Extracellular Signal-Regulated Kinase 1/2 Is Required for the Induction of Group I Metabotropic Glutamate Receptor-Mediated Epileptiform Discharges

Journal of Neuroscience

Volumn 24, Issue 1, 2004, Pages 76-84

  Zhao, Wangfa ^a   Bianchi, Riccardo ^a   Wang, Min ^a   Wong, Robert K S ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

DHPG; ERK1 2; Hippocampus; Metabotropic glutamate receptor; PKC; Tyrosine kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 5 METHOXY 1H INDOL 3 YL] 3 (1H INDOL 3 YL)MALEIMIDE; 3,5 DIHYDROXYPHENYLGLYCINE; 4 AMINO 5 (4 CHLOROPHENYL) 7 (TERT BUTYL)PYRAZOLO[3,4]PYRIMIDINE; CHELERYTHRINE; GENISTEIN; GLUTAMATE RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TETRODOTOXIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; ENZYME INHIBITION; EPILEPTIC DISCHARGE; GENE ACTIVATION; GENE EXPRESSION REGULATION; HIPPOCAMPUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN SYNTHESIS; RECEPTOR INTRINSIC ACTIVITY;

ACTION POTENTIALS; ANIMALS; CELLS, CULTURED; EPILEPSY; HIPPOCAMPUS; METHOXYHYDROXYPHENYLGLYCOL; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION;

EID: 0842344418     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4515-03.2004     Document Type: Article

References (51)

1. 2+ signal transduction. J Biol Chem 267:13361-13368.
2. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M, Fukami Y (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262:5592-5595.
3. Anwyl R (1999) Metabotropic glutamate receptors: electrophysiological properties and role in plasticity. Brain Res Brain Res Rev 29:83-120.
4. Bading H, Ginty DD, Greenberg ME (1993) Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science 260:181-186.
5. Bandrowski AE, Huguenard JR, Prince DA (2003) Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J Neurophysiol 89:1308-1316.
6. Berkeley JL, Levey AI (2003) Cell-specific extracellular signal-regulated kinase activation by multiple G protein-coupled receptor families in hippocampus. Mol Pharmacol 63:128-135.
7. Berkeley JL, Decker MJ, Levey AI (2002) The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures. J Neurochem 82:192-201.
8. Bortolotto ZA, Bashir ZI, Davies CH, Collingridge GL (1994) A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation. Nature 368:740-743.
9. Brown JH, Goldstein D (1986) Differences in muscarinic receptor reserve for inhibition of adenylate cyclase and stimulation of phosphoinositide hydrolysis in chick heart cells. Mol Pharmacol 30:566-570.
10. Chang L, Karin M (2001) Mammalian MAP kinase signalling cascades. Nature 410:37-40.
11. Chen X, Bianchi R, Wong RKS (1998) Involvement of protein kinase C in mGluR-mediated oscillatory activity in the guinea pig hippocampus. Soc Neurosci Abstr 24:1088.
12. Chuang SC, Bianchi R, Kim D, Shin H, Wong RKS (2001) Group I metabotropic glutamate receptors elicit epileptiform discharges in the hippocampus through PLCβ1 signaling. J Neurosci 21:6387-6394.
13. Cohen AS, Coussens CM, Raymond CR, Abraham WC (1999) Long-lasting increase in cellular excitability associated with the priming of LTP induction in rat hippocampus. J Neurophysiol 82:3139-3148.
14. English JD, Sweatt JD (1996) Activation of p42 mitogen-activated protein kinase in hippocampal long term potentiation. J Biol Chem 271:24329-24332.
15. Ferraguti F, Baldani-Guerra B, Corsi M, Nakanishi S, Corti C (1999) Activation of the extracellular signal-regulated kinase 2 by metabotropic glutamate receptors. Eur J Neurosci 11:2073-2082.
16. Garrido YC, Sanabria ER, Funke MG, Cavalheiro EA, Naffah-Mazzacoratti MG (1998) Mitogen-activated protein kinase is increased in the limbic structures of the rat brain during the early stages of status epilepticus. Brain Res Bull 47:223-229.
17. Gereau RW, Heinemann SF (1998) Role of protein kinase C phosphorylation in rapid desensitization of metabotropic glutamate receptor 5. Neuron 20:143-151.
18. Grewal SS, York RD, Stork PJ (1999) Extracellular-signal-regulated kinase signalling in neurons. Curr Opin Neurobiol 9:544-553.
19. Gschwendt M, Dieterich S, Rennecke J, Kittstein W, Mueller HJ, Johannes FJ (1996) Inhibition of protein kinase C mu by various inhibitors: differentiation from protein kinase C isoenzymes. FEBS Lett 392:77-80.
20. + current by metabotropic glutamate and muscarinic receptors in rat CA3 cells: mediation by G-proteins. J Physiol (Lond) 474:27-33.
21. Gutkind JS (2000) Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors. Sci STKE 2000:RE1.
22. Gutkind JS, Novotny EA, Brann MR, Robbins KC (1991) Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. Proc Natl Acad Sci USA 88:4703-4707.
23. Hamakawa T, Woodin MA, Bjorgum MC, Painter SD, Takasaki M, Lukowiak K, Nagle GT, Syed NI (1999) Excitatory synaptogenesis between identified Lymnaea neurons requires extrinsic trophic factors and is mediated by receptor tyrosine kinases. J Neurosci 19:9306-9312.
24. Hazzalin CA, Mahadevan LC (2002) MAPK-regulated transcription: a continuously variable gene switch? Nat Rev Mol Cell Biol 3:30-40.
25. Huber KM, Kayser MS, Bear MF (2000) Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression. Science 288:1254-1257.
26. Johnson GL, Vaillancourt RR (1994) Sequential protein kinase reactions controlling cell growth and differentiation. Curr Opin Cell Biol 6:230-238.
27. Lee AC, Wong RK, Chuang SC, Shin HS, Bianchi R (2002) Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices. J Neurophysiol 88:1625-1633.
28. Lin TA, Kong X, Haystead TA, Pause A, Belsham G, Sonenberg N, Lawrence JrJC (1994) PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science 266:653-656.
29. Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S (1991) Sequence and expression of a metabotropic glutamate receptor. Nature 349:760-765.
30. Merlin LR, Wong RK (1997) Role of group I metabo tropic glutamate receptors in the patterning of epileptiform activities in vitro. J Neurophysiol 78:539-544.
31. Merlin LR, Bergold PJ, Wong RK (1998) Requirement of protein synthesis for group I mGluR-mediated induction of epileptiform discharges. J Neurophysiol 80:989-993.
32. Mielke K, Brecht S, Dorst A, Herdegen T (1999) Activity and expression of JNK1, p38 and ERK kinases, c-Jun N-terminal phosphorylation, and c-jun promoter binding in the adult rat brain following kainate-induced seizures. Neuroscience 91:471-483.
33. Mochizuki N, Yamashita S, Kurokawa K, Ohba Y, Nagai T, Miyawaki A, Matsuda M (2001) Spatio-temporal images of growth-factor-induced activation of Ras and Rap1. Nature 411:1065-1068.
34. Morozov A, Muzzio IA, Bourtchouladze R, Van Strien N, Lapidus K, Yin D, Winder DG, Adams JP, Sweatt JD, Kandel ER (2003) Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory. Neuron 39:309-325.
35. Murray B, Alessandrini A, Cole AJ, Yee AG, Furshpan EJ (1998) Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity. Proc Natl Acad Sci USA 95:11975-11980.
36. Pearson G, Robinson F, Beers GT, Xu BE, Karandikar M, Berman K, Cobb MH (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22:153-183.
37. Peavy RD, Conn PJ (1998) Phosphorylation of mitogen-activated protein kinase in cultured rat cortical glia by stimulation of metabotropic glutamate receptors. J Neurochem 71:603-612.
38. Post GR, Brown JH (1996) G protein-coupled receptors and signaling pathways regulating growth responses. FASEB J 10:741-749.
39. Raymond CR, Thompson VL, Tate WP, Abraham WC (2000) Metabotropic glutamate receptors trigger homosynaptic protein synthesis to prolong long-term potentiation. J Neurosci 20:969-976.
40. Roberson ED, English JD, Adams JP, Selcher JC, Kondratick C, Sweatt JD (1999) The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus. J Neurosci 19:4337-4348.
41. Rosen LB, Ginty DD, Weber MJ, Greenberg ME (1994) Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. Neuron 12:1207-1221.
42. Sanna PP, Berton F, Cammalleri M, Tallent MK, Siggins GR, Bloom FE, Francesconi W (2000) A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus. Proc Natl Acad Sci USA 97:8653-8657.
43. Schmidt M, Goebeler M, Posern G, Feller SM, Seitz CS, Brocker EB, Rapp UR, Ludwig S (2000) Ras-independent activation of the Raf/MEK/ERK pathway upon calcium-induced differentiation of keratinocytes. J Biol Chem 275:41011-41017.
44. Taylor GW, Merlin LR, Wong RK (1995) Synchronized oscillations in hippocampal CA3 neurons induced by metabotropic glutamate receptor activation. J Neurosci 15:8039-8052.
45. Tian D, Litvak V, Lev S (2000) Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells. J Neurosci 20:6478-6487.
46. Watabe AM, Carlisle HJ, O'Dell TJ (2002) Postsynaptic induction and presynaptic expression of group 1 mGluR-dependent LTD in the hippocampal CA1 region. J Neurophysiol 87:1395-1403.
47. Weiler IJ, Greenough WT (1993) Metabotropic glutamate receptors trigger postsynaptic protein synthesis. Proc Natl Acad Sci USA 90:7168-7171.
48. Weiss FU, Daub H, Ullrich A (1997) Novel mechanisms of RTK signal generation. Curr Opin Genet Dev 7:80-86.
49. York RD, Yao H, Dillon T, Ellig CL, Eckert SP, McCleskey EW, Stork PJ (1998) Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392:622-626.
50. Young D, Waitches G, Birchmeier C, Fasano O, Wigler M (1986) Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell 45:711-719.
51. Zhao W, Wong RKS (2003) Pyk2/Src are involved in the induction of group I mGluR-mediated icta-like discharges in hippocampus. Soc Neurosci Abstr 29:574.3.