Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective tissue diseases

Journal of Clinical Virology

Volumn 46, Issue 1, 2009, Pages 43-46

  Broccolo, Francesco ^a   Drago, Francesco ^b   Paolino, Stefania ^b   Cassina, Giulia ^c   Gatto, Francesca ^c   Fusetti, Lisa ^d   Matteoli, Barbara ^d   Zaccaria, Elisa ^b   Parodi, Aurora ^b   Lusso, Paolo ^c,e   Ceccherini Nelli, Luca ^d   Malnati, Mauro S ^c  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b DiSEM   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d UNIVERSITY OF PISA   (Italy)

^e UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Connective tissue diseases; Herpesviruses; HHV 6; Real time PCR; Viral load; Viral reactivation

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; STEROID; VIRUS ANTIBODY; VIRUS DNA;

ADULT; AGED; ANTIBODY TITER; ARTICLE; AUTOIMMUNE DISEASE; BLOOD SAMPLING; CONNECTIVE TISSUE DISEASE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DNA DETERMINATION; DNA VIRUS; FEMALE; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 6; HUMAN HERPESVIRUS 7; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SCLERODERMA; SEROPREVALENCE; SYSTEMIC SCLEROSIS; TISSUE SECTION; VIREMIA; VIRUS DETECTION; VIRUS REACTIVATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, VIRAL; AUTOIMMUNE DISEASES; CHILD; CONNECTIVE TISSUE DISEASES; CROSS-SECTIONAL STUDIES; DNA, VIRAL; FEMALE; HERPESVIRUS 6, HUMAN; HERPESVIRUS 7, HUMAN; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PREVALENCE; ROSEOLOVIRUS INFECTIONS; VIREMIA; VIRUS ACTIVATION; YOUNG ADULT;

EID: 67949099185     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcv.2009.05.010     Document Type: Article

References (21)

1. Hamamdzic D., Kasman L.M., and LeRoy E.C. The role of infectious agents in the pathogenesis of systemic sclerosis. Curr Opin Rheumatol 14 (2002) 694-698 Review
2. Krueger G.R., Sander C., Hoffmann A., Barth A., Koch B., and Braun M. Isolation of human herpesvirus-6 (HHV-6) from patients with collagen vascular diseases. In Vivo 5 (1991) 217-225
3. Hoffmann A., Kirn E., Kuerten A., Sander C., Krueger G.R., and Ablashi D.V. Active human herpesvirus-6 (HHV-6) infection associated with Kikuchi-Fujimoto disease and systemic lupus erythematosus (SLE). In Vivo 5 (1991) 265-269
4. Yoshikawa T., Ihira M., Taguchi H., Yoshida S., and Asano Y. Analysis of shedding of 3 beta-herpesviruses in saliva from patients with connective tissue diseases. J Infect Dis 192 (2005) 1530-1536
5. Bombardier C., Gladman D.D., Urowitz M.B., Caron D., and Chang C.H. Derivation of the SLEDAI: a disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 35 (1992) 630
6. Albrecht J., Taylor L., Berlin J.A., et al. The CLASI (Cutaneous Lupus Erythematosus Disease Area and Severity Index): an outcome instrument for cutaneous lupus erythematosus. J Invest Dermatol 125 (2005) 889-894
7. Carroll C.L., Lang W., Snively B., Feldman S.R., Callen J., and Jorizzo J.L. Development and validation of the Dermatomyositis Skin Severity Index. Br J Dermatol 158 (2008) 345-350
8. Broccolo F., Drago F., Careddu A.M., et al. Additional evidence that Pityriasis rosea is associated with reactivation of Human Herpesviruses-6 and-7. J Invest Dermatol 124 (2005) 1234-1240
9. Locatelli G., Santoro F., Veglia F., Gobbi A., Lusso P., and Malnati M.S. Real-time quantitative PCR for human herpesvirus 6 DNA. J Clin Microbiol 38 (2000) 4042-4048
10. Broccolo F., Locatelli G., Sarmati L., et al. A calibrated Real-time PCR assay for the quantitation of Human herpesvirus 8 DNA in biological fluids. J Clin Microb 12 (2002) 4652-4658
11. Malnati M.S., Scarlatti G., Gatto F., et al. A universal real-time PCR assay for the quantification of group-M HIV-1 proviral load. Nat Protoc 3 (2008) 1240-1248
12. Ward K.N., Leong H.N., Nacheva E.P., et al. Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles. J Clin Microbiol 44 (2006) 1571-1574
13. Secchiero P., Carrigan D.R., Asano Y., et al. Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction. J Infect Dis 171 (1995) 273-280
14. Ogata M., Kikuchi H., Satou T., et al. Human herpesvirus 6 DNA load in plasma after allogeneic stem cell transplantation: incidence and clinical significance. J Infect Dis 193 (2006) 68-79
15. Achour A., Boutolleau D., Gautheret-Dejean A., and Agut H. Is human herpesvirus-6 DNA in plasma the right marker for active infection?. J Infect Dis 194 (2006) 1795-1796
16. Achour A., Boutolleau D., Slim A., Agut H., and Gautheret-Dejean A. Human herpesvirus-6 (HHV-6) DNA in plasma reflects the presence of infected blood cells rather than circulating viral particles. J Clin Virol 38 (2007) 280-285
17. Hall C.B., Caserta M.T., Schnabel K., et al. Chromosomal integration of human herpesvirus 6 is the major mode of congenital human herpesvirus 6 infection. Pediatrics 122 (2008) 513-520
18. Mori T., Kameda H., Ogawa H., Iizuka A., Sekiguchi N., Takei H., et al. Incidence of cytomegalovirus reactivation in patients with inflammatory connective tissue diseases who are under immunosuppressive therapy. J Rheumatol 31 (2004) 1349-1351
19. Chun H.Y., Chung J.W., Kim H.A., et al. Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus. J Clin Immunol 27 (2007) 461-466
20. Yoshikawa T., Fujita A., Yagami A., et al. Human herpesvirus 6 reactivation and inflammatory cytokine production in patients with drug-induced hypersensitivity syndrome. J Clin Virol 37 Suppl. 1 (2006) S92-S96
21. Fujita A., Ihira M., Suzuki R., et al. Elevated serum cytokine levels are associated with human herpesvirus 6 reactivation in hematopoietic stem cell transplantation recipients. J Infect 57 (2008) 241-248