Transfer of nitric oxide by blood from upstream to downstream resistance vessels causes microvascular dilation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 4, 2009, Pages

  Bohlen, H G ^a   Zhou, X ^a   Unthank, J L ^a   Miller, S J ^a   Bills, R ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Arteriole dilation; Artery; S nitrosoglutathione

Indexed keywords

ALBUMIN; BRADYKININ; HEMOGLOBIN; ISOPRENALINE; N(G) NITROARGININE; NITRIC OXIDE; S NITROSOGLUTATHIONE;

ANIMAL EXPERIMENT; ARTERIOLE; ARTERY WALL; ARTICLE; BLOOD VESSEL DIAMETER; BLOOD VESSEL TONE; BLOOD VESSEL WALL; CONTROLLED STUDY; MALE; MESENTERIC ARTERY; MICROELECTRODE; MICROVASCULATURE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; RESISTANCE BLOOD VESSEL; VASODILATATION;

ANIMALS; ARTERIOLES; BRADYKININ; COLLATERAL CIRCULATION; ENZYME INHIBITORS; INTESTINES; ION-SELECTIVE ELECTRODES; ISOPROTERENOL; MALE; MESENTERIC ARTERIES; MICROELECTRODES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; NITROARGININE; RATS; RATS, SPRAGUE-DAWLEY; S-NITROSOGLUTATHIONE; SPLANCHNIC CIRCULATION; TIME FACTORS; VASCULAR RESISTANCE; VASODILATION; VASODILATOR AGENTS;

EID: 70349616677     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00171.2009     Document Type: Article

References (47)

1. Bauser-Heaton HD, Bohlen HG. Cerebral microvascular dilation during hypotension and decreased oxygen tension: a role for nNOS. Am J Physiol Heart Circ Physiol 293: H2193-H2201, 2007.
2. Bauser-Heaton HD, Song J, Bohlen HG. Cerebral microvascular nNOS responds to lowered oxygen tension through a bumetanide-sensitive cotransporter and sodium-calcium exchanger. Am J Physiol Heart Circ Physiol 294: H2166-H2173, 2008.
3. Baydoun AR, Mann GE. Selective targeting of nitric oxide synthase inhibitors to system y+ in activated macrophages. Biochem Biophys Res Commun 200: 726-731, 1994. (Pubitemid 24146023)
4. Bohlen HG. Integration of intestinal structure, function, and microvascular regulation. Microcirculation 5: 27-37, 1998. (Pubitemid 128644121)
5. Bohlen HG. Mechanism of increased vessel wall nitric oxide concentrations during intestinal absorption. Am J Physiol Heart Circ Physiol 275: H542-H550, 1998.
6. Bohlen HG, Nase GP. Dependence of intestinal arteriolar regulation on flow-mediated nitric oxide formation. Am J Physiol Heart Circ Physiol 279: H2249-H2258, 2000.
7. Bohlen HG, Nase GP. Obesity lowers hyperglycemic threshold for impaired in vivo endothelial nitric oxide function. Am J Physiol Heart Circ Physiol 283: H391-H397, 2002.
8. Budel S, Bartlett IS, Segal SS. Homocellular conduction along endothelium and smooth muscle of arterioles in hamster cheek pouch: unmasking an NO wave. Circ Res 93: 61-68, 2003. (Pubitemid 36859042)
9. Buerk DG, Riva CE. Vasomotion and spontaneous low-frequency oscillations in blood flow and nitric oxide in cat optic nerve head. Microvasc Res 55: 103-112, 1998. (Pubitemid 28368417)
10. Buerk DG, Riva CE, Cranstoun SD. Nitric oxide has a vasodilatory role in cat optic nerve head during flicker stimuli. Microvas Res 52: 13-26, 1996.
11. Cannon RO, III, Schechter AN, Panza JA, Ognibene FP, Pease-Fye ME, Waclawiw MA, Shelhamer JH, Gladwin MT. Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery. J Clin Invest 108: 279-287, 2001.
12. Chen X, Jaron D, Barbee KA, Buerk DG. The influence of radial RBC distribution, blood velocity profiles, and glycocalyx on coupled NO/O2 transport. J Appl Physiol 100: 482-492, 2006. (Pubitemid 43671598)
13. Chu S, Bohlen HG. High concentration of glucose inhibits glomerular endothelial eNOS through a PKC mechanism. Am J Physiol Renal Physiol 287: F384-F392, 2004. (Pubitemid 39095951)
14. Crawford JH, Isbell TS, Huang Z, Shiva S, Chacko BK, Schechter AN, rley-Usmar VM, Kerby JD, Lang JD Jr, Kraus D, Ho C, Gladwin MT, Patel RP. Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. Blood 107: 566-574, 2006.
15. Dejam A, Hunter CJ, Pelletier MM, Hsu LL, Machado RF, Shiva S, Power GG, Kelm M, Gladwin MT, Schechter AN. Erythrocytes are the major intravascular storage sites of nitrite in human blood. Blood 106: 734-739, 2005. (Pubitemid 40981274)
16. Diesen DL, Hess DT, Stamler JS. Hypoxic vasodilation by red blood cells: evidence for an s-nitrosothiol-based signal. Circ Res 103: 545-553, 2008.
17. Dora KA, Xia J, Duling BR. Endothelial cell signaling during conducted vasomotor responses. Am J Physiol Heart Circ Physiol 285: H119-H126, 2003.
18. Doyle MP, Duling BR. Acetylcholine induces conducted vasodilation by nitric oxide-dependent and -independent mechanisms. Am J Physiol Heart Circ Physiol 272: H1364-H1371, 1997. (Pubitemid 27146759)
19. Foster MW, Pawloski JR, Singel DJ, Stamler JS. Role of circulating S-nitrosothiols in control of blood pressure. Hypertension 45: 15-17, 2005. (Pubitemid 40066406)
20. Fox-Robichaud A, Payne D, Hasan SU, Ostrovsky L, Fairhead T, Reinhardt P, Kubes P. Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds. J Clin Invest 101: 2497-2505, 1998. (Pubitemid 28270444)
21. Fox-Robichaud A, Payne D, Kubes P. Inhaled NO reaches distal vasculatures to inhibit endothelium- but not leukocyte-dependent cell adhesion. Am J Physiol Lung Cell Mol Physiol 277: L1224-L1231, 1999. (Pubitemid 30046051)
22. Gandley RE, Tyurin VA, Huang W, Arroyo A, Daftary A, Harger G, Jiang J, Pitt B, Taylor RN, Hubel CA, Kagan VE. S-nitrosoalbumin-mediated relaxation is enhanced by ascorbate and copper: effects in pregnancy and preeclampsia plasma. Hypertension 45: 21-27, 2005. (Pubitemid 40066408)
23. Heuil DJ, Hallen K, Feelisch M, Grishamn MB. Dynamic state of s-nitrosothiols in human plasma and whole blood. Free Rad Biol Med 28: 409-417. 2000. (Pubitemid 30110657)
24. Kempson S, Thompson N, Pezzuto L, Glenn BH. Nitric oxide production by mouse renal tubules can be increased by a sodium-dependent mechanism. Nitric Oxide 17: 33-43, 2007.
25. Kim DD, Kanetaka T, Duran RG, Sanchez FA, Bohlen HG, Duran WN. Independent regulation of periarteriolar and perivenular nitric oxide mechanisms in the in vivo hamster cheek pouch microvasculature. Microcirculation 16: 1-8, 2009.
26. Kim-Shapiro DB, Schechter AN, Gladwin MT. Unraveling the reactions of nitric oxide, nitrite, and hemoglobin in physiology and therapeutics. Arterioscler Thromb Vasc Biol 26: 697-705, 2006.
27. Kvietys PR, Granger DN. Effects of solute-coupled fluid absorption on blood flow and oxygen uptake in the dog colon. Gastroenterology 81: 450-457, 1981. (Pubitemid 11061543)
28. Lancaster JR Jr. A tutorial on the diffusibility and reactivity of free nitric oxide. Nitric Oxide 1: 18-30, 1997. (Pubitemid 28078124)
29. Lauer T, Preik M, Rassaf T, Strauer BE, Deussen A, Feelisch M, Kelm M. Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action. Proc Natl Acad Sci USA 98: 12814-12819, 2001.
30. Liao JC, Hein TW, Vaughn MW, Huang KT, Kuo L. Intravascular flow decreases erythrocyte consumption of nitric oxide. Proc Natl Acad Sci USA 96: 8757-8761, 1999. (Pubitemid 29354864)
31. Liu X, Miller MJ, Joshi MS, Sadowska-Krowicka H, Clark DA, Lancaster JR Jr. Diffusion-limited reaction of free nitric oxide with erythrocytes. J Biol Chem 273: 18709-18713, 1998. (Pubitemid 28366253)
32. MacAllister RJ, Calver AL, Riezebos J, Collier J, Vallance P. Relative potency and arteriovenous selectivity of nitrovasodilators on human blood vessels: an insight into the targeting of nitric oxide delivery. J Pharmacol Exp Ther 273: 154-160, 1995.
33. Ng ES, Jourd'heuil D, McCord JM, Hernandez D, Yasui M, Knight D, Kubes P. Enhanced S-nitroso-albumin formation from inhaled NO during ischemia/reperfusion. Circ Res 94: 559-565, 2004.
34. Pezzuto L, Bohlen HG. Extracellular arginine rapidly dilates in vivo intestinal arteries and arterioles through a nitric oxide mechanism. Microcirculation 15: 123-135, 2008. (Pubitemid 351228637)
35. Rassaf T, Kleinbongard P, Preik M, Dejam A, Gharini P, Lauer T, Erckenbrecht J, Duschin A, Schulz R, Heusch G, Feelisch M, Kelm M. Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO: experimental and clinical Study on the fate of NO in human blood. Circ Res 91: 470-477, 2002.
36. Rassaf T, Preik M, Kleinbongard P, Lauer T, Heiss C, Strauer BE, Feelisch M, Kelm M. Evidence for in vivo transport of bioactive nitric oxide in human plasma. J Clin Invest 109: 1241-1248, 2002. (Pubitemid 34496602)
37. Singel DJ, Stamler JS. Chemical physiology of blood flow regulation by red blood cells. Annu Rev Physiol 67: 99-145, 2005.
38. Sogo N, Campanella C, Webb DJ, Megson IL. S-nitrosothiols cause prolonged, nitric oxide-mediated relaxation in human saphenous vein and internal mammary artery: therapeutic potential in bypass surgery. Br J Pharmacol 131: 1236-1244, 2000. (Pubitemid 30953577)
39. Stamler JS. S-nitrosothiols in the blood: roles, amounts, and methods of analysis. Circ Res 94: 414-417, 2004.
40. Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T, Singel DJ, Loscalzo J. S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proc Natl Acad Sci USA 89: 444-448, 1992.
41. Stamler Jaraki O Osborne J Simon DI Keaney J Vita J Singel D Valeri CR Loscalzo J JS. Nitric oxide circulaates in mammalian plasma primerily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci USA 89: 7674-7677, 1992.
42. Uthus EO, Ross S. Dietary selenium (Se) and copper (Cu) interact to affect homocysteine metabolism in rats. Biol Trace Elem Res 129: 213-220, 2009.
43. Vaughn MW, Kuo L, Liao JC. Effective diffusion distance of nitric oxide in microcirculation. Am J Physiol Heart Circ Physiol 274: H1705-H1714, 1998. (Pubitemid 28257547)
44. Zani BG, Bohlen HG. Sodium channels are required during in vivo sodium chloride hyperosmolarity to stimulate an increase in intestinal endothelial nitric oxide production. Am J Physiol Heart Circ Physiol 288: H89-H95, 2005.
45. Zani BG, Bohlen HG. Transport of extracellular L-arginine via the cationic amino acid transporter is required during in vivo endothelial nitric oxide production. Am J Physiol Heart Circ Physiol 289: H1381-H1390, 2005.
46. Zhang ZG, Chopp M, Bailey F, Malinski T. Nitric oxide changes in the rat brain after transient middle cerebral artery occlusion. J Neurol Sci 128: 22-27, 1995.
47. Zhou X, Bohlen HG, Miller SJ, Unthank JL. NAD(P)H oxidase-derived peroxide mediates elevated basal and impaired flow-induced NO production in SHR mesenteric arteries in vivo. Am J Physiol Heart Circ Physiol 295: H1008-H1016, 2008.