The impact of copy number deletions on general cognitive ability and ventricle size in patients with schizophrenia and healthy control subjects

Biological Psychiatry

Volumn 73, Issue 6, 2013, Pages 540-545

  Yeo, Ronald A ^a,c   Gangestad, Steven W ^a   Liu, Jingyu ^b,c   Ehrlich, Stefan ^f   Thoma, Robert J ^a,c   Pommy, Jessica ^a   Mayer, Andrew R ^a,c   Schulz, S Charles ^d   Wassink, Thomas H ^g   Morrow, Eric M ^h   Bustillo, Juan R ^a   Sponheim, Scott R ^d,e   Ho, Beng Choon ^g   Calhoun, Vince D ^b,c  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b University of New Mexico   (United States)

^c MIND RESEARCH NETWORK   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e Mental Health Patient Service Line   (United States)

^f UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^g UNIVERSITY OF IOWA   (United States)

^h BROWN UNIVERSITY   (United States)

Author keywords

Cognition; copy number variations; intelligence; mutations; schizophrenia; ventricles

Indexed keywords

ABNORMAL INVOLUNTARY MOVEMENT SCALE; ADULT; ARTICLE; ATTENTION; AUTOSOME; BASE PAIRING; BLOOD SAMPLING; BRAIN SIZE; BRAIN VENTRICLE SIZE; COGNITION; CONTROLLED STUDY; COPY NUMBER VARIATION; DISEASE DURATION; EXECUTIVE FUNCTION; FEMALE; GENE DELETION; GENE FREQUENCY; GENETIC VARIABILITY; GRAY MATTER; HUMAN; INTELLIGENCE; LATERAL BRAIN VENTRICLE; MAJOR CLINICAL STUDY; MALE; NEGATIVE SYNDROME; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; PHENOTYPE; PHENOTYPIC VARIATION; POSITIVE SYNDROME; PRIORITY JOURNAL; READING; SCHIZOPHRENIA; VERBAL COMMUNICATION; WHITE MATTER; WORKING MEMORY;

ADULT; ATROPHY; CASE-CONTROL STUDIES; COGNITION; DNA COPY NUMBER VARIATIONS; FEMALE; GENE DELETION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LATERAL VENTRICLES; MALE; NERVE FIBERS, MYELINATED; NERVE FIBERS, UNMYELINATED; NEUROIMAGING; NEUROPSYCHOLOGICAL TESTS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 84874540444     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2012.10.013     Document Type: Article

References (50)

1. I.J. Deary, W. Johnson, and L.M. Houlihan Genetic foundations of human intelligence Hum Genet 126 2009 215 232
2. P.M. Visscher, M.E. Goddard, E.M. Derks, and N.R. Wray Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses Mol Psychiatry 17 2012 474 485
3. International Schizophrenia Consortium, S.M. Purcell, N.R. Wray, J.L. Stone, P.M. Visscher, and M.C. O'Donovan Common polygenic variation contributes to risk of schizophrenia and bipolar disorder Nature 460 2009 748 752
4. G. Davies, A. Tenesa, A. Payton, J. Yang, S.E. Harris, and D. Liewald Genome-wide association studies establish that human intelligence is highly heritable and polygenic Mol Psychiatry 16 2011 996 1005
5. K.J. Mitchell, and D.J. Porteous Rethinking the genetic architecture of schizophrenia Psychol Med 41 2011 19 32
6. D. Wahlsten The hunt for gene effects pertinent to behavioral traits and psychiatric disorders: From mouse to human Dev Psychobiol 54 2012 475 492
7. T.A. Manolio, F.S. Collins, N.J. Cox, D.B. Goldstein, L.A. Hindorff, and D.J. Hunter Finding the missing heritability of complex diseases Nature 461 2009 747 753
8. J.L. Stone, M.C. O'Donovan, H. Gurling, G.K. Kirov, D.H.R. Blackwood, and A. Corvin Rare chromosomal deletions and duplications increase risk of schizophrenia Nature 455 2008 237 241
9. J. Sebat, B. Lakshmi, D. Malhotra, J. Troge, C. Lese-Martin, and T. Walsh Strong association of de novo copy number mutations with autism Science 316 2007 445 449
10. H.C. Mefford, H. Muhle, P. Ostertag, S. von Spiczak, K. Buysse, and C. Baker Genome-wide copy number variation in epilepsy: Novel susceptibility loci in idiopathic generalized and focal epilepsies Plos Genetics 6 2010 e1000962
11. N.M. Williams, I. Zaharieva, A. Martin, K. Langley, K. Mantripragada, and R. Fossdal Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: A genome-wide analysis Lancet 376 2010 1401 1416
12. J.S. Beckmann, X. Estivill, and S.E. Antonarakis Copy number variants and genetic traits: Closer to the resolution of phenotypic to genotypic variability Nat Rev Genet 8 2007 639 646
13. A. Itsara, G.M. Cooper, C. Baker, S. Girirajan, J. Li, and D. Absher Population analysis of large copy number variants and hotspots of human genetic disease Am J Hum Genet 84 2009 148 161
14. F. Zhang, W.L. Gu, M.E. Hurles, and J.R. Lupski Copy number variation in human health, disease, and evolution Annu Rev Genomics Hum Genet 10 2009 451 481
15. I.J. Deary Intelligence Annu Rev Psychol 63 2011 453 482
16. R.A. Yeo, S.W. Gangestad, J. Liu, V.D. Calhoun, and K.E. Hutchison Rare copy number deletions predict individual variation in intelligence PLoS One 6 2011 e16339
17. A.P. Moller Developmental instability and sexual selection in stag beetles from Chernobyl and a control area Ethology 108 2002 193 204
18. V. Debat, A. Debelle, and I. Dworkin Plasticity, canalization, and developmental stability of the drosophila wing: Joint effects of mutations and developmental temperature Evolution 63 2009 2864 2876
19. A.J.R. Carter, T.M. Weier, and D. Houle The effect of inbreeding on fluctuating asymmetry of wing veins in two laboratory strains of Drosophila melanogaster Heredity 102 2009 563 572
20. S. Van Dongen, and S.W. Gangestad Human fluctuating asymmetry in relation to health and quality: A meta-analysis Evol Hum Behav 32 2011 380 398
21. K.J. Mitchell What is complex about complex disorders? Genome Biol 13 2012 237
22. S. Girirajan, Z. Brkanac, B.P. Coe, C. Baker, L. Vives, and T.H. Vu Relative burden of large CNVs on a range of neurodevelopmental phenotypes PloS Genet 7 2011 e1002334
23. W. Johnson Understanding the genetics of intelligence: Can height help? Can corn oil? Curr Dir Psychol Sci 19 2010 177 182
24. T. White, V.A. Magnotta, H.J. Bockholt, S. Williams, S. Wallace, and S. Ehrlich Global white matter abnormalities in schizophrenia: A multisite diffusion tensor imaging study Schizophr Bull 37 2011 222 232
25. M. First, R.L. Spitzer, M. Gibbon, and Williams Structured Clinical Interview for DSM-IV-TR Axis I Disorders 1997 American Psychiatric Press Washington, DC
26. N.C. Andreasen, M. Flaum, and S. Arndt The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology Arch Gen Psychiatry 49 1992 615 623
27. N.C. Andreasen The Scale for the Assessment of Positive Symptoms 1984 The University of Iowa Iowa City
28. N.C. Andreasen The Scale for the Assessment of Positive Symptoms 1983 University of Iowa Iowa City
29. Chen J, Liu J, Calhoun VD (2010): Correction of copy number variation data using principal component analysis. Conf Proc IEEE BIBMW. 2010:827-828.
30. J. Chen, J. Liu, and V.D. Calhoun A pipeline for copy number variation detection based on principal components analysis Conf Proc IEEE Eng Med Biol Soc 2011 2011 6975 6978
31. A.C. Need, D.L. Ge, M.E. Weale, J. Maia, S. Feng, and E.L. Heinzen A genome-wide investigation of SNPs and CNVs in schizophrenia PloS Genetics 5 2009 e1000373
32. S. Ehrlich, S. Brauns, A. Yendiki, B.C. Ho, V. Calhoun, and S.C. Schulz Associations of cortical thickness and cognition in patients with schizophrenia and healthy controls Schizophr Bull 38 2012 1050 1062
33. M.D. Prokosch, R.A. Yeo, and G.F. Miller Intelligence tests with higher g-loadings show higher correlations with body symmetry: Evidence for a general fitness factor mediated by developmental stability Intelligence 33 2005 203 213
34. M. Euler, R.J. Thoma, S.W. Gangestad, J.M. Canive, and R.A. Yeo The impact of developmental instability on voxel-based morphometry analyses of neuroanatomical abnormalities in schizophrenia Schizophr Res 115 2009 1 7
35. T.F. McNeil, E. Cantor-Graae, and D.R. Weinberger Relationship of obstetric complications and differences in size of brain structures in monozygotic twin pairs discordant for schizophrenia Am J Psychiatry 157 2000 203 212
36. K.A. Welch, A.M. McIntosh, D.E. Job, H.C. Whalley, T.W. Moorhead, and J. Hall The impact of substance use on brain structure in people at high risk of developing schizophrenia Schizophr Bull 37 2011 1066 1076
37. P. Habets, M. Marcelis, E. Gronenschild, M. Drukker, J. van Os, and Genetic Risk and Outcome of Psychosis (G.R.O.U.P) Reduced cortical thickness as an outcome of differential sensitivity to environmental risks in schizophrenia Biol Psychiatry 69 2011 487 494
38. P. Batel Addiction and schizophrenia Eur Psychiatry 15 2000 115 122
39. Y.J. Leung, S. Sannesy, M.J. Lyons, and M.T. Tsuang Familial vulnerability to schizophrenia increases the risk of substance use: A twin study Am J Med Genet B 130B 2004 133-133
40. R.J. Thoma, R.A. Yeo, S.W. Gangestad, E. Halgren, N.M. Sanchez, and J.D. Lewine Cortical volume and developmental instability are independent predictors of general intellectual ability Intelligence 33 2005 27 38
41. M.C. Chiang, M. Barysheva, D.W. Shattuck, A.D. Lee, S.K. Madsen, and C. Avedissian Genetics of brain fiber architecture and intellectual performance J Neurosci 29 2009 2212 2224
42. M.P. van den Heuvel, C.J. Stam, R.S. Kahn, and H.E.H. Pol Efficiency of functional brain networks and intellectual performance J Neurosci 29 2009 7619 7624
43. R.G.H. Brans, R.S. Kahn, H.G. Schnack, G.C.M. van Baal, D. Posthuma, and N.E.M. van Haren Brain plasticity and intellectual ability are influenced by shared genes J Neurosci 30 2010 5519 5524
44. S. Peng, Y. Zhang, J.N. Zhang, H. Wang, and B.X. Ren Glutamate receptors and signal transduction in learning and memory Mol Biol Rep 38 2011 453 460
45. R.A. Yeo, S.W. Gangestad, C. Gasparovic, J. Liu, V.D. Calhoun, and R.J. Thoma Rare copy number deletions predict individual variation in human brain neurometabolite concentrations in individuals with alcohol use disorders Biol Psychiatry 70 2011 537 544
46. F.V. Rijsdijk, I.I. Gottesman, P. McGuffin, and A.G. Cardno Heritability estimates for psychotic symptom dimensions in twins with psychotic disorders Am J Med Genet B Neuropsychiatr Genet 156B 2011 89 98
47. V. Bansal, O. Libiger, A. Torkamani, and N.J. Schork Statistical analysis strategies for association studies involving rare variants Nat Rev Genet 11 2010 773 785
48. J.E. Eckel-Passow, E.J. Atkinson, S. Maharjan, S.L.R. Kardia, and M. de Andrade Software comparison for evaluating genomic copy number variation for Affymetrix 6.0 SNP array platform BMC Bioinformatics 12 2011 220
49. M.T. Maurano, R. Humbert, E. Rynes, R.E. Thurman, E. Haugen, and H. Wang Systematic localization of common disease-associated variation in regulatory DNA Science 337 2012 1190 1195
50. Gangestad S.W., Yeo R.A., Liu J (2011): Rare deletions predict general cognitive ability, brain neurometabolite concentrations, and schizophrenia phenotype. Paper presented at: Annual meeting of the Human Behavior and Evolution Society; Montpellier, France.