Role of active-site residues of dispersin B, a biofilm-releasing β-hexosaminidase from a periodontal pathogen, in substrate hydrolysis

FEBS Journal

Volumn 274, Issue 22, 2007, Pages 5987-5999

  Manuel, Suba G A ^a   Ragunath, Chandran ^a   Sait, Hameetha B R ^a   Izano, Era A ^a   Kaplan, Jeffrey B ^a   Ramasubbu, Narayanan ^a  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

Biofilm detachment; Dispersin B; Enzyme mechanism; Hydrolysis; Site directed mutagenesis

Indexed keywords

ARGININE; BETA N ACETYLHEXOSAMINIDASE; DISPERSIN B; FUNCTIONAL GROUP; N ACETYLGLUCOSAMINE; UNCLASSIFIED DRUG;

ACIDITY; ACTINOBACILLUS ACTINOMYCETEMCOMITANS; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ALKALINITY; ARTICLE; BIOFILM; CATALYST; CONTROLLED STUDY; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROGEN BOND; HYDROLYSIS; MOLECULAR INTERACTION; MUTANT; MUTATION; NONHUMAN; PERIODONTIUM; PH; PRIORITY JOURNAL; REDUCTION KINETICS; SITE DIRECTED MUTAGENESIS;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BASE SEQUENCE; BETA-N-ACETYLHEXOSAMINIDASES; BINDING SITES; BIOFILMS; DNA PRIMERS; GLYCOSIDE HYDROLASES; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 35748984396     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2007.06121.x     Document Type: Article

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