Role of CU/ZN-SOD in the synthesis of endothelium-derived hyperpolarizing factor during reactive hyperemia in mouse mesenteric microvessels in vivo

IFMBE Proceedings

Volumn 14, Issue 1, 2007, Pages 3496-3499

  Yada, Toyotaka ^a   Shimokawa, Hiroaki ^b   Morikawa, Keiko ^c   Takaki, Aya ^c   Goto, Masami ^a   Ogasawara, Yasuo ^a   Kajiya, Fumihiko ^a  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Cu Zn SOD; Endothelium derived hyperpolarlizing factor; Hydrogen peroxide; Mouse mesenteric microcirculation; Reactive hyperemia

Indexed keywords

BIOMEDICAL ENGINEERING; HYDROGEN PEROXIDE; MAMMALS; MICROCIRCULATION; OXIDATION; PEROXIDES;

ARTERIAL ADMINISTRATION; CU/ZN-SOD; CU/ZN-SUPEROXIDE DISMUTASE; ENDOTHELIUM-DERIVED HYPERPOLARLIZING FACTOR; MESENTERIC ARTERIES; REACTIVE HYPEREMIA; SODIUM NITROPRUSSIDE; SYNTHASE INHIBITOR;

COPPER COMPOUNDS;

EID: 84874590410     PISSN: 16800737     EISSN: 14339277     Source Type: Conference Proceeding    
DOI: 10.1007/978-3-540-36841-0_884     Document Type: Conference Paper

References (5)

1. Yada T, Shimokawa H, Morikawa K, Takaki A, Goto M, Ogasawara Y, Kajiya F, Crucial Role of Cu/Zn-SOD in the Synthesis of Endothelium- Derived. Hyperpolarizing Factor (EDHF) during Reactive Hyperemia in Mouse Mesenteric Microcirculation in Vivo. Circulation 2005;112:1576 (abstract).
2. Morikawa K, Shimokawa H, Matoba T, Kubota H, Talukder MA, Hatanaka M, Fujiki T, Maeda H, Takahashi S, Takeshita A. Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization. J Clin Invest.2003;112:1871-9.
3. Matoba T, Shimokawa H, Nakashima M, Hirakawa Y, Mukai Y, Hirano K, Kanaide H, Takeshita A. Hydrogen peroxide is an endothelium- derived hyperpolarizing factor in mice. J Clin Invest. 2001;107:23-5.
4. Yada T, Shimokawa H, Hiramatsu O, Kajita T, Shigeto F, Goto M, Ogasawara Y, Kajiya F. Hydrogen peroxide,an endogenous endothelium- derived hyperpolarizing factor,plays an important role in coronary autoregulation in vivo. Circulation.2003;107:1040-5.
5. Yada T, Shimokawa H, Hiramatsu O, Haruna Y, Morita Y, Kashihara N, Shinozaki Y, Mori H, Goto M, Ogasawara Y, Kajiya F. Cardioprotective Role of Endogenous Hydrogen Peroxide during Ischemia- Reperfusion Injury in Canine Coronary Microcirculation in Vivo. Am J Physiol (in press).