Gremlin is a novel VTA derived neuroprotective factor for dopamine neurons

Brain Research

Volumn 1500, Issue , 2013, Pages 88-98

  Phani, Sudarshan ^a   Jablonski, Michael ^a,b   Pelta Heller, Josh ^a,b   Cai, Jingli ^a,b   Iacovitti, Lorraine ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Dopamine; Gremlin; MPTP; Parkinson's disease; VEGF receptor; Ventral tegmental area

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR 8; GREMLIN; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPROTECTIVE AGENT; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ARTICLE; CELL LOSS; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; VENTRAL TEGMENTUM; WESTERN BLOTTING;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 1-METHYL-4-PHENYLPYRIDINIUM; CELL LINE, TUMOR; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINERGIC NEURONS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; NERVE DEGENERATION; SUBSTANTIA NIGRA; VENTRAL TEGMENTAL AREA;

EID: 84874662218     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.01.017     Document Type: Article

References (30)

1. T. Alexi, and F. Hefti Trophic actions of transforming growth factor alpha on mesencephalic dopaminergic neurons developing in culture Neuroscience 55 1993 903 918 (Pubitemid 23231903)
2. O. Avsian-Kretchmer, and A.J.W. Hsueh Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists Mol. Endocrinol. (Baltimore, Md.) 18 2004 1 12 (Pubitemid 38073149)
3. R.E. Burke, M. Antonelli, and D. Sulzer Glial cell line-derived neurotrophic growth factor inhibits apoptotic death of postnatal substantia nigra dopamine neurons in primary culture J. Neurochem. 71 1998 517 525 (Pubitemid 28480398)
4. B. Connor, and M. Dragunow The role of neuronal growth factors in neurodegenerative disorders of the human brain Brain Res. Rev. 27 1998 1 39 (Pubitemid 28300281)
5. W. Dauer, and S. Przedborski Parkinson's disease: mechanisms and models Neuron 39 2003 889 909 (Pubitemid 37130207)
6. A.E. Donaldson, C.E. Marshall, M. Yang, S. Suon, and L. Iacovitti Purified mouse dopamine neurons thrive and function after transplantation into brain but require novel glial factors for survival in culture Mol. Cell. Neurosci. 30 2005 108 117 (Pubitemid 41133344)
7. J.D. Elsworth, A.Y. Deutch, D.E. Redmond Jr, J.R. Sladek Jr, and R.H. Roth Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum Life Sci. 40 1987 193 202 (Pubitemid 17215383)
8. E. Gomes, L. Papa, T. Hao, and P. Rockwell The VEGFR2 and PKA pathways converge at MEK/ERK1/2 to promote survival in serum deprived neuronal cells Mol. Cell. Biochem. 305 2007 179 190 (Pubitemid 47517180)
9. E. Gomes, and P. Rockwell p38 MAPK as a negative regulator of VEGF/VEGFR2 signaling pathway in serum deprived human SK-N-SH neuroblastoma cells Neurosci. Lett. 431 2008 95 100
10. E. Hirsch, A.M. Graybiel, and Y.A. Agid Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease Nature 334 1988 345 348
11. J.G. Hou, L.F. Lin, and C. Mytilineou Glial cell line-derived neurotrophic factor exerts neurotrophic effects on dopaminergic neurons in vitro and promotes their survival and regrowth after damage by 1-methyl-4- phenylpyridinium J. Neurochem. 66 1996 74 82 (Pubitemid 26010766)
12. D. Hsu, A. Economides, X. Wang, and P. Eimon The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities Mol. Cell. 1 1998 673 683 (Pubitemid 128379245)
13. N.W. Isaacs Cystine knots Curr. Opin. Struct. Biol. 5 1995 391 395
14. D.M. Jacobowitz, R.S. Burns, C.C. Chiueh, and I.J. Kopin N-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP) causes destruction of the nigrostriatal but not the mesolimbic dopamine system in the monkey Psychopharmacol. Bull. 20 1984 416 422 (Pubitemid 14091003)
15. Janowsky, A., Neve, K., Eshleman, A.J., 2001. Uptake and release of neurotransmitters. Current protocols in neuroscience/editorial board, Jacqueline N. Crawley... [et al.]. (Chapter 7), Unit 7.9.
16. M. Kessler The human tyrosine hydroxylase gene promoter Mol. Brain Res. 112 2003 8 23 (Pubitemid 36369242)
17. M.K. Khokha, D. Hsu, L.J. Brunet, M.S. Dionne, and R.M. Harland Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning Nat. Genet. 34 2003 303 307 (Pubitemid 36792863)
18. D. Kirik, B. Georgievska, and A. Bjorklund Localized striatal delivery of GDNF as a treatment for Parkinson disease Nat. Neurosci. 7 2004 105 110 (Pubitemid 38129784)
19. W. Le, O.M. Conneely, Y. He, J. Jankovic, and S.H. Appel Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury J. Neurochem. 73 1999 2218 2221 (Pubitemid 29491838)
20. S. Mitola, C. Ravelli, E. Moroni, V. Salvi, D. Leali, K. Ballmer-Hofer, L. Zammataro, and M. Presta Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2 Blood 116 2010 3677 3680
21. T.F. Oo, N. Kholodilov, and R.E. Burke Regulation of natural cell death in dopaminergic neurons of the substantia nigra by striatal glial cell line-derived neurotrophic factor in vivo J. Neurosci. Off. J. Soc. Neurosci. 23 2003 5141 5148 (Pubitemid 36793242)
22. J.J. Pearce, G. Penny, and J. Rossant A mouse cerberus/Dan-related gene family Dev. Biol. 209 1999 98 110 (Pubitemid 29194316)
23. S. Phani, G. Gonye, and L. Iacovitti VTA neurons show a potentially protective transcriptional response to MPTP Brain Res. 1343 2010 1 13
24. S. Piccolo, E. Agius, B. Lu, S. Goodman, L. Dale, and E.M. De Robertis Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity Cell 91 1997 407 416 (Pubitemid 27467971)
25. M. Piltonen, A. Planken, O. Leskela, T.T. Myohanen, A.L. Hanninen, P. Auvinen, K. Alitalo, J.O. Andressoo, M. Saarma, and P.T. Mannisto Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo Neuroscience 192 2011 550 563
26. J.S. Schneider, A. Yuwiler, and C.H. Markham Selective loss of subpopulations of ventral mesencephalic dopaminergic neurons in the monkey following exposure to MPTP Brain Res. 411 1987 144 150 (Pubitemid 17084779)
27. W.C. Smith, and R.M. Harland Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos Cell 70 1992 829 840
28. A. Tomac, E. Lindqvist, L.F. Lin, S.O. Ogren, D. Young, B.J. Hoffer, and L. Olson Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo Nature 373 1995 335 339
29. L.Z. Topol, W.S. Modi, S. Koochekpour, and D.G. Blair DRM/GREMLIN (CKTSF1B1) maps to human chromosome 15 and is highly expressed in adult and fetal brain Cytogenet. Cell Genet. 89 2000 79 84 (Pubitemid 30435263)
30. T. Yasuhara, T. Shingo, K. Kobayashi, A. Takeuchi, A. Yano, K. Muraoka, T. Matsui, Y. Miyoshi, H. Hamada, and I. Date Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of Parkinson's disease Eur. J. Neurosci. 19 2004 1494 1504 (Pubitemid 38437912)