Tripterine inhibits the expression of adhesion molecules in activated endothelial cells

Journal of Leukocyte Biology

Volumn 80, Issue 2, 2006, Pages 309-319

  Zhang, Deng Hai ^a,b   Marconi, Anthony ^a   Xu, Li Min ^b   Yang, Chun Xin ^c   Sun, Guo Wu ^b   Feng, Xiao Ling ^b   Ling, Chang Quan ^d   Qin, Wan Zhang ^c   Uzan, Georges ^a   D'Alessio, Patrizia ^a  

^a HÔPITAL PAUL BROUSSE   (France)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

^d SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Chinese medicinal plant; ICAM 1; Inflammation; NSAID; VCAM 1

Indexed keywords

CELL ADHESION MOLECULE; DEXAMETHASONE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GAMMA INTERFERON; IBUPROFEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MESSENGER RNA; METHOTREXATE; PROBUCOL; TRIPTERINE; TRIPTERYGIUM WILFORDII EXTRACT; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; ANTIINFLAMMATORY AGENT; INTERLEUKIN 1; TRITERPENE;

ARTICLE; CELL ACTIVATION; CELL ADHESION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IC 50; INCUBATION TIME; INFLAMMATION; LEUKOCYTE ADHERENCE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RNA TRANSCRIPTION; T LYMPHOCYTE; TRIPTERYGIUM; UMBILICAL VEIN; CELL LINE; CELL SURVIVAL; CHEMICAL STRUCTURE; COMPARATIVE STUDY; METABOLISM; PHYSIOLOGY;

ANIMALIA; TRIPTERYGIUM WILFORDII;

ANTI-INFLAMMATORY AGENTS; CELL ADHESION MOLECULES; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERFERON TYPE II; INTERLEUKIN-1; MODELS, MOLECULAR; NF-KAPPA B; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 33748854271     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1005611     Document Type: Article

References (37)

1. Luscinskas, F., Gimbrone, M. (1996) Endothelial-dependent mechanisms in chronic inflammatory leukocytes recruitment. Annu. Rev. Med. 47, 413-421.
2. Meager, A. (1999) Cytokine regulation of cellular adhesion molecule expression in inflammation. Cytokine Growth Factor Rev. 10, 27-39.
3. Szmitko, P., Wang, C., Weisel, R., d'Almeida, J., Anderson, T., Verma, S. (2003) New markers of inflammation and endothelial cell activation: part I. Circulation 108, 1917-1923.
4. d'Alessio, P. (2001) Endothelium as pharmacological target. Curr. Opin. Investig. Drugs 2, 1720-1724.
5. Neish, A., Williams, A., Palmer, H., Whitley, M., Collins, T. (1992) Functional analysis of the human vascular cell adhesion molecule 1 promoter. J. Exp. Med. 176, 1583-1593.
6. Schindler, U., Baichwal, V. (1994) Three NF-κB binding sites in the human E-selectin gene required for maximal TNFα-induced expression. Mol. Cell. Biol. 14, 5820-5831.
7. Ledebur, H., Parks, T. (1995) Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential roles of a variant NF-κB and p65 homodimers. J. Biol. Chem. 270, 933-943.
8. Weber, C., Erl, W., Pietsch, A., Weber, P. (1995) Aspirin inhibits NF-κB mobilization and monocyte adhesion in stimulation human endothelial cells. Circulation 91, 1914-1917.
9. Pierce, J., Read, M., Ding, H., Luscinskas, F., Collins, T. (1996) Salicylates inhibit IκB-α phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration. J. Immunol. 156, 3961-3969.
10. Pierce, J., Schoenleber, R., Jesmok, G., Best, J., Moore, S., Collins, T., Gerritsen, M. (1997) Novel inhibitors of cytokine-induced IκB-α phosphorylation and endothelial cell adhesion molecule expression show antiinflammatory effects in vivo. J. Biol. Chem. 272, 21096-21103.
11. Dagia, N., Goetz, D. (2003) A proteasome inhibitor reduces concurrent, sequential, and long-term IL-1 and TNFα-induced ECAM expression and adhesion. Am. J. Physiol. Cell Physiol. 285, C813-C822.
12. Chou, T., Mei, P. (1936) Study on Chinese herb Lei Gong Teng, Tripterygium wilfordii Hook f. I. The coloring substance and the sugars. Chin. J. Physiol. 10, 529-534.
13. Calixto, J., Campos, M., Otuki, M., Santos, A. (2004) Anti-inflammatory compounds of plant origin. Part II: modulation of pro-inflammatory cytokines, chemokines and adhesion molecules. Planta Med. 70, 93-103.
14. Guo, J. L., Yuan, S. X., Wang, X. C., Xu, S. X., Li, D. (1981) Tripterygium wilfordii Hook f in rheumatoid arthritis and ankylosing spondylitis. Preliminary report. Chin. Med. J. (Engl.) 94, 405-412.
15. Li, H., Jia, Y., Pan, Y., Pan, D., Li, D., Zhang, L. (1997) Effect of tripterine on collagen-induced arthritis in rats. Zhongguo Yao Li Xue Bao 18, 270-273.
16. Allison, A. C., Cacabelos, R., Lombardi, V. R., Alvarez, X. A., Vigo, C. (2001) Celastrol, a potent anti-oxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341-1357.
17. Liu, R., Liu, Z., Li, Q., Qiu, Z., Lu, H., Yang, Z., Hong, G. (2004) The experimental study on the inhibitory effect of tripterine on airway inflammation in asthmatic mice. Zhonghua Jie He He Hu Xi Za Zhi 27, 165-168.
18. Xu, X., Wu, Z., Xu, C., Ren, Y., Ge, Y. (2003) Observation on serum anti-double-stranded DNA antibodies of tripterine in systemic lupus erythematosus of (NZBxW)F1 mice. Ann. Rheum. Dis. 62, 377-378.
19. Li, H., Zhang, Y., Huang, X., Sun, Y., Jia, Y., Li, D. (2005) Beneficial effect of tripterine on systemic lupus erythematosus induced by active chromatin in BALB/c mice. Eur. J. Pharmacol. 512, 231-237.
20. Huang, F., Chan, W., Moriarty, K., Zhang, D., Chang, M., He, W., Yu, K., Zilberstein, A. (1998) Novel cytokine release inhibitors. Part I: triterpenes. Bioorg. Med. Chem. Lett. 8, 1883-1886.
21. Pinna, G., Fiorucci, M., Reimund, J., Taquet, N., Arondel, Y., Muller, C. (2004) Celastrol inhibits pro-inflammatory cytokine secretion in Crohn's disease biopsies. Biochem. Biophys. Res. Commun. 322, 778-786.
22. Jin, H. Z., Hwang, B. Y., Kim, H. S., Lee, J. H., Kim, Y. H., Lee, J. J. (2002) Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-κB activation and NO production. J. Nat. Prod. 65, 89-91.
23. Morota, T., Yang, C., Ogino, T., Qin, W., Katsuhara, T., Xu, L., Komatsu, Y., Miao, K., Maruno, M., Yang, B. (1995) A-friedo-24-noroleanane triterpenoids from Tripterigium wilfordii. Phytochemistry 39, 1159-1163.
24. Marconi, A., Darquenne, S., Boulmerka, A., Mosnier, M., d'Alessio, P. (2003) Naftidrofuryl-driven regulation of endothelial ICAM-1 involves nitric oxide. Free Radic. Biol. Med. 34, 616-625.
25. Kapiotis, S., Sengoelge, G., Sperr, W., Baghestaian, M., Quehenberger, P., Bebec, D., Li, S., Menzel, E., Mühl, A., Zapolska, D., Virgolini, I., Valent, P., Speiser, W. (1996) Ibuprofen inhibits pyrogen-dependent expression of VCAM-1 and ICAM-1 on human endothelial cells. Life Sci. 58, 2167-2181.
26. Zapolska-Downar, D., Zapolski-Downar, A., Markiewski, M., Ciechanowicz, A., Kaczmarczyk, M., Naruszewicz, M. (2001) Selective inhibition by probucol of vascular cell adhesion molecule-1 (VCAM-1) expression in human vascular endothelial cells. Atherosclerosis 155, 123-130.
27. Chen, W., Lee, J., Hsien, W. (2002) Effects of dexamethasone and sex hormones on cytokine-induced cellular adhesion molecule expression in human endothelial cells. Eur. J. Dermatol. 12, 445-448.
28. Yamasaki, E., Soma, Y., Kawa, Y., Mizoguchi, M. (2003) Methotrexate inhibits proliferation and regulation of the expression of ICAM-1 and VCAM-1 by culture human umbilical vein endothelial cells. Br. J. Dermatol. 149, 30-38.
29. Korlipara, L., Leon, M., Rix, D., Douglas, M., Gibbs, P., Bassendine, M., Kirby, J. (1996) Development of a flow cytometric assay to quantify lymphocyte adhesion to cytokine-stimulated human endothelial and biliary epithelial cells. J. Immunol. Methods 191, 121-130.
30. Zhang, X., Kelemen, S., Eisen, H. (2000) Quantitative assessment of cell adhesion molecule gene expression in endomyocardial biopsy specimens from cardiac transplant recipients using competitive polymerase chain reaction. Transplantation 70, 505-513.
31. Bompais, H., Chagraoui, J., Canron, X., Crisan, M., Liu, X. H., Anjo, A., Tolla-Le Port, C., Leboeuf, M., Charbord, P., Bikfalvi, A., Uzan, G. (2004) Human endothelial cells derived from circulating progenitors display specific functional properties compared with mature vessel wall endothelial cells. Blood 103, 2577-2584.
32. Marino, J., Cook, P., Miller, K. (2003) Accurate and statistically verified quantification of relative mRNA abundances using SYBR Green I and real-time RT-PCR. J. Immunol. Methods 283, 291-306.
33. Bao, Y., Yu, R., Zhang, D. (1999) In vitro study on cellular and molecular mechanism of tripterine treating leukemic mast cells. Zhonghua Xue Ye Xue Za Zhi 20, 146-148.
34. Nagase, M., Oto, J., Sugiyama, S., Yube, K., Takaishi, Y., Sakato, N. (2003) Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol. Biosci. Biotechnol. Biochem. 67, 1883-1887.
35. Chang, F., Hayashi, K., Chen, I., Liaw, C., Bastow, K., Nakanishi, Y., Nozaki, H., Cragg, G., Wu, Y., Lee, K. (2003) Antitumor agents. Five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii. J. Nat. Prod. 66, 1416-1420.
36. Hanada, T. (2002) Regulation of cytokine signaling and inflammation. Review. Cytokine Growth Factor Rev. 13, 413-421.
37. Zhuang, G., Yuan, Z., Zhang, Z., Qing, W., Jin, Y. (1992) Treatment of lupus erythematosus with integrated traditional Chinese medicine and Western medicine. Zhongguo Zhong Xi Yi Jie He Za Zhi 12, 199-202.