Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult danes

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Bille, Dorthe S ^a,b,c   Banasik, Karina ^a   Justesen, Johanne M ^a   Sandholt, Camilla H ^a,d   Sandbæk, Annelli ^e   Lauritzen, Torsten ^e   Jørgensen, Torben ^c,f   Witte, Daniel R ^g   Holm, Jens Christian ^b,c   Hansen, Torben ^a,h,i   Pedersen, Oluf ^a,c,i,j  

^a Capital Region   (Denmark)

^b Holbæk University Hospital   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d NOVO NORDISK A S   (Denmark)

^e AARHUS UNIVERSITY   (Denmark)

^f GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^g STENO DIABETES CENTER   (Denmark)

^h UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

ⁱ HAGEDORN RESEARCH INSTITUTE   (Denmark)

^j AARHUS UNIVERSITY   (Denmark)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CELL PROTEIN; INSULIN; LYSOPHOSPHOLIPASE; LYSOPHOSPHOLIPASE LIKE 1 PROTEIN; METHIONINE SULFOXIDE REDUCTASE A; NEUROXIN 3 PROTEIN; TRANSCRIPTION FACTOR ACTIVATING ENHANCER BINDING PROTEIN 2 BETA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; LYPLAL1 PROTEIN, HUMAN; METHIONINE SULFOXIDE REDUCTASE; NERVE PROTEIN; NEUREXIN IIIALPHA; TRANSCRIPTION FACTOR AP 2;

ADULT; ALLELE; ARTICLE; BODY MASS; CONTROLLED STUDY; DIET RESTRICTION; DISEASE ASSOCIATION; FEMALE; GENE; GENETIC VARIABILITY; GENOTYPE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LYPLAL1 GENE; MAJOR CLINICAL STUDY; MALE; MSRA GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; NRXN3 GENE; OBESITY; PATHOPHYSIOLOGY; PROTEIN FUNCTION; QUANTITATIVE TRAIT; SEX DIFFERENCE; TFAP2B GENE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; CASE CONTROL STUDY; CAUCASIAN; DENMARK; GENETIC ASSOCIATION; GENETICS; METABOLISM; MIDDLE AGED; SEXUAL DEVELOPMENT; WAIST HIP RATIO;

ADIPOSITY; ADULT; CASE-CONTROL STUDIES; DENMARK; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LYSOPHOSPHOLIPASE; MALE; METHIONINE SULFOXIDE REDUCTASES; MIDDLE AGED; NERVE TISSUE PROTEINS; OBESITY; SEX CHARACTERISTICS; TRANSCRIPTION FACTOR AP-2; WAIST CIRCUMFERENCE; WAIST-HIP RATIO;

EID: 79957945454     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020640     Document Type: Article

References (29)

1. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894.
2. Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, et al. (2009) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41: 18-24.
3. Benzinou M, Creemers JW, Choquet H, Lobbens S, Dina C, et al. (2008) Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat Genet 40: 943-945.
4. Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40: 768-775.
5. Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, et al. (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41: 25-34.
6. Meyre D, Delplanque J, Chevre JC, Lecoeur C, Lobbens S, et al. (2009) Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 41: 157-159.
7. Chambers JC, Elliott P, Zabaneh D, Zhang W, Li Y, et al. (2008) Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet 40: 716-718.
8. Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, et al. (2009) Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet 5: e1000508.
9. Heard-Costa NL, Zillikens MC, Monda KL, Johansson A, Harris TB, et al. (2009) NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet 5: e1000539.
10. Steinberg GR, Kemp BE, Watt MJ, (2007) Adipocyte triglyceride lipase expression in human obesity. Am J Physiol Endocrinol Metab 293: E958-964.
11. Hishimoto A, Liu QR, Drgon T, Pletnikova O, Walther D, et al. (2007) Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms. Hum Mol Genet 16: 2880-2891.
12. Novak G, Boukhadra J, Shaikh SA, Kennedy JL, Le Foll B, (2009) Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: a preliminary study. World J Biol Psychiatry 10: 929-935.
13. Tao Y, Maegawa H, Ugi S, Ikeda K, Nagai Y, et al. (2006) The transcription factor AP-2beta causes cell enlargement and insulin resistance in 3T3-L1 adipocytes. Endocrinology 147: 1685-1696.
14. Maeda S, Tsukada S, Kanazawa A, Sekine A, Tsunoda T, et al. (2005) Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. J Hum Genet 50: 283-292.
15. Tsukada S, Tanaka Y, Maegawa H, Kashiwagi A, Kawamori R, et al. (2006) Intronic polymorphisms within TFAP2B regulate transcriptional activity and affect adipocytokine gene expression in differentiated adipocytes. Mol Endocrinol 20: 1104-1111.
16. Nordquist N, Gokturk C, Comasco E, Eensoo D, Merenakk L, et al. (2009) The transcription factor TFAP2B is associated with insulin resistance and adiposity in healthy adolescents. Obesity (Silver Spring) 17: 1762-1767.
17. Ugi S, Nishio Y, Yamamoto H, Ikeda K, Kobayashi M, et al. (2010) Relation of the expression of transcriptional factor TFAP2B to that of adipokines in subcutaneous and omental adipose tissues. Obesity (Silver Spring) 18: 1277-1282.
18. Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, et al. (2010) Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet.
19. Ryan MC, Abbasi F, Lamendola C, Carter S, McLaughlin TL, (2007) Serum alanine aminotransferase levels decrease further with carbohydrate than fat restriction in insulin-resistant adults. Diabetes Care 30: 1075-1080.
20. Yoo J, Lee S, Kim K, Yoo S, Sung E, et al. (2008) Relationship between insulin resistance and serum alanine aminotransferase as a surrogate of NAFLD (nonalcoholic fatty liver disease) in obese Korean children. Diabetes Res Clin Pract 81: 321-326.
21. Peyot ML, Guay C, Latour MG, Lamontagne J, Lussier R, et al. (2009) Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion. J Biol Chem 284: 16848-16859.
22. Maheux P, Azhar S, Kern PA, Chen YD, Reuven GM, (1997) Relationship between insulin-mediated glucose disposal and regulation of plasma and adipose tissue lipoprotein lipase. Diabetologia 40: 850-858.
23. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet.
24. Zillikens MC, Yazdanpanah M, Pardo LM, Rivadeneira F, Aulchenko YS, et al. (2008) Sex-specific genetic effects influence variation in body composition. Diabetologia 51: 2233-2241.
25. Dieguez C, Fruhbeck G, Lopez M, (2009) Hypothalamic lipids and the regulation of energy homeostasis. Obes Facts 2: 126-135.
26. Jørgensen T, Borch-Johnsen K, Thomsen TF, Ibsen H, Glümer C, et al. (2003) A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99. EurJCardiovascPrevRehabil 10: 377-386.
27. Lauritzen T, Griffin S, Borch-Johnsen K, Wareham NJ, Wolffenbuttel BH, et al. (2000) The ADDITION study: proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening. IntJObesRelat Metab Disord 24 (Suppl 3): S6-11.
28. Alberti KG, Zimmet PZ, (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15: 539-553.
29. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.