Protein-tyrosine phosphatase 1B (PTP1B) deficiency confers resistance to transforming growth factor-β (TGF-β)-induced suppressor effects in hepatocytes

Journal of Biological Chemistry

Volumn 287, Issue 19, 2012, Pages 15263-15274

  Ortiz, Conrad ^a   Caja, Laia ^a   Bertran, Esther ^a   Gonzalez Rodriguez, Águeda ^b,c   Valverde, Ángela M ^b   Fabregat, Isabel ^a,d   Sancho, Patricia ^a  

^a BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RESPONSE; CELLULAR RESPONSE; CYTOKINES; DUAL ROLE; EXPRESSION PATTERNS; GENISTEIN; GROWTH INHIBITION; HEPATOCYTES; NADPH OXIDASE; NUCLEAR TRANSLOCATIONS; POSITIVE FEEDBACK LOOP; PROMOTER EFFECT; PROTEIN-TYROSINE PHOSPHATASE 1B; TRANSFORMING GROWTH FACTORS; TUMOR SUPPRESSORS; TYROSINE KINASE; TYROSINE KINASE INHIBITOR; UP-REGULATION;

AMINO ACIDS; CELL DEATH; PHOSPHATASES; PHOSPHORYLATION;

ENZYME INHIBITION;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN TYROSINE PHOSPHATASE 1B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; SMAD2 PROTEIN; SMAD3 PROTEIN; SYNAPTOTAGMIN I; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE TRANSLOCATION; GROWTH INHIBITION; IMMUNOCYTOCHEMISTRY; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TRANSFORMED; CELL NUCLEUS; CELL PROLIFERATION; CELLS, CULTURED; DRUG RESISTANCE; GENISTEIN; HEPATOCYTES; MICE; MICE, KNOCKOUT; NADH, NADPH OXIDOREDUCTASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RNA INTERFERENCE; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1;

MUS;

EID: 84860850926     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.303958     Document Type: Article

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