A structural model of the Staphylococcus aureus ClfA-fibrinogen interaction opens new avenues for the design of anti-staphylococcal therapeutics

PLoS Pathogens

Volumn 4, Issue 11, 2008, Pages

  Ganesh, Vannakambadi K ^a   Rivera, Jose J ^a,c   Smeds, Emanuel ^a   Ko, Ya Ping ^a   Bowden, M Gabriela ^a   Wann, Elisabeth R ^a   Gurusiddappa, Shivasankarappa ^a,d   Fitzgerald, J Ross ^b   Höök, Magnus ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d TEXAS CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 INTEGRIN; BACTERIAL PROTEIN; BETA3 INTEGRIN; CLUMPLING FACTOR A; UNCLASSIFIED DRUG; CLFA PROTEIN, STAPHYLOCOCCUS AUREUS; COAGULASE; FIBRINOGEN; PEPTIDE;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; LIGAND BINDING; MOLECULAR MECHANICS; MOLECULAR MODEL; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; CHEMICAL STRUCTURE; DRUG DESIGN; DRUG EFFECT; METABOLISM; STAPHYLOCOCCUS INFECTION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ORYCTOLAGUS CUNICULUS; RATTUS; RUMEX; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

BINDING SITES; COAGULASE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FIBRINOGEN; MODELS, MOLECULAR; PEPTIDES; PROTEIN BINDING; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 57149093798     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000226     Document Type: Article

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