-
1
-
-
33744935522
-
New pharmacologic approaches to therapy for age-related macular degeneration
-
Eter N, Krohne TU, Holz FG. New pharmacologic approaches to therapy for age-related macular degeneration. Biodrugs 2006; 20 (3): 167-79
-
(2006)
Biodrugs
, vol.20
, Issue.3
, pp. 167-179
-
-
Eter, N.1
Krohne, T.U.2
Holz, F.G.3
-
2
-
-
3242663235
-
Anti-vascular endothelial growth factor strategies for the treatment of choroidal neovascularization from age-related macular degeneration
-
Barouch FC, Miller JW. Anti-vascular endothelial growth factor strategies for the treatment of choroidal neovascularization from age-related macular degeneration. Int Ophthalmol Clin 2004; 44 (3): 23-32
-
(2004)
Int Ophthalmol Clin
, vol.44
, Issue.3
, pp. 23-32
-
-
Barouch, F.C.1
Miller, J.W.2
-
3
-
-
11444260529
-
Current and future treatment options for nonexudative and exudative age-related macular degeneration
-
Comer GM, Ciulla TA, Criswell MH, et al. Current and future treatment options for nonexudative and exudative age-related macular degeneration. Drugs Aging 2004; 21 (15): 967-92
-
(2004)
Drugs Aging
, vol.21
, Issue.15
, pp. 967-992
-
-
Comer, G.M.1
Ciulla, T.A.2
Criswell, M.H.3
-
4
-
-
0141746067
-
Ranibizumab: Treatment of age-related macular degeneration humanized monoclonal anti-VEGF antibody angiogenesis inhibitor
-
Sorbera LA, Leeson PA, Baýes M. Ranibizumab: treatment of age-related macular degeneration humanized monoclonal anti-VEGF antibody angiogenesis inhibitor. Drugs Future 2003; 28 (6): 541-5
-
(2003)
Drugs Future
, vol.28
, Issue.6
, pp. 541-545
-
-
Sorbera, L.A.1
Leeson, P.A.2
Baýes, M.3
-
5
-
-
11144239923
-
Pegaptanib for neovascular age-related macular degeneration
-
Dec 30;
-
Gragoudas ES, Adamis AP, Cunningham ET, et al. Pegaptanib for neovascular age-related macular degeneration. N Engl J Med 2004 Dec 30; 351 (27): 2805-16
-
(2004)
N Engl J Med
, vol.351
, Issue.27
, pp. 2805-2816
-
-
Gragoudas, E.S.1
Adamis, A.P.2
Cunningham, E.T.3
-
6
-
-
26044443312
-
Wet age-related macular degeneration
-
Sep;
-
Melnikova I. Wet age-related macular degeneration. Nat Rev Drug Discov 2005 Sep; 4 (9): 711-2
-
(2005)
Nat Rev Drug Discov
, vol.4
, Issue.9
, pp. 711-712
-
-
Melnikova, I.1
-
7
-
-
21744446220
-
Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration
-
Ng EWM, Adamis AP. Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration. Can J Ophthalmol 2005; 40 (3): 352-68
-
(2005)
Can J Ophthalmol
, vol.40
, Issue.3
, pp. 352-368
-
-
EWM, N.1
Adamis, A.P.2
-
9
-
-
34249875160
-
-
and Drug Administration, online, Available from URL:, Accessed May 10
-
US Food and Drug Administration. Ranibizumab: full prescribing information [online]. Available from URL: http://www.fda.gov/cder/foi/label/ 2006/125156lbl.pdf [Accessed 2007 May 10]
-
(2007)
Ranibizumab: Full prescribing information
-
-
Food, U.S.1
-
10
-
-
34249891904
-
RhuFab V2 inhibits VEGF-isoforms- stimulated HUVEC proliferation [E-abstract no. 1828]
-
Lowe J, Araujo J, Palma M, et al. RhuFab V2 inhibits VEGF-isoforms- stimulated HUVEC proliferation [E-abstract no. 1828]. Invest Ophthalmol Vis Sci 2003; 44
-
(2003)
Invest Ophthalmol Vis Sci
, pp. 44
-
-
Lowe, J.1
Araujo, J.2
Palma, M.3
-
11
-
-
33645331188
-
Tolerability and efficacy of multiple escalating doses of ranibizumab (Lucen-tis™) for neovascular age-related macular degeneration
-
Apr;
-
Rosenfeld PJ, Heier JS, Hantsbarger G, et al. Tolerability and efficacy of multiple escalating doses of ranibizumab (Lucen-tis™) for neovascular age-related macular degeneration. Ophthalmology 2006 Apr; 113 (4): 623-32
-
(2006)
Ophthalmology
, vol.113
, Issue.4
, pp. 623-632
-
-
Rosenfeld, P.J.1
Heier, J.S.2
Hantsbarger, G.3
-
12
-
-
33645641520
-
Ranibizumab for treatment of neovascular age-related macular degeneration a phase I/II multicenter, controlled, multidose study [abstract]
-
Heier JS, Antoszyk AN, Pavan PR, et al. Ranibizumab for treatment of neovascular age-related macular degeneration a phase I/II multicenter, controlled, multidose study [abstract]. Ophthalmology 2006; 113 (4): 642
-
(2006)
Ophthalmology
, vol.113
, Issue.4
, pp. 642
-
-
Heier, J.S.1
Antoszyk, A.N.2
Pavan, P.R.3
-
13
-
-
67649317616
-
Visual acuity outcomes following a variable-dosing regimen for ranibizumab (Lucentis™) in neovascular AMD: The PrONTO study
-
abstract no. 2958, Apr 30-May 4; Fort Lauderdale FL
-
Rosenfeld PJ, Fung AE, Lalwani GA, et al. Visual acuity outcomes following a variable-dosing regimen for ranibizumab (Lucentis™) in neovascular AMD: the PrONTO study [abstract no. 2958]. Annual Meeting of the Association for Research in Vision and Ophthalmology; 2006 Apr 30-May 4; Fort Lauderdale (FL)
-
(2006)
Annual Meeting of the Association for Research in Vision and Ophthalmology
-
-
Rosenfeld, P.J.1
Fung, A.E.2
Lalwani, G.A.3
-
14
-
-
34249890526
-
An emerging problem: Recurrence of CNV in AMD is common after cessation of 24 month treatment with ranibizumab (Lucentis®)
-
abstract no. 2961, Apr 30-May 4; Fort Lauderdale FL
-
Korotkin A, Kozak I, Morrison VL, et al. An emerging problem: recurrence of CNV in AMD is common after cessation of 24 month treatment with ranibizumab (Lucentis®) [abstract no. 2961]. Annual Meeting of the Association for Research in Vision and Ophthalmology; 2006 Apr 30-May 4; Fort Lauderdale (FL)
-
(2006)
Annual Meeting of the Association for Research in Vision and Ophthalmology
-
-
Korotkin, A.1
Kozak, I.2
Morrison, V.L.3
-
15
-
-
32844457184
-
Long-term experience with Lucentis™ (ranibizumab) in patients with neovascular age-related macular degeneration (AMD) [E-abstract no. 1393]
-
May;
-
Heier JS, Rosenfeld PJ, Antoszyk G, et al. Long-term experience with Lucentis™ (ranibizumab) in patients with neovascular age-related macular degeneration (AMD) [E-abstract no. 1393]. Invest Ophthalmol Vis Sci 2005 May; 46
-
(2005)
Invest Ophthalmol Vis Sci
, pp. 46
-
-
Heier, J.S.1
Rosenfeld, P.J.2
Antoszyk, G.3
-
16
-
-
33846409609
-
Optical coherence tomography findings in a variable-dosing regimen with ranibizumab (Lucentis™): The PrONTO study
-
abstract no. 2147, Apr 30-May 4; Fort Lauderdale FL
-
Lalwani G, Fung AE, Michels S, et al. Optical coherence tomography findings in a variable-dosing regimen with ranibizumab (Lucentis™): the PrONTO study [abstract no. 2147]. Annual Meeting of the Association for Research in Vision and Ophthamology; 2006 Apr 30-May 4; Fort Lauderdale (FL)
-
(2006)
Annual Meeting of the Association for Research in Vision and Ophthamology
-
-
Lalwani, G.1
Fung, A.E.2
Michels, S.3
-
17
-
-
33749451356
-
Ranibizumab versus verteporfin for neovascular age-related macular degeneration
-
Oct 5;
-
Brown DM, Kaiser PK, Michels M, et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 2006 Oct 5; 355 (14): 1432-44
-
(2006)
N Engl J Med
, vol.355
, Issue.14
, pp. 1432-1444
-
-
Brown, D.M.1
Kaiser, P.K.2
Michels, M.3
-
18
-
-
33749445317
-
Ranibizumab for neovascular age-related macular degeneration
-
Oct 5;
-
Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006 Oct 5; 355 (14): 1419-31
-
(2006)
N Engl J Med
, vol.355
, Issue.14
, pp. 1419-1431
-
-
Rosenfeld, P.J.1
Brown, D.M.2
Heier, J.S.3
-
19
-
-
20144368709
-
Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular age-related macular degeneration
-
Jun;
-
Rosenfeld PJ, Schwartz SD, Blumenkranz MS, et al. Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular age-related macular degeneration. Ophthalmology 2005 Jun; 112 (6): 1048-53
-
(2005)
Ophthalmology
, vol.112
, Issue.6
, pp. 1048-1053
-
-
Rosenfeld, P.J.1
Schwartz, S.D.2
Blumenkranz, M.S.3
-
20
-
-
34249915067
-
Clinical pharmacokinetics of ranibizumab (Lucentis™) in subjects with AMD [E-abstract no. 1383]
-
Haughney PC, Lowe J, Kearns A, et al. Clinical pharmacokinetics of ranibizumab (Lucentis™) in subjects with AMD [E-abstract no. 1383]. Invest Ophthalmol Vis Sci 2005; 46
-
(2005)
Invest Ophthalmol Vis Sci
, pp. 46
-
-
Haughney, P.C.1
Lowe, J.2
Kearns, A.3
-
21
-
-
34249903352
-
-
European Medicines Agency, online, Available from URL:, Accessed Apr 12
-
European Medicines Agency. Ranibizumab (Lucentis): summary of product characteristics [online]. Available from URL: http://www.emea.europa.eu/ humandocs/PDFs/EPAR/lucentis/ H-715-PI-en.pdf [Accessed 2007 Apr 12]
-
(2007)
Ranibizumab (Lucentis): Summary of product characteristics
-
-
-
22
-
-
13944266313
-
Preclinical pharmacokinetics of ranibizumab (rhuFabV2) after a single intravitreal administration
-
Feb;
-
Gaudreault J, Fei D, Rusit J, et al. Preclinical pharmacokinetics of ranibizumab (rhuFabV2) after a single intravitreal administration. Invest Ophthalmol Vis Sci 2005 Feb; 46 (2): 726-33
-
(2005)
Invest Ophthalmol Vis Sci
, vol.46
, Issue.2
, pp. 726-733
-
-
Gaudreault, J.1
Fei, D.2
Rusit, J.3
-
23
-
-
34249886827
-
The PIER study: Twelve month efficacy and safety results from a phase III study of ranibizumab 0.3mg and 0.5mg administered initially monthly and then every 3 months for subfoveal choroidal neovascularization secondary to age-related macular degeneration. PIER study group [abstract no. F1116]
-
Schmidt-Erfurth U. The PIER study: twelve month efficacy and safety results from a phase III study of ranibizumab 0.3mg and 0.5mg administered initially monthly and then every 3 months for subfoveal choroidal neovascularization secondary to age-related macular degeneration. PIER study group [abstract no. F1116]. Asian J Ophthalmol 2006; 8 (3 Suppl. 1): 176
-
(2006)
Asian J Ophthalmol
, vol.8
, Issue.3 SUPPL. 1
, pp. 176
-
-
Schmidt-Erfurth, U.1
-
24
-
-
34249905890
-
Ranibizumab (Lucentis) in ne-ovascular age-related macular degeneration (AMD): Subgroup analysis of year 1 PIER efficacy data
-
abstract no, May 6-10; Fort Lauderdale FL
-
Brown DM, Yue H, Shams N. Ranibizumab (Lucentis) in ne-ovascular age-related macular degeneration (AMD): subgroup analysis of year 1 PIER efficacy data [abstract no. 4540/B221]. Annual Meeting of the Association for Research in Vision and Ophthalmology; 2007 May 6-10; Fort Lauderdale (FL)
-
(2007)
4540/B221]. Annual Meeting of the Association for Research in Vision and Ophthalmology
-
-
Brown, D.M.1
Yue, H.2
Shams, N.3
-
25
-
-
54749154548
-
Self-reported vision-specific quality of life at 1 year in patients with neovascular age-related macular degeneration in 2 phase III randomized clinical trials of ranibizumab (Lucentis™)
-
abstract no. 5252, Apr 30-May 4; Fort Lauderdale FL
-
Chang TS, Fine JT, Bressler N, et al. Self-reported vision-specific quality of life at 1 year in patients with neovascular age-related macular degeneration in 2 phase III randomized clinical trials of ranibizumab (Lucentis™) [abstract no. 5252]. Annual Meeting of the Association for Research in Vision and Ophthamology; 2006 Apr 30-May 4; Fort Lauderdale (FL)
-
(2006)
Annual Meeting of the Association for Research in Vision and Ophthamology
-
-
Chang, T.S.1
Fine, J.T.2
Bressler, N.3
-
26
-
-
34249864800
-
Subgroup analysis of first-year results of ANCHOR: A phase III, double-masked, randomized comparison of ranibizumab and verteporfin photodynamic therapy for predominantly classic choroidal neovascularization related to age-related macular degeneration
-
abstract no. 2963, Apr 30-May 4; Fort Lauderdale FL
-
Brown DM, Shapiro H, Schneider S, et al. Subgroup analysis of first-year results of ANCHOR: a phase III, double-masked, randomized comparison of ranibizumab and verteporfin photodynamic therapy for predominantly classic choroidal neovascularization related to age-related macular degeneration [abstract no. 2963]. Annual Meeting of the Association for Research in Vision and Ophthamology; 2006 Apr 30-May 4; Fort Lauderdale (FL)
-
(2006)
Annual Meeting of the Association for Research in Vision and Ophthamology
-
-
Brown, D.M.1
Shapiro, H.2
Schneider, S.3
-
27
-
-
33750314559
-
Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration: Year 1 results of the FOCUS study
-
Heier JS, Boyer DS, Ciulla TA, et al. Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration: year 1 results of the FOCUS study. Arch Ophthalmol 2006; 124 (11): 1532-42
-
(2006)
Arch Ophthalmol
, vol.124
, Issue.11
, pp. 1532-1542
-
-
Heier, J.S.1
Boyer, D.S.2
Ciulla, T.A.3
-
28
-
-
34249882480
-
-
Genentech, Inc, online, Available from URL:, Accessed Jan 30
-
Genentech, Inc. Dear health care provider letter regarding Lucentis [online]. Available from URL: http://www.fda.gov/medwatch/ safety/2007/ Lucentis_DHCP_01-24-2007.pdf [Accessed 2007 Jan 30]
-
(2007)
Dear health care provider letter regarding Lucentis
-
-
-
29
-
-
38749103275
-
-
and Drug Administration, online, Available from URL:, Accessed May 4
-
US Food and Drug Administration. 2007 Safety alerts for drugs, biologics, medical devices, and dietary supplements [online]. Available from URL: http://www.fda.gov/medwatch/safety/ 2007/safety07.htm [Accessed 2007 May 4]
-
(2007)
Safety alerts for drugs, biologics, medical devices, and dietary supplements
-
-
Food, U.S.1
|