Crystal structure of the Haemophilus influenzae Hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation

EMBO Journal

Volumn 30, Issue 18, 2011, Pages 3864-3874

  Meng, Guoyu ^a   Spahich, Nicole ^b   Kenjale, Roma ^b,d   Waksman, Gabriel ^c   St Geme, Joseph W ^b  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

bacterial aggregation and biofilm formation; Haemophilus influenzae Hap adhesin; oligomerization; self associating autotransporter; structural biology

Indexed keywords

BACTERIAL PROTEIN; HAEMOPHILUS INFLUENZAE HAP PROTEIN; SERINE PROTEINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL CELL; CARBOXY TERMINAL SEQUENCE; CELL INTERACTION; CRYSTAL STRUCTURE; DIMERIZATION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

BACTERIAL ADHESION; BACTERIAL OUTER MEMBRANE PROTEINS; CRYSTALLOGRAPHY, X-RAY; HAEMOPHILUS INFLUENZAE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; SERINE ENDOPEPTIDASES;

BACTERIA (MICROORGANISMS); HAEMOPHILUS INFLUENZAE; NEGIBACTERIA;

EID: 80052722849     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.279     Document Type: Article

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