메뉴 건너뛰기




Volumn 24, Issue 8, 2007, Pages 643-662

Targeting vascular endothelial growth factor: A promising strategy for treating age-related macular degeneration

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; APTAMER; BENZOPORPHYRIN DERIVATIVE; BEVACIZUMAB; MONOCLONAL ANTIBODY; PEGAPTANIB; RANIBIZUMAB; TRIAMCINOLONE; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VITAMIN;

EID: 34548107597     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-200724080-00003     Document Type: Review
Times cited : (45)

References (70)
  • 1
    • 85136420259 scopus 로고    scopus 로고
    • Bressler NM. Age-related macular degeneration is the leading cause of blindness. JAMA 2004 Apr 21; 291 (15): 1900-1
    • Bressler NM. Age-related macular degeneration is the leading cause of blindness. JAMA 2004 Apr 21; 291 (15): 1900-1
  • 2
    • 0026681119 scopus 로고
    • Prevalence of age-related maculopathy: The Beaver Dam Eye Study
    • Jun;
    • Klein R, Klein BE, Linton KL. Prevalence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 1992 Jun; 99 (6): 933-43
    • (1992) Ophthalmology , vol.99 , Issue.6 , pp. 933-943
    • Klein, R.1    Klein, B.E.2    Linton, K.L.3
  • 3
    • 11144354339 scopus 로고    scopus 로고
    • Prevalence of age-related macular degeneration in the United States
    • Apr;
    • Friedman DS, O'Colmain BJ, Munoz B, et al. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol 2004 Apr; 122 (4): 564-72
    • (2004) Arch Ophthalmol , vol.122 , Issue.4 , pp. 564-572
    • Friedman, D.S.1    O'Colmain, B.J.2    Munoz, B.3
  • 4
    • 33749440219 scopus 로고    scopus 로고
    • Age-related macular degeneration
    • Oct 5;
    • de Jong PT. Age-related macular degeneration. N Engl J Med 2006 Oct 5; 355 (14): 1474-85
    • (2006) N Engl J Med , vol.355 , Issue.14 , pp. 1474-1485
    • de Jong, P.T.1
  • 5
    • 33750300224 scopus 로고    scopus 로고
    • Macular degeneration: Recent advances and therapeutic opportunities
    • Nov;
    • Rattner A, Nathans J. Macular degeneration: recent advances and therapeutic opportunities. Nat Rev Neurosci 2006 Nov; 7 (11): 860-72
    • (2006) Nat Rev Neurosci , vol.7 , Issue.11 , pp. 860-872
    • Rattner, A.1    Nathans, J.2
  • 6
    • 33745670172 scopus 로고    scopus 로고
    • The genetics of age-related macular degeneration: A review of progress to date
    • Jul-Aug;
    • Haddad S, Chen CA, Santangelo SL, et al. The genetics of age-related macular degeneration: a review of progress to date. Surv Ophthalmol 2006 Jul-Aug; 51 (4): 316-63
    • (2006) Surv Ophthalmol , vol.51 , Issue.4 , pp. 316-363
    • Haddad, S.1    Chen, C.A.2    Santangelo, S.L.3
  • 7
    • 0026409933 scopus 로고    scopus 로고
    • Argon laser photocoagulation for neovascular maculopathy: five-year results from randomized clinical trials. Macular Photocoagulation Study Group. Arch Ophthalmol 1991 Aug; 109 (8): 1109-14
    • Argon laser photocoagulation for neovascular maculopathy: five-year results from randomized clinical trials. Macular Photocoagulation Study Group. Arch Ophthalmol 1991 Aug; 109 (8): 1109-14
  • 8
    • 33644873981 scopus 로고    scopus 로고
    • Neovascular age-related macular degeneration: Natural history and treatment outcomes
    • Dec;
    • Pauleikhoff D. Neovascular age-related macular degeneration: natural history and treatment outcomes. Retina 2005 Dec; 25 (8): 1065-84
    • (2005) Retina , vol.25 , Issue.8 , pp. 1065-1084
    • Pauleikhoff, D.1
  • 9
    • 0034800655 scopus 로고    scopus 로고
    • A randomized, placebo-controlled clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8
    • Age-Related Eye Disease Study Group, Oct;
    • Age-Related Eye Disease Study Group. A randomized, placebo-controlled clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 2001 Oct; 119 (10): 1417-36
    • (2001) Arch Ophthalmol , vol.119 , Issue.10 , pp. 1417-1436
  • 10
    • 33747165599 scopus 로고    scopus 로고
    • Macular degeneration: The latest in current medical management
    • Jul-Aug;
    • Lim JI. Macular degeneration: the latest in current medical management. Retina 2006 Jul-Aug; 26 (6 Suppl.): S17-20
    • (2006) Retina , vol.26 , Issue.6 SUPPL.
    • Lim, J.I.1
  • 11
    • 33748474191 scopus 로고    scopus 로고
    • Evolving European guidance on the medical management of neovascular age related macular degeneration
    • Sep;
    • Chakravarthy U, Soubrane G, Bandello F, et al. Evolving European guidance on the medical management of neovascular age related macular degeneration. Br J Ophthalmol 2006 Sep; 90 (9): 1188-96
    • (2006) Br J Ophthalmol , vol.90 , Issue.9 , pp. 1188-1196
    • Chakravarthy, U.1    Soubrane, G.2    Bandello, F.3
  • 12
    • 16244362058 scopus 로고    scopus 로고
    • New treatments for age-related macular degeneration
    • Apr;
    • Schachat AP. New treatments for age-related macular degeneration. Ophthalmology 2005 Apr; 112 (4): 531-2
    • (2005) Ophthalmology , vol.112 , Issue.4 , pp. 531-532
    • Schachat, A.P.1
  • 13
    • 27544491447 scopus 로고    scopus 로고
    • Angiogenic and antiangiogenic gene therapy
    • Oct;
    • Malecki M, Kolsut P, Proczka R. Angiogenic and antiangiogenic gene therapy. Gene Ther 2005 Oct; 12 Suppl. 1: S159-69
    • (2005) Gene Ther , vol.12 , Issue.SUPPL. 1
    • Malecki, M.1    Kolsut, P.2    Proczka, R.3
  • 14
    • 0031050126 scopus 로고    scopus 로고
    • Increased expression of angiogenic growth factors in age-related maculopathy
    • Feb;
    • Kliffen M, Sharma HS, Mooy CM, et al. Increased expression of angiogenic growth factors in age-related maculopathy. Br J Ophthalmol 1997 Feb; 81 (2): 154-62
    • (1997) Br J Ophthalmol , vol.81 , Issue.2 , pp. 154-162
    • Kliffen, M.1    Sharma, H.S.2    Mooy, C.M.3
  • 15
    • 0036018746 scopus 로고    scopus 로고
    • Vascular endothelial growth factor family and receptor expression in human choroidal neovascular membranes
    • Jul;
    • Otani A, Takagi H, Oh H, et al. Vascular endothelial growth factor family and receptor expression in human choroidal neovascular membranes. Microvasc Res 2002 Jul; 64 (1): 162-9
    • (2002) Microvasc Res , vol.64 , Issue.1 , pp. 162-169
    • Otani, A.1    Takagi, H.2    Oh, H.3
  • 16
    • 0037900481 scopus 로고    scopus 로고
    • Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization
    • Jul;
    • Rakic JM, Lambert V, Devy L, et al. Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization. Invest Ophthalmol Vis Sci 2003 Jul; 44 (7): 3186-93
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , Issue.7 , pp. 3186-3193
    • Rakic, J.M.1    Lambert, V.2    Devy, L.3
  • 17
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Nov 18;
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971 Nov 18; 285 (21): 1182-6
    • (1971) N Engl J Med , vol.285 , Issue.21 , pp. 1182-1186
    • Folkman, J.1
  • 18
    • 10644279947 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and angiogenesis
    • Dec;
    • Hoeben A, Landuyt B, Highley MS, et al. Vascular endothelial growth factor and angiogenesis. Pharmacol Rev 2004 Dec; 56 (4): 549-80
    • (2004) Pharmacol Rev , vol.56 , Issue.4 , pp. 549-580
    • Hoeben, A.1    Landuyt, B.2    Highley, M.S.3
  • 19
    • 0035062394 scopus 로고    scopus 로고
    • The splice variants of vascular endothelial growth factor (VEGF) and their receptors
    • Mar;
    • Robinson CJ, Stringer SE. The splice variants of vascular endothelial growth factor (VEGF) and their receptors. J Cell Sci 2001 Mar; 114 (Pt 5): 853-65
    • (2001) J Cell Sci , vol.114 , Issue.PART 5 , pp. 853-865
    • Robinson, C.J.1    Stringer, S.E.2
  • 21
    • 0031770547 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: How it transmits its signal
    • Nov-Dec;
    • Zachary I. Vascular endothelial growth factor: how it transmits its signal. Exp Nephrol 1998 Nov-Dec; 6 (6): 480-7
    • (1998) Exp Nephrol , vol.6 , Issue.6 , pp. 480-487
    • Zachary, I.1
  • 22
    • 15044349368 scopus 로고    scopus 로고
    • Inhibitors of ocular neovascularization: Promises and potential problems
    • Mar 23;
    • van Wijngaarden P, Coster DJ, Williams KA. Inhibitors of ocular neovascularization: promises and potential problems. JAMA 2005 Mar 23; 293 (12): 1509-13
    • (2005) JAMA , vol.293 , Issue.12 , pp. 1509-1513
    • van Wijngaarden, P.1    Coster, D.J.2    Williams, K.A.3
  • 23
    • 32844458094 scopus 로고    scopus 로고
    • Pegaptanib sodium for the treatment of neovascular age-related macular degeneration: A review
    • Jan;
    • Kourlas H, Schiller DS. Pegaptanib sodium for the treatment of neovascular age-related macular degeneration: a review. Clin Ther 2006 Jan; 28 (1): 36-44
    • (2006) Clin Ther , vol.28 , Issue.1 , pp. 36-44
    • Kourlas, H.1    Schiller, D.S.2
  • 24
    • 11144239923 scopus 로고    scopus 로고
    • Pegaptanib for neovascular age-related macular degeneration
    • Dec 30;
    • Gragoudas ES, Adamis AP, Cunningham Jr ET, et al. Pegaptanib for neovascular age-related macular degeneration. N Engl J Med 2004 Dec 30; 351 (27): 2805-16
    • (2004) N Engl J Med , vol.351 , Issue.27 , pp. 2805-2816
    • Gragoudas, E.S.1    Adamis, A.P.2    Cunningham Jr, E.T.3
  • 25
    • 0036959644 scopus 로고    scopus 로고
    • Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration
    • Eyetech Study Group, Apr;
    • Eyetech Study Group. Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration. Retina 2002 Apr; 22 (2): 143-52
    • (2002) Retina , vol.22 , Issue.2 , pp. 143-152
  • 26
    • 0034466813 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeys
    • Dec;
    • Drolet DW, Nelson J, Tucker CE, et al. Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeys. Pharm Res 2000 Dec; 17 (12): 1503-10
    • (2000) Pharm Res , vol.17 , Issue.12 , pp. 1503-1510
    • Drolet, D.W.1    Nelson, J.2    Tucker, C.E.3
  • 27
    • 0345827805 scopus 로고    scopus 로고
    • Technology evaluation: Pegaptanib, Eyetech/Pfizer
    • Dec;
    • Vinores SA. Technology evaluation: pegaptanib, Eyetech/Pfizer. Curr Opin Mol Ther 2003 Dec; 5 (6): 673-9
    • (2003) Curr Opin Mol Ther , vol.5 , Issue.6 , pp. 673-679
    • Vinores, S.A.1
  • 28
    • 26844508345 scopus 로고    scopus 로고
    • Enhanced efficacy associated with early treatment of neovascular age-related macular degeneration with pegaptanib sodium: An exploratory analysis
    • Oct-Nov;
    • Gonzales CR. Enhanced efficacy associated with early treatment of neovascular age-related macular degeneration with pegaptanib sodium: an exploratory analysis. Retina 2005 Oct-Nov; 25 (7): 815-27
    • (2005) Retina , vol.25 , Issue.7 , pp. 815-827
    • Gonzales, C.R.1
  • 29
    • 33747891752 scopus 로고    scopus 로고
    • Chakravarthy U, Adamis AP, Cunningham Jr ET, et al. Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration: VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group. Ophthalmology 2006 Sep; 113 (9): 1508.e1-25. Epub 2006 Jul 7
    • Chakravarthy U, Adamis AP, Cunningham Jr ET, et al. Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration: VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group. Ophthalmology 2006 Sep; 113 (9): 1508.e1-25. Epub 2006 Jul 7
  • 30
    • 33644500722 scopus 로고    scopus 로고
    • Six-week outcomes after pegaptanib [letter]
    • Mar;
    • Schuman S, Rogers AH, Duker JS, et al. Six-week outcomes after pegaptanib [letter]. Ophthalmology 2006 Mar; 113 (3): 501
    • (2006) Ophthalmology , vol.113 , Issue.3 , pp. 501
    • Schuman, S.1    Rogers, A.H.2    Duker, J.S.3
  • 31
    • 33645283105 scopus 로고    scopus 로고
    • Retinal pigment epithelial tear following intravitreal pegaptanib sodium
    • Apr;
    • Dhalla MS, Blinder KJ, Tewari A, et al. Retinal pigment epithelial tear following intravitreal pegaptanib sodium. Am J Ophthalmol 2006 Apr; 141 (4): 752-4
    • (2006) Am J Ophthalmol , vol.141 , Issue.4 , pp. 752-754
    • Dhalla, M.S.1    Blinder, K.J.2    Tewari, A.3
  • 32
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab for neovascular age-related macular degeneration
    • Oct 5;
    • Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006 Oct 5; 355 (14): 1419-31
    • (2006) N Engl J Med , vol.355 , Issue.14 , pp. 1419-1431
    • Rosenfeld, P.J.1    Brown, D.M.2    Heier, J.S.3
  • 33
    • 33749426139 scopus 로고    scopus 로고
    • The price of sight: Ranibizumab, bevacizumab, and the treatment of macular degeneration
    • Oct 5;
    • Steinbrook R. The price of sight: ranibizumab, bevacizumab, and the treatment of macular degeneration. N Engl J Med 2006 Oct 5; 355 (14): 1409-12
    • (2006) N Engl J Med , vol.355 , Issue.14 , pp. 1409-1412
    • Steinbrook, R.1
  • 34
    • 0036129304 scopus 로고    scopus 로고
    • Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment
    • Mar;
    • Krzystolik MG, Afshari MA, Adamis AP, et al. Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch Ophthalmol 2002 Mar; 120 (3): 338-46
    • (2002) Arch Ophthalmol , vol.120 , Issue.3 , pp. 338-346
    • Krzystolik, M.G.1    Afshari, M.A.2    Adamis, A.P.3
  • 35
    • 20144387561 scopus 로고    scopus 로고
    • Safety and efficacy of intravitreal injection of ranibizumab in combination with verteporfin PDT on experimental choroidal neovascularization in the monkey
    • Apr;
    • Husain D, Kim I, Gauthier D, et al. Safety and efficacy of intravitreal injection of ranibizumab in combination with verteporfin PDT on experimental choroidal neovascularization in the monkey. Arch Ophthalmol 2005 Apr; 123 (4): 509-16
    • (2005) Arch Ophthalmol , vol.123 , Issue.4 , pp. 509-516
    • Husain, D.1    Kim, I.2    Gauthier, D.3
  • 36
    • 33644842022 scopus 로고    scopus 로고
    • Effect of intravitreal injection of ranibizumab in combination with verteporfin PDT on normal primate retina and choroid
    • Jan;
    • Kim IK, Husain D, Michaud N, et al. Effect of intravitreal injection of ranibizumab in combination with verteporfin PDT on normal primate retina and choroid. Invest Ophthalmol Vis Sci 2006 Jan; 47 (1): 357-63
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , Issue.1 , pp. 357-363
    • Kim, I.K.1    Husain, D.2    Michaud, N.3
  • 37
    • 13944266313 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics of ranibizumab (rhuFabV2) after a single intravitreal administration
    • Feb;
    • Gaudreault J, Fei D, Rusit J, et al. Preclinical pharmacokinetics of ranibizumab (rhuFabV2) after a single intravitreal administration. Invest Ophthalmol Vis Sci 2005 Feb; 46 (2): 726-33
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , Issue.2 , pp. 726-733
    • Gaudreault, J.1    Fei, D.2    Rusit, J.3
  • 38
    • 33749451356 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    • Oct 5;
    • Brown DM, Kaiser PK, Michels M, et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 2006 Oct 5; 355 (14): 1432-44
    • (2006) N Engl J Med , vol.355 , Issue.14 , pp. 1432-1444
    • Brown, D.M.1    Kaiser, P.K.2    Michels, M.3
  • 39
    • 33750314559 scopus 로고    scopus 로고
    • Heier JS, Boyer DS, Ciulla TA, et al.; FOCUS Study Group. Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration: year 1 results of the FOCUS study [published erratum appears in Arch Ophthalmol 2007 Jan; 125 (1): 138]. Arch Ophthalmol 2006 Nov; 124 (11): 1532-42
    • Heier JS, Boyer DS, Ciulla TA, et al.; FOCUS Study Group. Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration: year 1 results of the FOCUS study [published erratum appears in Arch Ophthalmol 2007 Jan; 125 (1): 138]. Arch Ophthalmol 2006 Nov; 124 (11): 1532-42
  • 41
    • 33645641520 scopus 로고    scopus 로고
    • Heier JS, Antoszyk AN, Pavan PR, et al. Ranibizumab for treatment of neovascular age-related macular degeneration: a phase I/II multicenter, controlled, multidose study. Ophthalmology 2006 Apr; 113 (4): 642.e1-4. Epub 2006 Feb 14
    • Heier JS, Antoszyk AN, Pavan PR, et al. Ranibizumab for treatment of neovascular age-related macular degeneration: a phase I/II multicenter, controlled, multidose study. Ophthalmology 2006 Apr; 113 (4): 642.e1-4. Epub 2006 Feb 14
  • 42
    • 34548064264 scopus 로고    scopus 로고
    • The FDA Safety Information and Adverse Effects Reporting Program. 2007 safety alerts for drugs, biological, medical devices and drug supplements; drugs and therapeutic biological products. Lucentis®. Barron H. Letter - January 24, 2007, Genentech [online]. Available from URL: http://www.fda.gov/Medwatch/ safety/2007/Lucentis_DHCP_01-24-2007.pdf [Accessed 2007 Feb 1]
    • The FDA Safety Information and Adverse Effects Reporting Program. 2007 safety alerts for drugs, biological, medical devices and drug supplements; drugs and therapeutic biological products. Lucentis®. Barron H. Letter - January 24, 2007, Genentech [online]. Available from URL: http://www.fda.gov/Medwatch/ safety/2007/Lucentis_DHCP_01-24-2007.pdf [Accessed 2007 Feb 1]
  • 43
    • 33645331188 scopus 로고    scopus 로고
    • Rosenfeld PJ, Heier JS, Hantsbarger G, et al. Tolerability and efficacy of multiple escalating doses of ranibizumab (Lucentis) for neovascular age-related macular degeneration. Ophthalmology 2006 Apr; 113 (4): 632.e1
    • Rosenfeld PJ, Heier JS, Hantsbarger G, et al. Tolerability and efficacy of multiple escalating doses of ranibizumab (Lucentis) for neovascular age-related macular degeneration. Ophthalmology 2006 Apr; 113 (4): 632.e1
  • 44
    • 20144368709 scopus 로고    scopus 로고
    • Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular age-related macular degeneration
    • Jun;
    • Rosenfeld PJ, Schwartz SD, Blumenkranz MS, et al. Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular age-related macular degeneration. Ophthalmology 2005 Jun; 112 (6): 1048-53
    • (2005) Ophthalmology , vol.112 , Issue.6 , pp. 1048-1053
    • Rosenfeld, P.J.1    Schwartz, S.D.2    Blumenkranz, M.S.3
  • 45
    • 33749632278 scopus 로고    scopus 로고
    • Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
    • Oct;
    • Ferrara N, Damico L, Shams N, et al. Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina 2006 Oct; 26 (8): 859-70
    • (2006) Retina , vol.26 , Issue.8 , pp. 859-870
    • Ferrara, N.1    Damico, L.2    Shams, N.3
  • 46
    • 0032864292 scopus 로고    scopus 로고
    • Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration
    • Sep-Oct;
    • Mordenti J, Cuthbertson RA, Ferrara N, et al. Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration. Toxicol Pathol 1999 Sep-Oct; 27 (5): 536-44
    • (1999) Toxicol Pathol , vol.27 , Issue.5 , pp. 536-544
    • Mordenti, J.1    Cuthbertson, R.A.2    Ferrara, N.3
  • 47
    • 33646440660 scopus 로고    scopus 로고
    • Testing intravitreal toxicity of bevacizumab (Avastin)
    • Mar;
    • Manzano RP, Peyman GA, Khan P, et al. Testing intravitreal toxicity of bevacizumab (Avastin). Retina 2006 Mar; 26 (3): 257-61
    • (2006) Retina , vol.26 , Issue.3 , pp. 257-261
    • Manzano, R.P.1    Peyman, G.A.2    Khan, P.3
  • 48
    • 33646464758 scopus 로고    scopus 로고
    • Electrophysiologic and retinal penetration studies following intravitreal injection of bevacizumab (Avastin)
    • Mar;
    • Shahar J, Avery RL, Heilweil G, et al. Electrophysiologic and retinal penetration studies following intravitreal injection of bevacizumab (Avastin). Retina 2006 Mar; 26 (3): 262-9
    • (2006) Retina , vol.26 , Issue.3 , pp. 262-269
    • Shahar, J.1    Avery, R.L.2    Heilweil, G.3
  • 49
    • 33749647304 scopus 로고    scopus 로고
    • Vitreous levels of unbound bevacizumab and unbound vascular endothelial growth factor in two patients
    • Oct;
    • Beer PM, Wong SJ, Hammad AM, et al. Vitreous levels of unbound bevacizumab and unbound vascular endothelial growth factor in two patients. Retina 2006 Oct; 26 (8): 871-6
    • (2006) Retina , vol.26 , Issue.8 , pp. 871-876
    • Beer, P.M.1    Wong, S.J.2    Hammad, A.M.3
  • 50
    • 20144372969 scopus 로고    scopus 로고
    • Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration twelve-week results of an uncontrolled open-label clinical study
    • Jun;
    • Michels S, Rosenfeld PJ, Puliafito CA, et al. Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration twelve-week results of an uncontrolled open-label clinical study. Ophthalmology 2005 Jun; 112 (6): 1035-47
    • (2005) Ophthalmology , vol.112 , Issue.6 , pp. 1035-1047
    • Michels, S.1    Rosenfeld, P.J.2    Puliafito, C.A.3
  • 51
    • 33750305221 scopus 로고    scopus 로고
    • Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration: Twenty-four-week results of an uncontrolled open-label clinical study
    • Nov;
    • Moshfeghi AA, Rosenfeld PJ, Puliafito CA, et al. Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration: twenty-four-week results of an uncontrolled open-label clinical study. Ophthalmology 2006 Nov; 113 (11): e1-12
    • (2006) Ophthalmology , vol.113 , Issue.11
    • Moshfeghi, A.A.1    Rosenfeld, P.J.2    Puliafito, C.A.3
  • 52
    • 33745091547 scopus 로고    scopus 로고
    • Intravitreal bevacizumab treatment of choroidal neovascularization secondary to age-related macular degeneration
    • Apr;
    • Spaide RF, Laud K, Fine HF, et al. Intravitreal bevacizumab treatment of choroidal neovascularization secondary to age-related macular degeneration. Retina 2006 Apr; 26 (4): 383-90
    • (2006) Retina , vol.26 , Issue.4 , pp. 383-390
    • Spaide, R.F.1    Laud, K.2    Fine, H.F.3
  • 53
    • 33644502828 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration
    • Mar;
    • Avery RL, Pieramici DJ, Rabena MD, et al. Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthalmology 2006 Mar; 113 (3): 363-72
    • (2006) Ophthalmology , vol.113 , Issue.3 , pp. 363-372
    • Avery, R.L.1    Pieramici, D.J.2    Rabena, M.D.3
  • 54
    • 33745782355 scopus 로고    scopus 로고
    • Short-term safety and efficacy of intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration
    • May-Jun;
    • Rich RM, Rosenfeld PJ, Puliafito CA, et al. Short-term safety and efficacy of intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. Retina 2006 May-Jun; 26 (5): 495-511
    • (2006) Retina , vol.26 , Issue.5 , pp. 495-511
    • Rich, R.M.1    Rosenfeld, P.J.2    Puliafito, C.A.3
  • 55
    • 33745418105 scopus 로고    scopus 로고
    • Intravitreal bevacizumab for the management of choroidal neovascularization in age-related macular degeneration
    • Jul;
    • Bashshur ZF, Bazarbachi A, Schakal A, et al. Intravitreal bevacizumab for the management of choroidal neovascularization in age-related macular degeneration. Am J Ophthalmol 2006 Jul; 142 (1): 1-9
    • (2006) Am J Ophthalmol , vol.142 , Issue.1 , pp. 1-9
    • Bashshur, Z.F.1    Bazarbachi, A.2    Schakal, A.3
  • 56
    • 34250769632 scopus 로고    scopus 로고
    • Intravitreal bevacizumab therapy for neovascular age-related macular degeneration: A pilot study
    • May;
    • Abrahám-Marin ML, Cortés-Luna CF, Alvarez-Rivera G, et al. Intravitreal bevacizumab therapy for neovascular age-related macular degeneration: a pilot study. Graefes Arch Clin Exp Ophthalmol 2007 May; 245 (5): 651-5
    • (2007) Graefes Arch Clin Exp Ophthalmol , vol.245 , Issue.5 , pp. 651-655
    • Abrahám-Marin, M.L.1    Cortés-Luna, C.F.2    Alvarez-Rivera, G.3
  • 57
    • 33750575485 scopus 로고    scopus 로고
    • Intravitreal bevacizumab for choroidal neovascularization caused by AMD (IBeNA Study): Results of a phase 1 dose-escalation study
    • Oct;
    • Costa RA, Jorge R, Calucci D, et al. Intravitreal bevacizumab for choroidal neovascularization caused by AMD (IBeNA Study): results of a phase 1 dose-escalation study. Invest Ophthalmol Vis Sci 2006 Oct; 47 (10): 4569-78
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , Issue.10 , pp. 4569-4578
    • Costa, R.A.1    Jorge, R.2    Calucci, D.3
  • 58
    • 23044505200 scopus 로고    scopus 로고
    • Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration
    • Jul-Aug;
    • Rosenfeld PJ, Moshfeghi AA, Puliafito CA. Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthalmic Surg Lasers Imaging 2005 Jul-Aug; 36 (4): 331-5
    • (2005) Ophthalmic Surg Lasers Imaging , vol.36 , Issue.4 , pp. 331-335
    • Rosenfeld, P.J.1    Moshfeghi, A.A.2    Puliafito, C.A.3
  • 59
    • 33748265684 scopus 로고    scopus 로고
    • Intravitreal bevacizumab for occult choroidal neovascularization with pigment epithelium detachment in age-related macular degeneration
    • Oct;
    • Bom Aggio F, Eid Farah M, Melo GB. Intravitreal bevacizumab for occult choroidal neovascularization with pigment epithelium detachment in age-related macular degeneration. Acta Ophthalmol Scand 2006 Oct; 84 (5): 713-4
    • (2006) Acta Ophthalmol Scand , vol.84 , Issue.5 , pp. 713-714
    • Bom Aggio, F.1    Eid Farah, M.2    Melo, G.B.3
  • 60
    • 33646438886 scopus 로고    scopus 로고
    • Electrophysiologic findings after intravitreal bevacizumab (Avastin) treatment
    • Mar;
    • Maturi RK, Bleau LA, Wilson DL. Electrophysiologic findings after intravitreal bevacizumab (Avastin) treatment. Retina 2006 Mar; 26 (3): 270-4
    • (2006) Retina , vol.26 , Issue.3 , pp. 270-274
    • Maturi, R.K.1    Bleau, L.A.2    Wilson, D.L.3
  • 61
    • 33750296920 scopus 로고    scopus 로고
    • The International Intravitreal Bevacizumab Safety Survey: Using the internet to assess drug safety worldwide
    • Nov;
    • Fung AE, Rosenfeld PJ, Reichel E. The International Intravitreal Bevacizumab Safety Survey: using the internet to assess drug safety worldwide. Br J Ophthalmol 2006 Nov; 90 (11): 1344-9
    • (2006) Br J Ophthalmol , vol.90 , Issue.11 , pp. 1344-1349
    • Fung, A.E.1    Rosenfeld, P.J.2    Reichel, E.3
  • 62
    • 33746276707 scopus 로고    scopus 로고
    • Acute retinal pigment epithelial tear following intravitreal bevacizumab (Avastin) injection for occult choroidal neovascularisation secondary to age related macular degeneration
    • Sep;
    • Meyer CH, Mennel S, Schmidt JC, et al. Acute retinal pigment epithelial tear following intravitreal bevacizumab (Avastin) injection for occult choroidal neovascularisation secondary to age related macular degeneration. Br J Ophthalmol 2006 Sep; 90 (9): 1207-8
    • (2006) Br J Ophthalmol , vol.90 , Issue.9 , pp. 1207-1208
    • Meyer, C.H.1    Mennel, S.2    Schmidt, J.C.3
  • 63
    • 33646490116 scopus 로고    scopus 로고
    • Occult with no classic subfoveal choroidal neovascular lesions in age-related macular degeneration: Clinically relevant natural history information in larger lesions with good vision from the Verteporfin in Photodynamic Therapy (VIP) Trial: VIP Report No. 4
    • May;
    • Pieramici DJ, Bressler SB, Koester JM, et al. Occult with no classic subfoveal choroidal neovascular lesions in age-related macular degeneration: clinically relevant natural history information in larger lesions with good vision from the Verteporfin in Photodynamic Therapy (VIP) Trial: VIP Report No. 4. Arch Ophthalmol 2006 May; 124 (5): 660-4
    • (2006) Arch Ophthalmol , vol.124 , Issue.5 , pp. 660-664
    • Pieramici, D.J.1    Bressler, S.B.2    Koester, J.M.3
  • 64
    • 33745119257 scopus 로고    scopus 로고
    • Does intravitreal injection of bevacizumab have an effect on the blood-aqueous barrier function? [letter]
    • Jul;
    • Ziemssen F, Warga M, Neuhann IM, et al. Does intravitreal injection of bevacizumab have an effect on the blood-aqueous barrier function? [letter]. Br J Ophthalmol 2006 Jul; 90 (7): 922
    • (2006) Br J Ophthalmol , vol.90 , Issue.7 , pp. 922
    • Ziemssen, F.1    Warga, M.2    Neuhann, I.M.3
  • 65
    • 33749598287 scopus 로고    scopus 로고
    • Evaluation of anterior chamber inflammatory activity in eyes treated with intravitreal bevacizumab
    • Oct;
    • Kiss C, Michels S, Prager F, et al. Evaluation of anterior chamber inflammatory activity in eyes treated with intravitreal bevacizumab. Retina 2006 Oct; 26 (8): 877-81
    • (2006) Retina , vol.26 , Issue.8 , pp. 877-881
    • Kiss, C.1    Michels, S.2    Prager, F.3
  • 66
    • 33745386921 scopus 로고    scopus 로고
    • Intravitreal Avastin: The low cost alternative to Lucentis?
    • Jul;
    • Rosenfeld PJ. Intravitreal Avastin: the low cost alternative to Lucentis? Am J Ophthalmol 2006 Jul; 142 (1): 141-3
    • (2006) Am J Ophthalmol , vol.142 , Issue.1 , pp. 141-143
    • Rosenfeld, P.J.1
  • 67
    • 34548080014 scopus 로고    scopus 로고
    • News and events, NEI statement (last modified December 2006)
    • National Eye Institute, National Institutes of Health, AMD, online, Available from URL:, Accessed Jul 3
    • National Eye Institute, National Institutes of Health. News and events, NEI statement (last modified December 2006). National Institutes of Health stimulates the development and testing of new therapies for advanced age-related macular degeneration (AMD) [online]. Available from URL: http://www.nei.nih. gov/news/statements/amd_therapy.asp [Accessed 2007 Jul 3]
    • (2007) National Institutes of Health stimulates the development and testing of new therapies for advanced age-related macular degeneration
  • 68
    • 33749557195 scopus 로고    scopus 로고
    • What we don't know about Avastin might hurt us
    • Oct;
    • Gillies MC. What we don't know about Avastin might hurt us. Arch Ophthalmol 2006 Oct; 124 (10): 1478-9
    • (2006) Arch Ophthalmol , vol.124 , Issue.10 , pp. 1478-1479
    • Gillies, M.C.1
  • 69
    • 0037251511 scopus 로고    scopus 로고
    • Controlled delivery of the anti-VEGF aptamer EYE001 with poly (lactic-coglycolic) acid microspheres
    • Jan;
    • Carrasquillo KG, Ricker JA, Rigas IK, et al. Controlled delivery of the anti-VEGF aptamer EYE001 with poly (lactic-coglycolic) acid microspheres. Invest Ophthalmol Vis Sci 2003 Jan; 44 (1): 290-9
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , Issue.1 , pp. 290-299
    • Carrasquillo, K.G.1    Ricker, J.A.2    Rigas, I.K.3
  • 70
    • 28444440585 scopus 로고    scopus 로고
    • Myles ME, Neumann DM, Hill JM. Recent progress in ocular drug delivery for posterior segment disease: emphasis on transscleral iontophoresis. Adv Drug Deliv Rev 2005 Dec 13; 57 (14): 2063-79
    • Myles ME, Neumann DM, Hill JM. Recent progress in ocular drug delivery for posterior segment disease: emphasis on transscleral iontophoresis. Adv Drug Deliv Rev 2005 Dec 13; 57 (14): 2063-79


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.