Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 6, 2013, Pages 1604-1607

  Zhang, Xiaojun ^a   Glunz, Peter W ^a   Jiang, Wen ^a   Schmitt, Aaron ^a   Newman, Makenzie ^a   Barbera, Frank A ^a   Bozarth, Jeffery M ^a   Rendina, Alan R ^a   Wei, Anzhi ^a   Wen, Xiao ^a   Rossi, Karen A ^a   Luettgen, Joseph M ^a   Wong, Pancras C ^a   Knabb, Robert M ^a   Wexler, Ruth R ^a   Scott Priestley, E ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Bicyclic pyrazinone; Bicyclic pyrimidinone; TF FVIIa inhibitor

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 11A; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 7A INHIBITOR; BLOOD CLOTTING FACTOR 9A; CHYMOTRYPSIN; PYRAZINE DERIVATIVE; PYRAZINONE AMIDE; PYRIMIDINONE AMIDE; PYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BINDING AFFINITY; BLOOD CLOTTING; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; HYDROGEN BOND; HYDROPHOBICITY; LIPOPHILICITY; X RAY CRYSTALLOGRAPHY;

AMIDES; AMIDINES; BICYCLO COMPOUNDS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FACTOR VIIA; PROTEIN BINDING; PYRAZINES; PYRIMIDINONES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84874654706     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.01.094     Document Type: Article

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