58.
29. XU Xiaojing, ZENG Hui, XIAO Di, ZHOU, Honghao, LIU Zhaoqian. Genome wide association study of obesity[J]. Journal of Central South University. Medical Science, 2013,38(1): 95-100. DOI:10.3969/j.issn.1672-7347.2013.01.018