Antiproliferative mechanisms of action of the flavin dehydrogenase inhibitors diphenylene iodonium and di-2-thienyliodonium based on molecular profiling of the NCI-60 human tumor cell panel

Biochemical Pharmacology

Volumn 83, Issue 9, 2012, Pages 1195-1207

  Doroshow, James H ^a   Juhasz, Agnes ^a   Ge, Yun ^a   Holbeck, Susan ^a   Lu, Jiamo ^a   Antony, Smitha ^a   Wu, Yongzhong ^a   Jiang, Guojian ^a   Roy, Krishnendu ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Diphenylene iodonium; Dithienyliodonium; NADPH oxidase; NCI 60 tumor panel; Reactive oxygen; Stat signaling

Indexed keywords

ACTIN; DI 2 THIENYLIODONIUM; DIPHENYLIODONIUM SALT; FLAVOPROTEIN; INTERLEUKIN 13; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NSC 734426; NSC 735294; OXIDOREDUCTASE INHIBITOR; PROTEIN DUOX1; PROTEIN DUOX2; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 3; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 5; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EXPOSURE; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; EPITHELIUM; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKOCYTE; MULTIGENE FAMILY; NOX GENE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEADY STATE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOKINES; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HT29 CELLS; HUMANS; MITOCHONDRIA; NADPH OXIDASE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONIUM COMPOUNDS; PHOSPHOPROTEIN PHOSPHATASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THIOPHENES;

EID: 84862781058     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.01.022     Document Type: Article

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