메뉴 건너뛰기




Volumn 5, Issue 2, 2013, Pages 48-56

Targeted drug delivery to the nucleus and its potential role in cancer chemotherapy

Author keywords

Biological barriers; Chemotherapy; Nuclear targeted drug delivery; Tumour cells

Indexed keywords

10 HYDROXYCAMPTOTHECIN; CISPLATIN; CURCUMIN; DOXORUBICIN; ELACRIDAR; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; FOLATE RECEPTOR; GONADORELIN RECEPTOR; INTEGRIN; KARYOPHERIN ALPHA; KARYOPHERIN BETA; MULTIDRUG RESISTANCE PROTEIN; NANOCARRIER; NANOPARTICLE; PROSTATE SPECIFIC MEMBRANE ANTIGEN; SMALL INTERFERING RNA; TARIQUIDAR; TOCOFERSOLAN; TRANSFERRIN;

EID: 84874676430     PISSN: 09751459     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (12)

References (76)
  • 3
    • 74049133619 scopus 로고    scopus 로고
    • Subcellular targeting strategies for drug design and delivery
    • L. Rajendran, H.J. Knolker, K. Simons, Subcellular targeting strategies for drug design and delivery, Nat. Rev. Drug Discov. 2010, 9 (1), 29-42.
    • (2010) Nat. Rev. Drug Discov , vol.9 , Issue.1 , pp. 29-42
    • Rajendran, L.1    Knolker, H.J.2    Simons, K.3
  • 4
    • 0037005423 scopus 로고    scopus 로고
    • Intracellular localization studies of doxorubicin and Victoria Blue BO in EMT6-S and EMT6-R cells using confocal microscopy
    • S.M. Burrow, D.A. Phoenix, M. Wainwright, M.J. Tobin, Intracellular localization studies of doxorubicin and Victoria Blue BO in EMT6-S and EMT6-R cells using confocal microscopy, Cytotechnology. 2002, 39 (1), 15-25.
    • (2002) Cytotechnology , vol.39 , Issue.1 , pp. 15-25
    • Burrow, S.M.1    Phoenix, D.A.2    Wainwright, M.3    Tobin, M.J.4
  • 5
    • 17244366637 scopus 로고    scopus 로고
    • Intracellular drug sequestration events associated with the emergence of multidrug resistance: A mechanistic review
    • M. Duvvuri, J.P. Krise, Intracellular drug sequestration events associated with the emergence of multidrug resistance: a mechanistic review, Front. Biosci. 2005, 10, 1499-1509.
    • (2005) Front. Biosci , vol.10 , pp. 1499-1509
    • Duvvuri, M.1    Krise, J.P.2
  • 6
    • 16544374489 scopus 로고    scopus 로고
    • Molecular basis of cellular response to cisplatin chemotherapy in non-small cell lung cancer (Review)
    • G.D. Wang, E. Reed, Q.Q. Li, Molecular basis of cellular response to cisplatin chemotherapy in non-small cell lung cancer (Review), Oncol. Rep. 2004, 12 (5), 955-965.
    • (2004) Oncol. Rep , vol.12 , Issue.5 , pp. 955-965
    • Wang, G.D.1    Reed, E.2    Li, Q.Q.3
  • 7
    • 0037366133 scopus 로고    scopus 로고
    • Biochemical modulation of cisplatin mechanisms of action: Enhancement of antitumor activity and circumvention of drug resistance
    • M.A. Fuertes, C. Alonso, J.M. Perez, Biochemical modulation of cisplatin mechanisms of action: enhancement of antitumor activity and circumvention of drug resistance, Chem. Rev. 2003,103 (3), 645-662.
    • (2003) Chem. Rev , vol.103 , Issue.3 , pp. 645-662
    • Fuertes, M.A.1    Alonso, C.2    Perez, J.M.3
  • 8
    • 33745226414 scopus 로고    scopus 로고
    • Tumor-specific nuclear targeting: Promises for anti-cancer therapy?
    • Alvisi, G., Poon, I.K., Jans, D.A., Tumor-specific nuclear targeting: promises for anti-cancer therapy? Drug Resist. Updat. 2006, 9, 40-50.
    • (2006) Drug Resist. Updat , vol.9 , pp. 40-50
    • Alvisi, G.1    Poon, I.K.2    Jans, D.A.3
  • 9
    • 34548178732 scopus 로고    scopus 로고
    • Nucleocytoplasmic transport of DNA: Enhancing nonviral gene transfer
    • Wagstaff, K.M., Jans, D.A., Nucleocytoplasmic transport of DNA: enhancing nonviral gene transfer. Biochem. J. 2007, 406, 185-202.
    • (2007) Biochem. J , vol.406 , pp. 185-202
    • Wagstaff, K.M.1    Jans, D.A.2
  • 11
    • 15944400651 scopus 로고    scopus 로고
    • Towards safe, non-viral therapeutic gene expression in humans
    • Glover, D.J., Lipps, H.J., Jans, D.A., Towards safe, non-viral therapeutic gene expression in humans. Nat. Rev. Genet. 2005, 6, 299-310.
    • (2005) Nat. Rev. Genet , vol.6 , pp. 299-310
    • Glover, D.J.1    Lipps, H.J.2    Jans, D.A.3
  • 12
    • 33646525645 scopus 로고    scopus 로고
    • Protein transduction: Cell penetrating peptides and their therapeutic applications
    • Wagstaff, K.M., Jans, D.A., Protein transduction: cell penetrating peptides and their therapeutic applications. Curr. Med. Chem. 2006b, 13, 1371-1387.
    • (2006) Curr. Med. Chem , vol.13 , pp. 1371-1387
    • Wagstaff, K.M.1    Jans, D.A.2
  • 13
    • 0028609450 scopus 로고
    • Mechanism of adenovirus-mediated endosome lysis: Role of the intact adenovirus capsid structure
    • Seth, P., Mechanism of adenovirus-mediated endosome lysis: role of the intact adenovirus capsid structure. Biochem. Biophys. Res. Commun. 1994, 205, 1318-1324.
    • (1994) Biochem. Biophys. Res. Commun , vol.205 , pp. 1318-1324
    • Seth, P.1
  • 14
    • 0037422066 scopus 로고    scopus 로고
    • Regulated portals of entry into the cell
    • Conner, S.D., Schmid, S.L., Regulated portals of entry into the cell. Nature. 2003, 422, 37-44.
    • (2003) Nature , vol.422 , pp. 37-44
    • Conner, S.D.1    Schmid, S.L.2
  • 15
    • 33845404380 scopus 로고    scopus 로고
    • Intracellular trafficking of plasmids for gene therapy: Mechanisms of cytoplasmicmovement and nuclear import
    • Vaughan, E.E., DeGiulio, J.V., Dean, D.A., Intracellular trafficking of plasmids for gene therapy: mechanisms of cytoplasmicmovement and nuclear import. Curr. Gene Ther. 2006, 6, 671-681.
    • (2006) Curr. Gene Ther , vol.6 , pp. 671-681
    • Vaughan, E.E.1    DeGiulio, J.V.2    Dean, D.A.3
  • 16
    • 8644262258 scopus 로고    scopus 로고
    • Importin beta: Conducting a much larger cellular symphony
    • Harel, A., Forbes, D.J., Importin beta: conducting a much larger cellular symphony. Mol. Cell. 2004, 16, 319-330.
    • (2004) Mol. Cell , vol.16 , pp. 319-330
    • Harel, A.1    Forbes, D.J.2
  • 17
    • 0034717044 scopus 로고    scopus 로고
    • Gatekeepers of the nucleus
    • Wente, S.R., Gatekeepers of the nucleus. Science. 2000, 288, 1374-1377.
    • (2000) Science , vol.288 , pp. 1374-1377
    • Wente, S.R.1
  • 18
    • 0035869022 scopus 로고    scopus 로고
    • Kinetic analysis of translocation through nuclear pore complexes
    • Ribbeck, K., Gorlich, D., Kinetic analysis of translocation through nuclear pore complexes. EMBO J. 2001, 20, 1320-1330.
    • (2001) EMBO J , vol.20 , pp. 1320-1330
    • Ribbeck, K.1    Gorlich, D.2
  • 19
    • 14544272335 scopus 로고    scopus 로고
    • Regulation of nuclear transport: Central role in development and transformation?
    • Poon, I.K., Jans, D.A., Regulation of nuclear transport: central role in development and transformation? Traffic.2005, 6, 173-186.
    • (2005) Traffic , vol.6 , pp. 173-186
    • Poon, I.K.1    Jans, D.A.2
  • 20
    • 0031869439 scopus 로고    scopus 로고
    • Signals mediating nuclear targeting and their regulation: Application in drug delivery
    • Jans, D.A., Chan, C.K., Huebner, S., Signals mediating nuclear targeting and their regulation: application in drug delivery. Med. Res. Rev. 1998, 18, 189-223.
    • (1998) Med. Res. Rev , vol.18 , pp. 189-223
    • Jans, D.A.1    Chan, C.K.2    Huebner, S.3
  • 21
    • 0021269089 scopus 로고
    • Sequence requirements for nuclear location of simian virus 40 large-T antigen
    • Kalderon, D., Richardson, W.D., Markham, A.F., Smith, A.E., Sequence requirements for nuclear location of simian virus 40 large-T antigen. Nature. 1984a, 311, 33-38.
    • (1984) Nature , vol.311 , pp. 33-38
    • Kalderon, D.1    Richardson, W.D.2    Markham, A.F.3    Smith, A.E.4
  • 22
    • 0021716406 scopus 로고
    • A short amino acid sequence able to specify nuclear location
    • Kalderon, D., Roberts, B.L., Richardson, W.D., Smith, A.E., A short amino acid sequence able to specify nuclear location. Cell. 1984b, 39, 499-509.
    • (1984) Cell , vol.39 , pp. 499-509
    • Kalderon, D.1    Roberts, B.L.2    Richardson, W.D.3    Smith, A.E.4
  • 23
    • 0026078249 scopus 로고
    • Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence
    • Robbins, J., Dilworth, S.M., Laskey, R.A., Dingwall, C., Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell. 1991, 64, 615-623.
    • (1991) Cell , vol.64 , pp. 615-623
    • Robbins, J.1    Dilworth, S.M.2    Laskey, R.A.3    Dingwall, C.4
  • 26
    • 0034208665 scopus 로고    scopus 로고
    • The molecular mechanism of transport of macromolecules through nuclear pore complexes
    • Bayliss, R., Corbett, A.H., Stewart, M., The molecular mechanism of transport of macromolecules through nuclear pore complexes. Traffic. 2000a, 1, 448-456.
    • (2000) Traffic , vol.1 , pp. 448-456
    • Bayliss, R.1    Corbett, A.H.2    Stewart, M.3
  • 27
    • 0034616910 scopus 로고    scopus 로고
    • Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking
    • Bayliss, R., Littlewood, T., Stewart, M., Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking. Cell. 2000b, 102, 99-108.
    • (2000) Cell , vol.102 , pp. 99-108
    • Bayliss, R.1    Littlewood, T.2    Stewart, M.3
  • 28
    • 0034065954 scopus 로고    scopus 로고
    • The role of Ran in nuclear function
    • Azuma, Y., Dasso, M., The role of Ran in nuclear function. Curr. Opin. Cell Biol. 2000, 12, 302-307.
    • (2000) Curr. Opin. Cell Biol , vol.12 , pp. 302-307
    • Azuma, Y.1    Dasso, M.2
  • 29
    • 33644972324 scopus 로고    scopus 로고
    • Importin alpha mRNAs have distinct expression profiles during spermatogenesis
    • Hogarth, C.A., Calanni, S., Jans, D.A., Loveland, K.L., Importin alpha mRNAs have distinct expression profiles during spermatogenesis. Dev. Dyn. 2006, 235, 253-262.s.
    • (2006) Dev. Dyn , vol.235
    • Hogarth, C.A.1    Calanni, S.2    Jans, D.A.3    Loveland, K.L.4
  • 31
    • 0034041537 scopus 로고    scopus 로고
    • Nuclear targeting signal recognition: A key control point in nuclear transport?
    • Jans, D.A., Xiao, C.Y., Lam, M.H., Nuclear targeting signal recognition: a key control point in nuclear transport? Bioessays. 2000, 22, 532-544.
    • (2000) Bioessays , vol.22 , pp. 532-544
    • Jans, D.A.1    Xiao, C.Y.2    Lam, M.H.3
  • 32
    • 0039468008 scopus 로고    scopus 로고
    • The protein kinase CK2 site (Ser111/112) enhances recognition of the simian virus 40 large Tantigen nuclear localization sequence by importin
    • Hubner, S., Xiao, C.Y., Jans, D.A., The protein kinase CK2 site (Ser111/112) enhances recognition of the simian virus 40 large Tantigen nuclear localization sequence by importin. J. Biol. Chem. 1997, 272, 17191-17195.
    • (1997) J. Biol. Chem , vol.272 , pp. 17191-17195
    • Hubner, S.1    Xiao, C.Y.2    Jans, D.A.3
  • 33
    • 26944433406 scopus 로고    scopus 로고
    • A protein kinase CK2 site flanking the nuclear targeting signal enhances nuclear transport of human cytomegalovirus ppUL44
    • Alvisi, G., Jans, D.A., Guo, J., Pinna, L.A., Ripalti, A., A protein kinase CK2 site flanking the nuclear targeting signal enhances nuclear transport of human cytomegalovirus ppUL44. Traffic. 2005, 6, 1002-1013.
    • (2005) Traffic , vol.6 , pp. 1002-1013
    • Alvisi, G.1    Jans, D.A.2    Guo, J.3    Pinna, L.A.4    Ripalti, A.5
  • 34
    • 1642464560 scopus 로고    scopus 로고
    • Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: Characterization of phosphorylation-and 14-3-3-dependent and-independent mechanisms
    • Zhao, X., Gan, L., Pan, H., Kan, D., Majeski, M., Adam, S.A., Unterman, T.G., Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation-and 14-3-3-dependent and-independent mechanisms. Biochem. 2004, J. 378, 839-849.
    • (2004) Biochem J , vol.378 , pp. 839-849
    • Zhao, X.1    Gan, L.2    Pan, H.3    Kan, D.4    Majeski, M.5    Adam, S.A.6    Unterman, T.G.7
  • 35
    • 13844275977 scopus 로고    scopus 로고
    • Nuclear delivery of macromolecules: Barriers and carriers
    • M. Belting, S. Sandgren, A. Wittrup, Nuclear delivery of macromolecules: barriers and carriers, Adv. Drug Deliv. Rev. 2005, 57 (4), 505-527.
    • (2005) Adv. Drug Deliv. Rev , vol.57 , Issue.4 , pp. 505-527
    • Belting, M.1    Sandgren, S.2    Wittrup, A.3
  • 36
    • 2642566088 scopus 로고    scopus 로고
    • Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
    • G. Minotti, P. Menna, E. Salvatorelli, G. Cairo, L. Gianni, Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity, Pharmacol. Rev. 2004, 56 (2) 185-229.
    • (2004) Pharmacol. Rev , vol.56 , Issue.2 , pp. 185-229
    • Minotti, G.1    Menna, P.2    Salvatorelli, E.3    Cairo, G.4    Gianni, L.5
  • 37
    • 0035866817 scopus 로고    scopus 로고
    • Mechanism of specific nuclear transport of adriamycin: The mode of nuclear translocation of adriamycin-proteasome complex
    • K. Kiyomiya, S. Matsuo, M. Kurebe, Mechanism of specific nuclear transport of adriamycin: the mode of nuclear translocation of adriamycin-proteasome complex, Cancer Res. 2001, 61 (6), 2467-2471
    • (2001) Cancer Res , vol.61 , Issue.6 , pp. 2467-2471
    • Kiyomiya, K.1    Matsuo, S.2    Kurebe, M.3
  • 38
    • 67649238437 scopus 로고    scopus 로고
    • Doxorubicin-conjugated immunonanoparticles for intracellular anticancer drug delivery
    • M. Shi, K. Ho, A. Keating, M.S. Shoichet, Doxorubicin-conjugated immunonanoparticles for intracellular anticancer drug delivery, Adv. Funct. Mater. 2009, 19 (11), 1689-1696.
    • (2009) Adv. Funct. Mater , vol.19 , Issue.11 , pp. 1689-1696
    • Shi, M.1    Ho, K.2    Keating, A.3    Shoichet, M.S.4
  • 41
    • 34948876843 scopus 로고    scopus 로고
    • Enhanced cytotoxicity of monoclonal anticancer antibody 2 C5-modified doxorubicin-loaded PEGylated liposomes against various tumor cell lines
    • T.A. Elbayoumi, V.P. Torchilin, Enhanced cytotoxicity of monoclonal anticancer antibody 2 C5-modified doxorubicin-loaded PEGylated liposomes against various tumor cell lines, Eur. J. Pharm. Sci. 2007, 32 (3), 159-168.
    • (2007) Eur. J. Pharm. Sci , vol.32 , Issue.3 , pp. 159-168
    • Elbayoumi, T.A.1    Torchilin, V.P.2
  • 42
    • 0034031080 scopus 로고    scopus 로고
    • Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrugresistance efflux pump
    • D. Goren, A.T. Horowitz, D. Tzemach, M. Tarshish, S. Zalipsky, A. Gabizon, Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrugresistance efflux pump, Clin. Cancer Res. 2000, 6 (5), 1949-1957.
    • (2000) Clin. Cancer Res , vol.6 , Issue.5 , pp. 1949-1957
    • Goren, D.1    Horowitz, A.T.2    Tzemach, D.3    Tarshish, M.4    Zalipsky, S.5    Gabizon, A.6
  • 44
    • 0017803647 scopus 로고
    • Extraction of daunorubicin and doxorubicin and their hydroxyl metabolites-self-association in aqueous-solution
    • S. Eksborg, Extraction of daunorubicin and doxorubicin and their hydroxyl metabolites-self-association in aqueous-solution, J. Pharm. Sci-US. 1978, 67 (6), 782-785.
    • (1978) J. Pharm. Sci-US , vol.67 , Issue.6 , pp. 782-785
    • Eksborg, S.1
  • 45
    • 0021249685 scopus 로고
    • Self-association of doxorubicin and related-compounds in aqueous-solution
    • M. Menozzi, L. Valentini, E. Vannini, F. Arcamone, Self-association of doxorubicin and related-compounds in aqueous-solution, J. Pharm. Sci-US. 1984, 73 (6), 766-770.
    • (1984) J. Pharm. Sci-US , vol.73 , Issue.6 , pp. 766-770
    • Menozzi, M.1    Valentini, L.2    Vannini, E.3    Arcamone, F.4
  • 46
    • 49749101644 scopus 로고    scopus 로고
    • Pluronic block copolymers: Evolution of drug delivery concept from inert nanocarriers to biological response modifiers
    • E.V. Batrakova, A.V. Kabanov, Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers, J. Control. Release. 2008, 130 (2), 98-106.
    • (2008) J. Control. Release , vol.130 , Issue.2 , pp. 98-106
    • Batrakova, E.V.1    Kabanov, A.V.2
  • 47
    • 0142010619 scopus 로고    scopus 로고
    • Sensitization of cells overexpressing multidrug-resistant proteins by Pluronic P85
    • E.V. Batrakova, S. Li, V.Y. Alakhov, W.F. Elmquist, D.W. Miller, A.V. Kabanov, Sensitization of cells overexpressing multidrug-resistant proteins by Pluronic P85, Pharm. Res. 2003, 20 (10), 1581-1590.
    • (2003) Pharm. Res , vol.20 , Issue.10 , pp. 1581-1590
    • Batrakova, E.V.1    Li, S.2    Alakhov, V.Y.3    Elmquist, W.F.4    Miller, D.W.5    Kabanov, A.V.6
  • 49
    • 0141955916 scopus 로고    scopus 로고
    • An essential relationship between ATP depletion and chemosensitizing activity of Pluronic(R) block copolymers
    • A.V. Kabanov, E.V. Batrakova, V.Y. Alakhov, An essential relationship between ATP depletion and chemosensitizing activity of Pluronic(R) block copolymers, J. Control. Release. 2003, 91 (1-2), 75-83.
    • (2003) J. Control. Release , vol.91 , Issue.1-2 , pp. 75-83
    • Kabanov, A.V.1    Batrakova, E.V.2    Alakhov, V.Y.3
  • 50
    • 67349243616 scopus 로고    scopus 로고
    • Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance
    • Y. Patil, T. Sadhukha, L.N. Ma, J. Panyam, Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance, J. Control. Release. 2009, 136 (1), 21-29.
    • (2009) J. Control. Release , vol.136 , Issue.1 , pp. 21-29
    • Patil, Y.1    Sadhukha, T.2    Ma, L.N.3    Panyam, J.4
  • 51
    • 67249106291 scopus 로고    scopus 로고
    • Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells
    • S. Ganta, M. Amiji, Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells, Mol. Pharm. 2009, 6 (3), 928-939.
    • (2009) Mol. Pharm , vol.6 , Issue.3 , pp. 928-939
    • Ganta, S.1    Amiji, M.2
  • 52
    • 37849185909 scopus 로고    scopus 로고
    • Simultaneous delivery of doxorubicin and GG918 (Elacridar) by new polymer-lipid Hybrid nanoparticle (PLN) for enhanced treatment of multidrugresistant breast cancer
    • H.L. Wong, R. Bendayan, A.M. Rauth, X.Y. Wu, Simultaneous delivery of doxorubicin and GG918 (Elacridar) by new polymer-lipid Hybrid nanoparticle (PLN) for enhanced treatment of multidrugresistant breast cancer, J. Control. Release. 2006, 116 (3), 275-284.
    • (2006) J. Control. Release , vol.116 , Issue.3 , pp. 275-284
    • Wong, H.L.1    Bendayan, R.2    Rauth, A.M.3    Wu, X.Y.4
  • 53
    • 77957880781 scopus 로고    scopus 로고
    • Poly(L-lactide)-vitamin E TPGS nanoparticles enhanced the cytotoxicity of doxorubicin in drugresistant MCF-7 breast cancer cells
    • P.Y. Li, P.S. Lai, W.C. Hung, W.J. Syu, Poly(L-lactide)-vitamin E TPGS nanoparticles enhanced the cytotoxicity of doxorubicin in drugresistant MCF-7 breast cancer cells, Biomacromolecules. 2010, 11 (10), 2576-2582.
    • (2010) Biomacromolecules , vol.11 , Issue.10 , pp. 2576-2582
    • Li, P.Y.1    Lai, P.S.2    Hung, W.C.3    Syu, W.J.4
  • 54
    • 78649605959 scopus 로고    scopus 로고
    • Cationic polymer-mediated small interfering RNA delivery for Pglycoprotein down regulation in tumor cells
    • M. Abbasi, A. Lavasanifar, L.G. Berthiaume, M. Weinfeld, H. Uludag, Cationic polymer-mediated small interfering RNA delivery for Pglycoprotein down regulation in tumor cells, Cancer. 2010, 116 (23), 5544-5554.
    • (2010) Cancer , vol.116 , Issue.23 , pp. 5544-5554
    • Abbasi, M.1    Lavasanifar, A.2    Berthiaume, L.G.3    Weinfeld, M.4    Uludag, H.5
  • 55
    • 77954599597 scopus 로고    scopus 로고
    • Multifunctional nanoparticles delivering small interfering RNA and doxorubicin overcome drug resistance in cancer
    • Y.C. Chen, S.R. Bathula, J. Li, L. Huang, Multifunctional nanoparticles delivering small interfering RNA and doxorubicin overcome drug resistance in cancer, J. Biol. Chem. 2010, 285 (29), 22639-22650.
    • (2010) J. Biol. Chem , vol.285 , Issue.29 , pp. 22639-22650
    • Chen, Y.C.1    Bathula, S.R.2    Li, J.3    Huang, L.4
  • 56
    • 70350707597 scopus 로고    scopus 로고
    • The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance
    • Y.B. Patil, S.K. Swaminathan, T. Sadhukha, L.A. Ma, J. Panyam, The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance, Biomaterials. 2010, 31 (2), 358-365.
    • (2010) Biomaterials , vol.31 , Issue.2 , pp. 358-365
    • Patil, Y.B.1    Swaminathan, S.K.2    Sadhukha, T.3    Ma, L.A.4    Panyam, J.5
  • 57
    • 77956544799 scopus 로고    scopus 로고
    • Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma
    • M. Susa, A.K. Iyer, K. Ryu, E. Choy, F.J. Hornicek, H. Mankin, L. Milane, M.M. Amiji, Z. Duan, Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma, Plos One. 2010, 5 (5).
    • (2010) Plos One , vol.5 , Issue.5
    • Susa, M.1    Iyer, A.K.2    Ryu, K.3    Choy, E.4    Hornicek, F.J.5    Mankin, H.6    Milane, L.7    Amiji, M.M.8    Duan, Z.9
  • 58
    • 58849095012 scopus 로고    scopus 로고
    • Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells
    • S. Yadav, L.E. van Vlerken, S.R. Little, M.M. Amiji, Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells, Cancer Chemoth. Pharm. 2009, 63 (4), 711-722.
    • (2009) Cancer Chemoth. Pharm , vol.63 , Issue.4 , pp. 711-722
    • Yadav, S.1    van Vlerken, L.E.2    Little, S.R.3    Amiji, M.M.4
  • 59
    • 33747877757 scopus 로고    scopus 로고
    • In vitro and in vivo intracellular liposomal delivery of antisense oligonucleotides and anticancer drug, J. Control
    • R.I. Pakunlu, Y. Wang, M. Saad, J.J. Khandare, V. Starovoytov, T. Minko, In vitro and in vivo intracellular liposomal delivery of antisense oligonucleotides and anticancer drug, J. Control. Release. 2006, 114 (2), 153-162.
    • (2006) Release , vol.114 , Issue.2 , pp. 153-162
    • Pakunlu, R.I.1    Wang, Y.2    Saad, M.3    Khandare, J.J.4    Starovoytov, V.5    Minko, T.6
  • 60
    • 77954880957 scopus 로고    scopus 로고
    • Gateways for the intracellular access of nanocarriers: A review of receptor-mediated endocytosis mechanisms and of strategies in receptor targeting
    • N.M. Zaki, N. Tirelli, Gateways for the intracellular access of nanocarriers: a review of receptor-mediated endocytosis mechanisms and of strategies in receptor targeting, Expert Opin. Drug Deliv. 2010, 7 (8), 895-913.
    • (2010) Expert Opin. Drug Deliv , vol.7 , Issue.8 , pp. 895-913
    • Zaki, N.M.1    Tirelli, N.2
  • 61
    • 79954421068 scopus 로고    scopus 로고
    • Intracellular trafficking considerations in the development of natural ligand-drug molecular conjugates for cancer
    • D.J. Yoon, C.T. Liu, D.S. Quinlan, P.M. Nafisi, D.T. Kamei, Intracellular trafficking considerations in the development of natural ligand-drug molecular conjugates for cancer, Annu. Biomed. Eng. 2011, 39 (4), 1235-1251.
    • (2011) Annu. Biomed. Eng , vol.39 , Issue.4 , pp. 1235-1251
    • Yoon, D.J.1    Liu, C.T.2    Quinlan, D.S.3    Nafisi, P.M.4    Kamei, D.T.5
  • 62
    • 67649849650 scopus 로고    scopus 로고
    • Folate-targeted therapeutic and imaging agents for cancer
    • P.S. Low, S.A. Kularatne, Folate-targeted therapeutic and imaging agents for cancer, Curr. Opin. Chem. Biol. 2009, 13 (3), 256-262.
    • (2009) Curr. Opin. Chem. Biol , vol.13 , Issue.3 , pp. 256-262
    • Low, P.S.1    Kularatne, S.A.2
  • 66
    • 50249159611 scopus 로고    scopus 로고
    • Targeted singlewall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device
    • S. Dhar, Z. Liu, J. Thomale, H.J. Dai, S.J. Lippard, Targeted singlewall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device, J. Am. Chem. Soc. 2008, 130 (34), 11467-11476.
    • (2008) J. Am. Chem. Soc , vol.130 , Issue.34 , pp. 11467-11476
    • Dhar, S.1    Liu, Z.2    Thomale, J.3    Dai, H.J.4    Lippard, S.J.5
  • 67
    • 77954764578 scopus 로고    scopus 로고
    • Doxorubicin conjugated to D-alphatocopheryl polyethylene glycol succinate and folic acid as a prodrug for targeted chemotherapy
    • V. Anbharasi, N. Cao, S.S. Feng, Doxorubicin conjugated to D-alphatocopheryl polyethylene glycol succinate and folic acid as a prodrug for targeted chemotherapy, J. Biomed. Mater. Res. 2010, A 94 (3), 730-743.
    • (2010) J. Biomed. Mater. Res. A , vol.94 , Issue.3 , pp. 730-743
    • Anbharasi, V.1    Cao, N.2    Feng, S.S.3
  • 69
    • 0016322758 scopus 로고
    • Role of surface carbohydrates in hepatic recognition and transport of circulating glycoproteins
    • G. Ashwell, A.G. Morell, Role of surface carbohydrates in hepatic recognition and transport of circulating glycoproteins, Adv. Enzymol. Relat. Areas Mol. Biol. 1974, 41 99-128.
    • (1974) Adv. Enzymol. Relat. Areas Mol. Biol , vol.41 , pp. 99-128
    • Ashwell, G.1    Morell, A.G.2
  • 70
    • 0021192483 scopus 로고
    • The hepatic asialoglycoprotein receptor
    • A.L. Schwartz, The hepatic asialoglycoprotein receptor, CRC Crit. Rev. Biochem. 1984, 16 (3), 207-233.
    • (1984) CRC Crit. Rev. Biochem , vol.16 , Issue.3 , pp. 207-233
    • Schwartz, A.L.1
  • 71
    • 77953396145 scopus 로고    scopus 로고
    • Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: An in vitro evaluation
    • W. Wei, Z.G. Yue, J.B. Qu, H. Yue, Z.G. Su, G.H. Ma, Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation, Nanomedicine-Uk.2010, 5 (4), 589-596.
    • (2010) Nanomedicine-Uk , vol.5 , Issue.4 , pp. 589-596
    • Wei, W.1    Yue, Z.G.2    Qu, J.B.3    Yue, H.4    Su, Z.G.5    Ma, G.H.6
  • 73
    • 53849093734 scopus 로고    scopus 로고
    • Multifunctional polymeric micelles for enhanced intracellular delivery of doxorubicin to metastatic cancer cells
    • X.B. Xiong, A. Mahmud, H. Uludag, A. Lavasanifar, Multifunctional polymeric micelles for enhanced intracellular delivery of doxorubicin to metastatic cancer cells, Pharm. Res. 2008, 25 (11), 2555-2566.
    • (2008) Pharm. Res , vol.25 , Issue.11 , pp. 2555-2566
    • Xiong, X.B.1    Mahmud, A.2    Uludag, H.3    Lavasanifar, A.4
  • 74
    • 34948876843 scopus 로고    scopus 로고
    • Enhanced cytotoxicity of monoclonal anticancer antibody 2 C5-modified doxorubicin-loaded PEGylated liposomes against various tumor cell lines
    • T.A. Elbayoumi, V.P. Torchilin, Enhanced cytotoxicity of monoclonal anticancer antibody 2 C5-modified doxorubicin-loaded PEGylated liposomes against various tumor cell lines, Eur. J. Pharm. Sci. 2007, 32 (3), 159-168.
    • (2007) Eur. J. Pharm. Sci , vol.32 , Issue.3 , pp. 159-168
    • Elbayoumi, T.A.1    Torchilin, V.P.2
  • 76
    • 80054108776 scopus 로고    scopus 로고
    • Nuclear drug delivery for cancer chemotherapy
    • Meihua Sui, Wenwen Liu, Youqing Shen, Nuclear drug delivery for cancer chemotherapy, Journal of Controlled Release. 2011, 155, 227-236
    • (2011) Journal of Controlled Release , vol.155 , pp. 227-236
    • Sui, M.1    Liu, W.2    Shen, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.