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Volumn 78-79, Issue , 2013, Pages 19-26

Simultaneous quantitation of 3-n-butylphthalide (NBP) and its four major metabolites in human plasma by LC-MS/MS using deuterated internal standards

Author keywords

3 n Butylphthalide (NBP); Deuterated internal standard; LC MS MS; Negative positive ionization switching; Pharmacokinetics

Indexed keywords

10 HYDROXY 3 N BUTYLPHTHALIDE; 10 KETO 3 N BUTYLPHTHALIDE; 3 BUTYLPHTHALIDE; 3 HYDROXY 3 N BUTYLPHTHALIDE; 3 N BUTYLPHTHALIDE 11 OIC ACID; ACETONITRILE; AMMONIUM ACETATE; DRUG METABOLITE; METHANOL; UNCLASSIFIED DRUG;

EID: 84874541655     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.01.033     Document Type: Article
Times cited : (50)

References (27)
  • 1
    • 0042703392 scopus 로고    scopus 로고
    • Effects of dl-3-n-butylphthalide on regional cerebral blood flow in right middle cerebral artery occlusion rats
    • Yan C., Feng Y., Zhang J. Effects of dl-3-n-butylphthalide on regional cerebral blood flow in right middle cerebral artery occlusion rats. Acta Pharmacol. Sin. 1998, 19:117-120.
    • (1998) Acta Pharmacol. Sin. , vol.19 , pp. 117-120
    • Yan, C.1    Feng, Y.2    Zhang, J.3
  • 2
    • 0033007264 scopus 로고    scopus 로고
    • DL-3-n-butylphthalide improves regional cerebral blood flow after experimental subarachnoid hemorrhage in rats
    • Chong Z., Feng Y. DL-3-n-butylphthalide improves regional cerebral blood flow after experimental subarachnoid hemorrhage in rats. Acta Pharmacol. Sin. 1999, 20:509-512.
    • (1999) Acta Pharmacol. Sin. , vol.20 , pp. 509-512
    • Chong, Z.1    Feng, Y.2
  • 3
    • 40849139194 scopus 로고    scopus 로고
    • L-3-n-butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells
    • Peng Y., Xing C., Lemere C.A., Chen G., Wang L., Feng Y., Wang X. L-3-n-butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells. Neurosci. Lett. 2008, 434:224-229.
    • (2008) Neurosci. Lett. , vol.434 , pp. 224-229
    • Peng, Y.1    Xing, C.2    Lemere, C.A.3    Chen, G.4    Wang, L.5    Feng, Y.6    Wang, X.7
  • 4
    • 77953750340 scopus 로고    scopus 로고
    • L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease
    • Peng Y., Sun J., Hon S., Nylander A.N., Xia W., Feng Y., Wang X., Lemere C.A. L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease. J. Neurosci. 2010, 30:8180-8189.
    • (2010) J. Neurosci. , vol.30 , pp. 8180-8189
    • Peng, Y.1    Sun, J.2    Hon, S.3    Nylander, A.N.4    Xia, W.5    Feng, Y.6    Wang, X.7    Lemere, C.A.8
  • 5
    • 77957980902 scopus 로고    scopus 로고
    • DL-3-n-butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway
    • Li J., Li Y., Ogle M., Zhou X., Song M., Yu S.P., Wei L. DL-3-n-butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway. Brain Res. 2010, 1359:216-226.
    • (2010) Brain Res. , vol.1359 , pp. 216-226
    • Li, J.1    Li, Y.2    Ogle, M.3    Zhou, X.4    Song, M.5    Yu, S.P.6    Wei, L.7
  • 6
    • 84872712319 scopus 로고    scopus 로고
    • Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation
    • Diao X., Deng P., Xie C., Li X., Zhong D., Zhang Y., Chen X. Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation. Drug Metab. Dispos. 2013, 41:430-444.
    • (2013) Drug Metab. Dispos. , vol.41 , pp. 430-444
    • Diao, X.1    Deng, P.2    Xie, C.3    Li, X.4    Zhong, D.5    Zhang, Y.6    Chen, X.7
  • 7
    • 0141590346 scopus 로고    scopus 로고
    • Determination of 3-n-butylphthalide in rabbit plasma by HPLC with fluorescence detection and its application in pharmacokinetic study
    • Zhao C., He Z., Cui S., Zhang R. Determination of 3-n-butylphthalide in rabbit plasma by HPLC with fluorescence detection and its application in pharmacokinetic study. Biomed. Chromatogr. 2003, 17:391-395.
    • (2003) Biomed. Chromatogr. , vol.17 , pp. 391-395
    • Zhao, C.1    He, Z.2    Cui, S.3    Zhang, R.4
  • 8
    • 45849132386 scopus 로고    scopus 로고
    • High-performance liquid chromatography for the determination of 3-n-butylphthalide in rat plasma by tandem quadrupole mass spectrometry: application to a pharmacokinetic study
    • Niu Z.Q., Chen F.J., Sun J., Liu X.H., Wang Y.J., Chen D.W., He Z.G. High-performance liquid chromatography for the determination of 3-n-butylphthalide in rat plasma by tandem quadrupole mass spectrometry: application to a pharmacokinetic study. J. Chromatogr. B 2008, 870:135-139.
    • (2008) J. Chromatogr. B , vol.870 , pp. 135-139
    • Niu, Z.Q.1    Chen, F.J.2    Sun, J.3    Liu, X.H.4    Wang, Y.J.5    Chen, D.W.6    He, Z.G.7
  • 9
    • 84874508912 scopus 로고    scopus 로고
    • US Food and Drug Administration, Guidance for Industry Safety Testing of Drug Metabolites, (accessed on 5 April 2012).
    • US Food and Drug Administration, Guidance for Industry Safety Testing of Drug Metabolites, 2008 (accessed on 5 April 2012).
    • (2008)
  • 10
    • 24944563781 scopus 로고    scopus 로고
    • Seeing through the mist: abundance versus percentage. Commentary on metabolites in safety testing
    • Smith D.A., Obach R.S. Seeing through the mist: abundance versus percentage. Commentary on metabolites in safety testing. Drug Metab. Dispos. 2005, 33:1409-1417.
    • (2005) Drug Metab. Dispos. , vol.33 , pp. 1409-1417
    • Smith, D.A.1    Obach, R.S.2
  • 11
    • 79961183211 scopus 로고    scopus 로고
    • Identification of circulatory and excretory metabolites of a novel nitric oxide donor ZJM-289 in rat plasma, bile, urine and faeces by liquid chromatography-tandem mass spectrometry
    • Li N., Wang X.L., Li T.T., Ji H., Zhang Y.H., Qiu Z.X., Zhao D., Chen X.J. Identification of circulatory and excretory metabolites of a novel nitric oxide donor ZJM-289 in rat plasma, bile, urine and faeces by liquid chromatography-tandem mass spectrometry. Xenobiotica 2011, 41:805-817.
    • (2011) Xenobiotica , vol.41 , pp. 805-817
    • Li, N.1    Wang, X.L.2    Li, T.T.3    Ji, H.4    Zhang, Y.H.5    Qiu, Z.X.6    Zhao, D.7    Chen, X.J.8
  • 12
    • 33845761419 scopus 로고    scopus 로고
    • Does a stable isotopically labeled internal standard always correct analyte response? A matrix effect study on a LC/MS/MS method for the determination of carvedilol enantiomers in human plasma
    • Wang S., Cyronak M., Yang E. Does a stable isotopically labeled internal standard always correct analyte response? A matrix effect study on a LC/MS/MS method for the determination of carvedilol enantiomers in human plasma. J. Pharm. Biomed. Anal. 2007, 43:701-707.
    • (2007) J. Pharm. Biomed. Anal. , vol.43 , pp. 701-707
    • Wang, S.1    Cyronak, M.2    Yang, E.3
  • 13
    • 84861220823 scopus 로고    scopus 로고
    • Determination of total and unbound sufentanil in human plasma by ultrafiltration and LC-MS/MS: application to clinical pharmacokinetic study
    • Saari T.I., Fechner J., Ihmsen H., Schüttler J., Jeleazcov C. Determination of total and unbound sufentanil in human plasma by ultrafiltration and LC-MS/MS: application to clinical pharmacokinetic study. J. Pharm. Biomed. Anal. 2012, 66:306-313.
    • (2012) J. Pharm. Biomed. Anal. , vol.66 , pp. 306-313
    • Saari, T.I.1    Fechner, J.2    Ihmsen, H.3    Schüttler, J.4    Jeleazcov, C.5
  • 14
    • 80255141842 scopus 로고    scopus 로고
    • Development and validation of a method using supported liquid extraction for the simultaneous determination of midazolam and 1'-hydroxy-midazolam in human plasma by liquid chromatography with tandem mass spectrometry detection
    • Svanström C., Hansson G.P., Svensson L.D., Sennbro C.J. Development and validation of a method using supported liquid extraction for the simultaneous determination of midazolam and 1'-hydroxy-midazolam in human plasma by liquid chromatography with tandem mass spectrometry detection. J. Pharm. Biomed. Anal. 2012, 58:71-77.
    • (2012) J. Pharm. Biomed. Anal. , vol.58 , pp. 71-77
    • Svanström, C.1    Hansson, G.P.2    Svensson, L.D.3    Sennbro, C.J.4
  • 16
    • 57349116037 scopus 로고    scopus 로고
    • Cunninghamella - a microbial model for drug metabolism studies - a review
    • Asha S., Vidyavathi M. Cunninghamella - a microbial model for drug metabolism studies - a review. Biotechnol. Adv. 2009, 27:16-29.
    • (2009) Biotechnol. Adv. , vol.27 , pp. 16-29
    • Asha, S.1    Vidyavathi, M.2
  • 17
    • 79956118493 scopus 로고    scopus 로고
    • Identification of amiodarone metabolites in human bile by ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry
    • Deng P., You T., Chen X., Yuan T., Huang H., Zhong D. Identification of amiodarone metabolites in human bile by ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry. Drug Metab. Dispos. 2011, 39:1058-1069.
    • (2011) Drug Metab. Dispos. , vol.39 , pp. 1058-1069
    • Deng, P.1    You, T.2    Chen, X.3    Yuan, T.4    Huang, H.5    Zhong, D.6
  • 18
    • 84874530196 scopus 로고    scopus 로고
    • US Food and Drug Administration, Guidance for Industry: Bioanalytical Method Validation, (accessed on 5 April 2012).
    • US Food and Drug Administration, Guidance for Industry: Bioanalytical Method Validation, 2001 (accessed on 5 April 2012).
    • (2001)
  • 19
    • 0028302413 scopus 로고
    • Directed ortho metalations of tertiary benzamides using lactones as electrophiles
    • Brenstrum T.J., Brimble M.A., Stevenson R.J. Directed ortho metalations of tertiary benzamides using lactones as electrophiles. Tetrahedron 1994, 50:4897-4904.
    • (1994) Tetrahedron , vol.50 , pp. 4897-4904
    • Brenstrum, T.J.1    Brimble, M.A.2    Stevenson, R.J.3
  • 21
    • 34547874599 scopus 로고    scopus 로고
    • Synthesis, resolution, and antiplatelet activity of 3-substituted 1(3H)-isobenzofuranone
    • Yang H., Hu G.Y., Chen J., Wang Y., Wang Z.H. Synthesis, resolution, and antiplatelet activity of 3-substituted 1(3H)-isobenzofuranone. Bioorg. Med. Chem. Lett. 2007, 17:5210-5213.
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 5210-5213
    • Yang, H.1    Hu, G.Y.2    Chen, J.3    Wang, Y.4    Wang, Z.H.5
  • 22
    • 79960041093 scopus 로고    scopus 로고
    • Analytical strategy for the confirmatory analysis of the non-steroidal anti-inflammatory drugs firocoxib, propyphenazone, ramifenazone and piroxicam in bovine plasma by liquid chromatography tandem mass spectrometry
    • Dowling G., Malone E. Analytical strategy for the confirmatory analysis of the non-steroidal anti-inflammatory drugs firocoxib, propyphenazone, ramifenazone and piroxicam in bovine plasma by liquid chromatography tandem mass spectrometry. J. Pharm. Biomed. Anal. 2011, 56:359-365.
    • (2011) J. Pharm. Biomed. Anal. , vol.56 , pp. 359-365
    • Dowling, G.1    Malone, E.2
  • 24
    • 84856233287 scopus 로고    scopus 로고
    • Trimethylsilyldiazomethane derivatization coupled with solid-phase extraction for the determination of alendronate in human plasma by LC-MS/MS
    • Chen M.X., Liu K., Zhong D.F., Chen X.Y. Trimethylsilyldiazomethane derivatization coupled with solid-phase extraction for the determination of alendronate in human plasma by LC-MS/MS. Anal. Bioanal. Chem. 2012, 402:791-798.
    • (2012) Anal. Bioanal. Chem. , vol.402 , pp. 791-798
    • Chen, M.X.1    Liu, K.2    Zhong, D.F.3    Chen, X.Y.4
  • 25
    • 79956135195 scopus 로고    scopus 로고
    • Determination of methylphenidate and ritalinic acid in blood, plasma and oral fluid from adolescents and adults using protein precipitation and liquid chromatography tandem mass spectrometry - a method applied on clinical and forensic investigations
    • Josefsson M., Rydberg I. Determination of methylphenidate and ritalinic acid in blood, plasma and oral fluid from adolescents and adults using protein precipitation and liquid chromatography tandem mass spectrometry - a method applied on clinical and forensic investigations. J. Pharm. Biomed. Anal. 2011, 55:1050-1059.
    • (2011) J. Pharm. Biomed. Anal. , vol.55 , pp. 1050-1059
    • Josefsson, M.1    Rydberg, I.2
  • 27
    • 84860206221 scopus 로고    scopus 로고
    • Simultaneous determination of apatinib and its four major metabolites in human plasma using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study
    • Ding J., Chen X., Dai X., Zhong D. Simultaneous determination of apatinib and its four major metabolites in human plasma using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study. J. Chromatogr. B 2012, 895-896:108-115.
    • (2012) J. Chromatogr. B , pp. 108-115
    • Ding, J.1    Chen, X.2    Dai, X.3    Zhong, D.4


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