Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 304, Issue 5, 2013, Pages

  Ritchie, Rebecca H ^a   Leo, Chen Huei ^b   Qin, Chengxue ^a   Stephenson, Erin J ^b   Bowden, Marissa A ^a   Buxton, Keith D ^a   Lessard, Sarah J ^b   Rivas, Donato A ^b   Koch, Lauren G ^c   Britton, Steven L ^c   Hawley, John A ^b   Woodman, Owen L ^b  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b RMIT UNIVERSITY   (Australia)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Cardiac fibrosis; Cardiomyocyte hypertrophy; EDHF; Insulin resistance; Low capacity runner; Metabolic syndrome; Resistance arteries

Indexed keywords

ENDOTHELIUM DERIVED CONSTRICTING FACTOR; GLUCOSE TRANSPORTER 4; INSULIN; MYOSIN HEAVY CHAIN;

ADRENERGIC SYSTEM; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; BODY MASS; CARDIAC REMODELING; CARDIOVASCULAR FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; EXERCISE; FEMALE; GENE EXPRESSION; GLUCOSE UTILIZATION; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; MESENTERIC ARTERY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; VASODILATATION;

AGING; ANIMALS; BIOLOGICAL FACTORS; CORONARY CIRCULATION; EXERCISE TOLERANCE; FEMALE; FIBROSIS; GLUCOSE TRANSPORTER TYPE 4; HEART; INSULIN RESISTANCE; METABOLIC SYNDROME X; MICROCIRCULATION; MYOCYTES, CARDIAC; NITRIC OXIDE; PHENOTYPE; RATS; RATS, INBRED STRAINS; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION; VASCULAR RESISTANCE; VASODILATION; VENTRICULAR MYOSINS; VENTRICULAR REMODELING;

EID: 84874628841     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00638.2012     Document Type: Article

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