The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors

FASEB Journal

Volumn 27, Issue 3, 2013, Pages 1048-1061

  Gracia, Eduard ^a,b   Farré, Daniel ^a,b   Cortés, Antoni ^a,b   Ferrer Costa, Carles ^c   Orozco, Modesto ^b,c   Mallol, Josefa ^a,b   Lluís, Carme ^a,b   Canela, Enric I ^a,b   McCormick, Peter J ^a,b   Franco, Rafael ^b,e   Fanelli, Francesca ^d   Casadó, Vicent ^a,b  

^a CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^d DULBECCO TELETHON INSTITUTE   (Italy)

^e UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Enzyme mutants; Immunological synapse; In silico docking; Multifunctional proteins; Protein protein interaction

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE DEAMINASE; ALPHA 2A ADRENERGIC RECEPTOR; DIPEPTIDYL PEPTIDASE IV;

ALLOSTERISM; ARTICLE; CATALYSIS; COMPUTER MODEL; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; IN VITRO STUDY; LIGAND BINDING; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

ADENOSINE DEAMINASE; ALLOSTERIC REGULATION; HUMANS; MOLECULAR DOCKING SIMULATION; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A;

EID: 84874625122     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-212621     Document Type: Article

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