Interactions in bacterial biofilm development: A structural perspective

Current Protein and Peptide Science

Volumn 13, Issue 8, 2012, Pages 739-755

  Garnett, James A ^a   Matthews, Steve ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Adhesion; Biofilm; Dispersin; Structural biology

Indexed keywords

COLLAGEN TYPE 4; FIBRONECTIN BINDING PROTEIN; GLYCOPROTEIN; LAMININ; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SERINE; TRICLOSAN;

ARTICLE; BACTERIAL GROWTH; BACTERIAL SURVIVAL; BACTERIUM PILUS; BIOFILM; CELL ADHESION; CELL COMMUNICATION; CELL INTERACTION; CELL SURFACE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DEHYDRATION; ENDOCARDITIS; ESCHERICHIA COLI; EXTRACELLULAR MATRIX; FIMBRIA; HAEMOPHILUS INFLUENZAE; HYDROPHOBICITY; INTERNALIZATION; MACROMOLECULE; NONHUMAN; PH; POLYMERIZATION; RADIATION INJURY; RECOGNITION; SOLID PHASE SYNTHESIS; STREPTOCOCCUS PARASANGUINIS;

BACTERIA; BACTERIAL ADHESION; BACTERIAL PROTEINS; BIOFILMS; BIOPOLYMERS;

EID: 84874817824     PISSN: 13892037     EISSN: 18755550     Source Type: Journal    
DOI: 10.2174/138920312804871166     Document Type: Article

References (187)

1. Zobell, C.E. The effect of solid surfaces upon bacterial activity. J. Bacteriol., 1943, 46, 39-56.
2. Costerton, J.W.; Geesey, G.G.; Cheng, K.J. How bacteria stick. Sci. Am., 1978, 238, 86.
3. Lawrence, J.R.; Korber, D.R.; Hoyle, B.D.; Costerton, J.W.; Caldwell, D.E. Optical sectioning of microbial biofilms. J. Bacteriol., 1991, 173, 6558-6567.
4. Costerton, J.W.; Stewart, P.S.; Greenberg, E.P. Bacterial biofilms: A common cause of persistent infections. Science, 1999, 284, 1318-1322.
5. Dunne, W.M., Jr. Bacterial adhesion: Seen any good biofilms lately? Clin. Microbiol. Rev., 2002, 15, 155-166.
6. Svensater, G.; Larsson, U.B.; Greif, E.C.; Cvitkovitch, D.G.; Hamilton, I.R. Acid tolerance response and survival by oral bacteria. Oral Microbiol. Immunol., 1997, 12, 266-273.
7. Espeland, E.M.; Wetzel, R.G. Complexation, stabilization, and uv photolysis of extracellular and surface-bound glucosidase and alkaline phosphatase: Implications for biofilm microbiota. Microb. Ecol., 2001, 42, 572-585.
8. Le Magrex-Debar, E.; Lemoine, J.; Gelle, M.P.; Jacquelin, L.F.; Choisy, C. Evaluation of biohazards in dehydrated biofilms on foodstuff packaging. Int. J. Food Microbiol., 2000, 55, 239-243.
9. Stewart, P.S.; Costerton, J.W. Antibiotic resistance of bacteria in biofilms. Lancet, 2001, 358, 135-138.
10. Mah, T.F.; O'Toole, G.A. Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol., 2001, 9, 34-39.
11. Rasmussen, B. Filamentous microfossils in a 3,235-million-yearold volcanogenic massive sulphide deposit. Nature, 2000, 405, 676-679.
12. Stoodley, P.; Sauer, K.; Davies, D.G.; Costerton, J.W. Biofilms as complex differentiated communities. Annu. Rev. Microbiol., 2002, 56, 187-209.
13. An, Y.H., R. B. Dickinson, and R. J. Doyle. Mechanisms of bacterial adhesion and pathogenesis of implant and tissue infections. In Y. H. An and R. J. Friedman (ed.), Handbook of bacterial adhesion: principles, methods, and applications. Humana Press, Totowa, N.J., 2000, 1-27.
14. Flemming, H.C.; Wingender, J. The biofilm matrix. Nat. Rev. Microbiol., 2010, 8, 623-633.
15. Davies, D.G.; Parsek, M.R.; Pearson, J.P.; Iglewski, B.H.; Costerton, J.W.; Greenberg, E.P. The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science, 1998, 280, 295-298.
16. McDougald, D.; Rice, S.A.; Barraud, N.; Steinberg, P.D.; Kjelleberg, S. Should we stay or should we go: Mechanisms and ecological consequences for biofilm dispersal. Nat. Rev. Microbiol., 2012, 10, 39-50.
17. Monds, R.D.; O'Toole, G.A. The developmental model of microbial biofilms: Ten years of a paradigm up for review. Trends Microbiol., 2009, 17, 73-87.
18. Waksman, G.; Hultgren, S.J. Structural biology of the chaperoneusher pathway of pilus biogenesis. Nat. Rev. Microbiol., 2009, 7, 765-774.
19. Geibel, S.; Waksman, G. Crystallography and electron microscopy of chaperone/usher pilus systems. Adv. Exp. Med. Biol., 2011, 715, 159-174.
20. Piatek, R.; Zalewska, B.; Bury, K.; Kur, J. The chaperone-usher pathway of bacterial adhesin biogenesis -- from molecular mechanism to strategies of anti-bacterial prevention and modern vaccine design. Acta. Biochim. Pol., 2005, 52, 639-646.
21. Remaut, H.; Tang, C.; Henderson, N.S.; Pinkner, J.S.; Wang, T.; Hultgren, S.J.; Thanassi, D.G.; Waksman, G.; Li, H. Fiber formation across the bacterial outer membrane by the chaperone/usher pathway. Cell, 2008, 133, 640-652.
22. Phan, G.; Remaut, H.; Wang, T.; Allen, W.J.; Pirker, K.F.; Lebedev, A.; Henderson, N.S.; Geibel, S.; Volkan, E.; Yan, J.; Kunze, M.B.; Pinkner, J.S.; Ford, B.; Kay, C.W.; Li, H.; Hultgren, S.J.; Thanassi, D.G.; Waksman, G. Crystal structure of the fimd usher bound to its cognate fimc-fimh substrate. Nature, 2011, 474, 49-53.
23. Wertheim, H.F.L.; Vos, M.C.; Ott, A.; van Belkum, A.; Voss, A.; Kluytmans, J.A.J.W.; van Keulen, P.H.J.; Vandenbroucke-Grauls, C.M.J.E.; Meester, M.H.M.; Verbrugh, H.A. Risk and outcome of nosocomial staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. Lancet, 2004, 364, 703-705.
24. Lowy, F.D. Medical progress - staphylococcus aureus infections. New Engl. J. Med., 1998, 339, 520-532.
25. Cramton, S.E.; Gerke, C.; Schnell, N.F.; Nichols, W.W.; Gotz, F. The intercellular adhesion (ica) locus is present in staphylococcus aureus and is required for biofilm formation. Infect. Immun., 1999, 67, 5427-5433.
26. Maira-Litran, T.; Kropec, A.; Abeygunawardana, C.; Joyce, J.; Mark, G.; Goldmann, D.A.; Pier, G.B. Immunochemical properties of the staphylococcal poly-n-acetylglucosamine surface polysaccharide. Infect. Immun., 2002, 70, 4433-4440.
27. Corrigan, R.M.; Rigby, D.; Handley, P.; Foster, T.J. The role of staphylococcus aureus surface protein sasg in adherence and biofilm formation. Microbiology-Sgm, 2007, 153, 2435-2446.
28. Merino, N.; Toledo-Arana, A.; Vergara-Irigaray, M.; Valle, J.; Solano, C.; Calvo, E.; Lopez, J.A.; Foster, T.J.; Penades, J.R.; Lasa, I. Protein a-mediated multicellular behavior in staphylococcus aureus. J. Bacteriol., 2009, 191, 832-843.
29. Sjodahl, J. Repetitive sequences in protein-a from staphylococcusaureus - arrangement of 5 regions within protein, 4 being highly homologous and fc-binding. Euro. J. Biochem., 1977, 73, 343-351.
30. O'Neill, E.; Pozzi, C.; Houston, P.; Humphreys, H.; Robinson, D.A.; Loughman, A.; Foster, T.J.; O'Gara, J.P. A novel staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, fnbpa and fnbpb. J. Bacteriol., 2008, 190, 3835-3850.
31. Vergara-Irigaray, M.; Valle, J.; Merino, N.; Latasa, C.; Garcia, B.; de los Mozos, I.R.; Solano, C.; Toledo-Arana, A.; Penades, J.R.; Lasa, I. Relevant role of fibronectin-binding proteins in staphylococcus aureus biofilm-associated foreign-body infections. Infect. Immun., 2009, 77, 3978-3991.
32. Cucarella, C.; Solano, C.; Valle, J.; Amorena, B.; Lasa, I.; Penades, J.R. Bap, a staphylococcus aureus surface protein involved in biofilm formation. J. Bacteriol., 2001, 183, 2888-2896.
33. Geoghegan, J.A.; Corrigan, R.M.; Gruszka, D.T.; Speziale, P.; O'Gara, J.P.; Potts, J.R.; Foster, T.J. Role of surface protein sasg in biofilm formation by staphylococcus aureus. J. Bacteriol., 2010, 192, 5663-5673.
34. Forsgren, A. Significance of protein a production by staphylococci. Infect. Immun., 1970, 2, 672-673.
35. Greene, C.; Mcdevitt, D.; Francois, P.; Vaudaux, P.E.; Lew, D.P.; Foster, T.J. Adhesion properties of mutants of staphylococcusaureus defective in fibronectin-binding proteins and studies on the expression of fnb genes. Mol. Microbiol., 1995, 17, 1143-1152.
36. Jonsson, K.; Signas, C.; Muller, H.P.; Lindberg, M. Two different genes encode fibronectin binding proteins in staphylococcus aureus. The complete nucleotide sequence and characterization of the second gene. Euro. J. Biochem., 1991, 202, 1041-1048.
37. Dziewanowska, K.; Patti, J.M.; Deobald, C.F.; Bayles, K.W.; Trumble, W.R.; Bohach, G.A. Fibronectin binding protein and host cell tyrosine kinase are required for internalization of staphylococcus aureus by epithelial cells. Infect. Immun., 1999, 67, 4673-4678.
38. Valle, J.; Latasa, C.; Gil, C.; Toledo-Arana, A.; Solano, C.; Penadés, J.R.; Lasa, I. Bap, a biofilm matrix protein of staphylococcus aureus prevents cellular internalization through binding to gp96 host receptor. PLoS Pathog., 2012, 8, e1002843.
39. Patti, J.M.; Allen, B.L.; McGavin, M.J.; Hook, M. Mscrammmediated adherence of microorganisms to host tissues. Annu. Rev. Microbiol., 1994, 48, 585-617.
40. Eidhin, D.N.; Perkins, S.; Francois, P.; Vaudaux, P.; Hook, M.; Foster, T.J. Clumping factor b (clfb), a new surface-located fibrinogen-binding adhesin of staphylococcus aureus. Mol. Microbiol., 1998, 30, 245-257.
41. McDevitt, D.; Nanavaty, T.; HousePompeo, K.; Bell, E.; Turner, N.; McIntire, L.; Foster, T.; Hook, M. Characterization of the interaction between the staphylococcus aureus clumping factor (clfa) and fibrinogen. Euro. J. Biochem., 1997, 247, 416-424.
42. Mcdevitt, D.; Francois, P.; Vaudaux, P.; Foster, T.J. Molecular characterization of the clumping factor (fibrinogen receptor) of staphylococcus-aureus. Mol. Microbiol., 1994, 11, 237-248.
43. McDevitt, D.; Francois, P.; Vaudaux, P.; Foster, T.J. Identification of the ligand-binding domain of the surface-located fibrinogen receptor (clumping factor) of staphylococcus aureus. Mol. Microbiol., 1995, 16, 895-907.
44. Signas, C.; Raucci, G.; Jonsson, K.; Lindgren, P.E.; Anantharamaiah, G.M.; Hook, M.; Lindberg, M. Nucleotidesequence of the gene for a fibronectin-binding protein from staphylococcus-aureus - use of this peptide sequence in the synthesis of biologically-active peptides. Proc. Natl. Acad. Sci. USA., 1989, 86, 699-703.
45. Vaudaux, P.E.; Francois, P.; Proctor, R.A.; Mcdevitt, D.; Foster, T.J.; Albrecht, R.M.; Lew, D.P.; Wabers, H.; Cooper, S.L. Use of adhesion-defective mutants of staphylococcus-aureus to define the role of specific plasma-proteins in promoting bacterial adhesion to canine arteriovenous shunts (vol 63, pg 585, 1995). Infect. Immun., 1995, 63, 3239-3239.
46. Vengadesan, K.; Narayana, S.V. Structural biology of grampositive bacterial adhesins. Protein Sci, 2011, 20, 759-772.
47. Ganesh, V.K.; Rivera, J.J.; Smeds, E.; Ko, Y.P.; Bowden, M.G.; Wann, E.R.; Gurusiddappa, S.; Fitzgerald, J.R.; Hook, M. A structural model of the staphylococcus aureus clfa-fibrinogen interaction opens new avenues for the design of anti-staphylococcal therapeutics. PLoS Pathog., 2008, 4, e1000226.
48. McAleese, F.M.; Walsh, E.J.; Sieprawska, M.; Potempa, J.; Foster, T.J. Loss of clumping factor b fibrinogen binding activity by staphylococcus aureus involves cessation of transcription, shedding and cleavage by metalloprotease. J. Biologica. Chem., 2001, 276, 29969-29978.
49. Deivanayagam, C.C.S.; Perkins, S.; Danthuluri, S.; Owens, R.T.; Bice, T.; Nanavathy, T.; Foster, T.J.; Hook, M.; Narayana, S.V.L. Crystallization of clfa and clfb fragments: The fibrinogen-binding surface proteins of staphylococcus aureus. Acta. Crystallographica. Sec. D-Biologica. Crystallograph., 1999, 55, 554-556.
50. Deivanayagam, C.C.S.; Wann, E.R.; Chen, W.; Carson, M.; Rajashankar, K.R.; Hook, M.; Narayana, S.V.L. A novel variant of the immunoglobulin fold in surface adhesins of staphylococcus aureus: Crystal structure of the fibrinogen-binding mscramm, clumping factor a. Embo. J., 2002, 21, 6660-6672.
51. Symersky, J.; Patti, J.M.; Carson, M.; House-Pompeo, K.; Teale, M.; Moore, D.; Jin, L.; Schneider, A.; DeLucas, L.J.; Hook, M.; Narayana, S.V. Structure of the collagen-binding domain from a staphylococcus aureus adhesin. Nat. Struct. Biol., 1997, 4, 833-838.
52. Pyburn, T.M.; Bensing, B.A.; Xiong, Y.Q.; Melancon, B.J.; Tomasiak, T.M.; Ward, N.J.; Yankovskaya, V.; Oliver, K.M.; Cecchini, G.; Sulikowski, G.A.; Tyska, M.J.; Sullam, P.M.; Iverson, T.M. A structural model for binding of the serine-rich repeat adhesin gspb to host carbohydrate receptors. PLoS Pathog., 2011, 7, e1002112.
53. Ramboarina, S.; Garnett, J.A.; Zhou, M.; Li, Y.; Peng, Z.; Taylor, J.D.; Lee, W.C.; Bodey, A.; Murray, J.W.; Alguel, Y.; Bergeron, J.; Bardiaux, B.; Sawyer, E.; Isaacson, R.; Tagliaferri, C.; Cota, E.; Nilges, M.; Simpson, P.; Ruiz, T.; Wu, H.; Matthews, S. Structural insights into serine-rich fimbriae from gram-positive bacteria. J. Biol. Chem., 2010, 285, 32446-32457.
54. Kang, H.J.; Coulibaly, F.; Clow, F.; Proft, T.; Baker, E.N. Stabilizing isopeptide bonds revealed in gram-positive bacterial pilus structure. Science, 2007, 318, 1625-1628.
55. Forsgren, N.; Lamont, R.J.; Persson, K. Two intramolecular isopeptide bonds are identified in the crystal structure of the streptococcus gordonii sspb c-terminal domain. J. Mol. Biol., 2010, 397, 740-751.
56. Wann, E.R.; Gurusiddappa, S.; Hook, M. The fibronectin-binding mscramm fnbpa of staphylococcus aureus is a bifunctional protein that also binds to fibrinogen. J. Biol. Chem., 2000, 275, 13863-13871.
57. Meenan, N.A.; Visai, L.; Valtulina, V.; Schwarz-Linek, U.; Norris, N.C.; Gurusiddappa, S.; Hook, M.; Speziale, P.; Potts, J.R. The tandem beta-zipper model defines high affinity fibronectin-binding repeats within staphylococcus aureus fnbpa. J. Biol. Chem., 2007, 282, 25893-25902.
58. Bingham, R.J.; Rudino-Pinera, E.; Meenan, N.A.G.; Schwarz- Linek, U.; Turkenburg, J.P.; Hook, M.; Garman, E.F.; Potts, J.R. Crystal structures of fibronectin-binding sites from staphylococcus aureus fnbpa in complex with fibronectin domains. Proc. Natl. Acad. Sci. USA., 2008, 105, 12254-12258.
59. Schwarz-Linek, U.; Werner, J.M.; Pickford, A.R.; Gurusiddappa, S.; Kim, J.H.; Pilka, E.S.; Briggs, J.A.G.; Gough, T.S.; Hook, M.; Campbell, I.D.; Potts, J.R. Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper. Nature, 2003, 423, 177-181.
60. Froman, G.; Switalski, L.M.; Speziale, P.; Hook, M. Isolation and characterization of a fibronectin receptor from staphylococcusaureus. J. Biologica. Chem., 1987, 262, 6564-6571.
61. Ingham, K.C.; Brew, S.; Vaz, D.; Sauder, D.N.; McGavin, M.J. Interaction of staphylococcus aureus fibronectin-binding protein with fibronectin - affinity, stoichiometry, and modular requirements. J. Biologica. Chem., 2004, 279, 42945-42953.
62. Wu, H.; Mintz, K.P.; Ladha, M.; Fives-Taylor, P.M. Isolation and characterization of fap1, a fimbriae-associated adhesin of streptococcus parasanguis fw213. Mol. Microbiol., 1998, 28, 487-500.
63. Gibbons, R.J. Adherent interactions which may affect microbial ecology in the mouth. J. Dent. Res., 1984, 63, 378-385.
64. Kolenbrander, P.E. Oral microbial communities: Biofilms, interactions, and genetic systems. Annu. Rev. Microbiol., 2000, 54, 413-437.
65. Cates, J.E.C. R. V. Subacute bacterial endocarditis. Quarter. J. Med., 1951, 20, 93-130.
66. Lutwick, L.I.; Vaghjimal, A.; Connolly, M.W. Postcardiac surgery infections. Crit. Care Clin., 1998, 14, 221-250.
67. Froeliger, E.H.; Fives-Taylor, P. Streptococcus parasanguis fimbria-associated adhesin fap1 is required for biofilm formation. Infect. Immun., 2001, 69, 2512-2519.
68. Wu, H.; Fives-Taylor, P.M. Identification of dipeptide repeats and a cell wall sorting signal in the fimbriae-associated adhesin, fap1, of streptococcus parasanguis. Mol. Microbiol., 1999, 34, 1070-1081.
69. Stephenson, A.E.; Wu, H.; Novak, J.; Tomana, M.; Mintz, K.; Fives-Taylor, P. The fap1 fimbrial adhesin is a glycoprotein: Antibodies specific for the glycan moiety block the adhesion of streptococcus parasanguis in an in vitro tooth model. Mol. Microbiol., 2002, 43, 147-157.
70. Zhou, M.; Peng, Z.; Fives-Taylor, P.; Wu, H. A conserved cterminal 13-amino-acid motif of gap1 is required for gap1 function and necessary for the biogenesis of a serine-rich glycoprotein of streptococcus parasanguinis. Infect. Immun., 2008, 76, 5624-5631.
71. Wu, R.; Wu, H. A molecular chaperone mediates a two-protein enzyme complex and glycosylation of serine-rich streptococcal adhesins. J. Biol. Chem., 2011, 286, 34923-34931.
72. Zhou, M.; Wu, H. Glycosylation and biogenesis of a family of serine-rich bacterial adhesins. Microbiology, 2009, 155, 317-327.
73. Zhou, M.; Zhu, F.; Li, Y.; Zhang, H.; Wu, H. Gap1 functions as a molecular chaperone to stabilize its interactive partner gap3 during biogenesis of serine-rich repeat bacterial adhesin. Mol. Microbiol., 2012, 83, 866-878.
74. Li, Y.; Chen, Y.; Huang, X.; Zhou, M.; Wu, R.; Dong, S.; Pritchard, D.G.; Fives-Taylor, P.; Wu, H. A conserved domain of previously unknown function in gap1 mediates protein-protein interaction and is required for biogenesis of a serine-rich streptococcal adhesin. Mol. Microbiol., 2008, 70, 1094-1104.
75. Peng, Z.; Fives-Taylor, P.; Ruiz, T.; Zhou, M.; Sun, B.; Chen, Q.; Wu, H. Identification of critical residues in gap3 of streptococcus parasanguinis involved in fap1 glycosylation, fimbrial formation and in vitro adhesion. BMC Microbiol., 2008, 8, 52.
76. Peng, Z.; Wu, H.; Ruiz, T.; Chen, Q.; Zhou, M.; Sun, B.; Fives- Taylor, P. Role of gap3 in fap1 glycosylation, stability, in vitro adhesion, and fimbrial and biofilm formation of streptococcus parasanguinis. Oral Microbiol. Immunol., 2008, 23, 70-78.
77. Siboo, I.R.; Chambers, H.F.; Sullam, P.M. Role of srap, a serinerich surface protein of staphylococcus aureus, in binding to human platelets. Infect. Immun., 2005, 73, 2273-2280.
78. Sundaresan, R.; Samen, U.; Ponnuraj, K. Expression, purification, crystallization and preliminary x-ray diffraction studies of the human keratin 4-binding domain of serine-rich repeat protein 1 from streptococcus agalactiae. Acta Crystallogr. Sect. F. Struct. Biol. Cryst. Commun., 2011, 67, 1582-1585.
79. Samen, U.; Eikmanns, B.J.; Reinscheid, D.J.; Borges, F. The surface protein srr-1 of streptococcus agalactiae binds human keratin 4 and promotes adherence to epithelial hep-2 cells. Infect. Immun., 2007, 75, 5405-5414.
80. Seifert, K.N.; Adderson, E.E.; Whiting, A.A.; Bohnsack, J.F.; Crowley, P.J.; Brady, L.J. A unique serine-rich repeat protein (srr- 2) and novel surface antigen (epsilon) associated with a virulent lineage of serotype iii streptococcus agalactiae. Microbiology, 2006, 152, 1029-1040.
81. Bensing, B.A.; Sullam, P.M. An accessory sec locus of streptococcus gordonii is required for export of the surface protein gspb and for normal levels of binding to human platelets. Mol. Microbiol., 2002, 44, 1081-1094.
82. Takahashi, Y.; Konishi, K.; Cisar, J.O.; Yoshikawa, M. Identification and characterization of hsa, the gene encoding the sialic acid-binding adhesin of streptococcus gordonii dl1. Infect. Immun., 2002, 70, 1209-1218.
83. King, N.P.; Beatson, S.A.; Totsika, M.; Ulett, G.C.; Alm, R.A.; Manning, P.A.; Schembri, M.A. Uafb is a serine-rich repeat adhesin of staphylococcus saprophyticus that mediates binding to fibronectin, fibrinogen and human uroepithelial cells. Microbiology, 2011, 157, 1161-1175.
84. Munoz-Almagro, C.; Selva, L.; Sanchez, C.J.; Esteva, C.; de Sevilla, M.F.; Pallares, R.; Orihuela, C.J. Psrp, a protective pneumococcal antigen, is highly prevalent in children with pneumonia and is strongly associated with clonal type. Clin. Vaccine Immunol., 2010, 17, 1672-1678.
85. Shivshankar, P.; Sanchez, C.; Rose, L.F.; Orihuela, C.J. The streptococcus pneumoniae adhesin psrp binds to keratin 10 on lung cells. Mol. Microbiol., 2009, 73, 663-679.
86. Rose, L.; Shivshankar, P.; Hinojosa, E.; Rodriguez, A.; Sanchez, C.J.; Orihuela, C.J. Antibodies against psrp, a novel streptococcus pneumoniae adhesin, block adhesion and protect mice against pneumococcal challenge. J. Infect. Dis., 2008, 198, 375-383.
87. Sanchez, C.J.; Kumar, N.; Lizcano, A.; Shivshankar, P.; Dunning Hotopp, J.C.; Jorgensen, J.H.; Tettelin, H.; Orihuela, C.J. Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production. PLoS One, 2011, 6, e28738.
88. Handley, P.S.; Correia, F.F.; Russell, K.; Rosan, B.; DiRienzo, J.M. Association of a novel high molecular weight, serine-rich protein (srpa) with fibril-mediated adhesion of the oral biofilm bacterium streptococcus cristatus. Oral Microbiol. Immunol., 2005, 20, 131-140.
89. Chen, Q.; Wu, H.; Fives-Taylor, P.M. Investigating the role of seca2 in secretion and glycosylation of a fimbrial adhesin in streptococcus parasanguis fw213. Mol. Microbiol., 2004, 53, 843-856.
90. Bu, S.; Li, Y.; Zhou, M.; Azadin, P.; Zeng, M.; Fives-Taylor, P.; Wu, H. Interaction between two putative glycosyltransferases is required for glycosylation of a serine-rich streptococcal adhesin. J. Bacteriol., 2008, 190, 1256-1266.
91. Takamatsu, D.; Bensing, B.A.; Sullam, P.M. Four proteins encoded in the gspb-secy2a2 operon of streptococcus gordonii mediate the intracellular glycosylation of the platelet-binding protein gspb. J. Bacteriol., 2004, 186, 7100-7111.
92. Rigel, N.W.; Braunstein, M. A new twist on an old pathway--accessory sec [corrected] systems. Mol. Microbiol., 2008, 69, 291-302.
93. Garnett, J.A.; Simpson, P.J.; Taylor, J.; Benjamin, S.V.; Tagliaferri, C.; Cota, E.; Chen, Y.Y.; Wu, H.; Matthews, S. Structural insight into the role of streptococcus parasanguinis fap1 within oral biofilm formation. Biochem. Biophys. Res. Commun., 2012, 417, 421-426.
94. Garnett, J.A.; Ramboarina, S.; Lee, W.C.; Tagliaferri, C.; Wu, W.; Matthews, S. Crystallization and initial crystallographic analysis of the streptococcus parasanguinis fw213 fap1-nralpha adhesive domain at ph 5.0. Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun., 2011, 67, 274-276.
95. Wu, H.; Zeng, M.; Fives-Taylor, P. The glycan moieties and the nterminal polypeptide backbone of a fimbria-associated adhesin, fap1, play distinct roles in the biofilm development of streptococcus parasanguinis. Infect. Immun., 2007, 75, 2181-2188.
96. Takahashi, N.; Yamada, T. Acid-induced acid tolerance and acidogenicity of non-mutans streptococci. Oral Microbiol. Immunol., 1999, 14, 43-48.
97. Welin-Neilands, J.; Svensater, G. Acid tolerance of biofilm cells of streptococcus mutans. Appl. Environ. Microbiol., 2007, 73, 5633-5638.
98. Sanchez, C.J.; Shivshankar, P.; Stol, K.; Trakhtenbroit, S.; Sullam, P.M.; Sauer, K.; Hermans, P.W.; Orihuela, C.J. The pneumococcal serine-rich repeat protein is an intra-species bacterial adhesin that promotes bacterial aggregation in vivo and in biofilms. PLoS Pathog., 2010, 6, e1001044.
99. Takahashi, Y.; Takashima, E.; Shimazu, K.; Yagishita, H.; Aoba, T.; Konishi, K. Contribution of sialic acid-binding adhesin to pathogenesis of experimental endocarditis caused by streptococcus gordonii dl1. Infect. Immun., 2006, 74, 740-743.
100. Takamatsu, D.; Bensing, B.A.; Cheng, H.; Jarvis, G.A.; Siboo, I.R.; Lopez, J.A.; Griffiss, J.M.; Sullam, P.M. Binding of the streptococcus gordonii surface glycoproteins gspb and hsa to specific carbohydrate structures on platelet membrane glycoprotein ibalpha. Mol. Microbiol., 2005, 58, 380-392.
101. Bensing, B.A.; Lopez, J.A.; Sullam, P.M. The streptococcus gordonii surface proteins gspb and hsa mediate binding to sialylated carbohydrate epitopes on the platelet membrane glycoprotein ibalpha. Infect. Immun., 2004, 72, 6528-6537.
102. Gruszka, D.T.; Wojdyla, J.A.; Bingham, R.J.; Turkenburg, J.P.; Manfield, I.W.; Steward, A.; Leech, A.P.; Geoghegan, J.A.; Foster, T.J.; Clarke, J.; Potts, J.R. Staphylococcal biofilm-forming protein has a contiguous rod-like structure. Proc. Natl. Acad. Sci. USA., 2012, 109, E1011-1018.
103. Leyton, D.L.; Rossiter, A.E.; Henderson, I.R. From self sufficiency to dependence: Mechanisms and factors important for autotransporter biogenesis. Nat. Rev. Microbiol., 2012, 10, 213-225.
104. Gentle, I.E.; Burri, L.; Lithgow, T. Molecular architecture and function of the omp85 family of proteins. Mol. Microbiol., 2005, 58, 1216-1225.
105. Selkrig, J.; Mosbahi, K.; Webb, C.T.; Belousoff, M.J.; Perry, A.J.; Wells, T.J.; Morris, F.; Leyton, D.L.; Totsika, M.; Phan, M.D.; Celik, N.; Kelly, M.; Oates, C.; Hartland, E.L.; Robins-Browne, R.M.; Ramarathinam, S.H.; Purcell, A.W.; Schembri, M.A.; Strugnell, R.A.; Henderson, I.R.; Walker, D.; Lithgow, T. Discovery of an archetypal protein transport system in bacterial outer membranes. Nat. Struct. Mol. Biol., 2012, 19, 506-510.
106. Henderson, I.R.; Nataro, J.P. Virulence functions of autotransporter proteins. Infect. Immun., 2001, 69, 1231-1243.
107. Klemm, P.; Vejborg, R.M.; Sherlock, O. Self-associating autotransporters, saats: Functional and structural similarities. Int. J. Med. Microbiol., 2006, 296, 187-195.
108. Kenjale, R.; Meng, G.; Fink, D.L.; Juehne, T.; Ohashi, T.; Erickson, H.P.; Waksman, G.; St Geme, J.W., 3rd. Structural determinants of autoproteolysis of the haemophilus influenzae hap autotransporter. Infect. Immun., 2009, 77, 4704-4713.
109. Meng, G.; Spahich, N.; Kenjale, R.; Waksman, G.; St Geme, J.W., 3rd. Crystal structure of the haemophilus influenzae hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation. EMBO J., 2011, 30, 3864-3874.
110. Rao, V.K.; Krasan, G.P.; Hendrixson, D.R.; Dawid, S.; St Geme, J.W., 3rd. Molecular determinants of the pathogenesis of disease due to non-typable haemophilus influenzae. FEMS Microbiol. Rev., 1999, 23, 99-129.
111. Fink, D.L.; Green, B.A.; St Geme, J.W., 3rd. The haemophilus influenzae hap autotransporter binds to fibronectin, laminin, and collagen iv. Infect. Immun., 2002, 70, 4902-4907.
112. Fink, D.L.; Buscher, A.Z.; Green, B.; Fernsten, P.; St Geme, J.W., 3rd. The haemophilus influenzae hap autotransporter mediates microcolony formation and adherence to epithelial cells and extracellular matrix via binding regions in the c-terminal end of the passenger domain. Cell Microbiol., 2003, 5, 175-186.
113. Hendrixson, D.R.; St Geme, J.W., 3rd. The haemophilus influenzae hap serine protease promotes adherence and microcolony formation, potentiated by a soluble host protein. Mol. Cell, 1998, 2, 841-850.
114. Koizumi, M.; Fujino, A.; Fukushima, K.; Kamimura, T.; Takimoto- Kamimura, M. Complex of human neutrophil elastase with 1/2slpi. J. Synchrotron Radiat., 2008, 15, 308-311.
115. Pouttu, R.; Westerlund-Wikstrom, B.; Lang, H.; Alsti, K.; Virkola, R.; Saarela, U.; Siitonen, A.; Kalkkinen, N.; Korhonen, T.K. Matb, a common fimbrillin gene of escherichia coli, expressed in a genetically conserved, virulent clonal group. J. Bacteriol., 2001, 183, 4727-4736.
116. Rendon, M.A.; Saldana, Z.; Erdem, A.L.; Monteiro-Neto, V.; Vazquez, A.; Kaper, J.B.; Puente, J.L.; Giron, J.A. Commensal and pathogenic escherichia coli use a common pilus adherence factor for epithelial cell colonization. Proc. Natl. Acad. Sci. USA., 2007, 104, 10637-10642.
117. Saldana, Z.; Erdem, A.L.; Schuller, S.; Okeke, I.N.; Lucas, M.; Sivananthan, A.; Phillips, A.D.; Kaper, J.B.; Puente, J.L.; Giron, J.A. The escherichia coli common pilus and the bundle-forming pilus act in concert during the formation of localized adherence by enteropathogenic e. Coli. J. Bacteriol., 2009, 191, 3451-3461.
118. Blackburn, D.; Husband, A.; Saldana, Z.; Nada, R.A.; Klena, J.; Qadri, F.; Giron, J.A. Distribution of the escherichia coli common pilus among diverse strains of human enterotoxigenic e. Coli. J. Clin. Microbiol., 2009, 47, 1781-1784.
119. Avelino, F.; Saldana, Z.; Islam, S.; Monteiro-Neto, V.; Dall'Agnol, M.; Eslava, C.A.; Giron, J.A. The majority of enteroaggregative escherichia coli strains produce the e. Coli common pilus when adhering to cultured epithelial cells. Int. J. Med. Microbiol., 2010, 300, 440-448.
120. Croxen, M.A.; Finlay, B.B. Molecular mechanisms of escherichia coli pathogenicity. Nat. Rev. Microbiol., 2010, 8, 26-38.
121. Picard, B.; Garcia, J.S.; Gouriou, S.; Duriez, P.; Brahimi, N.; Bingen, E.; Elion, J.; Denamur, E. The link between phylogeny and virulence in escherichia coli extraintestinal infection. Infect. Immun., 1999, 67, 546-553.
122. Garnett, J.A.; Martinez-Santos, V.I.; Saldana, Z.; Pape, T.; Hawthorne, W.; Chan, J.; Simpson, P.J.; Cota, E.; Puente, J.L.; Giron, J.A.; Matthews, S. Structural insights into the biogenesis and biofilm formation by the escherichia coli common pilus. Proc. Natl. Acad. Sci. USA., 2012, 109, 3950-3955.
123. Lehti, T.A.; Bauchart, P.; Heikkinen, J.; Hacker, J.; Korhonen, T.K.; Dobrindt, U.; Westerlund-Wikstrom, B. Mat fimbriae promote biofilm formation by meningitis-associated escherichia coli. Microbiology, 2010, 156, 2408-2417.
124. Anderson, K.L.; Billington, J.; Pettigrew, D.; Cota, E.; Simpson, P.; Roversi, P.; Chen, H.A.; Urvil, P.; du Merle, L.; Barlow, P.N.; Medof, M.E.; Smith, R.A.; Nowicki, B.; Le Bouguenec, C.; Lea, S.M.; Matthews, S. An atomic resolution model for assembly, architecture, and function of the dr adhesins. Mol. Cell, 2004, 15, 647-657.
125. Hahn, E.; Wild, P.; Hermanns, U.; Sebbel, P.; Glockshuber, R.; Haner, M.; Taschner, N.; Burkhard, P.; Aebi, U.; Muller, S.A. Exploring the 3d molecular architecture of escherichia coli type 1 pili. J. Mol. Biol., 2002, 323, 845-857.
126. Atkins, E.D.T.; Attwool, P.T.; Miles, M.J.; Morris, V.J.; Oneill, M.A.; Sutherland, I.W. Effect of acetylation on the molecularinteractions and gelling properties of a bacterial polysaccharide. Intern. J. Biologica. Macromol., 1987, 9, 115-117.
127. Morris, K.L.; Serpell, L.C. X-ray fibre diffraction studies of amyloid fibrils. Amyloid Proteins: Meth. Protocol., Sec. Ed., 2012, 849, 121-135.
128. Lakdawala, A.S.; Morgan, D.M.; Liotta, D.C.; Lynn, D.G.; Snyder, J.P. Dynamics and fluidity of amyloid fibrils: A model of fibrous protein aggregates. J. Am. Chem. Soc., 2002, 124, 15150-15151.
129. Wasmer, C.; Lange, A.; Van Melckebeke, H.; Siemer, A.B.; Riek, R.; Meier, B.H. Amyloid fibrils of the het-s(218-289) prion form a beta solenoid with a triangular hydrophobic core. Science, 2008, 319, 1523-1526.
130. Wingender, J.; Strathmann, M.; Rode, A.; Leis, A.; Flemming, H.C. Isolation and biochemical characterization of extracellular polymeric substances from pseudomonas aeruginosa. Methods Enzymol., 2001, 336, 302-314.
131. Danese, P.N.; Pratt, L.A.; Kolter, R. Exopolysaccharide production is required for development of escherichia coli k-12 biofilm architecture. J. Bacteriol., 2000, 182, 3593-3596.
132. Thomas, V.C.; Hiromasa, Y.; Harms, N.; Thurlow, L.; Tomich, J.; Hancock, L.E. A fratricidal mechanism is responsible for edna release and contributes to biofilm development of enterococcus faecalis. Mol. Microbiol., 2009, 72, 1022-1036.
133. Ryder, C.; Byrd, M.; Wozniak, D.J. Role of polysaccharides in pseudomonas aeruginosa biofilm development. Curr. Opin. Microbiol., 2007, 10, 644-648.
134. Hu, W.; Yang, Z.; Lux, R.; Zhao, M.; Wang, J.; He, X.; Shi, W. Direct visualization of the interaction between pilin and exopolysaccharides of myxococcus xanthus with egfp-fused pila protein. FEMS Microbiol. Lett., 2012, 326, 23-30.
135. Sand, W.; Gehrke, T. Extracellular polymeric substances mediate bioleaching/biocorrosion via interfacial processes involving iron(iii) ions and acidophilic bacteria. Res. Microbiol., 2006, 157, 49-56.
136. Izano, E.A.; Amarante, M.A.; Kher, W.B.; Kaplan, J.B. Differential roles of poly-n-acetylglucosamine surface polysaccharide and extracellular DNA in staphylococcus aureus and staphylococcus epidermidis biofilms. Appl. Environ. Microbiol., 2008, 74, 470-476.
137. Yang, L.; Barken, K.B.; Skindersoe, M.E.; Christensen, A.B.; Givskov, M.; Tolker-Nielsen, T. Effects of iron on DNA release and biofilm development by pseudomonas aeruginosa. Microbiology, 2007, 153, 1318-1328.
138. Whitchurch, C.B.; Tolker-Nielsen, T.; Ragas, P.C.; Mattick, J.S. Extracellular DNA required for bacterial biofilm formation. Science, 2002, 295, 1487.
139. Vilain, S.; Pretorius, J.M.; Theron, J.; Brozel, V.S. DNA as an adhesin: Bacillus cereus requires extracellular DNA to form biofilms. Appl. Environ. Microbiol., 2009, 75, 2861-2868.
140. van Schaik, E.J.; Giltner, C.L.; Audette, G.F.; Keizer, D.W.; Bautista, D.L.; Slupsky, C.M.; Sykes, B.D.; Irvin, R.T. DNA binding: A novel function of pseudomonas aeruginosa type iv pili. J. Bacteriol., 2005, 187, 1455-1464.
141. Blanco, L.P.; Evans, M.L.; Smith, D.R.; Badtke, M.P.; Chapman, M.R. Diversity, biogenesis and function of microbial amyloids. Trends Microbiol., 2012, 20, 66-73.
142. Dobson, C.M. Structural biology: Prying into prions. Nature, 2005, 435, 747-749.
143. Collinson, S.K.; Parker, J.M.; Hodges, R.S.; Kay, W.W. Structural predictions of agfa, the insoluble fimbrial subunit of salmonella thin aggregative fimbriae. J. Mol. Biol., 1999, 290, 741-756.
144. Barnhart, M.M.; Chapman, M.R. Curli biogenesis and function. Annu. Rev. Microbiol., 2006, 60, 131-147.
145. Taylor, J.D.; Zhou, Y.; Salgado, P.S.; Patwardhan, A.; McGuffie, M.; Pape, T.; Grabe, G.; Ashman, E.; Constable, S.C.; Simpson, P.J.; Lee, W.C.; Cota, E.; Chapman, M.R.; Matthews, S.J. Atomic resolution insights into curli fiber biogenesis. Structure, 2011, 19, 1307-1316.
146. Castonguay, M.H.; van der Schaaf, S.; Koester, W.; Krooneman, J.; van der Meer, W.; Harmsen, H.; Landini, P. Biofilm formation by escherichia coli is stimulated by synergistic interactions and coadhesion mechanisms with adherence-proficient bacteria. Res. Microbiol., 2006, 157, 471-478.
147. Prigent-Combaret, C.; Brombacher, E.; Vidal, O.; Ambert, A.; Lejeune, P.; Landini, P.; Dorel, C. Complex regulatory network controls initial adhesion and biofilm formation in escherichia coli via regulation of the csgd gene. J. Bacteriol., 2001, 183, 7213-7223.
148. Karatan, E.; Watnick, P. Signals, regulatory networks, and materials that build and break bacterial biofilms. Microbiol. Mol. Biol. Rev., 2009, 73, 310-347.
149. Allison, D.G.; Ruiz, B.; SanJose, C.; Jaspe, A.; Gilbert, P. Extracellular products as mediators of the formation and detachment of pseudomonas fluorescens biofilms. FEMS Microbiol. Lett., 1998, 167, 179-184.
150. Boles, B.R.; Horswill, A.R. Agr-mediated dispersal of staphylococcus aureus biofilms. PLoS Pathog., 2008, 4, e1000052.
151. Mann, E.E.; Rice, K.C.; Boles, B.R.; Endres, J.L.; Ranjit, D.; Chandramohan, L.; Tsang, L.H.; Smeltzer, M.S.; Horswill, A.R.; Bayles, K.W. Modulation of edna release and degradation affects staphylococcus aureus biofilm maturation. PLoS One, 2009, 4, e5822.
152. Periasamy, S.; Joo, H.S.; Duong, A.C.; Bach, T.H.; Tan, V.Y.; Chatterjee, S.S.; Cheung, G.Y.; Otto, M. How staphylococcus aureus biofilms develop their characteristic structure. Proc. Natl. Acad. Sci. USA., 2012, 109, 1281-1286.
153. Boles, B.R.; Thoendel, M.; Singh, P.K. Rhamnolipids mediate detachment of pseudomonas aeruginosa from biofilms. Mol. Microbiol., 2005, 57, 1210-1223.
154. Sillankorva, S.; Neubauer, P.; Azeredo, J. Phage control of dual species biofilms of pseudomonas fluorescens and staphylococcus lentus. Biofouling, 2010, 26, 567-575.
155. Ramasubbu, N.; Thomas, L.M.; Ragunath, C.; Kaplan, J.B. Structural analysis of dispersin b, a biofilm-releasing glycoside hydrolase from the periodontopathogen actinobacillus actinomycetemcomitans. J. Mol. Biol., 2005, 349, 475-486.
156. Manuel, S.G.; Ragunath, C.; Sait, H.B.; Izano, E.A.; Kaplan, J.B.; Ramasubbu, N. Role of active-site residues of dispersin b, a biofilm-releasing beta-hexosaminidase from a periodontal pathogen, in substrate hydrolysis. FEBS J., 2007, 274, 5987-5999.
157. Kaplan, J.B.; Meyenhofer, M.F.; Fine, D.H. Biofilm growth and detachment of actinobacillus actinomycetemcomitans. J. Bacteriol., 2003, 185, 1399-1404.
158. Kaplan, J.B.; Ragunath, C.; Velliyagounder, K.; Fine, D.H.; Ramasubbu, N. Enzymatic detachment of staphylococcus epidermidis biofilms. Antimicrob. Agents Chemother., 2004, 48, 2633-2636.
159. Chaignon, P.; Sadovskaya, I.; Ragunah, C.; Ramasubbu, N.; Kaplan, J.B.; Jabbouri, S. Susceptibility of staphylococcal biofilms to enzymatic treatments depends on their chemical composition. Appl. Microbiol. Biotechnol., 2007, 75, 125-132.
160. Davey, M.E.; Caiazza, N.C.; O'Toole, G.A. Rhamnolipid surfactant production affects biofilm architecture in pseudomonas aeruginosa pao1. J. Bacteriol., 2003, 185, 1027-1036.
161. Wang, R.; Khan, B.A.; Cheung, G.Y.; Bach, T.H.; Jameson-Lee, M.; Kong, K.F.; Queck, S.Y.; Otto, M. Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice. J. Clin. Invest., 2011, 121, 238-248.
162. Mehlin, C.; Headley, C.M.; Klebanoff, S.J. An inflammatory polypeptide complex from staphylococcus epidermidis: Isolation and characterization. J. Exp. Med., 1999, 189, 907-918.
163. Wang, R.; Braughton, K.R.; Kretschmer, D.; Bach, T.H.; Queck, S.Y.; Li, M.; Kennedy, A.D.; Dorward, D.W.; Klebanoff, S.J.; Peschel, A.; DeLeo, F.R.; Otto, M. Identification of novel cytolytic peptides as key virulence determinants for community-associated mrsa. Nat. Med., 2007, 13, 1510-1514.
164. Cheung, G.Y.; Rigby, K.; Wang, R.; Queck, S.Y.; Braughton, K.R.; Whitney, A.R.; Teintze, M.; DeLeo, F.R.; Otto, M. Staphylococcus epidermidis strategies to avoid killing by human neutrophils. PLoS Pathog., 2010, 6, e1001133.
165. Gerbersdorf, S.; Hollert, H.; Brinkmann, M.; Wieprecht, S.; Schüttrumpf, H.; Manz, W. Anthropogenic pollutants affect ecosystem services of freshwater sediments: The need for a "triad plus x" approach. J. Soils Sediments, 2011, 11, 1099-1114.
166. Lubarsky, H.V.; Gerbersdorf, S.U.; Hubas, C.; Behrens, S.; Ricciardi, F.; Paterson, D.M. Impairment of the bacterial biofilm stability by triclosan. PLoS One, 2012, 7, e31183.
167. Hedenstrom, M.; Emtenas, H.; Pemberton, N.; Aberg, V.; Hultgren, S.J.; Pinkner, J.S.; Tegman, V.; Almqvist, F.; Sethson, I.; Kihlberg, J. Nmr studies of interactions between periplasmic chaperones from uropathogenic e. Coli and pilicides that interfere with chaperone function and pilus assembly. Org. Biomol. Chem., 2005, 3, 4193-4200.
168. Pinkner, J.S.; Remaut, H.; Buelens, F.; Miller, E.; Aberg, V.; Pemberton, N.; Hedenstrom, M.; Larsson, A.; Seed, P.; Waksman, G.; Hultgren, S.J.; Almqvist, F. Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria. Proc. Natl. Acad. Sci. USA., 2006, 103, 17897-17902.
169. Kazemzadeh-Narbat, M.; Kindrachuk, J.; Duan, K.; Jenssen, H.; Hancock, R.E.; Wang, R. Antimicrobial peptides on calcium phosphate-coated titanium for the prevention of implant-associated infections. Biomaterials, 2010, 31, 9519-9526.
170. Vecitis, C.D.; Zodrow, K.R.; Kang, S.; Elimelech, M. Electronicstructure- dependent bacterial cytotoxicity of single-walled carbon nanotubes. ACS Nano, 2010, 4, 5471-5479.
171. Sheng, J.; Nguyen, P.T.; Marquis, R.E. Multi-target antimicrobial actions of zinc against oral anaerobes. Arch. Oral Biol., 2005, 50, 747-757.
172. Diaz, C.; Schilardi, P.; de Mele, M.F. Influence of surface submicropattern on the adhesion of pioneer bacteria on metals. Artif Organs, 2008, 32, 292-298.
173. Drenkard, E.; Ausubel, F.M. Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation. Nature, 2002, 416, 740-743.
174. Ito, A.; Taniuchi, A.; May, T.; Kawata, K.; Okabe, S. Increased antibiotic resistance of escherichia coli in mature biofilms. Appl. Environ. Microbiol., 2009, 75, 4093-4100.
175. Anderl, J.N.; Franklin, M.J.; Stewart, P.S. Role of antibiotic penetration limitation in klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin. Antimicrob. Agents Chemother., 2000, 44, 1818-1824.
176. Bjarnsholt, T.; Jensen, P.O.; Burmolle, M.; Hentzer, M.; Haagensen, J.A.; Hougen, H.P.; Calum, H.; Madsen, K.G.; Moser, C.; Molin, S.; Hoiby, N.; Givskov, M. Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent. Microbiology, 2005, 151, 373-383.
177. Verma, V.; Harjai, K.; Chhibber, S. Structural changes induced by a lytic bacteriophage make ciprofloxacin effective against older biofilm of klebsiella pneumoniae. Biofouling, 2010, 26, 729-737.
178. Rivardo, F.; Martinotti, M.G.; Turner, R.J.; Ceri, H. Synergistic effect of lipopeptide biosurfactant with antibiotics against escherichia coli cft073 biofilm. Int. J. Antimicrob. Agents, 2011, 37, 324-331.
179. Kolodkin-Gal, I.; Romero, D.; Cao, S.; Clardy, J.; Kolter, R.; Losick, R. D-amino acids trigger biofilm disassembly. Science, 2010, 328, 627-629.
180. Romero, D.; Vlamakis, H.; Losick, R.; Kolter, R. An accessory protein required for anchoring and assembly of amyloid fibres in b. Subtilis biofilms. Mol. Microbiol., 2011, 80, 1155-1168.
181. Cava, F.; de Pedro, M.A.; Lam, H.; Davis, B.M.; Waldor, M.K. Distinct pathways for modification of the bacterial cell wall by non-canonical d-amino acids. EMBO J., 2011, 30, 3442-3453.
182. Kolodkin-Gal, I.; Cao, S.; Chai, L.; Bottcher, T.; Kolter, R.; Clardy, J.; Losick, R. A self-produced trigger for biofilm disassembly that targets exopolysaccharide. Cell, 2012, 149, 684-692.
183. Vuong, C.; Saenz, H.L.; Gotz, F.; Otto, M. Impact of the agr quorum-sensing system on adherence to polystyrene in staphylococcus aureus. J. Infect. Dis., 2000, 182, 1688-1693.
184. Beenken, K.E.; Blevins, J.S.; Smeltzer, M.S. Mutation of sara in staphylococcus aureus limits biofilm formation. Infect. Immun., 2003, 71, 4206-4211.
185. Ji, G.; Beavis, R.; Novick, R.P. Bacterial interference caused by autoinducing peptide variants. Science, 1997, 276, 2027-2030.
186. Davies, D.G.; Marques, C.N. A fatty acid messenger is responsible for inducing dispersion in microbial biofilms. J. Bacteriol., 2009, 191, 1393-1403.
187. Estrela, A.B.; Heck, M.G.; Abraham, W.R. Novel approaches to control biofilm infections. Curr. Med. Chem., 2009, 16, 1512-1530.