Immunohistochemical evidence for the relationship between microglia and GnRH neurons in the preoptic area of ovariectomized rats with and without steroid replacement

Endocrine Journal

Volumn 60, Issue 2, 2013, Pages 191-196

  Fujioka, Hitomi ^a   Kakehashi, Chiaki ^a   Funabashi, Toshiya ^a   Akema, Tatsuo ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Gonadotropin releasing hormone (GnRH) neuron; Immunohistochemistry; Microglia; Preoptic area

Indexed keywords

CD11B ANTIGEN; CYCLOOXYGENASE 1; GONADORELIN; STEROID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COMMUNICATION; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; IMMUNOCOMPETENT CELL; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MICROGLIA; NONHUMAN; OVARIECTOMY; PERIKARYON; PREOPTIC AREA; PROTEIN EXPRESSION; RAT; STEROID ANALYSIS; STEROID THERAPY;

ANIMALS; ANTIGENS, CD11B; BIOLOGICAL MARKERS; CELL COMMUNICATION; CELL SHAPE; CELL SIZE; CYCLOOXYGENASE 1; ESTROGEN REPLACEMENT THERAPY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GONADOTROPIN-RELEASING HORMONE; IMAGING, THREE-DIMENSIONAL; MICROGLIA; MICROSCOPY, CONFOCAL; NERVE TISSUE PROTEINS; NEURONS; OVARIECTOMY; PREOPTIC AREA; RATS; RATS, INBRED STRAINS;

EID: 84874611015     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.EJ12-0280     Document Type: Article

References (32)

1. Tomaszewska-Zaremba D, Herman A (2009) The role of immunological system in the regulation of gonadoliberin and gonadotropin secretion. Reprod Biol 9: 11-23.
2. Ojeda SR, Jameson HE, McCann SM (1977) Hypothalamic areas involved in prostaglandin (PG)-induced gonadotropin release. II: effect of PGE2 and PGF2alpha implants on follicle stimulating hormone release. Endocrinology 100: 1595-1603.
3. Ojeda SR, Jameson HE, McCann SM (1977) Hypothalamic areas involved in prostaglandin (PG)-induced gonadotropin release. I: effects of PGE2 and PGF2alpha implants on luteinizing hormone release. Endocrinology 100: 1585-1594.
4. Merchenthaler I, Gorcs T, Setalo G, Petrusz P, Flerko B (1984) Gonadotropin-releasing hormone (GnRH) neurons and pathways in the rat brain. Cell Tissue Res 237: 15-29.
5. Witkin JW, Paden CM, Silverman AJ (1982) The luteinizing hormone-releasing hormone (LHRH) systems in the rat brain. Neuroendocrinology 35: 429-438.
6. Jasoni CL, Todman MG, Han SK, Herbison AE (2005) Expression of mRNAs encoding receptors that mediate stress signals in gonadotropin-releasing hormone neurons of the mouse. Neuroendocrinology 82: 320-328.
7. Pimpinelli F, Rovati GE, Capra V, Piva F, Martini L, et al. (1999) Expression of prostacyclin receptors in luteinizing hormone-releasing hormone immortalized neurons: role in the control of hormone secretion. Endocrinology 140: 171-177.
8. Clasadonte J, Poulain P, Hanchate NK, Corfas G, Ojeda SR, et al. (2011) Prostaglandin E2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activation. Proc Natl Acad Sci U S A 108: 16104-16109.
9. Vane JR, Bakhle YS, Botting RM (1998) Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 38: 97-120.
10. Simmons DL, Botting RM, Hla T (2004) Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev 56: 387-437.
11. Brown CG, Poyser NL (1984) Studies on the control of prostaglandin production by the hypothalamus in relation to LH release in the rat. J Endocrinol 103: 155-164.
12. Conte D, Nordio M, Fillo S, De Giorgio G, Isidori A, et al. (1996) Aspirin inhibition of naloxone-induced luteinizing hormone secretion in man. J Clin Endocrinol Metab 81: 1772-1775.
13. Adachi S, Fujioka H, Kakehashi C, Matsuwaki T, Nishihara M, et al. (2009) Possible involvement of microglia containing cyclooxygenase-1 in the accumulation of gonadotrophin-releasing hormone in the preoptic area in female rats. J Neuroendocrinol 21: 1029-1037.
14. McCarthy MM (2010) How it's made: organisational effects of hormones on the developing brain. J Neuroendocrinol 22: 736-742.
15. Yermakova AV, Rollins J, Callahan LM, Rogers J, O'Banion MK (1999) Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. J Neuropathol Exp Neurol 58: 1135-1146.
16. Chopra B, Giblett S, Little JG, Donaldson LF, Tate S, et al. (2000) Cyclooxygenase-1 is a marker for a subpopulation of putative nociceptive neurons in rat dorsal root ganglia. Eur J Neurosci 12: 911-920.
17. Ju WK, Neufeld AH (2002) Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J Comp Neurol 452: 392-399.
18. Kroin JS, Takatori M, Li J, Chen EY, Buvanendran A, et al. (2008) Upregulation of dorsal horn microglial cyclooxygenase-1 and neuronal cyclooxygenase-2 after thoracic deep muscle incisions in the rat. Anesth Analg 106: 1288-1295.
19. Luo J, Lindstrom CL, Donahue A, Miller MW (2001) Differential effects of ethanol on the expression of cyclo-oxygenase in cultured cortical astrocytes and neurons. J Neurochem 76: 1354-1363.
20. He D, Sato I, Kimura F, Akema T (2003) Lipopolysaccharide inhibits luteinizing hormone release through interaction with opioid and excitatory amino acid inputs to gonadotropin-releasing hormone neurones in female rats: possible evidence for a common mechanism involved in infection and immobilization stress. J Neuroendocrinol 15: 559-563.
21. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Australia: Academic Press.
22. Park MK, Wakabayashi K (1986) Preparation of a monoclonal antibody to common amino acid sequence of LHRH and its application. Endocrinol Japon 33: 257-272.
23. Kettenmann H, Hanisch UK, Noda M, Verkhratsky A (2011) Physiology of microglia. Physiol Rev 91: 461-553.
24. Sierra A, Gottfried-Blackmore A, Milner TA, McEwen BS, Bulloch K (2008) Steroid hormone receptor expression and function in microglia. Glia 56: 659-674.
25. Tapia-Gonzalez S, Carrero P, Pernia O, Garcia-Segura LM, Diz-Chaves Y (2008) Selective oestrogen receptor (ER) modulators reduce microglia reactivity in vivo after peripheral inflammation: potential role of microglial ERs. J Endocrinol 198: 219-230.
26. Shapiro LA, Perez ZD, Foresti ML, Arisi GM, Ribak CE (2009) Morphological and ultrastructural features of Iba1-immunolabeled microglial cells in the hippocampal dentate gyrus. Brain Res 1266: 29-36.
27. Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308: 1314-1318.
28. Hanisch UK, Kettenmann H (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10: 1387-1394.
29. Wake H, Moorhouse AJ, Jinno S, Kohsaka S, Nabekura J (2009) Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci 29: 3974-3980.
30. Pocock JM, Kettenmann H (2007) Neurotransmitter receptors on microglia. Trends Neurosci 30: 527-535.
31. Kim SU, de Vellis J (2005) Microglia in health and disease. J Neurosci Res 81: 302-313.
32. Saura J (2007) Microglial cells in astroglial cultures: a cautionary note. J Neuroinflammation 4: 26.