Development and validation of a method using supported liquid extraction for the simultaneous determination of midazolam and 1'-hydroxy-midazolam in human plasma by liquid chromatography with tandem mass spectrometry detection

Journal of Pharmaceutical and Biomedical Analysis

Volumn 58, Issue 1, 2012, Pages 71-77

  Svanström, Camilla ^a   Hansson, Gunnar P ^a   Svensson, Leif D ^a   Sennbro, Carl Johan ^a  

^a Active Biotech AB ^*  (Sweden)

Author keywords

1' Hydroxy midazolam; Bioanalysis; LC MS MS; Midazolam; Supported liquid extraction (96 well format)

Indexed keywords

1' HYDROXY MIDAZOLAM; ACETIC ACID ETHYL ESTER; DRUG METABOLITE; METHANOL; MIDAZOLAM; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; DRUG METABOLISM; DRUG STRUCTURE; HUMAN; ISOLATION PROCEDURE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; NORMAL HUMAN; POSITIVE ION ELECTROSPRAY; PRIORITY JOURNAL; REPRODUCIBILITY; SINGLE DRUG DOSE; SUPPORTED LIQUID EXTRACTION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

CALIBRATION; CHROMATOGRAPHY, LIQUID; HUMANS; LIQUID-LIQUID EXTRACTION; MIDAZOLAM; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 80255141842     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.09.015     Document Type: Article

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