-
1
-
-
43749096100
-
Neovascular age-related macular degeneration: Potential therapies
-
DOI 10.2165/00003495-200868080-00002
-
Chappelow AV, Kaiser PK. Neovascular age-related macular degeneration: potential therapies. Drugs. 2008;68(8):1029-36. (Pubitemid 351693673)
-
(2008)
Drugs
, vol.68
, Issue.8
, pp. 1029-1036
-
-
Chappelow, A.V.1
Kaiser, P.K.2
-
2
-
-
0036253277
-
Age-related macular degeneration: Epidemiology and optimal treatment
-
La Cour M, Kiilgaard JF, Nissen MH. Age-related macular degeneration: epidemiology and optimal treatment. Drugs Aging. 2002;19(2):101-33. (Pubitemid 34494034)
-
(2002)
Drugs and Aging
, vol.19
, Issue.2
, pp. 101-133
-
-
La Cour, M.1
Kiilgaard, J.F.2
Nissen, M.H.3
-
3
-
-
33749440219
-
Age-related macular degeneration
-
DOI 10.1056/NEJMra062326
-
de Jong PTVM. Age-related macular degeneration. N Engl J Med. 2006;355:1474-85. (Pubitemid 44511562)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.14
, pp. 1474-1485
-
-
De Jong, P.T.V.M.1
-
4
-
-
0028934221
-
An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group
-
7604360 10.1016/S0039-6257(05)80092-X 1:STN:280:DyaK2MzivVSnsg%3D%3D
-
Bird AC, Bressler NM, Bressler SB, et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol. 1995;39(5):367-74.
-
(1995)
Surv Ophthalmol
, vol.39
, Issue.5
, pp. 367-374
-
-
Bird, A.C.1
Bressler, N.M.2
Bressler, S.B.3
-
5
-
-
84855655264
-
The expanding role of vascular endothelial growth factor inhibitors in ophthalmology
-
22212972 10.1016/j.mayocp.2011.10.001 1:CAS:528:DC%2BC38Xjt1WhsL0%3D
-
Stewart MW. The expanding role of vascular endothelial growth factor inhibitors in ophthalmology. Mayo Clin Proc. 2012;87(1):77-88.
-
(2012)
Mayo Clin Proc
, vol.87
, Issue.1
, pp. 77-88
-
-
Stewart, M.W.1
-
6
-
-
34548107597
-
Targeting vascular endothelial growth factor: A promising strategy for treating age-related macular degeneration
-
17702534 10.2165/00002512-200724080-00003 1:CAS:528:DC%2BD2sXhtVKhtbfO
-
Waisbourd M, Loewenstein A, Goldstein M, et al. Targeting vascular endothelial growth factor: a promising strategy for treating age-related macular degeneration. Drugs Aging. 2007;24(8):643-62.
-
(2007)
Drugs Aging
, vol.24
, Issue.8
, pp. 643-662
-
-
Waisbourd, M.1
Loewenstein, A.2
Goldstein, M.3
-
7
-
-
25144511910
-
The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions
-
DOI 10.1042/CS20040370
-
Takahashi H, Shibuya M. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci (Lond). 2005;109(3):227-41. (Pubitemid 41337127)
-
(2005)
Clinical Science
, vol.109
, Issue.3
, pp. 227-241
-
-
Takahashi, H.1
Shibuya, M.2
-
8
-
-
0037699954
-
The biology of VEGF and its receptors
-
DOI 10.1038/nm0603-669
-
Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9(6):669-76. (Pubitemid 36749215)
-
(2003)
Nature Medicine
, vol.9
, Issue.6
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.-P.2
LeCouter, J.3
-
9
-
-
34548755527
-
Pegaptanib in the treatment of wet, age-related macular degeneration
-
1:CAS:528:DC%2BD28Xhtlantb7I
-
Vinores SA. Pegaptanib in the treatment of wet, age-related macular degeneration. Int J Nanomed. 2006;1(3):263-8.
-
(2006)
Int J Nanomed
, vol.1
, Issue.3
, pp. 263-268
-
-
Vinores, S.A.1
-
10
-
-
34249914760
-
Ranibizumab
-
DOI 10.2165/00003495-200767080-00007
-
Blick SKA, Keating GM, Wagstaff AJ. Ranibizumab. Drugs. 2007;67(8):1199-206. (Pubitemid 46871027)
-
(2007)
Drugs
, vol.67
, Issue.8
, pp. 1199-1206
-
-
Blick, S.K.A.1
Keating, G.M.2
Wagstaff, A.J.3
-
11
-
-
84857260889
-
Ranibizumab: In diabetic macular oedema
-
22356289 10.2165/11208410-000000000-00000 1:CAS:528:DC%2BC38XmsFelt74%3D
-
Frampton JE. Ranibizumab: in diabetic macular oedema. Drugs. 2012;72(4):509-23.
-
(2012)
Drugs
, vol.72
, Issue.4
, pp. 509-523
-
-
Frampton, J.E.1
-
12
-
-
79956218863
-
Ranibizumab and bevacizumab for neovascular age-related macular degeneration
-
The CATT Research Group
-
The CATT Research Group. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 2011;19(364):1897-908.
-
(2011)
N Engl J Med
, vol.19
, Issue.364
, pp. 1897-1908
-
-
-
13
-
-
84869225440
-
Anti-VEGF treatment strategies for wet AMD
-
22523653 (Epub 2012 Feb 28)
-
Kovach JL, Schwartz SG, Flynn HW Jr, et al. Anti-VEGF treatment strategies for wet AMD. J Ophthalmol. 2012;2012:786870. (Epub 2012 Feb 28).
-
(2012)
J Ophthalmol
, vol.2012
, pp. 786870
-
-
Kovach, J.L.1
Schwartz, S.G.2
Flynn, Jr.H.W.3
-
15
-
-
84866091781
-
Aflibercept (VEGF Trap-eye): The newest anti-VEGF drug
-
(Epub 2012 Mar 23)
-
Stewart MW. Aflibercept (VEGF Trap-eye): the newest anti-VEGF drug. Br J Ophthalmol. (Epub 2012 Mar 23).
-
Br J Ophthalmol.
-
-
Stewart, M.W.1
-
16
-
-
84865129521
-
Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab
-
10.1007/s10456-011-9249-6
-
Papadopoulous N, Martin J, Ruan Q, et al. Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis. 2012;15(2):171-85.
-
(2012)
Angiogenesis
, vol.15
, Issue.2
, pp. 171-185
-
-
Papadopoulous, N.1
Martin, J.2
Ruan, Q.3
-
17
-
-
65549139264
-
VEGF-B is dispensible for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
-
19369214 10.1073/pnas.0813061106 1:CAS:528:DC%2BD1MXlsV2htbc%3D
-
Zhang F, Tang Z, Hou X, et al. VEGF-B is dispensible for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. PNAS. 2009;106(15):6152-7.
-
(2009)
PNAS
, vol.106
, Issue.15
, pp. 6152-6157
-
-
Zhang, F.1
Tang, Z.2
Hou, X.3
-
18
-
-
0037900481
-
Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization
-
DOI 10.1167/iovs.02-1092
-
Rakic J-M, Lambert V, Devy L, et al. Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003;44:3186-93. (Pubitemid 36759791)
-
(2003)
Investigative Ophthalmology and Visual Science
, vol.44
, Issue.7
, pp. 3186-3193
-
-
Rakic, J.-M.1
Lambert, V.2
Devy, L.3
Luttun, A.4
Carmeliet, P.5
Claes, C.6
Nguyen, L.7
Foidart, J.-M.8
Noel, A.9
Munaut, C.10
-
21
-
-
0037143764
-
VEGF-Trap: A VEGF blocker with potent antitumor effects
-
DOI 10.1073/pnas.172398299
-
Holash J, Davis S, Papadopoulos N, et al. VEGF-trap: a VEGF blocker with potent antitumor effects. PNAS. 2002;99(17):11393-8. (Pubitemid 34920936)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.17
, pp. 11393-11398
-
-
Holash, J.1
Davis, S.2
Papadopoulos, N.3
Croll, S.D.4
Ho, L.5
Russell, M.6
Boland, P.7
Leidich, R.8
Hylton, D.9
Burova, E.10
Ioffe, E.11
Huang, T.12
Radziejewski, C.13
Bailey, K.14
Fandl, J.P.15
Daly, T.16
Wiegand, S.J.17
Yancopoulos, G.D.18
Rudge, J.S.19
-
22
-
-
7444261960
-
Use of soluble recombinant decoy receptor vascular endothelial growth factor trap (VEGF trap) to inhibit vascular endothelial growth factor activity
-
15479484 10.3816/CCC.2004.s.013 1:CAS:528:DC%2BD2cXpslOmtbk%3D
-
Konner JDJ. Use of soluble recombinant decoy receptor vascular endothelial growth factor trap (VEGF trap) to inhibit vascular endothelial growth factor activity. Clin Colorectal Cancer. 2004;4(Suppl. 2):S81-5.
-
(2004)
Clin Colorectal Cancer
, vol.4
, Issue.SUPPL. 2
-
-
Konner, J.D.J.1
-
23
-
-
85081775709
-
-
Application number: 125387Orig1s000. Pharmacology review(s) Accessed 4 Apr 2012
-
Application number: 125387Orig1s000. Pharmacology review(s). http://www.accessdata.fda.gov/drugsatfda-docs/nda/2011/125387Orig1s000PharmR. pdf. Accessed 4 Apr 2012.
-
-
-
-
24
-
-
79957986348
-
Primary endpoint results of a phase II study of vascular endothelial growth factor trap-eye in wet age-related macular degeneration
-
21640257 10.1016/j.ophtha.2011.02.039
-
Brown DM, Heier JS, Ciulla T, et al. Primary endpoint results of a phase II study of vascular endothelial growth factor trap-eye in wet age-related macular degeneration. Ophthalmology. 2011;118(6):1089-97.
-
(2011)
Ophthalmology
, vol.118
, Issue.6
, pp. 1089-1097
-
-
Brown, D.M.1
Heier, J.S.2
Ciulla, T.3
-
25
-
-
36749040908
-
VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade
-
DOI 10.1073/pnas.0708865104
-
Rudge JS, Holash J, Hylton D, et al. VEGF trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade. PNAS. 2007;104(47):18363-70. (Pubitemid 350210713)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.47
, pp. 18363-18370
-
-
Rudge, J.S.1
Holash, J.2
Hylton, D.3
Russell, M.4
Jiang, S.5
Leidich, R.6
Papadopoulos, N.7
Pyles, E.A.8
Torri, A.9
Wiegand, S.J.10
Thurston, G.11
Stahl, N.12
Yancopoulos, G.D.13
-
26
-
-
33845251640
-
Vascular endothelial growth factor biology: Clinical implications for ocular treatments
-
DOI 10.1136/bjo.2006.098426
-
Bhisitkul RB. Vascular endothelial growth factor biology: clinical implications for ocular treatments. Br J Ophthalmol. 2006;90:1542-7. (Pubitemid 44862578)
-
(2006)
British Journal of Ophthalmology
, vol.90
, Issue.12
, pp. 1542-1547
-
-
Bhisitkul, R.B.1
-
27
-
-
33746433784
-
VEGF trap both prevents experimental choroidal neovascularization and causes regression of established lesions in non-human primates
-
E-abstract 1411-B180 Accessed 4 Apr 2012
-
Wiegand SJ, Zimmer E, Nork TM, et al. VEGF trap both prevents experimental choroidal neovascularization and causes regression of established lesions in non-human primates. Invest Ophthalmol Vis Sci. 2005; 46: E-abstract 1411-B180. http://abstracts.iovs.org/cgi/content/abstract/46/5/1411. Accessed 4 Apr 2012.
-
(2005)
Invest Ophthalmol Vis Sci.
, vol.46
-
-
Wiegand, S.J.1
Zimmer, E.2
Nork, T.M.3
-
28
-
-
0037401890
-
R1R2 suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrier
-
DOI 10.1002/jcp.10246
-
Saishin Y, Saishin Y, Takahashi K, et al. VEGF-trap (R1R2) suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrier. J Cell Physiol. 2003;195(2):241-8. (Pubitemid 36384298)
-
(2003)
Journal of Cellular Physiology
, vol.195
, Issue.2
, pp. 241-248
-
-
Saishin, Y.1
Saishin, Y.2
Takahashi, K.3
Silva, R.L.E.4
Hylton, D.5
Rudge, J.S.6
Wiegand, S.J.7
Campochiaro, P.A.8
-
29
-
-
70350757650
-
A phase i study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration
-
19700196
-
Nguyen QD, Shah SM, Browning DJ, et al. A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration. Ophthalmology. 2009;116(11):2141-8.e1.
-
(2009)
Ophthalmology
, vol.116
, Issue.11
-
-
Nguyen, Q.D.1
Shah, S.M.2
Browning, D.J.3
-
30
-
-
84857107913
-
-
Application number: 125387Orig1s000 Accessed 4 Apr 2012
-
Application number: 125387Orig1s000. Clinical pharmacology and biopharmaceutics review(s). http://www.accessdata.fda.gov/drugsatfda-docs/nda/ 2011/125387Orig1s000ClinPharmR.pdf. Accessed 4 Apr 2012.
-
Clinical Pharmacology and Biopharmaceutics Review(s)
-
-
-
34
-
-
84888638161
-
Randomized, double-masked, active-controlled phase 3 trial of the efficacy and safety of intravitreal VEGF-Trap-Eye in wet AMD: One-year results of the VIEW-1 study
-
[abstract no. 3073] May 1-5; Fort Lauderdale (FL)
-
Nguyen QD, Heier J, Brown D, et al. Randomized, double-masked, active-controlled phase 3 trial of the efficacy and safety of intravitreal VEGF-Trap-Eye in wet AMD: one-year results of the VIEW-1 study [abstract no. 3073]. 2011 Annual Meeting of the Association for Research in Vision and Ophthalmology; 2011 May 1-5; Fort Lauderdale (FL).
-
(2011)
2011 Annual Meeting of the Association for Research in Vision and Ophthalmology
-
-
Nguyen, Q.D.1
Heier, J.2
Brown, D.3
-
35
-
-
84873861815
-
Primary results of an international phase III study using intravitreal VEGF Trap-Eye compared to ranibizumab in patients with wet AMD (VIEW 2)
-
[abstract no. 1650] May 1-5; Fort Lauderdale (FL)
-
Schmidt-Erfurth U, Chong V, Kirchhof B, et al. Primary results of an international phase III study using intravitreal VEGF Trap-Eye compared to ranibizumab in patients with wet AMD (VIEW 2) [abstract no. 1650]. 2011 Annual Meeting of the Association for Research in Vision and Ophthalmology; 2011 May 1-5; Fort Lauderdale (FL).
-
(2011)
2011 Annual Meeting of the Association for Research in Vision and Ophthalmology
-
-
Schmidt-Erfurth, U.1
Chong, V.2
Kirchhof, B.3
-
36
-
-
79957990661
-
The 1-year results of CLEAR-IT 2, a phase 2 study of vascular endothelial growth factor trap-eye dosed as-needed after 12-week fixed dosing
-
21640258 10.1016/j.ophtha.2011.03.020
-
Heier JS, Boyer D, Nguyen QD, et al. The 1-year results of CLEAR-IT 2, a phase 2 study of vascular endothelial growth factor trap-eye dosed as-needed after 12-week fixed dosing. Ophthalmology. 2011;118(6):1098-106.
-
(2011)
Ophthalmology
, vol.118
, Issue.6
, pp. 1098-1106
-
-
Heier, J.S.1
Boyer, D.2
Nguyen, Q.D.3
-
38
-
-
85081784177
-
-
Application number: 125387Orig1s000. Medical review(s). Accessed 4 Apr 2012
-
Application number: 125387Orig1s000. Medical review(s). http://www.accessdata.fda.gov/drugsatfda-docs/nda/2011/125387Orig1s000MedR.pdf. Accessed 4 Apr 2012.
-
-
-
-
39
-
-
25844468887
-
-
European Medicines Agency (initial authorization): Eylea (aflibercept) Accessed 28 Sep 2012
-
European Medicines Agency, Committee for Medicinal Products for Human Use. Summary of opinion (initial authorization): Eylea (aflibercept). http://www.ema.europa.eu/docs/en-GB/document-library/Summary-of-opinion--- Initial-authorisation/human/002392/WC500132884.pdf. Accessed 28 Sep 2012.
-
Committee for Medicinal Products for Human Use. Summary of Opinion
-
-
|