Synovial tissue analysis for the discovery of diagnostic and prognostic biomarkers in patients with early arthritis

Journal of Rheumatology

Volumn 38, Issue 9, 2011, Pages 2068-2072

  De Hair, Maria J H ^a   Harty, Leonard C ^b   Gerlag, Danielle M ^a   Pitzalis, Costantino ^c   Veale, Douglas J ^b   Tak, Paul P ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Biomarker; Early arthritis; Synovium

Indexed keywords

CD68 ANTIGEN; CYTOKINE;

ANGIOGENESIS; ANTIGEN EXPRESSION; ARTHRITIS; ARTHROSCOPY; CELL INFILTRATION; CONFERENCE PAPER; DISEASE ACTIVITY; DISEASE ACTIVITY SCORE 28; DISEASE MARKER; DNA MICROARRAY; DOPPLER ECHOGRAPHY; EARLY DIAGNOSIS; GENE EXPRESSION PROFILING; HUMAN; JOINT BIOPSY; JOINT DESTRUCTION; MACROPHAGE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SCORING SYSTEM; SYNOVITIS; SYNOVIUM;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; ARTHRITIS, RHEUMATOID; B-LYMPHOCYTE SUBSETS; BIOLOGICAL MARKERS; EARLY DIAGNOSIS; HUMANS; MACROPHAGES; PROGNOSIS; SYNOVIAL MEMBRANE; T-LYMPHOCYTE SUBSETS;

EID: 80052307481     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.110426     Document Type: Conference Paper

References (40)

1. Tak P.P., Bresnihan B. The pathogenesis and prevention of joint damage in rheumatoid arthritis: Advances from synovial biopsy and tissue analysis. Arthritis Rheum 2000;43:2619-2633 (Pubitemid 32001727)
2. Finckh A., Liang M.H., Van Herckenrode C.M., De Pablo P. Long-term impact of early treatment on radiographic progression in rheumatoid arthritis: A meta-analysis. Arthritis Rheum 2006;55:864-872 (Pubitemid 44917458)
3. Tak P.P. Analyzing synovial tissue samples. What can we learn about early rheumatoid arthritis, the heterogeneity of the disease, and the effects of treatment? J Rheumatol Suppl 2005;72:25-26 (Pubitemid 40075948)
4. Smith M.D., Barg E., Weedon H., Papengelis V., Smeets T., Tak P.P., et al. Microarchitecture and protective mechanisms in synovial tissue from clinically and arthroscopically normal knee joints. Ann Rheum Dis 2003;62:303-307 (Pubitemid 36363434)
5. Tak P.P., Smeets T.J., Daha M.R., Kluin P.M., Meijers K.A., Brand R., et al. Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity. Arthritis Rheum 1997;40:217-225 (Pubitemid 27114085)
6. Fearon U., Veale D.J. Angiogenesis in arthritis: Methodological and analytical details. Methods Mol Med 2007;135:343-357
7. Kennedy A., Ng C.T., Biniecka M., Saber T., Taylor C., O'Sullivan J., et al. Angiogenesis and blood vessel stability in inflammatory arthritis. Arthritis Rheum 2010;62:711-721
8. Biniecka M., Kennedy A., Fearon U., Ng C.T., Veale D.J., O'Sullivan J.N. Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint. Ann Rheum Dis 2010;69:1172-1178
9. Gerlag D.M., Borges E., Tak P.P., Ellerby H.M., Bredesen D.E., Pasqualini R., et al. Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature. Arthritis Res 2001;3:357-361 (Pubitemid 33077115)
10. Van de Sande M.G., Gerlag D.M., Lodde B.M., Van Baarsen L.G., Alivernini S., Codullo V., et al. Evaluating antirheumatic treatment using synovial biopsy: A recommendation for standardisation to be used in clinical trials. Ann Rheum Dis 2011;70:423-427
11. Gerlag D.M., Tak P.P. How to perform and analyse synovial biopsies. Best Pract Res Clin Rheumatol 2009;23:221-232
12. Scire C.A., Epis O., Codullo V., Humby F., Morbini P., Manzo A., et al. Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: Validation of a minimally invasive ultrasound-guided synovial biopsy procedure. Arthritis Res Ther 2007;9:R101.
13. Reece R.J., Canete J.D., Parsons W.J., Emery P., Veale D.J. Distinct vascular patterns of early synovitis in psoriatic, reactive, and rheumatoid arthritis. Arthritis Rheum 1999;42:1481-1484 (Pubitemid 30265607)
14. Gerlag D.M., Tak P.P. Novel approaches for the treatment of rheumatoid arthritis: Lessons from the evaluation of synovial biomarkers in clinical trials. Best Pract Res Clin Rheumatol 2008;22:311-323 (Pubitemid 351606951)
15. Van der Pouw Kraan T.C., Wijbrandts C.A., Van Baarsen L.G., Rustenburg F., Baggen J.M., Verweij C.L., et al. Responsiveness to anti-tumour necrosis factor alpha therapy is related to pre-treatment tissue inflammation levels in rheumatoid arthritis patients. Ann Rheum Dis 2008;67:563-566 (Pubitemid 351498442)
16. Wijbrandts C.A., Dijkgraaf M.G., Kraan M.C., Vinkenoog M., Smeets T.J., Dinant H., et al. The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor alpha expression in the synovium. Ann Rheum Dis 2008;67:1139-1144
17. Gerlag D.M., Haringman J.J., Smeets T.J., Zwinderman A.H., Kraan M.C., Laud P.J., et al. Effects of oral prednisolone on biomarkers in synovial tissue and clinical improvement in rheumatoid arthritis. Arthritis Rheum 2004;50:3783-3791 (Pubitemid 39643925)
18. Kavanaugh A., Rosengren S., Lee S.J., Hammaker D., Firestein G.S., Kalunian K., et al. Assessment of rituximab's immunomodulatory synovial effects (ARISE trial). 1: Clinical and synovial biomarker results. Ann Rheum Dis 2008;67:402-408 (Pubitemid 351281278)
19. Vos K., Thurlings R.M., Wijbrandts C.A., Van Schaardenburg D., Gerlag D.M., Tak P.P. Early effects of rituximab on the synovial cell infiltrate in patients with rheumatoid arthritis. Arthritis Rheum 2007;56:772-778 (Pubitemid 46399424)
20. Haringman J.J., Gerlag D.M., Zwinderman A.H., Smeets T.J., Kraan M.C., Baeten D., et al. Synovial tissue macrophages: A sensitive biomarker for response to treatment in patients with rheumatoid arthritis. Ann Rheum Dis 2005;64:834-838 (Pubitemid 40733904)
21. Wijbrandts C.A., Vergunst C.E., Haringman J.J., Gerlag D.M., Smeets T.J., Tak P.P. Absence of changes in the number of synovial sublining macrophages after ineffective treatment for rheumatoid arthritis: Implications for use of synovial sublining macrophages as a biomarker. Arthritis Rheum 2007;56:3869-3871 (Pubitemid 350100720)
22. Bresnihan B., Pontifex E., Thurlings R.M., Vinkenoog M., El-Gabalawy H., Fearon U., et al. Synovial tissue sublining CD68 expression is a biomarker of therapeutic response in rheumatoid arthritis clinical trials: Consistency across centers. J Rheumatol 2009;36:1800-1802
23. Kraan M.C., Reece R.J., Barg E.C., Smeets T.J., Farnell J., Rosenburg R., et al. Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine patients at two centers. Arthritis Rheum 2000;43:1820-1830
24. Smeets T.J., Kraan M.C., Van Loon M.E., Tak P.P. Tumor necrosis factor alpha blockade reduces the synovial cell infiltrate early after initiation of treatment, but apparently not by induction of apoptosis in synovial tissue. Arthritis Rheum 2003;48:2155-2162 (Pubitemid 36959195)
25. Haringman J.J., Kraan M.C., Smeets T.J., Zwinderman K.H., Tak P.P. Chemokine blockade and chronic inflammatory disease: Proof of concept in patients with rheumatoid arthritis. Ann Rheum Dis 2003;62:715-721 (Pubitemid 36886404)
26. Haringman J.J., Gerlag D.M., Smeets T.J., Baeten D., Van den Bosch F., Bresnihan B., et al. A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis. Arthritis Rheum 2006;54:2387-2392 (Pubitemid 44204998)
27. Vergunst C.E., Gerlag D.M., Dinant H., Schulz L., Vinkenoog M., Smeets T.J., et al. Blocking the receptor for C5a in patients with rheumatoid arthritis does not reduce synovial inflammation. Rheumatology 2007;46:1773-1778 (Pubitemid 350168291)
28. Thurlings R.M., Vos K., Wijbrandts C.A., Zwinderman A.H., Gerlag D.M., Tak P.P. Synovial tissue response to rituximab: Mechanism of action and identification of biomarkers of response. Ann Rheum Dis 2008;67:917-925 (Pubitemid 351956651)
29. Vergunst C.E., Gerlag D.M., Lopatinskaya L., Klareskog L., Smith M.D., Van den Bosch F., et al. Modulation of CCR2 in rheumatoid arthritis: A double-blind, randomized, placebo-controlled clinical trial. Arthritis Rheum 2008;58:1931-1939 (Pubitemid 351988084)
30. Van Kuijk A.W., Vergunst C.E., Gerlag D.M., Bresnihan B., Gomez-Reino J.J., Rouzier R., et al. CCR5 blockade in rheumatoid arthritis: A randomised, double-blind, placebo-controlled clinical trial. Ann Rheum Dis 2010;69:2013-2016
31. Drossaers-Bakker K.W., Zwinderman A.H., Vliet Vlieland T.P., Van Zeben D., Vos K., Breedveld F.C., et al. Long-term outcome in rheumatoid arthritis: A simple algorithm of baseline parameters can predict radiographic damage, disability, and disease course at 12-year followup. Arthritis Rheum 2002;47:383-390 (Pubitemid 34856126)
32. Mottonen T., Hannonen P., Korpela M., Nissila M., Kautiainen H., Ilonen J., et al. Delay to institution of therapy and induction of remission using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis. Arthritis Rheum 2002;46:894-898 (Pubitemid 34303799)
33. Scott D.L. The diagnosis and prognosis of early arthritis: Rationale for new prognostic criteria. Arthritis Rheum 2002;46:286-290 (Pubitemid 34136565)
34. Haupl T., Stuhlmuller B., Grutzkau A., Radbruch A., Burmester G.R. Does gene expression analysis inform us in rheumatoid arthritis? Ann Rheum Dis 2010;69 Suppl 1:i37-i42.
35. Van Baarsen L.G., Wijbrandts C.A., Timmer T.C., Van der Pouw Kraan T.C., Tak P.P., Verweij C.L. Synovial tissue heterogeneity in rheumatoid arthritis in relationship to disease activity and biomarkers in peripheral blood. Arthritis Rheum 2010;62:1602-1607
36. Van der Pouw Kraan T.C., Van Gaalen F.A., Kasperkovitz P.V., Verbeet N.L., Smeets T.J., Kraan M.C., et al. Rheumatoid arthritis is a heterogeneous disease: Evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues. Arthritis Rheum 2003;48:2132-2145 (Pubitemid 36959193)
37. Aletaha D., Neogi T., Silman A.J., Funovits J., Felson D.T., Bingham C.O. III, et al. 2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010;62:2569-2581
38. Aletaha D., Neogi T., Silman A.J., Funovits J., Felson D.T., Bingham C.O. III, et al. 2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 2010;69:1580-1588
39. Visser H., le Cessie S., Vos K., Breedveld F.C., Hazes J.M. How to diagnose rheumatoid arthritis early: A prediction model for persistent (erosive) arthritis. Arthritis Rheum 2002;46:357-365 (Pubitemid 34136572)
40. Boers M., Brooks P., Strand C.V., Tugwell P. The OMERACT filter for Outcome Measures in Rheumatology. J Rheumatol 1998;25:198-199