Type 2 diabetes mellitus and exercise impairment

Reviews in Endocrine and Metabolic Disorders

Volumn 14, Issue 1, 2013, Pages 77-86

  Reusch, Jane E B ^a,b   Bridenstine, Mark ^b   Regensteiner, Judith G ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Diabetes; Diastolic dysfunction; Endothelial function; Exercise capacity; Vascular

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PLACEBO; ROSIGLITAZONE;

AEROBIC EXERCISE; BICYCLE ERGOMETRY; BLOOD FLOW; BLOOD OXYGEN TENSION; CAPILLARY BASEMENT MEMBRANE; CARDIOVASCULAR MAGNETIC RESONANCE; CARDIOVASCULAR MORTALITY; DIABETIC PATIENT; DISEASE MODEL; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; EXERCISE; FITNESS; GLYCEMIC CONTROL; HEART MUSCLE PERFUSION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; INSULIN SENSITIVITY; LEFT VENTRICULAR DIASTOLIC DYSFUNCTION; LIFESTYLE; METABOLIC SYNDROME X; MUSCLE BLOOD FLOW; MUSCLE ISOMETRIC CONTRACTION; NEAR INFRARED SPECTROSCOPY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PLETHYSMOGRAPHY; PROCESS OPTIMIZATION; PROTEIN EXPRESSION; PUBLIC HEALTH SERVICE; REVIEW; SPRAGUE DAWLEY RAT;

ANIMALS; DIABETES MELLITUS, TYPE 2; ENDOTHELIUM, VASCULAR; EXERCISE; HUMANS; MUSCLE, SKELETAL; PHYSICAL FITNESS;

EID: 84874648470     PISSN: 13899155     EISSN: 15732606     Source Type: Journal    
DOI: 10.1007/s11154-012-9234-4     Document Type: Review

References (87)

1. Church TS, Thomas DM, Tudor-Locke C, Katzmarzyk PT, Earnest CP, Rodarte RQ, et al. Trends over 5 decades in U.S. occupation-related physical activity and their associations with obesity. PLoS One. 2011;6(5):e19657. doi: 10.1371/journal.pone.0019657.
2. Olshansky SJ, Passaro DJ, Hershow RC, Layden J, Carnes BA, Brody J, et al. A potential decline in life expectancy in the United States in the 21st century. N Engl J Med. 2005;352(11):1138-45. (Pubitemid 40365358)
3. Bauer TA, Reusch JE, Levi M, Regensteiner JG. Skeletal muscle deoxygenation following the onset of moderate exercise suggests slowed microvascular blood flow kinetics in type 2 diabetes. Diabetes Care. 2007
4. Brandenburg SL, Reusch JE, Bauer TA, Jeffers BW, Hiatt WR, Regensteiner JG. Effects of exercise training on oxygen uptake kinetic responses in women with type 2 diabetes. Diabetes Care. 1999;22(10):1640-6. (Pubitemid 29458386)
5. Nadeau KJ, Regensteiner JG, Bauer TA, Brown MS, Dorosz JL, Hull A, et al. Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function. J Clin Endocrinol Metab. 2009
6. Nadeau KJ, Regensteiner JG, Bauer TA, Brown MS, Dorosz JL, Hull A, et al. Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function. J Clin Endocrinol Metab. 2010;95(2):513-21.
7. Vamos EP, Millett C, Parsons C, Aylin P, Majeed A, Bottle A. Nationwide study on trends in hospital admissions for major cardiovascular events and procedures among people with and without diabetes in England, 2004-2009. Diabetes Care. 2012;35(2):265-72. doi: 10.2337/dc11-1682.
8. Center for Disease Contro and Preventionl. Data and statistics: diabetes data & trends. 2011.
9. Wei M, Gibbons LW, Kampert JB, Nichaman MZ, Blair SN. Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with type 2 diabetes. Ann Intern Med. 2000;132(8):605-11. (Pubitemid 30217552)
10. Wei M, Kampert JB, Barlow CE, Nichaman MZ, Gibbons LW, Paffenbarger Jr RS, et al. Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. JAMA. 1999;282(16):1547-53. (Pubitemid 29504048)
11. Weintraub WS, Daniels SR, Burke LE, Franklin BA, Goff Jr DC, Hayman LL, et al. Value of primordial and primary prevention for cardiovascular disease: a policy statement from the American Heart Association. Circulation. 2011;124(8):967-90.
12. Centers for Disease Control and Prevention. Data and statistics: obesity rates among all children in the United States 2010. http://www.cdc.gov/obesity/ data/childhood.html.
13. Lee CD, Blair SN, Jackson AS. Cardiorespiratory fitness, body composition, and all-cause and cardiovascular disease mortality in men. Am J Clin Nutr. 1999;69(3):373-80. (Pubitemid 29104555)
14. Lee DC, Artero EG, Sui X, Blair SN. Mortality trends in the general population: the importance of cardiorespiratory fitness. J Psychopharmacol. 2010;24(4 Suppl):27-35. doi: 10.1177/1359786810382057.
15. Kokkinos P, Myers J, Nylen E, Panagiotakos DB, Manolis A, Pittaras A, et al. Exercise capacity and all-cause mortality in African American and Caucasian men with type 2 diabetes. Diabetes Care. 2009;32(4):623-8. doi: 10.2337/dc08-1876.
16. Lee DC, Sui X, Ortega FB, Kim YS, Church TS, Winett RA, et al. Comparisons of leisure-time physical activity and cardiorespiratory fitness as predictors of all-cause mortality in men and women. Br J Sports Med. 2011;45(6):504-10. doi: 10.1136/bjsm.2009.066209.
17. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346(11):793-801. doi: 10.1056/NEJMoa011858. (Pubitemid 34987553)
18. Nelson KM, Boyko EJ, Koepsell T. All-cause mortality risk among a national sample of individuals with diabetes. Diabetes Care. 2010;33(11):2360-4. doi: 10.2337/dc10-0846.
19. Reddigan JI, Riddell MC, Kuk JL. The joint association of physical activity and glycaemic control in predicting cardiovascular death and all-cause mortality in the US population. Diabetologia. 2012;55(3):632-5. doi: 10.1007/s00125-011-2374-3.
20. Sluik D, Buijsse B, Muckelbauer R, Kaaks R, Teucher B, Johnsen NF, et al. Physical activity and mortality in individuals with diabetes mellitus: a prospective study and meta-analysis. Arch Intern Med. 2012;1-11. doi: 10.1001/archinternmed.2012.3130.
21. Manson JE, Rimm EB, Stampfer MJ, Colditz GA, Willett WC, Krolewski AS, et al. Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet. 1991;338(8770):774-8.
22. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346(6):393-403. doi: 10.1056/NEJMoa012512. (Pubitemid 34437694)
23. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344(18):1343-50. doi: 10.1056/NEJM200105033441801. (Pubitemid 32378388)
24. Hamman RF, Wing RR, Edelstein SL, Lachin JM, Bray GA, Delahanty L, et al. Effect of weight loss with lifestyle intervention on risk of diabetes. Diabetes Care. 2006;29(9):2102-7. doi: 10.2337/dc06-0560. (Pubitemid 44871194)
25. InterAct Consortium. Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study. Diabetologia. 2012;55(7):1944-52. doi: 10.1007/s00125-012- 2532-2.
26. Sieverdes JC, Sui X, Lee DC, Church TS, McClain A, Hand GA, et al. Physical activity, cardiorespiratory fitness and the incidence of type 2 diabetes in a prospective study of men. Br J Sports Med. 2010;44(4):238-44. doi: 10.1136/bjsm.2009.062117.
27. Bouchard C, Blair SN, Church TS, Earnest CP, Hagberg JM, Hakkinen K, et al. Adverse metabolic response to regular exercise: is it a rare or common occurrence? PLoS One. 2012;7(5):e37887. doi: 10.1371/journal.pone.0037887.
28. Regensteiner JG, Sippel J, McFarling ET, Wolfel EE, Hiatt WR. Effects of non-insulin-dependent diabetes on oxygen consumption during treadmill exercise. Med Sci Sports Exerc. 1995;27(5):661-7.
29. Bouchard C, Leon AS, Rao DC, Skinner JS, Wilmore JH, Gagnon J. The HERITAGE family study. Aims, design, and measurement protocol. Med Sci Sports Exerc. 1995;27(5):721-9.
30. Morss GM, Jordan AN, Skinner JS, Dunn AL, Church TS, Earnest CP, et al. Dose response to exercise in women aged 45-75 yr (DREW): design and rationale. Med Sci Sports Exerc. 2004;36(2):336-44. doi: 10.1249/01.MSS.0000113738.06267. E5. (Pubitemid 38177065)
31. Sisson SB, Katzmarzyk PT, Earnest CP, Bouchard C, Blair SN, Church TS. Volume of exercise and fitness nonresponse in sedentary, postmenopausal women. Med Sci Sports Exerc. 2009;41(3):539-45. doi: 10.1249/MSS.0b013e3181896c4e.
32. Slentz CA, Aiken LB, Houmard JA, Bales CW, Johnson JL, Tanner CJ, et al. Inactivity, exercise, and visceral fat. STRRIDE: a randomized, controlled study of exercise intensity and amount. J Appl Physiol. 2005;99(4):1613-8. doi: 10.1152/japplphysiol.00124.2005. (Pubitemid 43014374)
33. Thompson AM, Mikus CR, Rodarte RQ, Distefano B, Priest EL, Sinclair E, et al. Inflammation and exercise (INFLAME): study rationale, design, and methods. Contemp Clin Trials. 2008;29(3):418-27. doi: 10.1016/j.cct.2007.09.009. (Pubitemid 351509808)
34. Booth FW, Laye MJ, Roberts MD. Lifetime sedentary living accelerates some aspects of secondary aging. J Appl Physiol. 2012;111(5):1497-504.
35. Kokkinos P, Myers J, Faselis C, Panagiotakos DB, Doumas M, Pittaras A, et al. Exercise capacity and mortality in older men: a 20-year follow-up study. Circulation. 2010;122(8):790-7.
36. Schneider SH, Amorosa LF, Khachadurian AK, Ruderman NB. Studies on the mechanism of improved glucose control during regular exercise in type 2 (non-insulin-dependent) diabetes. Diabetologia. 1984;26(5):355-60. (Pubitemid 14110081)
37. Kjaer M, Hollenbeck CB, Frey-Hewitt B, Galbo H, Haskell W, Reaven GM. Glucoregulation and hormonal responses to maximal exercise in non-insulin-dependent diabetes. J Appl Physiol. 1990;68(5):2067-74. (Pubitemid 20183098)
38. Mac Ananey O, Malone J, Warmington S, O'Shea D, Green S, Egana M. Cardiac output is not related to the slowed O2 uptake kinetics in type 2 diabetes. Med Sci Sports Exerc. 2011;43(6):935-42. doi: 10.1249/MSS.0b013e3182061cdb.
39. Regensteiner JG, Bauer TA, Reusch JE, Quaife RA, Chen MY, Smith SC, et al. Cardiac dysfunction during exercise in uncomplicated type 2 diabetes. Med Sci Sports Exerc. 2009;41(5):977-84. doi: 10.1249/MSS.0b013e3181942051.
40. Regensteiner JG, Sippel J, McFarling ET, Wolfel EE, Hiatt WR. Effects of non-insulin-dependent diabetes on oxygen consumption during treadmill exercise. Med Sci Sports Exerc. 1995;27(6):875-81.
41. Gusso S, Hofman P, Lalande S, Cutfield W, Robinson E, Baldi JC. Impaired stroke volume and aerobic capacity in female adolescents with type 1 and type 2 diabetes mellitus. Diabetologia. 2008;51(7):1317-20. doi: 10.1007/s00125-008- 1012-1.
42. Wilkerson DP, Poole DC, Jones AM, Fulford J, Mawson DM, Ball CI, et al. Older type 2 diabetic males do not exhibit abnormal pulmonary oxygen uptake and muscle oxygen utilization dynamics during submaximal cycling exercise. Am J Physiol Regul Integr Comp Physiol. 2011;300(3):R685-92. doi: 10.1152/ajpregu.00479.2010.
43. Fang ZY, Sharman J, Prins JB, Marwick TH. Determinants of exercise capacity in patients with type 2 diabetes. Diabetes Care. 2005;28(7):1643-8. (Pubitemid 41340903)
44. Ribisl PM, Lang W, Jaramillo SA, Jakicic JM, Stewart KJ, Bahnson J, et al. Exercise capacity and cardiovascular/metabolic characteristics of overweight and obese individuals with type 2 diabetes: the Look AHEAD clinical trial. Diabetes Care. 2007;30(10):2679-84. doi: 10.2337/dc06-2487. (Pubitemid 47554229)
45. Hollenbeck CB, Chen N, Chen YD, Reaven GM. Relationship between the plasma insulin response to oral glucose and insulin-stimulated glucose utilization in normal subjects. Diabetes. 1984;33(5):460-3. (Pubitemid 14105632)
46. Laws A, Reaven GM. Effect of physical activity on age-related glucose intolerance. Clin Geriatr Med. 1990;6(4):849-63. (Pubitemid 20381246)
47. Reusch JE, Regensteiner JG, Watson PA. Novel actions of thiazolidinediones on vascular function and exercise capacity. Am J Med. 2003;115(Suppl 8A):69S-74. (Pubitemid 37532895)
48. Schneider SH, Khachadurian AK, Amorosa LF, Gavras H, Fineberg SE, Ruderman NB. Abnormal glucoregulation during exercise in type II (non-insulin-dependent) diabetes. Metabolism. 1987;36(12):1161-6.
49. Regensteiner JG, Bauer TA, Reusch JE, Brandenburg SL, Sippel JM, Vogelsong AM, et al. Abnormal oxygen uptake kinetic responses in women with type II diabetes mellitus. J Appl Physiol. 1998;85(1):310-7. (Pubitemid 28334941)
50. DeFronzo RA, Hendler R, Simonson D. Insulin resistance is a prominent feature of insulin-dependent diabetes. Diabetes. 1982;31(9):795-801. (Pubitemid 12062869)
51. Yki-Jarvinen H, Kiviluoto T, Taskinen MR. Insulin resistance is a prominent feature of patients with pancreatogenic diabetes. Metabolism. 1986;35(8):718-27. (Pubitemid 16040623)
52. Yki-Jarvinen H, Koivisto VA. Natural course of insulin resistance in type I diabetes. N Engl J Med. 1986;315(4):224-30. (Pubitemid 16097124)
53. Williams KV, Erbey JR, Becker D, Arslanian S, Orchard TJ. Can clinical factors estimate insulin resistance in type 1 diabetes? Diabetes. 2000;49(4):626-32. (Pubitemid 30183752)
54. Orchard TJ, Olson JC, Erbey JR, Williams K, Forrest KY, Smithline Kinder L, et al. Insulin resistance-related factors, but not glycemia, predict coronary artery disease in type 1 diabetes: 10-year follow-up data from the Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes Care. 2003;26(5):1374-9. (Pubitemid 36929165)
55. Kilpatrick ES, Rigby AS, Atkin SL. Insulin resistance, the metabolic syndrome, and complication risk in type 1 diabetes: "double diabetes" in the Diabetes Control and Complications Trial. Diabetes Care. 2007;30(3):707-12. (Pubitemid 46354357)
56. Soedamah-Muthu SS, Chaturvedi N, Toeller M, Ferriss B, Reboldi P, Michel G, et al. Risk factors for coronary heart disease in type 1 diabetic patients in Europe: the EURODIAB Prospective Complications Study. Diabetes Care. 2004;27(2):530-7. (Pubitemid 38174083)
57. Regensteiner JG, Bauer TA, Reusch JE. Rosiglitazone improves exercise capacity in individuals with type 2 diabetes. [Comparative Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.]. Diabetes Care. 2005;28(12):2877-83. (Pubitemid 43942918)
58. Poirier P, Garneau C, Bogaty P, Nadeau A, Marois L, Brochu C, et al. Impact of left ventricular diastolic dysfunction on maximal treadmill performance in normotensive subjects with well-controlled type 2 diabetes mellitus. Am J Cardiol. 2000;85(4):473-7. (Pubitemid 30089624)
59. Diamant M, Lamb HJ, Groeneveld Y, Endert EL, Smit JW, Bax JJ, et al. Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus. J Am Coll Cardiol. 2003;42(2):328-35. (Pubitemid 36851426)
60. Wong TC, Piehler K, Meier CG, Testa SM, Klock AM, Aneizi AA, et al. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality. Circulation. 2012;126(10):1206-16.
61. Schindler TH, Facta AD, Prior JO, Cadenas J, Hsueh WA, Quinones MJ, et al. Improvement in coronary vascular dysfunction produced with euglycaemic control in patients with type 2 diabetes. Heart. 2007;93(3):345-9. doi: 10.1136/hrt.2006.094128. (Pubitemid 46579525)
62. Joshi D, Shiwalkar A, Cross MR, Sharma SK, Vachhani A, Dutt C. Continuous, non-invasive measurement of the haemodynamic response to submaximal exercise in patients with diabetes mellitus: evidence of impaired cardiac reserve and peripheral vascular response. Heart. 2010;96(1):36-41. doi: 10.1136/hrt.2009.177113.
63. Brassard P, Legault S, Garneau C, Bogaty P, Dumesnil JG, Poirier P. Normalization of diastolic dysfunction in type 2 diabetics after exercise training. Med Sci Sports Exerc. 2007;39(11):1896-901. doi: 10.1249/mss. 0b013e318145b642. (Pubitemid 350073351)
64. DeFronzo RA, Gunnarsson R, Bjorkman O, Olsson M, Wahren J. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest. 1985;76(1):149-55. (Pubitemid 15240430)
65. Befroy DE, Petersen KF, Dufour S, Mason GF, de Graaf RA, Rothman DL, et al. Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients. Diabetes. 2007;56(5):1376-81. (Pubitemid 46715630)
66. Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med. 2004;350(7):664-71. (Pubitemid 38364625)
67. Scheuermann-Freestone M, Madsen PL, Manners D, Blamire AM, Buckingham RE, Styles P, et al. Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes. Circulation. 2003;107(24):3040-6. (Pubitemid 36758977)
68. Barrett EJ, Eggleston EM, Inyard AC, Wang H, Li G, Chai W, et al. The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action. Diabetologia. 2009;52(5):752-64. doi: 10.1007/s00125-009-1313-z.
69. Barrett EJ, Rattigan S. Muscle perfusion: its measurement and role in metabolic regulation. Diabetes. 2012;61(11):2661-8.
70. Liu Z, Liu J, Jahn LA, Fowler DE, Barrett EJ. Infusing lipid raises plasma free fatty acids and induces insulin resistance in muscle microvasculature. J Clin Endocrinol Metab. 2009;94(9):3543-9.
71. Sanchez OA, Copenhaver EA, Chance MA, Fowler MJ, Towse TF, Kent-Braun JA, et al. Postmaximal contraction blood volume responses are blunted in obese and type 2 diabetic subjects in a muscle-specific manner. Am J Physiol Heart Circ Physiol. 2011;301(2):H418-27.
72. Williamson JR, Chang K, Frangos M, Hasan KS, Ido Y, Kawamura T, et al. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes. 1993;42(6):801-13. (Pubitemid 23151571)
73. He J, Watkins S, Kelley DE. Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity. Diabetes. 2001;50(4):817-23. (Pubitemid 32242639)
74. Clark MG. Impaired microvascular perfusion: a consequence of vascular dysfunction and a potential cause of insulin resistance in muscle. Am J Physiol Endocrinol Metab. 2008;295(4):E732-50.
75. Mikus CR, Fairfax ST, Libla JL, Boyle LJ, Vianna LC, Oberlin DJ, et al. Seven days of aerobic exercise training improves conduit artery blood flow following glucose ingestion in patients with type 2 diabetes. J Appl Physiol. 2011;111(3):657-64.
76. Green HJ, Burnett M, Kollias H, Ouyang J, Smith I, Tupling S. Can increases in capillarization explain the early adaptations in metabolic regulation in human muscle to short-term training? Can J Physiol Pharmacol. 2012;90(5):557-66.
77. Mackenzie RW, Watt PW, Maxwell NS. Acute normobaric hypoxia stimulates erythropoietin release. High Alt Med Biol. 2008;9(1):28-37. (Pubitemid 351363937)
78. Mackenzie R, Maxwell N, Castle P, Brickley G, Watt P. Acute hypoxia and exercise improve insulin sensitivity (S(I) (2*)) in individuals with type 2 diabetes. Diabetes Metab Res Rev. 2011;27(1):94-101.
79. Mackenzie R, Maxwell N, Castle P, Elliott B, Brickley G, Watt P. Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes. J Clin Endocrinol Metab. 2012;97(4):E546-55.
80. Nisoli E, Clementi E, Paolucci C, Cozzi V, Tonello C, Sciorati C, et al. Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science. 2003;299(5608):896-9. (Pubitemid 36182449)
81. Nisoli E, Tonello C, Cardile A, Cozzi V, Bracale R, Tedesco L, et al. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science. 2005;310(5746):314-7. (Pubitemid 41457197)
82. Gutsaeva DR, Carraway MS, Suliman HB, Demchenko IT, Shitara H, Yonekawa H, et al. Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. J Neurosci. 2008;28(9):2015-24. (Pubitemid 351317613)
83. Ringholm S, Bienso RS, Kiilerich K, Guadalupe-Grau A, Aachmann-Andersen NJ, Saltin B, et al. Bed rest reduces metabolic protein content and abolishes exercise-induced mRNA responses in human skeletal muscle. Am J Physiol Endocrinol Metab. 2011;301(4):E649-58.
84. Lee-Young RS, Ayala JE, Fueger PT, Mayes WH, Kang L, Wasserman DH. Obesity impairs skeletal muscle AMPK signaling during exercise: role of AMPKalpha2 in the regulation of exercise capacity in vivo. Int J Obes (Lond). 2011;35(7):982-9.
85. Young CG, Knight CA, Vickers KC, Westbrook D, Madamanchi NR, Runge MS, et al. Differential effects of exercise on aortic mitochondria. Am J Physiol Heart Circ Physiol. 2005;288(4):H1683-9. (Pubitemid 40417992)
86. Knaub LA, McCune S, Chicco AJ, Miller M, Moore RL, Birdsey N et al. Impaired response to exercise intervention in the vasculature in metabolic syndrome. Diab Vasc Dis Res. 2012
87. Blair SN, Kohl 3rd HW, Barlow CE, Paffenbarger Jr RS, Gibbons LW, Macera CA. Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy men. JAMA. 1995;273(14):1093-8.