Aerobic capacity-dependent differences in cardiac gene expression

Physiological Genomics

Volumn 33, Issue 1, 2008, Pages 100-109

  Bye, Anja ^a   Langaas, Mette ^a   Høydal, Morten A ^a   Kemi, Ole Johan ^b   Heinrich, Garrett ^c   Koch, Lauren G ^d   Britton, Steven L ^d   Najjar, Sonia M ^c   Ellingsen, Øyvind ^a   Wisløff, Ulrik ^a,e  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF TOLEDO   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e Medisinsk Teknisk Forskningssenter   (Norway)

Author keywords

Hypertrophy; Hypoxia; Metabolic syndrome; Metabolism; V o2max

Indexed keywords

AEROBIC CAPACITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CELL STRESS; FATTY ACID OXIDATION; FEMALE; GENE EXPRESSION; GENETIC DIFFERENCE; GENETIC SCREENING; GLUCOSE METABOLISM; HEART LEFT VENTRICLE; LIPID METABOLISM; MICROARRAY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; TREADMILL EXERCISE;

ANIMALS; CLUSTER ANALYSIS; EXERCISE TOLERANCE; FEMALE; GENE EXPRESSION PROFILING; HEART VENTRICLES; MYOCARDIUM; MYOCYTES, CARDIAC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHYSICAL CONDITIONING, ANIMAL; RATS; RUNNING; SIGNAL TRANSDUCTION; VITAL CAPACITY;

ANIMALIA; RATTUS;

EID: 41449090971     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00269.2007     Document Type: Article

References (55)

1. Ajima R, Ikematsu N, Ohsugi M, Yoshida Y, Yamamoto T. Cloning and characterization of the mouse tob2 gene. Gene 253: 215-220, 2000.
2. Aoki T, Okada N, Ishida M, Yogosawa S, Makino Y, Tamura TA. TIP120B: a novel TIP120-family protein that is expressed specifically in muscle tissues. Biochem Biophys Res Commun 261: 911-916, 1999.
3. Beisvag V, Junge FK, Bergum H, Jolsum L, Lydersen S, Gunther CC, Ramampiaro H, Langaas M, Sandvik AK, Laegreid A. GeneTools-application for functional annotation and statistical hypothesis testing. BMC Bioinformatics 7: 470, 2006.
4. Benjamini Y, Hochberg Y. Controlling the false discovery rate - a practical and powerful approach to multiple testing. J Royal Statistical Society Series B: 289-300, 1995.
5. Bolstad BM, Irizarry RA, Astrand M, Speed TP. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics (Oxford) 19: 185-193, 2003.
6. Boss O, Hagen T, Lowell BB. Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism. Diabetes 49: 143-156, 2000.
7. Bouchard C, Lesage R, Lortie G, Simoneau JA, Hamel P, Boulay MR, Perusse L, Theriault G, Leblanc C. Aerobic performance in brothers, dizygotic and monozygotic twins. Med Sci Sports Exerc 18: 639-646, 1986.
8. Clapham JC, Arch JR, Chapman H, Haynes A, Lister C, Moore GB, Piercy V, Carter SA, Lehner I, Smith SA, Beeley LJ, Godden RJ, Herrity N, Skehel M, Changani KK, Hockings PD, Reid DG, Squires SM, Hatcher J, Trail B, Latcham J, Rastan S, Harper AJ, Cadenas S, Buckingham JA, Brand MD, Abuin A. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 406: 415-418, 2000.
9. Cooper GT. Cardiocyte cytoskeleton in hypertrophied myocardium. Heart Failure Rev 5: 187-201, 2000.
10. Ellisen LW, Ramsayer KD, Johannessen CM, Yang A, Beppu H, Minda K, Oliner JD, McKeon F, Haber DA. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell 10: 995-1005, 2002.
11. Escuin D, Kline ER, Giannakakou P. Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function. Cancer Res 65: 9021-9028, 2005.
12. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5: R80, 2004.
13. Gerdes AM, Capasso JM. Structural remodeling and mechanical dysfunction of cardiac myocytes in heart failure. J Mol Cell Cardiol 27: 849-856, 1995.
14. Gerdes AM, Liu Z, Zimmer HG. Changes in nuclear size of cardiac myocytes during the development and progression of hypertrophy in rats. Cardioscience 5: 203-208, 1994.
15. 2max of rats artificially selected for running endurance is mediated by greater convective blood O2 delivery. J Appl Physiol 101: 1288-1296, 2006.
16. 2 uptake in rats selectively bred for endurance running capacity. J Appl Physiol 93: 1265-1274, 2002.
17. Høydal MA, Wisløff U, Kemi OJ, Britton SL, Koch LG, Smith GL, Ellingsen O. Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity. Eur J Cardiovasc Prev Rehabil 14: 319-325, 2007.
18. Hume DA, Pavli P, Donahue RE, Fidler IJ. The effect of human recombinant macrophage colony-stimulating factor (CSF-1) on the murine mononuclear phagocyte system in vivo. J Immunol 141: 3405-3409, 1988.
19. 2-dependent modulation of mitochondrial fatty acid oxidation. J Biol Chem 276: 27605-27612, 2001.
20. Iemitsu M, Maeda S, Miyauchi T, Matsuda M, Tanaka H. Gene expression profiling of exercise-induced cardiac hypertrophy in rats. Acta Physiol Scand 185: 259-270, 2005.
21. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31: e15, 2003.
22. Jin H, Yang R, Li W, Lu H, Ryan AM, Ogasawara AK, Van Peborgh J, Paoni NF. Effects of exercise training on cardiac function, gene expression, and apoptosis in rats. Am J Physiol Heart Circ Physiol 279: H2994-H3002, 2000.
23. Kavanagh T, Mertens DJ, Hamm LF, Beyene J, Kennedy J, Corey P, Shephard RJ. Peak oxygen intake and cardiac mortality in women referred for cardiac rehabilitation. J Am Coll Cardiol 42: 2139-2143, 2003.
24. Kellerman S, Moore JA, Zierhut W, Zimmer HG, Campbell J, Gerdes AM. Nuclear DNA content and nucleation patterns in rat cardiac myocytes from different models of cardiac hypertrophy. J Mol Cell Cardiol 24: 497-505, 1992.
25. Koch LG, Britton SL. Artificial selection for intrinsic aerobic endurance running capacity in rats. Physiol Genomics 5: 45-52, 2001.
26. + channel response to acetylcholine and to G protein-mediated activation in atrial myocytes isolated from failing human hearts. Circulation 90: 2213-2224, 1994.
27. Lee JW, Bae SH, Jeong JW, Kim SH, Kim KW. Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions. Exp Mol Med 36: 1-12, 2004.
28. Leong HS, Brownsey RW, Kulpa JE, Allard MF. Glycolysis and pyruvate oxidation in cardiac hypertrophy-why so unbalanced? Comp Biochem Physiol A 135: 499-513, 2003.
29. Li W, Yu S, Zhao H. Expression of MHC-I and MHC-II antigens in endomyocardial biopsies from patients with viral myocarditis and cardiomyopathy. Chin Med J (Engl) 108: 809-811, 1995.
30. Lujan HL, Britton SL, Koch LG, DiCarlo SE. Reduced susceptibility to ventricular tachyarrhythmias in rats selectively bred for high aerobic capacity. Am J Physiol Heart Circ Physiol 291: H2933-H2941, 2006.
31. Lutz S, Mura R, Baltus D, Movsesian M, Kubler W, Niroomand F. Increased activity of membrane-associated nucleoside diphosphate kinase and inhibition of cAMP synthesis in failing human myocardium. Cardiovasc Res 49: 48-55, 2001.
32. Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, Willard MT, Zhong H, Simons JW, Giannakakou P. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 3: 363-375, 2003.
33. Malys N, Carroll K, Miyan J, Tollervey D, McCarthy JE. The 'scavenger' m7GpppX pyrophosphatase activity of Dcs1 modulates nutrient-induced responses in yeast. Nucleic Acids Res 32: 3590-3600, 2004.
34. Marini M, Lapalombella R, Margonato V, Ronchi R, Samaja M, Scapin C, Gorza L, Maraldi T, Carinci P, Ventura C, Veicsteinas A. Mild exercise training, cardioprotection and stress genes profile. Eur J Appl Physiol 99: 503-510, 2007.
35. 2+ channel in transgenic mice. Loss of isoproterenol-induced contraction. J Biol Chem 274: 21503-21506, 1999.
36. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 346: 793-801, 2002.
37. Nimer SD, Champlin RE, Golde DW. Serum cholesterol-lowering activity of granulocyte-macrophage colony-stimulating factor. JAMA 260: 3297-3300, 1988.
38. Sack MN, Rader TA, Park S, Bastin J, McCune SA, Kelly DP. Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation 94: 2837-2842, 1996.
39. Saltin B, Strange S. Maximal oxygen uptake: "old" and "new" arguments for a cardiovascular limitation. Med Sci Sports Exerc 24: 30-37, 1992.
40. Sato H, Nagai T, Kuppuswamy D, Narishige T, Koide M, Menick DR, Cooper GT. Microtubule stabilization in pressure overload cardiac hypertrophy. J Cell Biol 139: 963-973, 1997.
41. Schwartz K, Carrier L, Guicheney P, Komajda M. Molecular basis of familial cardiomyopathies. Circulation 91: 532-540, 1995.
42. Shiojima I, Sato K, Izumiya Y, Schiekofer S, Ito M, Liao R, Colucci WS, Walsh K. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest 115: 2108-2118, 2005.
43. Shoshani T, Faerman A, Mett I, Zelin E, Tenne T, Gorodin S, Moshel Y, Elbaz S, Budanov A, Chajut A, Kalinski H, Kamer I, Rozen A, Mor O, Keshet E, Leshkowitz D, Einat P, Skaliter R, Feinstein E. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol 22: 2283-2293, 2002.
44. Smyth GK. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article3, 2004.
45. Tagawa H, Rozich JD, Tsutsui H, Narishige T, Kuppuswamy D, Sato H, McDermott PJ, Koide M, Cooper GT. Basis for increased microtubules in pressure-hypertrophied cardiocytes. Circulation 93: 1230-1243, 1996.
46. Takahashi J, Kagaya Y, Kato I, Ohta J, Isoyama S, Miura M, Sugai Y, Hirose M, Wakayama Y, Ninomiya M, Watanabe J, Takasawa S, Okamoto H, Shirato K. Deficit of CD38/cyclic ADP-ribose is differentially compensated in hearts by gender. Biochem Biophys Res Commun 312: 434-440, 2003.
47. Van Dijk E, Le Hir H, Seraphin B. DcpS can act in the 5′-3′ mRNA decay pathway in addition to the 3′-5′ pathway. Proc Natl Acad Sci USA 100: 12081-12086, 2003.
48. Ventura-Clapier R, Garnier A, Veksler V. Energy metabolism in heart failure. J Physiol 555: 1-13, 2004.
49. 2max. Exerc Sport Sci Rev 28: 10-14, 2000.
50. Wang J, Wang S, Lu Y, Weng Y, Gown AM. GM-CSF and M-CSF expression is associated with macrophage proliferation in progressing and regressing rabbit atheromatous lesions. Exp Mol Pathol 61: 109-118, 1994.
51. 2max and cardiac hypertrophy. Am J Physiol Heart Circ Physiol 280: H1301-H1310, 2001.
52. Wisloff U, Najjar SM, Ellingsen O, Haram PM, Swoap S, Al-Share Q, Fernstrom M, Rezaei K, Lee SJ, Koch LG, Britton SL. Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science 307: 418-420, 2005.
53. Yamanaka H, Kamimura K, Tanahashi H, Takahashi K, Asada T, Tabira T. Genetic risk factors in Japanese Alzheimer's disease patients: alpha1-ACT, VLDLR, and ApoE. Neurobiol Aging 19: S43-S46, 1998.
54. Zhang T, Miyamoto S, Brown JH. Cardiomyocyte calcium and calcium/ calmodulin-dependent protein kinase II: friends or foes? Recent Prog Horm Res 59: 141-168, 2004.
55. Zierhut W, Zimmer HG, Gerdes AM. Effect of angiotensin converting enzyme inhibition on pressure-induced left ventricular hypertrophy in rats. Circ Res 69: 609-617, 1991.